Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Child Nutrition Disorders D015362 1 associated lipids
Refeeding Syndrome D055677 1 associated lipids
Pellagra D010383 1 associated lipids
Refractive Errors D012030 1 associated lipids
Carcinoma, Krebs 2 D002287 1 associated lipids
Encopresis D004688 1 associated lipids
Enuresis D004775 1 associated lipids
Onchocerciasis D009855 1 associated lipids
Malaria, Cerebral D016779 1 associated lipids
Liposarcoma D008080 1 associated lipids
Gastroschisis D020139 1 associated lipids
Fat Necrosis D005218 1 associated lipids
Facial Nerve Diseases D005155 1 associated lipids
Darier Disease D007644 2 associated lipids
Aneurysm D000783 2 associated lipids
Circoviridae Infections D018173 2 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Lymphopenia D008231 2 associated lipids
Leptospirosis D007922 2 associated lipids
Lactose Intolerance D007787 2 associated lipids
Disease D004194 2 associated lipids
Hypokinesia D018476 2 associated lipids
Hepatolenticular Degeneration D006527 3 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Dermatitis, Toxicodendron D011040 3 associated lipids
Infertility D007246 3 associated lipids
Wasting Syndrome D019282 3 associated lipids
Haemophilus Infections D006192 3 associated lipids
Dermatitis, Phototoxic D017484 4 associated lipids
Esophagitis, Peptic D004942 4 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Biliary Atresia D001656 4 associated lipids
Epilepsy, Temporal Lobe D004833 4 associated lipids
Varicose Ulcer D014647 4 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Melanosis D008548 4 associated lipids
Varicocele D014646 4 associated lipids
Embolism, Fat D004620 4 associated lipids
Sigmoid Neoplasms D012811 5 associated lipids
Tinea Versicolor D014010 5 associated lipids
Meningeal Neoplasms D008577 5 associated lipids
Choroidal Neovascularization D020256 5 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Anemia, Iron-Deficiency D018798 6 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Nausea D009325 7 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Mucositis D052016 7 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Anorexia D000855 8 associated lipids
Constipation D003248 8 associated lipids
Otitis Externa D010032 8 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Protein-Energy Malnutrition D011502 9 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Retinal Degeneration D012162 9 associated lipids
Hypertension, Renal D006977 9 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Dry Eye Syndromes D015352 10 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Foreign-Body Reaction D005549 10 associated lipids
Coronary Restenosis D023903 10 associated lipids
Myocardial Stunning D017682 10 associated lipids
Wounds, Penetrating D014950 10 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Fatty Liver, Alcoholic D005235 11 associated lipids
Hyperpigmentation D017495 11 associated lipids
Infertility, Male D007248 11 associated lipids
Aortic Diseases D001018 11 associated lipids
Migraine Disorders D008881 11 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Deficiency Diseases D003677 12 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Retinoblastoma D012175 12 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Keloid D007627 12 associated lipids
Acidosis D000138 13 associated lipids
Critical Illness D016638 13 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Liver Diseases, Alcoholic D008108 13 associated lipids
Mitochondrial Myopathies D017240 13 associated lipids
Glucose Intolerance D018149 13 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Alopecia D000505 14 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Tremor D014202 15 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

