Linoelaidic acid
Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
Cross Reference
Introduction
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoelaidic acid?
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoelaidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Linoelaidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoelaidic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoelaidic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoelaidic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoelaidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kashulin PA et al. | Extremely rapid effects of polyunsaturated fatty acids and N-acetylglucosamine on free-radical metabolism in cultured potato plant cells. | 2000 | Biochem. Soc. Trans. | pmid:11171236 |
| Nuñez A et al. | Anaerobic lipoxygenase activity from Chlorella pyrenoidosa. | 2000 | Biochem. Soc. Trans. | pmid:11171268 |
| Kaushik N and Agnihotri A | GLC analysis of Indian rapeseed-mustard to study the variability of fatty acid composition. | 2000 | Biochem. Soc. Trans. | pmid:11171132 |
| Bates D | Lipids and multiple sclerosis. | 1989 | Biochem. Soc. Trans. | pmid:2546837 |
| Avery SV et al. | Low temperature-induced adaptations in lipid metabolism and physiological function in Acanthamoeba castellanii cultures of different ages. | 1994 | Biochem. Soc. Trans. | pmid:7821519 |
| O'Shea M et al. | The effect of a conjugated dienoic derivative of linoleic acid on the in vitro growth of MCF-7 and SW480 human cancer cell lines. | 1998 | Biochem. Soc. Trans. | pmid:10909819 |
| Cantwell H et al. | The effect of a conjugated linoleic acid on superoxide dismutase, catalase and glutathione peroxidase in oxidatively-challenged liver cells. | 1998 | Biochem. Soc. Trans. | pmid:10909820 |
| Sanderson P et al. | Dietary fish oil diminishes the antigen presentation activity of rat dendritic cells. | 1997 | Biochem. Soc. Trans. | pmid:9191396 |
| Campbell FM and Dutta-Roy AK | Asymmetric distribution of the plasma membrane fatty acid-binding protein (FABPpm) in the human placenta. | 1996 | Biochem. Soc. Trans. | pmid:8736907 |
| Colquhoun A and Curi R | Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. | 1997 | Biochem. Soc. Trans. | pmid:9450108 |
| Lloyd D et al. | Adaptive changes in yeast membranes: catabolite repression and oxygen. | 1983 | Biochem. Soc. Trans. | pmid:6617968 |
| Kaushik N and Vir S | Variations in fatty acid composition of neem seeds collected from the Rajasthan state of India. | 2000 | Biochem. Soc. Trans. | pmid:11171243 |
| Clouet P et al. | Mitochondrial respiration on rumenic and linoleic acids. | 2001 | Biochem. Soc. Trans. | pmid:11356175 |
| Toomey S et al. | Regression of pre-established atherosclerosis in the apoE-/- mouse by conjugated linoleic acid. | 2003 | Biochem. Soc. Trans. | pmid:14505483 |
| Liu Q et al. | Genetic modification of cotton seed oil using inverted-repeat gene-silencing techniques. | 2000 | Biochem. Soc. Trans. | pmid:11288706 |
| Devery R et al. | Conjugated linoleic acid and oxidative behaviour in cancer cells. | 2001 | Biochem. Soc. Trans. | pmid:11356179 |
| Mogul R and Holman TR | Inhibition studies of soybean and human 15-lipoxygenases with long-chain alkenyl sulfate substrates. | 2001 | Biochemistry | pmid:11284695 |
| Kleinfeld AM et al. | Transport of long-chain native fatty acids across lipid bilayer membranes indicates that transbilayer flip-flop is rate limiting. | 1997 | Biochemistry | pmid:9369487 |
| Nelson MJ et al. | Photolysis of "purple" lipoxygenase: implications for the structure of the chromophore. | 1995 | Biochemistry | pmid:7742320 |
| Surette ME et al. | Relationship between arachidonate--phospholipid remodeling and apoptosis. | 1996 | Biochemistry | pmid:8703924 |
| Glickman MH and Klinman JP | Lipoxygenase reaction mechanism: demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover. | 1996 | Biochemistry | pmid:8841132 |
| Jin SJ and Tserng KY | Metabolic origins of urinary unsaturated dicarboxylic acids. | 1990 | Biochemistry | pmid:2271537 |
| Biro A et al. | Complement protein C1q recognizes enzymatically modified low-density lipoprotein through unesterified fatty acids generated by cholesterol esterase. | 2010 | Biochemistry | pmid:20166680 |
