Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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O'Brien PM et al. | The effect of dietary supplementation with linoleic and gammalinolenic acids on the pressor response to angiotensin II--a possible role in pregnancy-induced hypertension? | 1985 | Br J Clin Pharmacol | pmid:2985102 |
Salafsky B and Fusco AC | Schistosoma mansoni: cercarial eicosanoid production and penetration response inhibited by esculetin and ibuprofen. | 1985 | Exp. Parasitol. | pmid:2990990 |
Eren R and Duksin D | Inhibition of the formation of lipid-linked intermediates in normal and transformed cells by a purified tunicamycin homologue. | 1985 | Mol. Cell. Biochem. | pmid:2991743 |
Kharasch ED and Novak RF | Mitoxantrone and ametantrone inhibit hydroperoxide-dependent initiation and propagation reactions in fatty acid peroxidation. | 1985 | J. Biol. Chem. | pmid:2993283 |
Claeys M et al. | Metabolic profile of linoleic acid in porcine leukocytes through the lipoxygenase pathway. | 1985 | Biochim. Biophys. Acta | pmid:2996610 |
Hansen HS and Jensen B | Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate. | 1985 | Biochim. Biophys. Acta | pmid:3922424 |
Nugteren DH et al. | Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat. | 1985 | Biochim. Biophys. Acta | pmid:3922425 |
Margetts BM et al. | Blood pressure and dietary polyunsaturated and saturated fats: a controlled trial. | 1985 | Clin. Sci. | pmid:3905211 |
Allen RE et al. | A serum-free medium that supports the growth of cultured skeletal muscle satellite cells. | 1985 | In Vitro Cell. Dev. Biol. | pmid:3905759 |
Carroll KK | Dietary fat in relation to mammary carcinogenesis. | 1985 | Int. Symp. Princess Takamatsu Cancer Res. Fund | pmid:3916197 |
Ip C et al. | Requirement of essential fatty acid for mammary tumorigenesis in the rat. | 1985 | Cancer Res. | pmid:3921234 |
Stumpf DA | The inherited ataxias. | 1985 | Neurol Clin | pmid:3921817 |
Lankin VZ et al. | On the nature of the stimulation of the lipoxygenase from rabbit reticulocytes by biological membranes. | 1985 | Biomed. Biochim. Acta | pmid:3933493 |
Yoshikawa H et al. | Potentiation of antitumor effect of bleomycin by lipid-surfactant mixed micelles. I. In vivo and tumor-neutralizing activity against mouse Ehrlich ascites tumor and rat ascites hepatoma AH66. | 1985 | J. Pharmacobio-dyn. | pmid:2411907 |
Wolff JA et al. | The role of lipid in the management of methylmalonic acidaemia: administration of linoleic acid does not increase excretion of methylmalonic acid. | 1985 | J. Inherit. Metab. Dis. | pmid:3939583 |
Jäntti J et al. | Linoleic acid treatment in inflammatory arthritis. | 1985 | Int J Clin Pharmacol Ther Toxicol | pmid:3886567 |
Calderbank J et al. | Plasma-membrane phospholipid unsaturation affects expression of the general amino-acid permease in Saccharomyces cerevisiae Y185. | 1985 | J. Gen. Microbiol. | pmid:3886834 |
Allen RE et al. | Effect of insulin and linoleic acid on satellite cell differentiation. | 1985 | J. Anim. Sci. | pmid:3894312 |
McMaster JD et al. | Incorporation in vitro of 14C fatty acids into bovine sebaceous gland and dermal lipids. | 1985 | Res. Vet. Sci. | pmid:4012036 |
Howard-Williams J et al. | Polyunsaturated fatty acids and diabetic retinopathy. | 1985 | Br J Ophthalmol | pmid:3965024 |
Montalto MB et al. | Nutrient intakes of formula-fed infants and infants fed cow's milk. | 1985 | Pediatrics | pmid:3969338 |
Reid JC and Husbands DR | Oxidative metabolism of long-chain fatty acids in mitochondria from sheep and rat liver. Evidence that sheep conserve linoleate by limiting its oxidation. | 1985 | Biochem. J. | pmid:3977825 |
Vergroesen AJ | Effects of dietary lipid composition on serum lipoproteins. | 1985 | Prog. Clin. Biol. Res. | pmid:3903769 |
Noble RC et al. | Synthesis of C20 and C22 polyunsaturated fatty acids by the placenta of the sheep. | 1985 | Biol. Neonate | pmid:4027296 |
Goldstein R et al. | Increased maternal-fetal transport of fat in diabetes assessed by polyunsaturated fatty acid content in fetal lipids. | 1985 | Biol. Neonate | pmid:4027297 |
Jett M et al. | Metabolic fate of liposomal phosphatidylinositol in murine tumor cells: implications for the mechanism of tumor cell cytotoxicity. | 1985 | Cancer Res. | pmid:4027970 |
