Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Saddik M and Lopaschuk GD | The fate of arachidonic acid and linoleic acid in isolated working rat hearts containing normal or elevated levels of coenzyme A. | 1991 | Biochim. Biophys. Acta | pmid:1932104 |
Martin JC et al. | Essential fatty acid composition of human colostrum triglycerides: its relationship with adipose tissue composition. | 1991 | Am. J. Clin. Nutr. | pmid:1951153 |
Seidell JC et al. | Polyunsaturated fatty acids in adipose tissue in European men aged 38 years in relation to serum lipids, smoking habits, and fat distribution. | 1991 | Am. J. Epidemiol. | pmid:1951263 |
Andrianarison RH et al. | Oxodiene formation during the Vicia sativa lipoxygenase-catalyzed reaction: occurrence of dioxygenase and fatty acid lyase activities associated in a single protein. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1953704 |
Kanazawa K | Hepatic dysfunction caused by dietary products of lipid peroxidation. | 1991 | Int J Tissue React | pmid:1955295 |
Takamura H et al. | Inhibition by lipoxygenase-3 of n-hexanal generation in soybeans. | 1991 | FEBS Lett. | pmid:1959624 |
Engels F et al. | Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. | 1991 | Prostaglandins | pmid:1662406 |
Schreiner GF | Dietary treatment of immunologically mediated renal disease. | 1991 | Kidney Int. Suppl. | pmid:2046271 |
Izumi T et al. | Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes. | 1991 | Eur. J. Biochem. | pmid:1662607 |
Venkatraman JT et al. | Influence of genotype on diet-induced changes in membrane phosphatidylcholine and phosphatidylethanolamine composition of splenocytes, liver nuclear envelope and liver mitochondria. | 1991 | Lipids | pmid:2046486 |
Rubinstein A et al. | Fatty acid composition of adipose tissue in Ethiopian immigrants: a prospective study during their first year in Israel. | 1991 | Isr. J. Med. Sci. | pmid:2050506 |
Sakai T et al. | Chorea-acanthocytosis: abnormal composition of covalently bound fatty acids of erythrocyte membrane proteins. | 1991 | Ann. Neurol. | pmid:1832532 |
Le Petit-Thevenin J et al. | Changes in pattern of phospholipid acylation during in vivo aging of rat red blood cells. | 1991 | Am. J. Physiol. | pmid:1887869 |
Iwahashi H et al. | Isolation and identification of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenase. | 1991 | Arch. Biochem. Biophys. | pmid:1846731 |
Thomson AB et al. | Feeding rats a diet enriched with saturated fatty acids prevents the inhibitory effects of acute and chronic ethanol exposure on the in vitro uptake of hexoses and lipids. | 1991 | Biochim. Biophys. Acta | pmid:1854796 |
Bellomonte G et al. | Quantitative determination of linoleic acid in infant formulas. | 1991 | Int J Vitam Nutr Res | pmid:1856052 |
Schmitz PG et al. | Glomerular hemodynamic effects of dietary polyunsaturated fatty acid supplementation. | 1991 | J. Lab. Clin. Med. | pmid:1856576 |
Eling TE and Glasgow WC | Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825423 |
Rose DP et al. | Effect of dietary fat on human breast cancer growth and lung metastasis in nude mice. | 1991 | J. Natl. Cancer Inst. | pmid:1920496 |
Burri BJ et al. | Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid. | 1991 | Am. J. Clin. Nutr. | pmid:1858699 |
Bell JG et al. | High dietary linoleic acid affects the fatty acid compositions of individual phospholipids from tissues of Atlantic salmon (Salmo salar): association with stress susceptibility and cardiac lesion. | 1991 | J. Nutr. | pmid:1861166 |
DaTorre SD and Creer MH | Differential turnover of polyunsaturated fatty acids in plasmalogen and diacyl glycerophospholipids of isolated cardiac myocytes. | 1991 | J. Lipid Res. | pmid:1940640 |
Byczkowski JZ et al. | Proline hydroxylation by soybean lipoxygenase. | 1991 | Biochem. Int. | pmid:1815499 |
Ulmann L et al. | Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. | 1991 | Biochim. Biophys. Acta | pmid:1657182 |