Download all related citations
Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
CAMPBELL AM et al. SERUM LIPIDS OF MEN FED DIETS DIFFERING IN PROTEIN QUALITY AND LINOLEIC ACID CONTENT. 1965 Am. J. Clin. Nutr. pmid:14332349
Hennig B et al. Linoleic acid activates nuclear transcription factor-kappa B (NF-kappa B) and induces NF-kappa B-dependent transcription in cultured endothelial cells. 1996 Am. J. Clin. Nutr. pmid:8602587
Routi T et al. Effects of prospective, randomized cholesterol-lowering dietary intervention and apolipoprotein E phenotype on serum lipoprotein(a) concentrations of infants aged 7-24 mo. 1996 Am. J. Clin. Nutr. pmid:8602597
Martinelli N et al. FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. 2008 Am. J. Clin. Nutr. pmid:18842780
SCOTT RF et al. FATTY ACIDS OF SERUM AND ADIPOSE TISSUE IN SIX GROUPS EATING NATURAL DIETS CONTAINING 7 TO 40 PER CENT FAT. 1964 Am. J. Clin. Nutr. pmid:14157830
Jannace PW et al. Effects of oral soy phosphatidylcholine on phagocytosis, arachidonate concentrations, and killing by human polymorphonuclear leukocytes. 1992 Am. J. Clin. Nutr. pmid:1323926
Bradbury KE et al. The serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations. 2010 Am. J. Clin. Nutr. pmid:19955401
CENTURY B et al. INTERRELATIONSHIPS OF DIETARY LIPIDS UPON FATTY ACID COMPOSITION OF BRAIN MITOCHONDRIA, ERYTHROCYTES AND HEART TISSUE IN CHICKS. 1963 Am. J. Clin. Nutr. pmid:14101397
Carnielli VP et al. Medium-chain triacylglycerols in formulas for preterm infants: effect on plasma lipids, circulating concentrations of medium-chain fatty acids, and essential fatty acids. 1996 Am. J. Clin. Nutr. pmid:8694014
Blair IA et al. Dietary modification of omega 6 fatty acid intake and its effect on urinary eicosanoid excretion. 1993 Am. J. Clin. Nutr. pmid:8424383
Reaven P et al. Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. 1991 Am. J. Clin. Nutr. pmid:1897476
Murphy J et al. Fat malabsorption in cystic fibrosis patients. 1999 Am. J. Clin. Nutr. pmid:10539762
Chevrot M et al. Obesity interferes with the orosensory detection of long-chain fatty acids in humans. 2014 Am. J. Clin. Nutr. pmid:24522446
Cunnane SC et al. Beta-oxidation of linoleate in obese men undergoing weight loss. 2001 Am. J. Clin. Nutr. pmid:11273844
Elias SL and Innis SM Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. 2001 Am. J. Clin. Nutr. pmid:11273857
Freeman VL et al. Assessing the effect of fatty acids on prostate carcinogenesis in humans: does self-reported dietary intake rank prostatic exposure correctly? 2001 Am. J. Clin. Nutr. pmid:11273858
Merchant AT et al. Intake of n-6 and n-3 fatty acids and fish and risk of community-acquired pneumonia in US men. 2005 Am. J. Clin. Nutr. pmid:16155282
Horrobin DF Fatty acid metabolism in health and disease: the role of delta-6-desaturase. 1993 Am. J. Clin. Nutr. pmid:8386433
Martinez GA et al. Nutrient intakes of American infants and children fed cow's milk or infant formula. 1985 Am. J. Dis. Child. pmid:4036886
BAUGHAN MA et al. TIME, TEMPERATURE EXPOSURE TO AIR OF MILK PREPARATIONS. EFFECT ON FATTY ACIDS. 1963 Am. J. Dis. Child. pmid:14063701
van Staveren WA et al. Validity of the fatty acid composition of subcutaneous fat tissue microbiopsies as an estimate of the long-term average fatty acid composition of the diet of separate individuals. 1986 Am. J. Epidemiol. pmid:3946391
Andersen LF et al. Evaluation of a food frequency questionnaire with weighed records, fatty acids, and alpha-tocopherol in adipose tissue and serum. 1999 Am. J. Epidemiol. pmid:10400557