Takada K et al. | Promotion of the selective lymphatic delivery of cyclosporin A by lipid-surfactant mixed micelles. | 1985 | J. Pharmacobio-dyn. | pmid:4032221 |
Kanazawa K et al. | Uptake of secondary autoxidation products of linoleic acid by the rat. | 1985 | Lipids | pmid:4033361 |
Martinez GA et al. | Nutrient intakes of American infants and children fed cow's milk or infant formula. | 1985 | Am. J. Dis. Child. | pmid:4036886 |
Roshanai F and Sanders TA | Influence of different supplements of N-3 polyunsaturated fatty acids on blood and tissue lipids in rats receiving high intakes of linoleic acid. | 1985 | Ann. Nutr. Metab. | pmid:4037727 |
Becker W and MÃ¥nsson JE | Incorporation of 14C into tissue lipids after oral administration of [1-14C]linoleic acid in rats fed different levels of essential fatty acids. | 1985 | J. Nutr. | pmid:4045568 |
Chirkov VA et al. | [Correction of intracellular metabolism in acute pneumonia in young children]. | 1985 | Pediatriia | pmid:4047863 |
Kher V et al. | Effects of dietary linoleic acid enrichment on induction of immune complex nephritis in mice. | 1985 | Nephron | pmid:3156280 |
Wertz PW et al. | The composition of the ceramides from human stratum corneum and from comedones. | 1985 | J. Invest. Dermatol. | pmid:3158712 |
Nordøy A et al. | Effect of dietary (n--3) fatty acids on platelet function and lipid metabolism in rats. | 1985 | Biochim. Biophys. Acta | pmid:2861854 |
Moilanen T et al. | Atherosclerosis precursors in Finnish children and adolescents. V. Fatty acid composition of serum cholesteryl esters: regional differences in Finland. | 1985 | Acta Paediatr Scand Suppl | pmid:3867222 |
Fusco AC et al. | Schistosoma mansoni: eicosanoid production by cercariae. | 1985 | Exp. Parasitol. | pmid:3917929 |
Farrell PM et al. | Fatty acid abnormalities in cystic fibrosis. | 1985 | Pediatr. Res. | pmid:3918287 |
Smith MT and Thompson S | Free radicals and alcoholics. | 1985 | Lancet | pmid:2864501 |
Ohsugi M et al. | Biosynthesis of biotin-vitamers from unsaturated higher fatty acids by bacteria. | 1985 | J. Nutr. Sci. Vitaminol. | pmid:2866239 |
Boberg M et al. | Platelet fatty acid composition in relation to fatty acid composition in plasma and to serum lipoprotein lipids in healthy subjects with special reference to the linoleic acid pathway. | 1985 | Clin. Sci. | pmid:3919990 |
Poisson JP | Comparative in vivo and in vitro study of the influence of experimental diabetes on rat liver linoleic acid delta 6- and delta 5-desaturation. | 1985 | Enzyme | pmid:3002783 |
Banerjee N and Rosenthal MD | High-affinity incorporation of 20-carbon polyunsaturated fatty acids by human skin fibroblasts. | 1985 | Biochim. Biophys. Acta | pmid:2990563 |
Burton AF and Anderson FH | Increased cholesteryl ester content in liver of mice fed lipid emulsion diets high in polyunsaturated fats. | 1985 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:3839859 |
Andersen GE et al. | Fatty acid changes in plasma lipids and lymphocyte phospholipids after infusion of intralipid to newborn infants. | 1985 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:3934403 |
Geer BW et al. | The effect of dietary ethanol on the composition of lipids of Drosophila melanogaster larvae. | 1986 | Biochem. Genet. | pmid:2938574 |
Boberg M et al. | High content of dietary linoleic acid does not reduce platelet reactivity in patients with hyperlipoproteinaemia. | 1986 | Eur. J. Clin. Invest. | pmid:2938965 |
Orchard S et al. | Poison ivy/oak dermatitis. Use of polyamine salts of a linoleic acid dimer for topical prophylaxis. | 1986 | Arch Dermatol | pmid:2942115 |
May V and Eipper BA | Long term culture of primary rat pituitary adrenocorticotropin/endorphin-producing cells in serum-free medium. | 1986 | Endocrinology | pmid:3004908 |
Kühn H et al. | The stoichiometry of oxygen uptake and conjugated diene formation during the dioxygenation of linoleic acid by the pure reticulocyte lipoxygenase. Evidence for aerobic hydroperoxidase activity. | 1986 | Biochim. Biophys. Acta | pmid:3006782 |
Murphy MG | Studies of the regulation of basal adenylate cyclase activity by membrane polyunsaturated fatty acids in cultured neuroblastoma. | 1986 | J. Neurochem. | pmid:3011993 |