| Pandey NR et al. | Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein A-I secretion. | 2008 | Biochemistry | pmid:18189424 |
| SGOUTAS DS and KUMMEROW FA | CHEMICAL SYNTHESIS OF TRITIUM-LABELED LINOLEIC ACID. | 1964 | Biochemistry | pmid:14155105 |
| Lima ES et al. | Characterization of linoleic acid nitration in human blood plasma by mass spectrometry. | 2002 | Biochemistry | pmid:12186558 |
| Glickman MH and Klinman JP | Nature of rate-limiting steps in the soybean lipoxygenase-1 reaction. | 1995 | Biochemistry | pmid:7578005 |
| Nieuwenhuizen WF et al. | Lipoxygenase is irreversibly inactivated by the hydroperoxides formed from the enynoic analogues of linoleic acid. | 1997 | Biochemistry | pmid:9109655 |
| Jones GD et al. | Role of lipid hydroperoxides in the activation of 15-lipoxygenase. | 1996 | Biochemistry | pmid:8679548 |
| Kleinfeld AM et al. | Transport of long-chain native fatty acids across human erythrocyte ghost membranes. | 1998 | Biochemistry | pmid:9609694 |
| Léger CL et al. | Evidence for a structurally specific role of essential polyunsaturated fatty acids depending on their peculiar double-bond distribution in biomembranes. | 1990 | Biochemistry | pmid:2169876 |
| Wecksler AT et al. | Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. | 2009 | Biochemistry | pmid:19469483 |
| Nelson MJ et al. | Structural characterization of alkyl and peroxyl radicals in solutions of purple lipoxygenase. | 1994 | Biochemistry | pmid:8161558 |
| Rickert KW and Klinman JP | Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects. | 1999 | Biochemistry | pmid:10493789 |
| Desmarais SR et al. | Inhibition of soybean lipoxygenase-1 by a diaryl-N-hydroxyurea by reduction of the ferric enzyme. | 1994 | Biochemistry | pmid:7947748 |
| Mukherjee A et al. | Molecular oxygen dependent steps in fatty acid oxidation by cyclooxygenase-1. | 2007 | Biochemistry | pmid:17355126 |
| Henderson WR et al. | Toxoplasma gondii stimulates the release of 13- and 9-hydroxyoctadecadienoic acids by human platelets. | 1992 | Biochemistry | pmid:1606159 |
| BAER E and BLACKWELL J | SYNTHESIS OF ALPHA-CEPHALINS BY A NEW PROCEDURE. II. DIOLEOYL AND DILINOLEOYL L-ALPHA-CEPHALINS. | 1964 | Biochemistry | pmid:14214090 |
| Mogul R et al. | Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase. | 2000 | Biochemistry | pmid:10769137 |
| Widstrom RL et al. | Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase. | 2003 | Biochemistry | pmid:14529287 |
| Arnold WR et al. | Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase. | 2016 | Biochemistry | pmid:27992998 |
| Widstrom RL et al. | Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. | 2001 | Biochemistry | pmid:11170430 |
| Nagler LG et al. | Rate of free-radical oxidation of C18 diene and triene fatty acids in aqueous micellar solutions and effectiveness of beta-carotene as an inhibitor of their oxidation. | 2003 | Biochemistry Mosc. | pmid:12693967 |
| Yang J et al. | Study of the inhibitory effect of fatty acids on the interaction between DNA and polymerase beta. | 2009 | Biochemistry Mosc. | pmid:19747104 |
| Zhan ZJ et al. | Preparation and characterization of Cu,Zn-superoxide dismutase covalently modified by polyunsaturated fatty acids. | 2009 | Biochemistry Mosc. | pmid:19916943 |
| Chechetkin IR et al. | Specificity of oxidation of linoleic acid homologs by plant lipoxygenases. | 2009 | Biochemistry Mosc. | pmid:19817685 |
| WEENINK RO and SHORLAND FB | THE ISOLATION OF TRANS-3-HEXADECENOIC ACID FROM THE LIPIDS OF RED-CLOVER (TRIFOLIUM PRATENSE) LEAVES. | 1964 | Biochim. Biophys. Acta | pmid:14250500 |
| Herzberg GR et al. | Intestinal absorption of fish oil in rats previously adapted to diets containing fish oil or corn oil. | 1992 | Biochim. Biophys. Acta | pmid:1531932 |
| Puebla C et al. | Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism. | 2016 | Biochim. Biophys. Acta | pmid:26869446 |
| Girón MD et al. | Changes in lipid composition and desaturase activities of duodenal mucosa induced by dietary fat. | 1990 | Biochim. Biophys. Acta | pmid:2369586 |
| Cheng Z et al. | The effect of supplementation with n-6 polyunsaturated fatty acids on 1-, 2- and 3-series prostaglandin F production by ovine uterine epithelial cells. | 2005 | Biochim. Biophys. Acta | pmid:16140575 |