Seidell JC et al. Polyunsaturated fatty acids in adipose tissue in European men aged 38 years in relation to serum lipids, smoking habits, and fat distribution. 1991 Am. J. Epidemiol. pmid:1951263
Jacobsen BK et al. Re: "Comparison of measures of fatty acid intake by subcutaneous fat aspirate, food frequency questionnaire, and diet records in a free-living population of US men". 1993 Am. J. Epidemiol. pmid:8333420
Brosnan MJ and Carkner RD Hepatic effects of a fructose diet in the stroke-prone spontaneously hypertensive rat. 2008 Am. J. Hypertens. pmid:18437120
Zhang HY et al. A high sucrose, high linoleic acid diet potentiates hypertension in the Dahl salt sensitive rat. 1999 Am. J. Hypertens. pmid:10090346
Taylor EN et al. Fatty acid intake and incident nephrolithiasis. 2005 Am. J. Kidney Dis. pmid:15685503
Ascherio A Epidemiologic studies on dietary fats and coronary heart disease. 2002 Am. J. Med. pmid:12566133
Weiss LA et al. The omega-6 fatty acid linoleic acid is associated with risk of gastroschisis: a novel dietary risk factor. 2012 Am. J. Med. Genet. A pmid:22315197
SCHWARTZ S et al. LIPID THROMBOPLASTINS AND MYOCARDIAL INFARCTION. 1965 Am. J. Med. Sci. pmid:14254823
Brush MG et al. Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. 1984 Am. J. Obstet. Gynecol. pmid:6091462
Kääpä P et al. Dietary fatty acids and platelet thromboxane production in puerperal women and their offspring. 1986 Am. J. Obstet. Gynecol. pmid:3089014
MacKenzie LW et al. Prostacyclin biosynthesis by cultured human myometrial smooth muscle cells: dependency on arachidonic or linoleic acid in the culture medium. 1988 Am. J. Obstet. Gynecol. pmid:3144917
Vaughan JE and Walsh SW Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-alpha in response to linoleic acid and oxidative stress. 2005 Am. J. Obstet. Gynecol. pmid:16150282
Liu H et al. Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease. 2015 Am. J. Pathol. pmid:25447051
McEntee MF et al. Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer. 2008 Am. J. Pathol. pmid:18556778
Pandey NR et al. An induction in hepatic HDL secretion associated with reduced ATPase expression. 2009 Am. J. Pathol. pmid:19717637
Murray MJ et al. Effects of endotoxin on pigs prefed omega-3 vs. omega-6 fatty acid-enriched diets. 1993 Am. J. Physiol. pmid:8279548
Sarel I and Widmaier EP Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. 1995 Am. J. Physiol. pmid:7611525
Rosenblum WI Unsaturated fatty acids and cyclooxygenase inhibitors: effects on pial arterioles. 1982 Am. J. Physiol. pmid:6801999
Meikle AW et al. Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells. 1989 Am. J. Physiol. pmid:2558577
West DB et al. Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. 1998 Am. J. Physiol. pmid:9728060
Jensen MD et al. Measurement of non-steady-state free fatty acid turnover. 1990 Am. J. Physiol. pmid:2405695
GOLD M and SPITZER JJ METABOLISM OF FREE FATTY ACIDS BY MYOCARDIUM AND KIDNEY. 1964 Am. J. Physiol. pmid:14111431
SPITZER JJ and GOLD M FREE FATTY ACID METABOLISM BY SKELETAL MUSCLE. 1964 Am. J. Physiol. pmid:14111432
Kerner J et al. Impaired gut lipid absorptive capacity after trauma-hemorrhage and resuscitation. 1995 Am. J. Physiol. pmid:7485605
Thomas ME et al. Metabolic effects of fatty acid-bearing albumin on a proximal tubule cell line. 1995 Am. J. Physiol. pmid:7611458
Spalinger JH et al. Uptake and metabolism of structured triglyceride by Caco-2 cells: reversal of essential fatty acid deficiency. 1998 Am. J. Physiol. pmid:9756493
Reddy SR et al. Effect of linoleic acid infusion on blood pressure in normotensive and hypertensive rats. 1989 Am. J. Physiol. pmid:2764141
Sebokova E et al. Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. 1988 Am. J. Physiol. pmid:2897795