Skogh M | Atopic eczema unresponsive to evening primrose oil (linoleic and gamma-linolenic acids) | 1986 | J. Am. Acad. Dermatol. | pmid:3013957 |
Kher V et al. | Protective effect of polyunsaturated fatty acid supplementation in apoferritin induced murine glomerulonephritis. | 1986 | Prostaglandins Leukot Med | pmid:3014561 |
Alexander JW et al. | The importance of lipid type in the diet after burn injury. | 1986 | Ann. Surg. | pmid:3015058 |
Yamamoto T et al. | Purification of the two forms of the high-molecular-weight neutral proteinase ingensin from rat liver. | 1986 | Biochim. Biophys. Acta | pmid:3015226 |
Kelly RA et al. | Identification of NaK-ATPase inhibitors in human plasma as nonesterified fatty acids and lysophospholipids. | 1986 | J. Biol. Chem. | pmid:3017943 |
Kääpä P et al. | Dietary fatty acids and platelet thromboxane production in puerperal women and their offspring. | 1986 | Am. J. Obstet. Gynecol. | pmid:3089014 |
Maddaiah VT and Clejan S | Growth hormone and liver mitochondria: time course of effects on respiration and fatty acid composition in hypophysectomized rats. | 1986 | Endocrinology | pmid:2941269 |
Connor HD et al. | A search for oxygen-centered free radicals in the lipoxygenase/linoleic acid system. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3026385 |
Stymne S and Stobart AK | Biosynthesis of gamma-linolenic acid in cotyledons and microsomal preparations of the developing seeds of common borage (Borago officinalis). | 1986 | Biochem. J. | pmid:3028375 |
van Staveren WA et al. | Validity of the fatty acid composition of subcutaneous fat tissue microbiopsies as an estimate of the long-term average fatty acid composition of the diet of separate individuals. | 1986 | Am. J. Epidemiol. | pmid:3946391 |
Nijssen JG and van den Bosch H | Cytosol-stimulated remodeling of phosphatidylcholine in rat lung microsomes. | 1986 | Biochim. Biophys. Acta | pmid:3947653 |
Kryvi H et al. | Effects of essential fatty acid deficiency on mitochondria and peroxisomes in rat hepatocytes with special reference to a partially hydrogenated fish oil diet. | 1986 | Biochim. Biophys. Acta | pmid:3947675 |
De Villiers M and Lochner A | Mitochondrial Ca2+ fluxes: role of free fatty acids, acyl-CoA and acylcarnitine. | 1986 | Biochim. Biophys. Acta | pmid:3955069 |
Fressinaud C et al. | Fatty acid composition of endoneurium and perineurium from adult rat sciatic nerve. | 1986 | J. Neurochem. | pmid:3958717 |
Becker W and Bruce A | Retention of linoleic acid in carcass lipids of rats fed different levels of essential fatty acids. | 1986 | Lipids | pmid:3959773 |
Otsuki T et al. | Two geometrical isomers of linoleic acid: improved total syntheses. | 1986 | Lipids | pmid:3959777 |
Hansen HS et al. | Apparent in vivo retroconversion of dietary arachidonic to linoleic acid in essential fatty acid-deficient rats. | 1986 | Biochim. Biophys. Acta | pmid:3092868 |
Chambaz J et al. | Essential fatty acid uptake and esterification in primary culture of rat hepatocytes. | 1986 | Biochim. Biophys. Acta | pmid:3092869 |
Kanofsky JR and Axelrod B | Singlet oxygen production by soybean lipoxygenase isozymes. | 1986 | J. Biol. Chem. | pmid:3080416 |
Renner F et al. | Effect of saturated and unsaturated lipid on the composition of mesenteric triglyceride-rich lipoproteins in the rat. | 1986 | J. Lipid Res. | pmid:3083032 |
Innis SM | Effect of total parenteral nutrition with linoleic acid-rich emulsions on tissue omega 6 and omega 3 fatty acids in the rat. | 1986 | Lipids | pmid:3083173 |
Kanazawa K et al. | The effect of orally administered secondary autoxidation products of linoleic acid on the activity of detoxifying enzymes in the rat liver. | 1986 | Biochim. Biophys. Acta | pmid:3768385 |
Jones DB et al. | Indirect evidence of impairment of platelet desaturase enzymes in diabetes mellitus. | 1986 | Horm. Metab. Res. | pmid:3013745 |
Lehmann J et al. | Vitamin E in foods from high and low linoleic acid diets. | 1986 | J Am Diet Assoc | pmid:3745745 |
Fusco AC et al. | Schistosoma mansoni: production of cercarial eicosanoids as correlates of penetration and transformation. | 1986 | J. Parasitol. | pmid:3746561 |