| Lam YY et al. | Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. | 2011 Jul-Aug | Biochim. Biophys. Acta | pmid:21570480 |
| Villasuso AL et al. | Culture age and carbamoylcholine increase the incorporation of endogenously synthesized linoleic acid in lipids of Trypanosoma cruzi epimastigotes. | 2005 | Biochim. Biophys. Acta | pmid:16024291 |
| Grossman S et al. | Methylmercuric iodide modification of lipoxygenase-1. Effects on the anaerobic reaction and pigment bleaching. | 1984 | Biochim. Biophys. Acta | pmid:6424722 |
| Mitranic MM et al. | The effect of linoleic acid and benzyl alcohol on the activity of glycosyltransferases of rat liver Golgi membranes and some soluble glycosyltransferases. | 1982 | Biochim. Biophys. Acta | pmid:6217837 |
| Dutta-Roy AK et al. | Purification and characterization of fatty acid-binding proteins from brown adipose tissue of the rat. | 1993 | Biochim. Biophys. Acta | pmid:8334153 |
| Funk CD et al. | Effects of selenium-deficient diets on the production of prostaglandins and other oxygenated metabolites of arachidonic acid and linoleic acid by rat and rabbit aortae. | 1987 | Biochim. Biophys. Acta | pmid:3115301 |
| Kitagawa S et al. | Effects of four types of reagents on ADP-induced aggregation and Ca2+ mobilization of bovine blood platelets. | 1984 | Biochim. Biophys. Acta | pmid:6324876 |
| Bernbäck S et al. | Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase. | 1989 | Biochim. Biophys. Acta | pmid:2917153 |
| Cheah AM | Effect of long chain unsaturated fatty acids on the calcium transport of sarcoplasmic reticulum. | 1981 | Biochim. Biophys. Acta | pmid:6118177 |
| Jernerén F et al. | Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus. | 2010 | Biochim. Biophys. Acta | pmid:20045744 |
| Liffmann SM and Lynch RD | Incorporation of [3H]acetate into L-cell lipids. Dependence on method of linoleate administration and timing of the pulse label. | 1981 | Biochim. Biophys. Acta | pmid:7295748 |
| Leekumjorn S et al. | The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes. | 2009 | Biochim. Biophys. Acta | pmid:19371719 |
| Mizushina Y et al. | Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro. | 1996 | Biochim. Biophys. Acta | pmid:8809118 |
| HEALD PJ et al. | LIPID METABOLISM AND THE LAYING HEN. II. THE NATURE AND QUANTITIES OF THE FREE FATTY ACIDS OF THE PLASMA DURING THE ONSET OF LAYING. | 1964 | Biochim. Biophys. Acta | pmid:14124752 |
| Gurvitz A et al. | Degradation of conjugated linoleic acid isomers in the yeast Saccharomyces cerevisiae. | 2001 | Biochim. Biophys. Acta | pmid:11566445 |
| Saddik M and Lopaschuk GD | The fate of arachidonic acid and linoleic acid in isolated working rat hearts containing normal or elevated levels of coenzyme A. | 1991 | Biochim. Biophys. Acta | pmid:1932104 |
| Earles SM et al. | Metabolism of oxidized linoleic acid: characterization of 13-hydroxyoctadecadienoic acid dehydrogenase activity from rat colonic tissue. | 1991 | Biochim. Biophys. Acta | pmid:1998735 |
| Meuillet EJ et al. | Incorporation of exogenous lipids modulates insulin signaling in the hepatoma cell line, HepG2. | 1999 | Biochim. Biophys. Acta | pmid:10354513 |
| Lester DS | In vitro linoleic acid activation of protein kinase C. | 1990 | Biochim. Biophys. Acta | pmid:2207179 |
| Mahmmoud YA and Christensen SB | Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. | 2011 | Biochim. Biophys. Acta | pmid:21767529 |
| Rich MR | Conformational analysis of arachidonic and related fatty acids using molecular dynamics simulations. | 1993 | Biochim. Biophys. Acta | pmid:8329458 |
| Battu S et al. | Linoleic acid peroxidation by Solanum tuberosum lipoxygenase was activated in the presence of human 5-lipoxygenase-activating protein. | 1998 | Biochim. Biophys. Acta | pmid:9630716 |
| Gibson RA et al. | Incorporation of dietary oleate, linoleate, alpha-linolenate and eicosapentaenoate into the plasma lipid fractions of four strains of rat. | 1992 | Biochim. Biophys. Acta | pmid:1351403 |
| Konrad SD et al. | Use of deuterium oxide to measure de novo fatty acid synthesis in normal subjects consuming different dietary fatty acid composition1. | 1998 | Biochim. Biophys. Acta | pmid:9714781 |
