| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| López-López A et al. | Fatty acid and sn-2 fatty acid composition in human milk from Granada (Spain) and in infant formulas. | 2002 | Eur J Clin Nutr | pmid:12494309 |
| Hou WC et al. | Yam (Dioscorea batatas) tuber mucilage exhibited antioxidant activities in vitro. | 2002 | Planta Med. | pmid:12494332 |
| Su BN et al. | Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. | 2002 | Planta Med. | pmid:12494342 |
| Briscoe CP et al. | The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. | 2003 | J. Biol. Chem. | pmid:12496284 |
| Ishiguro K et al. | Effects of conjugated linoleic acid on anaphylaxis and allergic pruritus. | 2002 | Biol. Pharm. Bull. | pmid:12499660 |
| Fukuda S et al. | Production of conjugated linoleic acid by intestinal bacteria in dogs and cats. | 2002 | J. Vet. Med. Sci. | pmid:12499682 |
| de Kok TM et al. | Analysis of oxidative DNA damage after human dietary supplementation with linoleic acid. | 2003 | Food Chem. Toxicol. | pmid:12504167 |
| Kanicky JR and Shah DO | Effect of degree, type, and position of unsaturation on the pKa of long-chain fatty acids. | 2002 | J Colloid Interface Sci | pmid:12505514 |
| Yamasaki M et al. | Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets. | 2003 | Nutrition | pmid:12507636 |
| Chen BQ et al. | Inhibition of conjugated linoleic acid on mouse forestomach neoplasia induced by benzo (a) pyrene and chemopreventive mechanisms. | 2003 | World J. Gastroenterol. | pmid:12508349 |
| Belury MA et al. | The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. | 2003 | J. Nutr. | pmid:12514304 |
| Vaughan JE and Walsh SW | Oxidative stress reproduces placental abnormalities of preeclampsia. | 2002 | Hypertens Pregnancy | pmid:12517328 |
| Rodriguez M et al. | Plasma fatty acids and [13C]linoleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides. | 2003 | J. Lipid Res. | pmid:12518021 |
| Cohen LA et al. | Effect of soy protein isolate and conjugated linoleic acid on the growth of Dunning R-3327-AT-1 rat prostate tumors. | 2003 | Prostate | pmid:12518321 |
| Hubbard NE et al. | Effect of separate conjugated linoleic acid isomers on murine mammary tumorigenesis. | 2003 | Cancer Lett. | pmid:12536072 |
| Pasqualini ME et al. | Association between E-cadherin expression by human colon, bladder and breast cancer cells and the 13-HODE:15-HETE ratio. A possible role of their metastatic potential. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538085 |
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| Vos E and Cunnane SC | Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality. | 2003 | Am. J. Clin. Nutr. | pmid:12540417 |
| Martin SA and Jenkins TC | Factors affecting conjugated linoleic acid and trans-C18:1 fatty acid production by mixed ruminal bacteria. | 2002 | J. Anim. Sci. | pmid:12542176 |
| Duckett SK et al. | Effect of high-oil corn or added corn oil on ruminal biohydrogenation of fatty acids and conjugated linoleic acid formation in beef steers fed finishing diets. | 2002 | J. Anim. Sci. | pmid:12542177 |
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| Gorard DA | Enteral nutrition in Crohn's disease: fat in the formula. | 2003 | Eur J Gastroenterol Hepatol | pmid:12560753 |
| Valianpour F et al. | Linoleic acid supplementation of Barth syndrome fibroblasts restores cardiolipin levels: implications for treatment. | 2003 | J. Lipid Res. | pmid:12562862 |
| Lee JY et al. | Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. | 2003 | J. Lipid Res. | pmid:12562875 |
| Kotarsky K et al. | A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565875 |
| Ascherio A | Epidemiologic studies on dietary fats and coronary heart disease. | 2002 | Am. J. Med. | pmid:12566133 |
| Sher J et al. | Dietary conjugated linoleic acid lowers plasma cholesterol during cholesterol supplementation, but accentuates the atherogenic lipid profile during the acute phase response in hamsters. | 2003 | J. Nutr. | pmid:12566483 |
| Rollin X et al. | The effects of dietary lipid and strain difference on polyunsaturated fatty acid composition and conversion in anadromous and landlocked salmon (Salmo salar L.) parr. | 2003 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:12568812 |
| Cho HJ et al. | Conjugated linoleic acid inhibits cell proliferation and ErbB3 signaling in HT-29 human colon cell line. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12571082 |
| Ostrowska E et al. | Conjugated linoleic acid decreases fat accretion in pigs: evaluation by dual-energy X-ray absorptiometry. | 2003 | Br. J. Nutr. | pmid:12575906 |
| Hellemans K et al. | PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation. | 2003 | J. Lipid Res. | pmid:12576510 |
| Bazinet RP et al. | Whole-body beta-oxidation of 18:2omega6 and 18:3omega3 in the pig varies markedly with weaning strategy and dietary 18:3omega3. | 2003 | J. Lipid Res. | pmid:12576513 |
| Badinga L et al. | Dietary conjugated linoleic acid alters hepatic lipid content and fatty acid composition in broiler chickens. | 2003 | Poult. Sci. | pmid:12580252 |
| Liang CF et al. | Effects of epidermal growth factor and linoleic acid on lipid contents in human intestinal C2BBe1 cells. | 2002 | IUBMB Life | pmid:12587978 |
| Tsydendambaev VD and Vereshchagin AG | Changes in triacylglycerol composition during ripening of sea buckthorn (Hippophaë rhamnoides L.) seeds. | 2003 | J. Agric. Food Chem. | pmid:12590468 |
| Barabino S et al. | Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. | 2003 | Cornea | pmid:12605039 |
| Xu X et al. | Short-term intake of conjugated linoleic acid inhibits lipoprotein lipase and glucose metabolism but does not enhance lipolysis in mouse adipose tissue. | 2003 | J. Nutr. | pmid:12612134 |
