Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Siguel EN and Lerman RH | Altered fatty acid metabolism in patients with angiographically documented coronary artery disease. | 1994 | Metab. Clin. Exp. | pmid:8052156 |
Meerarani P et al. | Cholesterol attenuates linoleic acid-induced endothelial cell activation. | 2003 | Metab. Clin. Exp. | pmid:12701065 |
Wang L et al. | The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation. | 2008 | Metab. Clin. Exp. | pmid:18803934 |
Even P et al. | Postprandial effects of a lipid-rich meal in the rat are modulated by the degree of unsaturation of 18C fatty acids. | 2010 | Metab. Clin. Exp. | pmid:19775712 |
Jones PJ et al. | The effect of dietary oleic, linoleic, and linolenic acids on fat oxidation and energy expenditure in healthy men. | 2008 | Metab. Clin. Exp. | pmid:18702944 |
Pelikánová T et al. | Serum phospholipid fatty acid composition and insulin action in type 2 diabetic patients. | 2001 | Metab. Clin. Exp. | pmid:11735096 |
Yang J et al. | Application of the balance method to determining accumulation, metabolism, and apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. | 1994 | Metab. Clin. Exp. | pmid:7914345 |
Fernández-Real JM et al. | Circulating granulocyte-macrophage colony-stimulating factor and serum fatty acid composition in men and women. | 2001 | Metab. Clin. Exp. | pmid:11735097 |
Hennig B et al. | Fatty acid-mediated activation of vascular endothelial cells. | 2000 | Metab. Clin. Exp. | pmid:10954018 |
Felton CV et al. | Erythrocyte-derived measures of membrane lipid composition in healthy men: associations with arachidonic acid at low to moderate but not high insulin sensitivity. | 2004 | Metab. Clin. Exp. | pmid:15131759 |
CARLSTEN A et al. | MYOCARDIAL ARTERIOVENOUS DIFFERENCES OF INDIVIDUAL FREE FATTY ACIDS IN HEALTHY HUMAN INDIVIDUALS. | 1963 | Metab. Clin. Exp. | pmid:14100278 |
MORIN RJ and ALFIN-SLATER RB | FACTORS AFFECTING HEPATIC PHOSPHOLIPID SYNTHESIS. | 1964 | Metab. Clin. Exp. | pmid:14105462 |
Pitchumoni S et al. | Reoxygenation injury affects isolated islet response to fatty acid stimulation. | 1998 | Metab. Clin. Exp. | pmid:9667226 |
de La Puerta Vázquez R et al. | Effects of different dietary oils on inflammatory mediator generation and fatty acid composition in rat neutrophils. | 2004 | Metab. Clin. Exp. | pmid:14681843 |
Dichtl W et al. | Linoleic acid-stimulated vascular adhesion molecule-1 expression in endothelial cells depends on nuclear factor-kappaB activation. | 2002 | Metab. Clin. Exp. | pmid:11887169 |
Siguel EN and Lerman RH | Prevalence of essential fatty acid deficiency in patients with chronic gastrointestinal disorders. | 1996 | Metab. Clin. Exp. | pmid:8544768 |
Ollero M et al. | Evidence of increased flux to n-6 docosapentaenoic acid in phospholipids of pancreas from cftr-/- knockout mice. | 2006 | Metab. Clin. Exp. | pmid:16919538 |
Klein A et al. | The effect of fatty acids on the vulnerability of lymphocytes to cortisol. | 1989 | Metab. Clin. Exp. | pmid:2537454 |
Hamel FG | Preliminary report: inhibition of cellular proteasome activity by free fatty acids. | 2009 | Metab. Clin. Exp. | pmid:19423142 |
Lautenslager GT et al. | Effects of nonenzymatic glycation and fatty acids on functional properties of human albumin. | 2011 | Metab. Clin. Exp. | pmid:21632076 |
Ling PR et al. | Purified fish oil eliminating linoleic and alpha linolenic acid meets essential fatty acid requirements in rats. | 2012 | Metab. Clin. Exp. | pmid:22512821 |
Teachey MK et al. | Interactions of conjugated linoleic acid and lipoic acid on insulin action in the obese Zucker rat. | 2003 | Metab. Clin. Exp. | pmid:14506623 |
Romon M et al. | Comparison between fat intake assessed by a 3-day food record and phospholipid fatty acid composition of red blood cells: results from the Monitoring of Cardiovascular Disease-Lille Study. | 1995 | Metab. Clin. Exp. | pmid:7666786 |
Kwok CF et al. | Linoleic acid and oleic acid increase the endothelin-1 binding and action in cultured rat aortic smooth muscle cells. | 2000 | Metab. Clin. Exp. | pmid:11092498 |