Takase S and Hosoya N | Effect of dietary medium chain triglyceride on lipogenic enzyme activity in rat liver. | 1986 | J. Nutr. Sci. Vitaminol. | pmid:3761045 |
Takagi M et al. | Effects of lipophilic derivatives of L-ascorbic acid and dehydro-L-ascorbic acid on the peroxidation of linoleic acid in neutral phosphate buffer containing alcohol. | 1986 | J. Nutr. Sci. Vitaminol. | pmid:3806253 |
Masuda Y et al. | The mode of enhanced enteral absorption of macromolecules by lipid-surfactant mixed micelles. I. | 1986 | J. Pharmacobio-dyn. | pmid:3820056 |
Wertz PW and Downing DT | Linoleate content of epidermal acylglucosylceramide in newborn, growing and mature mice. | 1986 | Biochim. Biophys. Acta | pmid:3707979 |
Vericel E et al. | Effects of linoleic acid and gamma-linolenic acid intake on platelet functions in elderly people. | 1986 | Thromb. Res. | pmid:3715813 |
Hajarine M and Lagarde M | Studies on polyenoic acid incorporation into human platelet lipid stores: interactions with linoleic and arachidonic acids. | 1986 | Biochim. Biophys. Acta | pmid:3719006 |
Dowd TC et al. | Diabetic retinopathy: different risk factors for exudates and haemorrhages. | 1986 | Int Ophthalmol | pmid:3721707 |
Awad AB and Chattopadhyay JP | Effect of dietary saturated fatty acids on intracellular free fatty acids and kinetic properties of hormone-sensitive lipase of rat adipocytes. | 1986 | J. Nutr. | pmid:3723204 |
Hansen HS and Jensen B | Urinary excretion of arginine-vasopressin and prostaglandin E2 in essential fatty acid-deficient rats after oral supplementation with unsaturated fatty acid esters. | 1986 | J. Nutr. | pmid:3080561 |
Okabe H et al. | Effects of anti-convulsants on fatty acid metabolism in human serum. | 1986 | Tohoku J. Exp. Med. | pmid:3705068 |
Isaacs CE et al. | Membrane-disruptive effect of human milk: inactivation of enveloped viruses. | 1986 | J. Infect. Dis. | pmid:3491166 |
Rocquelin G et al. | [Influence of linoleic acid (18:2 n-6) and alpha-linolenic acid (18:3 n-3) on the composition, permeability and fluidity of cardiac phospholipids in the rat: study using membrane models (liposomes)]. | 1986 | Reprod Nutr Dev | pmid:2871601 |
Gabor H and Abraham S | Effect of dietary menhaden oil on tumor cell loss and the accumulation of mass of a transplantable mammary adenocarcinoma in BALB/c mice. | 1986 | J. Natl. Cancer Inst. | pmid:3458958 |
Köhler VH et al. | [Results of a long-term study of arteriosclerotic circulatory disorders with polyene fatty acid therapy]. | 1986 | Z Gesamte Inn Med | pmid:2871668 |
Elliott GR et al. | Linoleic and dihomo-gamma-linolenic acids modulate granuloma growth and granuloma macrophage eicosanoid release. | 1986 | Eur. J. Pharmacol. | pmid:3460810 |
Nijssen JG and van den Bosch H | Coenzyme A-mediated transacylation of sn-2 fatty acids from phosphatidylcholine in rat lung microsomes. | 1986 | Biochim. Biophys. Acta | pmid:3081034 |
Leat WM et al. | Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. | 1986 | Ann. Nutr. Metab. | pmid:2872851 |
Jenkins KJ and Kramer JK | Influence of low linoleic and linolenic acids in milk replacer on calf performance and lipids in blood plasma, heart, and liver. | 1986 | J. Dairy Sci. | pmid:2873158 |
Siguel EN et al. | Monitoring the optimal infusion of intravenous lipids. Detection of essential fatty acid deficiency. | 1986 | Arch. Pathol. Lab. Med. | pmid:2875703 |
Morson LA and Clandinin MT | Diets varying in linoleic and linolenic acid content alter liver plasma membrane lipid composition and glucagon-stimulated adenylate cyclase activity. | 1986 | J. Nutr. | pmid:2879899 |
Andre JC and Funk MO | Determination of stereochemistry in the fatty acid hydroperoxide products of lipoxygenase catalysis. | 1986 | Anal. Biochem. | pmid:3101541 |
Hoffmann P et al. | Circadian rhythm of eicosanoid formation as affected by dietary linoleate. | 1986 | Prostaglandins Leukot Med | pmid:3547416 |
Siegel I et al. | Inhibition of sperm motility and agglutination of sperm cells by free fatty acids in whole semen. | 1986 | Fertil. Steril. | pmid:2868925 |
Tabachnick M and Korcek L | Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. | 1986 | Biochim. Biophys. Acta | pmid:2869786 |