| Ryu SB and Wang X | Increase in free linolenic and linoleic acids associated with phospholipase D-mediated hydrolysis of phospholipids in wounded castor bean leaves. | 1998 | Biochim. Biophys. Acta | pmid:9714802 |
| Hu ZY et al. | cAMP inhibits linoleic acid-induced growth by antagonizing p27(kip1) depletion, but not interfering with the extracellular signal-regulated kinase or AP-1 activities. | 1998 | Biochim. Biophys. Acta | pmid:9784625 |
| Stein O et al. | Modification of cellular fatty acid composition of Hep-G2 cells: effect of antioxidants on cholesterol esterification and secretion. | 1989 | Biochim. Biophys. Acta | pmid:2730885 |
| Mahfouz MM et al. | Changes of linoleic acid metabolism and cellular phospholipid fatty acid composition in LLC-PK cells cultured at low magnesium concentrations. | 1989 | Biochim. Biophys. Acta | pmid:2804072 |
| Parsons HG et al. | Modulation of human erythrocyte shape and fatty acids by diet. | 1986 | Biochim. Biophys. Acta | pmid:3741859 |
| Hirabara SM et al. | Acute effect of fatty acids on metabolism and mitochondrial coupling in skeletal muscle. | 2006 | Biochim. Biophys. Acta | pmid:16375848 |
| Göbel C et al. | Oxylipin profiling in pathogen-infected potato leaves. | 2002 | Biochim. Biophys. Acta | pmid:12213493 |
| Loidl-Stahlhofen A et al. | Generation of alpha-hydroxyaldehydic compounds in the course of lipid peroxidation. | 1994 | Biochim. Biophys. Acta | pmid:8025124 |
| Jyothirmayi N and Ramadoss CS | Soybean lipoxygenase catalysed oxygenation of unsaturated fatty acid encapsulated in cyclodextrin. | 1991 | Biochim. Biophys. Acta | pmid:1903659 |
| Macrì F et al. | Lipoxygenase activity associated to isolated soybean plasma membranes. | 1994 | Biochim. Biophys. Acta | pmid:7947991 |
| Christon R et al. | Modification of fluidity and lipid-protein relationships in pig intestinal brush-border membrane by dietary essential fatty acid deficiency. | 1989 | Biochim. Biophys. Acta | pmid:2538158 |
| KHAN NA | Infrared studies on initiation of the autoxidation of some fatty acid esters with and without light-sensitized chlorophyll, ultraviolet light and lipoxidase. | 1955 | Biochim. Biophys. Acta | pmid:14363243 |
| Bester R and Lochner A | Sarcolemmal phospholipid fatty acid composition and permeability. | 1988 | Biochim. Biophys. Acta | pmid:3382645 |
| Shires SE et al. | Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. | 1989 | Biochim. Biophys. Acta | pmid:2493807 |
| Ulmann L et al. | Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. | 1991 | Biochim. Biophys. Acta | pmid:1657182 |
| Nijssen JG and van den Bosch H | Coenzyme A-mediated transacylation of sn-2 fatty acids from phosphatidylcholine in rat lung microsomes. | 1986 | Biochim. Biophys. Acta | pmid:3081034 |
| Mizushina Y et al. | Mode analysis of binding of fatty acids to mammalian DNA polymerases. | 2000 | Biochim. Biophys. Acta | pmid:10903472 |
| Croft KD et al. | Differential inhibition of thromboxane B2 and leukotriene B4 biosynthesis by two naturally occurring acetylenic fatty acids. | 1987 | Biochim. Biophys. Acta | pmid:2822134 |
| Subbaiah PV et al. | Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. | 2011 | Biochim. Biophys. Acta | pmid:20920595 |
| Clementz T et al. | Membrane potential, lipid regulation and adenylate energy charge in acyl chain modified Acholeplasma laidlawii. | 1987 | Biochim. Biophys. Acta | pmid:3567184 |
| Kwon B et al. | Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. | 2014 | Biochim. Biophys. Acta | pmid:24732014 |
| Jaudszus A et al. | Cis-9,trans-11-CLA exerts anti-inflammatory effects in human bronchial epithelial cells and eosinophils: comparison to trans-10,cis-12-CLA and to linoleic acid. | 2005 | Biochim. Biophys. Acta | pmid:16303327 |
| Chander A and Fisher AB | Choline-phosphate cytidyltransferase activity and phosphatidylcholine synthesis in rat granular pneumocytes are increased with exogenous fatty acids. | 1988 | Biochim. Biophys. Acta | pmid:2893643 |
| Tabachnick M and Korcek L | Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. | 1986 | Biochim. Biophys. Acta | pmid:2869786 |
| Nugteren DH and Kivits GA | Conversion of linoleic acid and arachidonic acid by skin epidermal lipoxygenases. | 1987 | Biochim. Biophys. Acta | pmid:3113487 |