Banti CN et al. | Mixed ligand-silver(I) complexes with anti-inflammatory agents which can bind to lipoxygenase and calf-thymus DNA, modulating their function and inducing apoptosis. | 2012 | Metallomics | pmid:22552402 |
Murphy DJ and Stumpf PK | Polyunsaturation systems from higher plants. | 1981 | Meth. Enzymol. | pmid:7311864 |
Christen MO et al. | Use of linoleic acid radiolysis for assay of antioxidant action of anethole dithiolethione. | 1995 | Meth. Enzymol. | pmid:7476369 |
Stocker R et al. | Antioxidant activities of bile pigments: biliverdin and bilirubin. | 1990 | Meth. Enzymol. | pmid:2233302 |
Kovár J and Franĕk F | Serum-free medium for hybridoma and parental myeloma cell cultivation. | 1986 | Meth. Enzymol. | pmid:3523123 |
Livrea MA and Tesoriere L | Lipoperoxyl radical-scavenging activity of vitamin A and analogs in homogeneous solution. | 1994 | Meth. Enzymol. | pmid:7808312 |
Miura K et al. | The effects of unsaturated fatty acids, oxidizing agents and Michael reaction acceptors on the induction of N-ethylmaleimide reductase in Escherichia coli: possible application for drug design of chemoprotectors. | 1997 | Methods Find Exp Clin Pharmacol | pmid:9203161 |
Armstrong D et al. | Preparation of microspheres and incorporation of lipid hydroperoxide for sustained release studies. | 2002 | Methods Mol. Biol. | pmid:12152211 |
Devillard E et al. | Differences between human subjects in the composition of the faecal bacterial community and faecal metabolism of linoleic acid. | 2009 | Microbiology (Reading, Engl.) | pmid:19202099 |
Wilson RA et al. | Characterization of the Aspergillus parasiticus delta12-desaturase gene: a role for lipid metabolism in the Aspergillus-seed interaction. | 2004 | Microbiology (Reading, Engl.) | pmid:15347747 |
Goodrich-Tanrikulu M et al. | Changes in fatty acid composition of Neurospora crassa accompany sexual development and ascospore germination. | 1998 | Microbiology (Reading, Engl.) | pmid:9695905 |
Murayama SY et al. | Construction and functional analysis of fatty acid desaturase gene disruptants in Candida albicans. | 2006 | Microbiology (Reading, Engl.) | pmid:16622072 |
Chatterjee MT et al. | Alterations in cellular lipids may be responsible for the transient nature of the yeast heat shock response. | 1997 | Microbiology (Reading, Engl.) | pmid:9308188 |
Rosberg-Cody E et al. | Heterologous expression of linoleic acid isomerase from Propionibacterium acnes and anti-proliferative activity of recombinant trans-10, cis-12 conjugated linoleic acid. | 2007 | Microbiology (Reading, Engl.) | pmid:17660413 |
Rosberg-Cody E et al. | Recombinant lactobacilli expressing linoleic acid isomerase can modulate the fatty acid composition of host adipose tissue in mice. | 2011 | Microbiology (Reading, Engl.) | pmid:21178166 |
Stewart CJ et al. | Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease. | 2016 | Microbiome | pmid:28034304 |
Mysiakina IS et al. | [Lipid composition of fungus Mucor hiemalis mycelium grown in the presence of trehalose, triacylglycerols, and itraconazole]. | 2012 Nov-Dec | Mikrobiologiia | pmid:23610922 |
Mysiakina IS et al. | [Effect of biological factors on morphogenesis, growth, and lipid composition of fungus Mucor hiemalis mycelium]. | 2012 Nov-Dec | Mikrobiologiia | pmid:23610923 |
Feofilova EP et al. | [Biochemical mechanisms of temperature adaptation in the (+) and (-) strains of Blakeslea trispora]. | 2005 Nov-Dec | Mikrobiologiia | pmid:16400984 |
GORBACH G and MALISSA H | [Not Available]. | 1947 | Mikrochemie | pmid:18921865 |
CORTELLA E | [Vitamin F in therapy of psoriasis]. | 1952 | Minerva Dermatol | pmid:12982586 |
Salzano P et al. | [Prevention of gestational hypertension with calcium, linoleic acid, mono and polyunsaturated fatty acid supplements]. | 2001 | Minerva Ginecol | pmid:11431639 |
Fritsche KL | Linoleic acid, vegetable oils & inflammation. | 2014 Jan-Feb | Mo Med | pmid:24645297 |
Shen SR et al. | Fatty acids in tea shoots (Camellia sinensis (L.) O. Kuntze) and their effects on the growth of retinal RF/6A endothelial cell lines. | 2007 | Mol Nutr Food Res | pmid:17262883 |
