Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Netsu S et al. | Oral eicosapentaenoic acid supplementation as possible therapy for endometriosis. | 2008 | Fertil. Steril. | pmid:18054352 |
Diniz YS et al. | Conjugated linoleic acid and cardiac health: oxidative stress and energetic metabolism in standard and sucrose-rich diets. | 2008 | Eur. J. Pharmacol. | pmid:18054909 |
Kim CH et al. | Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. | 2008 | Anaerobe | pmid:17996466 |
Vögler O et al. | Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats. | 2008 | Int J Obes (Lond) | pmid:18059405 |
Ogata K et al. | Dosage plan of a flurbiprofen injection product using inhibition of protein binding by lipid emulsion in rats. | 2008 | J. Pharm. Pharmacol. | pmid:18088500 |
Ruths M et al. | Friction of fatty acids in nanometer-sized contacts of different adhesive strength. | 2008 | Langmuir | pmid:18085802 |
Kim T et al. | Pharmacokinetics of formulated tenoxicam transdermal delivery systems. | 2008 | J. Pharm. Pharmacol. | pmid:18088513 |
Lei Q and Boatright WL | Lipoxygenase independent hexanal formation in isolated soy proteins induced by reducing agents. | 2008 | J. Food Sci. | pmid:19241535 |
Yen CH et al. | Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. | 2008 | Ann. Allergy Asthma Immunol. | pmid:18254485 |
Moate PJ et al. | Milk fatty acids II: prediction of the production of individual fatty acids in bovine milk. | 2008 | J. Dairy Sci. | pmid:18292274 |
Pandey NR et al. | Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein A-I secretion. | 2008 | Biochemistry | pmid:18189424 |
Jang A et al. | Comparison of hypolipidemic activity of synthetic gallic acid-linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice. | 2008 | Chem. Biol. Interact. | pmid:18571153 |
Koszelak-Rosenblum M et al. | His-311 and Arg-559 are key residues involved in fatty acid oxygenation in pathogen-inducible oxygenase. | 2008 | J. Biol. Chem. | pmid:18596034 |
Frenette M and Scaiano JC | Evidence for hydroxyl radical generation during lipid (linoleate) peroxidation. | 2008 | J. Am. Chem. Soc. | pmid:18597469 |
Pinnick KE et al. | Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. | 2008 | Obesity (Silver Spring) | pmid:18239594 |
Eder E et al. | Lipid peroxidation-related 1,N2-propanodeoxyguanosine-DNA adducts induced by endogenously formed 4-hydroxy-2-nonenal in organs of female rats fed diets supplemented with sunflower, rapeseed, olive or coconut oil. | 2008 | Mutat. Res. | pmid:18602860 |
Li Y et al. | Molecular recognition of nitrated fatty acids by PPAR gamma. | 2008 | Nat. Struct. Mol. Biol. | pmid:18604218 |
Kuiper HC et al. | Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress. | 2008 | J. Biol. Chem. | pmid:18442969 |
Ohmori H et al. | Linoleic-acid-induced growth suppression induces quiescent cancer cell nests in nude mice. | 2008 | Pathobiology | pmid:18580068 |
Xin HL et al. | [Alpha-linolenic acid and linoleic acid in extract of Portulaca oleracea L. determined by high-performance liquid chromatography]. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18990345 |
Meguid NA et al. | Role of polyunsaturated fatty acids in the management of Egyptian children with autism. | 2008 | Clin. Biochem. | pmid:18582451 |
Garscha U and Oliw E | Pichia expression and mutagenesis of 7,8-linoleate diol synthase change the dioxygenase and hydroperoxide isomerase. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18586008 |
Rhayem Y et al. | Chain-breaking activity of resveratrol and piceatannol in a linoleate micellar model. | 2008 | Chem. Phys. Lipids | pmid:18590713 |
Wang L et al. | The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation. | 2008 | Metab. Clin. Exp. | pmid:18803934 |
Wejnerowska G et al. | Determination of linoleic acid in toothpaste by gas chromatography with flame ionization detection. | 2008 | Anal Sci | pmid:18544865 |
Morishita M et al. | Usefulness of colon targeted DHA and EPA as novel diabetes medications that promote intrinsic GLP-1 secretion. | 2008 | J Control Release | pmid:18804128 |