Huynh S et al. | Metabolic utilization of linoleate and alpha-linolenate in cultured Sertoli cells. | 1991 | Comp. Biochem. Physiol., B | pmid:1684926 |
de Tomás ME et al. | Metabolic transformation of intracraneally injected [1-14C]linoleic and [1-14C]alpha-linolenic acids in malnourished developing rats. | 1991 | Lipids | pmid:1687158 |
Zakhariv OIa et al. | [Metabolism of linoleic acid given with the feed in the calf liver]. | 1990 Jan-Feb | Ukr. Biokhim. Zh. | pmid:2336726 |
Brodersen R et al. | Multiple fatty acid binding to albumin in human blood plasma. | 1990 | Eur. J. Biochem. | pmid:2338079 |
Haas TA et al. | Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity. | 1990 | Biochim. Biophys. Acta | pmid:2155665 |
Barros H et al. | Arachidonic acid absorption in human jejunum in organ culture: effects of ethanol. | 1990 | Eur. J. Clin. Invest. | pmid:2124981 |
Parinandi NL et al. | Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. | 1990 | Biochim. Biophys. Acta | pmid:2123402 |
Miyashita K et al. | Preferential hydrolysis of monohydroperoxides of linoleoyl and linolenoyl triacylglycerol by pancreatic lipase. | 1990 | Biochim. Biophys. Acta | pmid:2386795 |
Schlame M and Rüstow B | Lysocardiolipin formation and reacylation in isolated rat liver mitochondria. | 1990 | Biochem. J. | pmid:2268287 |
Jin SJ and Tserng KY | Metabolic origins of urinary unsaturated dicarboxylic acids. | 1990 | Biochemistry | pmid:2271537 |
Hamberg M and Hamberg G | Hydroperoxide-dependent epoxidation of unsaturated fatty acids in the broad bean (Vicia faba L.). | 1990 | Arch. Biochem. Biophys. | pmid:2275553 |
Ohtani H et al. | Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism. | 1990 | J. Lipid Res. | pmid:2280182 |
Lefkowith J et al. | Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes. | 1990 | J. Exp. Med. | pmid:2307932 |
Buckman DK et al. | Modulation of mouse mammary tumor growth and linoleate enhanced metastasis by oleate. | 1990 | J. Nutr. | pmid:2313378 |
MacIver DH et al. | The effect of short chain fatty acid supplementation on membrane electrolyte transport and blood pressure. | 1990 | J Hum Hypertens | pmid:2283638 |
Jakobsson A et al. | Metabolism of fatty acids and their incorporation into phospholipids of the mitochondria and endoplasmic reticulum in isolated hepatocytes determined by isolation of fluorescence derivatives. | 1990 | Biochim. Biophys. Acta | pmid:2223867 |
Buset M et al. | Injury induced by fatty acids or bile acid in isolated human colonocytes prevented by calcium. | 1990 | Cancer Lett. | pmid:2322935 |
Katzenellenbogen BS and Norman MJ | Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen. | 1990 | Endocrinology | pmid:2404751 |
Jensen MD et al. | Measurement of non-steady-state free fatty acid turnover. | 1990 | Am. J. Physiol. | pmid:2405695 |
Kinsella JE and Lokesh B | Dietary lipids, eicosanoids, and the immune system. | 1990 | Crit. Care Med. | pmid:2105185 |
Kawada H et al. | Improved maintenance of adult rat alveolar type II cell differentiation in vitro: effect of serum-free, hormonally defined medium and a reconstituted basement membrane. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2363935 |
Lernhardt W | Fatty acid requirement of B lymphocytes activated in vitro. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2302243 |
Galaris D et al. | Ferrylmyoglobin-catalyzed linoleic acid peroxidation. | 1990 | Arch. Biochem. Biophys. | pmid:2383021 |
Miller CC and Ziboh VA | Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). | 1990 | J. Invest. Dermatol. | pmid:2106562 |
Conquer J and Mahadevappa VG | Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2106881 |
Okuyama H | [Does food affect brain functions?]. | 1990 | Tanpakushitsu Kakusan Koso | pmid:1970438 |
elAttar TM et al. | Comparison of the inhibitory effect of polyunsaturated fatty acids on prostaglandin synthesis. II. Fibroblasts. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1971442 |