| Yamasaki M et al. | Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid. | 2003 | J. Nutr. | pmid:12612153 |
| Arab L | Biomarkers of fat and fatty acid intake. | 2003 | J. Nutr. | pmid:12612178 |
| Campbell W et al. | The impact of fortification with conjugated linoleic acid (CLA) on the quality of fluid milk. | 2003 | J. Dairy Sci. | pmid:12613847 |
| Gonzalez S et al. | Oxidation and textural characteristics of butter and ice cream with modified fatty acid profiles. | 2003 | J. Dairy Sci. | pmid:12613850 |
| Cui YF et al. | Effect of unsaturated fatty acid on muscarinic current in guinea pig gastric antral circular myocytes. | 2003 | Acta Pharmacol. Sin. | pmid:12617780 |
| Waddington EI et al. | Fatty acid oxidation products in human atherosclerotic plaque: an analysis of clinical and histopathological correlates. | 2003 | Atherosclerosis | pmid:12618275 |
| Henriksen EJ et al. | Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12618357 |
| Koba K et al. | Effect of phytate in soy protein on the serum and liver cholesterol levels and liver fatty acid profile in rats. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12619668 |
| Kishino S et al. | Structural analysis of conjugated linoleic acid produced by Lactobacillus plantarum, and factors affecting isomer production. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12619692 |
| Bergman M et al. | Scavenging of reactive oxygen species by a novel glucurinated flavonoid antioxidant isolated and purified from spinach. | 2003 | Phytochemistry | pmid:12620328 |
| Yang H et al. | Conjugated linoleic acid inhibits mutagenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the prostate of Big Blue rats. | 2003 | Mutagenesis | pmid:12621076 |
| Adam O et al. | Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers. | 2003 | Ann. Nutr. Metab. | pmid:12624485 |
| Fernández-Moya V et al. | Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds. | 2003 | Planta | pmid:12624771 |
| Enoki M et al. | Oxidative degradation of cis- and trans-1,4-polyisoprenes and vulcanized natural rubber with enzyme-mediator systems. | 2003 Mar-Apr | Biomacromolecules | pmid:12625726 |
| Bauman DE and Griinari JM | Nutritional regulation of milk fat synthesis. | 2003 | Annu. Rev. Nutr. | pmid:12626693 |
| Park KY et al. | Antimutagenic effects of doenjang (Korean fermented soypaste) and its active compounds. | 2003 Feb-Mar | Mutat. Res. | pmid:12628502 |
| Itoh Y et al. | Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. | 2003 | Nature | pmid:12629551 |
| Turgeon D et al. | Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases. | 2003 | J. Lipid Res. | pmid:12639971 |
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| Mackle TR et al. | Effects of abomasal infusion of conjugated linoleic acid on milk fat concentration and yield from pasture-fed dairy cows. | 2003 | J. Dairy Sci. | pmid:12647970 |
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| Eitel K et al. | Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. | 2003 | Diabetes | pmid:12663471 |
| Mitchell LA et al. | Linoleic acid metabolites act to increase contractility in isolated rat heart. | 2002 | Cardiovasc. Toxicol. | pmid:12665667 |
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| Qian SY et al. | Identification of all classes of spin-trapped carbon-centered radicals in soybean lipoxygenase-dependent lipid peroxidations of omega-6 polyunsaturated fatty acids via LC/ESR, LC/MS, and tandem MS. | 2003 | Free Radic. Biol. Med. | pmid:12684086 |
| Nakanishi T et al. | Dietary conjugated linoleic acid reduces cerebral prostaglandin E(2) in mice. | 2003 | Neurosci. Lett. | pmid:12686384 |
| Bruder ED et al. | An oxidized metabolite of linoleic acid stimulates corticosterone production by rat adrenal cells. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12689852 |
| Itakura K and Uchida K | Lysine-derived fluorophores formed by autoxidation of linoleic acid. | 2003 | Chem. Phys. Lipids | pmid:12691851 |
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| Ma DW et al. | An enriched mixture of trans-10,cis-12-CLA inhibits linoleic acid metabolism and PGE2 synthesis in MDA-MB-231 cells. | 2002 | Nutr Cancer | pmid:12734056 |
| Wiesenfeld PW et al. | Flaxseed increased alpha-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring. | 2003 | Food Chem. Toxicol. | pmid:12738189 |
| Babu US et al. | Impact of high flaxseed diet on mitogen-induced proliferation, IL-2 production, cell subsets and fatty acid composition of spleen cells from pregnant and F1 generation Sprague-Dawley rats. | 2003 | Food Chem. Toxicol. | pmid:12738196 |
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| Rotta AT et al. | Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems. | 2003 | Pediatr Crit Care Med | pmid:12749658 |
| Buckner JS and Hagen MM | Triacylglycerol and phospholipid fatty acids of the silverleaf whitefly: composition and biosynthesis. | 2003 | Arch. Insect Biochem. Physiol. | pmid:12761874 |
| Aletor VA et al. | The effects of conjugated linoleic acids or an alpha-glucosidase inhibitor on tissue lipid concentrations and fatty acid composition of broiler chicks fed a low-protein diet. | 2003 | Poult. Sci. | pmid:12762403 |
| Macrì A et al. | Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy. | 2003 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:12768289 |
| Ward AT et al. | Fresh forage and solin supplementation on conjugated linoleic acid levels in plasma and milk. | 2003 | J. Dairy Sci. | pmid:12778585 |
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