Iqbal MJ et al. | A combination of CLA-DAG oil modifies the diabetic phenotype in male Zucker diabetic fatty rats. | 2008 | Horm. Metab. Res. | pmid:18548385 |
Zhao YF et al. | Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. | 2008 | J. Endocrinol. | pmid:18550787 |
Still K et al. | The peroxisome proliferator activator receptor alpha/delta agonists linoleic acid and bezafibrate upregulate osteoblast differentiation and induce periosteal bone formation in vivo. | 2008 | Calcif. Tissue Int. | pmid:18836674 |
Burenjargal M and Totani N | Effects of thermally processed oil on weight loss in rats. | 2008 | J Oleo Sci | pmid:18685228 |
Martinelli N et al. | FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease. | 2008 | Am. J. Clin. Nutr. | pmid:18842780 |
Saez G et al. | Is the hepatic metabolism of glucose and linoleic acid influenced by species in overfed ducks? | 2008 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:18687407 |
Suh HN et al. | Linoleic acid stimulates gluconeogenesis via Ca2+/PLC, cPLA2, and PPAR pathways through GPR40 in primary cultured chicken hepatocytes. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:18842827 |
Rahuman AA et al. | Mosquito larvicidal activity of oleic and linoleic acids isolated from Citrullus colocynthis (Linn.) Schrad. | 2008 | Parasitol. Res. | pmid:18688644 |
Wang J et al. | 5-lipoxygenase and 5-lipoxygenase-activating protein gene polymorphisms, dietary linoleic acid, and risk for breast cancer. | 2008 | Cancer Epidemiol. Biomarkers Prev. | pmid:18843019 |
Luna P et al. | Gas chromatography and silver-ion high-performance liquid chromatography analysis of conjugated linoleic acid isomers in free fatty acid form using sulphuric acid in methanol as catalyst. | 2008 | J Chromatogr A | pmid:18692191 |
Miura K et al. | Relationship of dietary linoleic acid to blood pressure. The International Study of Macro-Micronutrients and Blood Pressure Study [corrected]. | 2008 | Hypertension | pmid:18606902 |
Damsgaard CT et al. | Fish oil in combination with high or low intakes of linoleic acid lowers plasma triacylglycerols but does not affect other cardiovascular risk markers in healthy men. | 2008 | J. Nutr. | pmid:18492834 |
Ogorodnikova AV et al. | Detection of divinyl ether synthase in Lily-of-the-Valley (Convallaria majalis) roots. | 2008 | Phytochemistry | pmid:18952245 |
Williams M and Harwood JL | Characterisation of lipoxygenase isoforms from olive callus cultures. | 2008 | Phytochemistry | pmid:18790508 |
Methy N et al. | Dietary fatty acids and recurrence of colorectal adenomas in a European intervention trial. | 2008 | Nutr Cancer | pmid:18791918 |
Jacquot C et al. | Kinetic isotope effects in the oxidation of arachidonic acid by soybean lipoxygenase-1. | 2008 | Bioorg. Med. Chem. Lett. | pmid:18793849 |
Tao X et al. | GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia. | 2008 | Anal Bioanal Chem | pmid:18622754 |
Carrasco MP et al. | Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells. | 2008 | FEBS J. | pmid:18312412 |
Maeda H et al. | Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. | 2008 | Plant Cell | pmid:18314499 |
Gülçin I | In vitro prooxidant effect of caffeine. | 2008 | J Enzyme Inhib Med Chem | pmid:18341268 |
Minami Y et al. | Occurrence of singlet oxygen oxygenation of oleic acid and linoleic acid in the skin of live mice. | 2008 | Free Radic. Res. | pmid:18344113 |
Zachut M et al. | Dietary unsaturated fatty acids influence preovulatory follicle characteristics in dairy cows. | 2008 | Reproduction | pmid:18296508 |
Horowitz Brown S et al. | Morphological transitions governed by density dependence and lipoxygenase activity in Aspergillus flavus. | 2008 | Appl. Environ. Microbiol. | pmid:18658287 |
Ashby RD et al. | Property control of sophorolipids: influence of fatty acid substrate and blending. | 2008 | Biotechnol. Lett. | pmid:18264681 |
Zhu H et al. | 15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity. | 2008 | Int. J. Cancer | pmid:18785202 |