Kestin M et al. | n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. | 1990 | Am. J. Clin. Nutr. | pmid:1971991 |
Watanabe S et al. | Effect of dietary alpha-linolenate/linoleate balance on crescent type-anti-glomerular basement membrane nephritis in rats. | 1990 | Lipids | pmid:1972260 |
Singer P et al. | Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension. | 1990 | J Hum Hypertens | pmid:1972963 |
Lipids and multiple sclerosis. | 1990 | Lancet | pmid:1973215 | |
Oxholm A et al. | Abnormal essential fatty acid metabolism in Darier's disease. | 1990 | Arch Dermatol | pmid:1977367 |
Kitagawa S et al. | Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. | 1990 | Biochim. Biophys. Acta | pmid:2166588 |
Anel A et al. | Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. | 1990 | Biochim. Biophys. Acta | pmid:2114179 |
Moch D et al. | The linoleic acid metabolite 9DS-hydroxy-10,12(E,Z)-octadecadienoic acid is a strong proinflammatory mediator in an experimental wound healing model of the rat. | 1990 | Biomed. Biochim. Acta | pmid:2169722 |
Léger CL et al. | Evidence for a structurally specific role of essential polyunsaturated fatty acids depending on their peculiar double-bond distribution in biomembranes. | 1990 | Biochemistry | pmid:2169876 |
Fletcher MP and Ziboh VA | Effects of dietary supplementation with eicosapentaenoic acid or gamma-linolenic acid on neutrophil phospholipid fatty acid composition and activation responses. | 1990 | Inflammation | pmid:2174410 |
Kulkarni AP et al. | Hydrogen peroxide: a potent activator of dioxygenase activity of soybean lipoxygenase. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2105721 |
Umeda F et al. | Modification of prostacyclin-stimulatory activity in sera by glucose, insulin, low density lipoprotein, linoleic acid and linoleic acid hydroperoxide. | 1990 | Diabetes Res. Clin. Pract. | pmid:2106424 |
Lasekan JB et al. | Dietary olive and safflower oils in promotion of DMBA-induced mammary tumorigenesis in rats. | 1990 | Nutr Cancer | pmid:2106675 |
Tonogai Y and Tai HH | Quantitation of 13-hydroxyoctadecadienoic acid (13-HODE) by radioimmunoassay. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2111553 |
Green P et al. | Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study. | 1990 | Am. J. Clin. Nutr. | pmid:2239789 |
Fletcher JE et al. | Fatty acid uptake and catecholamine-stimulated phospholipid metabolism in immortalized airway epithelial cells established from primary cultures. | 1990 | Biochem. Int. | pmid:2241999 |
Mimouni V and Poisson JP | Spontaneous diabetes in BB rats: evidence for insulin dependent liver microsomal delta 6 and delta 5 desaturase activities. | 1990 | Horm. Metab. Res. | pmid:2227799 |
Pariza MW and Ha YL | Conjugated dienoic derivatives of linoleic acid: a new class of anticarcinogens. | 1990 | Med Oncol Tumor Pharmacother | pmid:2232933 |
Moore SA et al. | Role of the blood-brain barrier in the formation of long-chain omega-3 and omega-6 fatty acids from essential fatty acid precursors. | 1990 | J. Neurochem. | pmid:2115069 |
Nikolaev V et al. | Stereochemical nature of the products of linoleic acid oxidation catalyzed by lipoxygenases from potato and soybean. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2116790 |
Mensink RP et al. | Effect of a monounsaturated diet vs. a polyunsaturated fatty acid-enriched diet on blood pressure in normotensive women and men. | 1990 | Eur. J. Clin. Invest. | pmid:2121507 |
Newman MJ | Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2371287 |
Gyllenhammar H et al. | Dietary linoleate supplementation modulates formyl-peptide receptor expression and functional responses of rat neutrophils. | 1990 | J. Lab. Clin. Med. | pmid:2157784 |
Chatterjee S and Ghosh N | Phosphatidylcholine stimulates the activity of UDP-Gal beta 1-4 galactosyltransferase in normal human kidney proximal tumour cells. | 1990 | Indian J. Biochem. Biophys. | pmid:2129343 |