Lagarde M et al. | Lipidomics of essential fatty acids and oxygenated metabolites. | 2013 | Mol Nutr Food Res | pmid:23818385 |
Fang IM et al. | Comparative effects of fatty acids on proinflammatory gene cyclooxygenase 2 and inducible nitric oxide synthase expression in retinal pigment epithelial cells. | 2009 | Mol Nutr Food Res | pmid:19437483 |
Reynolds CM et al. | Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. | 2012 | Mol Nutr Food Res | pmid:22700321 |
Staprans I et al. | The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis. | 2005 | Mol Nutr Food Res | pmid:16270280 |
Bradley RM et al. | Influence of tissue, diet, and enzymatic remodeling on cardiolipin fatty acyl profile. | 2016 | Mol Nutr Food Res | pmid:27061349 |
Lindenmeier M et al. | A novel method to measure both the reductive and the radical scavenging activity in a linoleic acid model system. | 2007 | Mol Nutr Food Res | pmid:17680718 |
Ruparel S et al. | The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. | 2012 | Mol Pain | pmid:23006841 |
Green D et al. | Central activation of TRPV1 and TRPA1 by novel endogenous agonists contributes to mechanical allodynia and thermal hyperalgesia after burn injury. | 2016 | Mol Pain | pmid:27411353 |
Ramsden CE et al. | Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids: Implications for idiopathic pain syndromes? | 2016 | Mol Pain | pmid:27030719 |
Abdel Baset H et al. | Characterization of arachidonic-acid-metabolizing enzymes in adult Schistisoma mansoni. | 1995 | Mol. Biochem. Parasitol. | pmid:8577345 |
Rainey PM et al. | Biochemical and molecular characterization of Leishmania pifanoi amastigotes in continuous axenic culture. | 1991 | Mol. Biochem. Parasitol. | pmid:1775152 |
Alloatti A and Uttaro AD | Highly specific methyl-end fatty-acid desaturases of trypanosomatids. | 2011 | Mol. Biochem. Parasitol. | pmid:20974196 |
Buckley MT et al. | Selection in Europeans on Fatty Acid Desaturases Associated with Dietary Changes. | 2017 | Mol. Biol. Evol. | pmid:28333262 |
Luo X et al. | Comparison of enzymatic activity of two linoleic acid isomerases expressed in E. coli. | 2013 | Mol. Biol. Rep. | pmid:24062071 |
Moonen HJ et al. | Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. | 2004 | Mol. Carcinog. | pmid:15224350 |
Thuillier P et al. | Activators of peroxisome proliferator-activated receptor-alpha partially inhibit mouse skin tumor promotion. | 2000 | Mol. Carcinog. | pmid:11108658 |
Eren R and Duksin D | Inhibition of the formation of lipid-linked intermediates in normal and transformed cells by a purified tunicamycin homologue. | 1985 | Mol. Cell. Biochem. | pmid:2991743 |
Berdeaux O et al. | In vitro desaturation or elongation of monotrans isomers of linoleic acid by rat liver microsomes. | 1998 | Mol. Cell. Biochem. | pmid:9746207 |
Huang YS et al. | N-3 and n-6 fatty acid metabolism in undifferentiated and differentiated human intestine cell line (Caco-2). | 1995 | Mol. Cell. Biochem. | pmid:8569757 |
Narce M et al. | Age-related changes in linoleic acid bioconversion by isolated hepatocytes from spontaneously hypertensive and normotensive rats. | 1994 | Mol. Cell. Biochem. | pmid:7877612 |
Ves-Losada A and Brenner RR | Long-chain fatty Acyl-CoA synthetase enzymatic activity in rat liver cell nuclei. | 1996 | Mol. Cell. Biochem. | pmid:8813703 |
Chang W et al. | Induction of cardiac FABP gene expression by long chain fatty acids in cultured rat muscle cells. | 2001 | Mol. Cell. Biochem. | pmid:11506175 |
Kitts DD et al. | Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. | 1999 | Mol. Cell. Biochem. | pmid:10705999 |
Bordoni A et al. | Metabolism of linoleic and alpha-linolenic acids in cultured cardiomyocytes: effect of different N-6 and N-3 fatty acid supplementation. | 1996 Apr 12-26 | Mol. Cell. Biochem. | pmid:8739249 |
Tappia PS et al. | Influence of unsaturated fatty acids on the production of tumour necrosis factor and interleukin-6 by rat peritoneal macrophages. | 1995 | Mol. Cell. Biochem. | pmid:7596352 |
Raju M et al. | Micellar oleic and eicosapentaenoic acid but not linoleic acid influences the beta-carotene uptake and its cleavage into retinol in rats. | 2006 | Mol. Cell. Biochem. | pmid:16845492 |