Ringseis R et al. | Conjugated linoleic acid isomers inhibit platelet-derived growth factor-induced NF-kappaB transactivation and collagen formation in human vascular smooth muscle cells. | 2008 | Eur J Nutr | pmid:18264811 |
Fang KM et al. | Free fatty acids act as endogenous ionophores, resulting in Na+ and Ca2+ influx and myocyte apoptosis. | 2008 | Cardiovasc. Res. | pmid:18267958 |
Kishino T et al. | Visceral fat thickness in overweight men correlates with alterations in serum fatty acid composition. | 2008 | Clin. Chim. Acta | pmid:18771663 |
Rashid S et al. | Topical omega-3 and omega-6 fatty acids for treatment of dry eye. | 2008 | Arch. Ophthalmol. | pmid:18268213 |
Jones PJ et al. | The effect of dietary oleic, linoleic, and linolenic acids on fat oxidation and energy expenditure in healthy men. | 2008 | Metab. Clin. Exp. | pmid:18702944 |
Hofmann E and Pollmann S | Molecular mechanism of enzymatic allene oxide cyclization in plants. | 2008 | Plant Physiol. Biochem. | pmid:18272375 |
Dai F et al. | Antioxidant synergism of green tea polyphenols with alpha-tocopherol and L-ascorbic acid in SDS micelles. | 2008 | Biochimie | pmid:18554517 |
Artmann A et al. | Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine. | 2008 | Biochim. Biophys. Acta | pmid:18316044 |
McEntee MF et al. | Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer. | 2008 | Am. J. Pathol. | pmid:18556778 |
Or-Rashid MM et al. | Studies on the production of conjugated linoleic acid from linoleic and vaccenic acids by mixed rumen protozoa. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18797866 |
Sasaki N et al. | Down-regulation of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase by polyunsaturated fatty acids in hepatocytes is not mediated by PPARalpha. | 2008 | Eur J Nutr | pmid:18320257 |
Chicco AJ et al. | Linoleate-rich high-fat diet decreases mortality in hypertensive heart failure rats compared with lard and low-fat diets. | 2008 | Hypertension | pmid:18663155 |
El-Yassimi A et al. | Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells. | 2008 | J. Biol. Chem. | pmid:18321850 |
de Virville JD et al. | Changes in electron transport pathways in endoplasmic reticulum of rapeseed in response to cold. | 2008 | Planta | pmid:18663470 |
Zhao ZY et al. | Influence of dietary conjugated linoleic acid on growth, fatty acid composition and hepatic lipogenesis in large yellow croaker (Pseudosciaena crocea R.). | 2008 | J Zhejiang Univ Sci B | pmid:18763301 |
Ferrini G et al. | Dietary polyunsaturated fat reduces skin fat as well as abdominal fat in broiler chickens. | 2008 | Poult. Sci. | pmid:18281580 |
Wang L et al. | Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells. | 2008 | Chem. Biol. Interact. | pmid:18155686 |
Chavarro JE et al. | A prospective study of trans-fatty acid levels in blood and risk of prostate cancer. | 2008 | Cancer Epidemiol. Biomarkers Prev. | pmid:18199715 |
Brosnan MJ and Carkner RD | Hepatic effects of a fructose diet in the stroke-prone spontaneously hypertensive rat. | 2008 | Am. J. Hypertens. | pmid:18437120 |
Lang I et al. | A lipoxygenase with linoleate diol synthase activity from Nostoc sp. PCC 7120. | 2008 | Biochem. J. | pmid:18031288 |
Andersson C et al. | Cell culture models demonstrate that CFTR dysfunction leads to defective fatty acid composition and metabolism. | 2008 | J. Lipid Res. | pmid:18441018 |
Petit HV et al. | Quality of embryos produced from dairy cows fed whole flaxseed and the success of embryo transfer. | 2008 | J. Dairy Sci. | pmid:18420609 |
Fan X et al. | Factors affecting thermally induced furan formation. | 2008 | J. Agric. Food Chem. | pmid:18811167 |
Caffieri S et al. | UVB photolysis of hydrocortisone 21-acetate. | 2008 | J Pharm Biomed Anal | pmid:18423938 |
Godkin JD et al. | Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin production. | 2008 | Reprod. Biol. Endocrinol. | pmid:18811942 |
Morawicki RO and Beelman RB | Study of the biosynthesis of 1-octen-3-ol using a crude homogenate of Agaricus bisporus in a bioreactor. | 2008 | J. Food Sci. | pmid:18387089 |