Kawashima Y et al. | Peroxisome proliferators enhance linoleic acid metabolism in rat liver. Increased biosynthesis of omega 6 polyunsaturated fatty acids. | 1990 | J. Biol. Chem. | pmid:2160962 |
Bedotti R et al. | Stimulatory effect of serum albumin on the proliferation of serum-free SV40-transformed Balb/c 3T3 cells. | 1990 | Biochim. Biophys. Acta | pmid:2163687 |
Koba K and Sugano M | Dietary protein influences polyunsaturated fatty acid patterns of rat tissue lipids. | 1990 | J. Nutr. Sci. Vitaminol. | pmid:2130152 |
Akamatsu H et al. | Suppressive effects of linoleic acid on neutrophil oxygen metabolism and phagocytosis. | 1990 | J. Invest. Dermatol. | pmid:2143521 |
Piché LA and Mahadevappa VG | Modification of rat platelet fatty acid composition by dietary lipids of animal and vegetable origin. | 1990 | J. Nutr. | pmid:2111377 |
Yashiro K et al. | [Changes in the free fatty acid composition of rat salivary glands induced by chronic administration of isoproterenol]. | 1990 | Gifu Shika Gakkai Zasshi | pmid:2133668 |
Weaver BJ et al. | Dietary canola oil: effect on the accumulation of eicosapentaenoic acid in the alkenylacyl fraction of human platelet ethanolamine phosphoglyceride. | 1990 | Am. J. Clin. Nutr. | pmid:2181858 |
Renner HW | Anticlastogenic dietary factors assessed in mammalian assays. | 1990 | Basic Life Sci. | pmid:2183774 |
Farnworth ER and Kramer JK | Fat supplementation to the gestation diet of older sows and its effect on maternal and fetal fat metabolism. | 1990 | Reprod. Nutr. Dev. | pmid:1981311 |
Marra CA and de Alaniz MJ | Mineralocorticoids modify rat liver delta 6 desaturase activity and other parameters of lipid metabolism. | 1990 | Biochem. Int. | pmid:1981670 |
Byczkowski JZ and Kulkarni AP | Lipid peroxidation and benzo(a)pyrene derivative co-oxygenation by environmental pollutants. | 1990 | Bull Environ Contam Toxicol | pmid:2176112 |
Mullarkey CJ et al. | Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2176495 |
Abraham RD et al. | Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. | 1990 | Atherosclerosis | pmid:2112389 |
Vaughan PF and Ball SG | The effect of unsaturated fatty acids on sodium nitroprusside stimulation of guanylate cyclase in the human astrocytoma clone, D384, and the human neuroblastoma clone, NB1-G. | 1990 | Biochem. Pharmacol. | pmid:1968340 |
Field CJ et al. | Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals. | 1990 | J. Biol. Chem. | pmid:2113530 |
Kim D and Duff RA | Regulation of K+ channels in cardiac myocytes by free fatty acids. | 1990 | Circ. Res. | pmid:2119911 |
Hori T et al. | Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2114113 |
Molina MT et al. | Caecal and colonic uptake of both linoleic acid and cholesterol in rats following intestinal resection. | 1990 | Lipids | pmid:2079865 |
Hjelte L et al. | Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats. | 1990 | Am. J. Physiol. | pmid:2115302 |
Corner EJ et al. | Accumulation of eicosapentaenoic acid in plasma phospholipids of subjects fed canola oil. | 1990 | Lipids | pmid:2079866 |
Henricks PA et al. | Epithelium-derived linoleic acid metabolites modulate airway smooth muscle function. | 1990 | Agents Actions Suppl. | pmid:2080762 |
Emken EA et al. | Metabolism in vivo of deuterium-labelled linolenic and linoleic acids in humans. | 1990 | Biochem. Soc. Trans. | pmid:2083671 |
James SR et al. | Linoleic acid increases cytosolic Ca2+ in lymphocytes. | 1990 | Biochem. Soc. Trans. | pmid:2083720 |
Bell JG and Raynard RS | Effects of a high linoleic acid diet on the fatty acid composition of leucocytes from Atlantic salmon (Salmo salar). | 1990 | Biochem. Soc. Trans. | pmid:2083726 |
Palmblad J | Eicosanoids and modulation of inflammatory and immune responses. | 1990 | Scand. J. Clin. Lab. Invest. Suppl. | pmid:1963704 |