Szachowicz-Petelska B et al. | Altered membrane free unsaturated fatty acid composition in human colorectal cancer tissue. | 2007 | Mol. Cell. Biochem. | pmid:16858511 |
Huang YS et al. | Eicosadienoic acid differentially modulates production of pro-inflammatory modulators in murine macrophages. | 2011 | Mol. Cell. Biochem. | pmid:21688154 |
Grasso EJ and Calderón RO | Urinary bladder membrane permeability differentially induced by membrane lipid composition. | 2009 | Mol. Cell. Biochem. | pmid:19412731 |
Maheswari SU et al. | Inhibition of Fe(II) catalyzed linoleic acid oxidation and DNA damage by phosvitin. | 1997 | Mol. Cell. Biochem. | pmid:9450644 |
Liu WM et al. | Effects of linoleic acid and eicosapentaenoic acid on cell proliferation and lipid-metabolism gene expression in primary duck hepatocytes. | 2011 | Mol. Cell. Biochem. | pmid:21274596 |
Kelder B et al. | Expression of fungal desaturase genes in cultured mammalian cells. | 2001 | Mol. Cell. Biochem. | pmid:11354256 |
Kim S et al. | C/EBPbeta (NF-M) is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts. | 1999 | Mol. Cell. Biol. | pmid:10409760 |
Grammatopoulos D et al. | The human myometrial CRH receptor: G proteins and second messengers. | 1994 | Mol. Cell. Endocrinol. | pmid:8206332 |
Plaisance V et al. | Role of the transcriptional factor C/EBPbeta in free fatty acid-elicited beta-cell failure. | 2009 | Mol. Cell. Endocrinol. | pmid:19133313 |
Warnotte C et al. | Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion. | 1999 | Mol. Cell. Endocrinol. | pmid:10459862 |
Kim SY et al. | S-adenosyl methionine prevents endothelial dysfunction by inducing heme oxygenase-1 in vascular endothelial cells. | 2013 | Mol. Cells | pmid:24046187 |
Lee C et al. | Quantitative trait loci mapping for fatty acid contents in the backfat on porcine chromosomes 1, 13, and 18. | 2003 | Mol. Cells | pmid:12661762 |
Lee MJ et al. | The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. | 2011 | Mol. Cells | pmid:21331775 |
Sakai H and Kajiwara S | Cloning and functional characterization of a Delta12 fatty acid desaturase gene from the basidiomycete Lentinula edodes. | 2005 | Mol. Genet. Genomics | pmid:15838640 |
Ripoll-Rozada J et al. | Type IV traffic ATPase TrwD as molecular target to inhibit bacterial conjugation. | 2016 | Mol. Microbiol. | pmid:26915347 |
King LM et al. | Cloning of CYP2J2 gene and identification of functional polymorphisms. | 2002 | Mol. Pharmacol. | pmid:11901223 |
Glasgow WC and Eling TE | Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts. | 1990 | Mol. Pharmacol. | pmid:2233691 |
Duan X et al. | Evaluation of the antioxidant properties of litchi fruit phenolics in relation to pericarp browning prevention. | 2007 | Molecules | pmid:17851428 |
You Y et al. | Identification of major phenolic compounds of Chinese water chestnut and their antioxidant activity. | 2007 | Molecules | pmid:17851436 |
Sousa A et al. | Chemical characterization of "alcaparras" stoned table olives from northeast Portugal. | 2011 | Molecules | pmid:22031066 |
KonÄić MZ et al. | Antiradical, chelating and antioxidant activities of hydroxamic acids and hydroxyureas. | 2011 | Molecules | pmid:21788931 |
Sandoval-Montemayor NE et al. | Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. | 2012 | Molecules | pmid:22992784 |
Ndhlala AR et al. | Anti-oxidative and cholinesterase inhibitory effects of leaf extracts and their isolated compounds from two closely related Croton species. | 2013 | Molecules | pmid:23377133 |
Olszewska MA et al. | Assessment of the content of phenolics and antioxidant action of inflorescences and leaves of selected species from the genus Sorbus sensu stricto. | 2010 | Molecules | pmid:21127463 |
Sajid ZI et al. | Antioxidant, antimicrobial properties and phenolics of different solvent extracts from bark, leaves and seeds of Pongamia pinnata (L.) Pierre. | 2012 | Molecules | pmid:22466852 |
Gull J et al. | Variation in antioxidant attributes at three ripening stages of guava (Psidium guajava L.) fruit from different geographical regions of Pakistan. | 2012 | Molecules | pmid:22418924 |