Kwon JI et al. | Induction of apoptosis by linoleic acid is associated with the modulation of Bcl-2 family and Fas/FasL system and activation of caspases in AGS human gastric adenocarcinoma cells. | 2008 | J Med Food | pmid:18361731 |
Warensjö E et al. | Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. | 2008 | Nutr Metab Cardiovasc Dis | pmid:18367385 |
Chung SH et al. | Synthesis of conjugated linoleic acid by human-derived Bifidobacterium breve LMC 017: utilization as a functional starter culture for milk fermentation. | 2008 | J. Agric. Food Chem. | pmid:18410112 |
Kanwar RK et al. | Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic airway disease in mice. | 2008 | Clin. Exp. Allergy | pmid:18005183 |
Maqbool A et al. | Serum linoleic acid status as a clinical indicator of essential fatty acid status in children with cystic fibrosis. | 2008 | J. Pediatr. Gastroenterol. Nutr. | pmid:18955866 |
Zuo Y et al. | ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. | 2008 | J. Biol. Chem. | pmid:18957418 |
Ueda Y et al. | Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease. | 2008 | Nutr Res | pmid:19083414 |
Lopes PA et al. | Diet supplementation with the cis-9,trans-11 conjugated linoleic acid isomer affects the size of adipocytes in Wistar rats. | 2008 | Nutr Res | pmid:19083449 |
Hoashi S et al. | Association between fatty acid compositions and genotypes of FABP4 and LXR-alpha in Japanese black cattle. | 2008 | BMC Genet. | pmid:19077218 |
Higashi-Okai K et al. | Potent antioxidant and radical-scavenging activities of traditional Japanese cereal grains. | 2008 | J. UOEH | pmid:19086696 |
Tao M et al. | Relationship of polyunsaturated fatty acid intake to peripheral neuropathy among adults with diabetes in the National Health and Nutrition Examination Survey (NHANES) 1999 2004. | 2008 | Diabetes Care | pmid:17914029 |
Mateu-de Antonio J et al. | Comparative effects of olive oil-based and soyabean oil-based emulsions on infection rate and leucocyte count in critically ill patients receiving parenteral nutrition. | 2008 | Br. J. Nutr. | pmid:17916276 |
Crean C et al. | Pathways of arachidonic acid peroxyl radical reactions and product formation with guanine radicals. | 2008 | Chem. Res. Toxicol. | pmid:18159932 |
Rahman MM et al. | Docosahexaenoic acid is more potent inhibitor of osteoclast differentiation in RAW 264.7 cells than eicosapentaenoic acid. | 2008 | J. Cell. Physiol. | pmid:17929247 |
Ku CS and Mun SP | Antioxidant activities of ethanol extracts from seeds in fresh Bokbunja (Rubus coreanus Miq.) and wine processing waste. | 2008 | Bioresour. Technol. | pmid:17931856 |
Sarikurkcu C et al. | Studies on the antioxidant activity of the essential oil and methanol extract of Marrubium globosum subsp. globosum (lamiaceae) by three different chemical assays. | 2008 | Bioresour. Technol. | pmid:17920880 |
Bueno AA et al. | Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue. | 2008 | Pflugers Arch. | pmid:17717684 |
Tepe B | Antioxidant potentials and rosmarinic acid levels of the methanolic extracts of Salvia virgata (Jacq), Salvia staminea (Montbret & Aucher ex Bentham) and Salvia verbenaca (L.) from Turkey. | 2008 | Bioresour. Technol. | pmid:17531471 |
Xanthopoulou MN et al. | Biological studies of new organotin(IV) complexes of thioamide ligands. | 2008 | Eur J Med Chem | pmid:17509733 |
Moon CD et al. | Reclassification of Clostridium proteoclasticum as Butyrivibrio proteoclasticus comb. nov., a butyrate-producing ruminal bacterium. | 2008 | Int. J. Syst. Evol. Microbiol. | pmid:18768601 |
Vinceti M et al. | Food intake and risk of cutaneous melanoma in an Italian population. | 2008 | Eur J Clin Nutr | pmid:17657227 |
Damsgaard CT et al. | The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cells. | 2008 | Br. J. Nutr. | pmid:17663804 |
Chen J et al. | [Mechanism of linoleic acid on the expression of plasminogen activator inhibitor type-1 in HepG2 cells]. | 2008 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21141508 |