Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Kromhout D et al. | Long-term effects of a linoleic acid-enriched diet, changes in body weight and alcohol consumption on serum total and HDL-cholesterol. | 1987 | Atherosclerosis | pmid:3632757 |
Berlin E et al. | Dietary linoleate increases fluidity and influences chemical composition of plasma low density lipoprotein in adult men. | 1987 | Atherosclerosis | pmid:3632760 |
Field EJ and Joyce G | Duchenne muscular dystrophy: do both parents contribute genetically to the disease? | 1987 | J. Neurol. Sci. | pmid:3126270 |
Funk CD et al. | Effects of selenium-deficient diets on the production of prostaglandins and other oxygenated metabolites of arachidonic acid and linoleic acid by rat and rabbit aortae. | 1987 | Biochim. Biophys. Acta | pmid:3115301 |
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Colard O et al. | Hydrolysis of endogenous phospholipids by rat platelet phospholipase A2: ether or acyl bond and polar head group selectivity. | 1987 | Biochim. Biophys. Acta | pmid:3115303 |
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Murphy MG et al. | Effects of membrane polyunsaturated fatty acids on opiate peptide inhibition of basal and prostaglandin E1-stimulated cyclic AMP formation in intact N1E-115 neuroblastoma cells. | 1987 | Biochem. Pharmacol. | pmid:2825714 |
Hagve TA and Christophersen BO | In vitro effects of alpha-bromopalmitate on metabolism of essential fatty acids studied in isolated rat hepatocytes: sex differences. | 1987 | Biochim. Biophys. Acta | pmid:3099848 |
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Cunnane SC and McAdoo KR | Iron intake influences essential fatty acid and lipid composition of rat plasma and erythrocytes. | 1987 | J. Nutr. | pmid:3116180 |
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Uotila P et al. | Relaxing effects of 15-lipoxygenase products of arachidonic acid on rat aorta. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3116200 |
Bomalaski JS et al. | Alteration of uptake and distribution of eicosanoid precursor fatty acids by aspirin. | 1987 | Biochem. Pharmacol. | pmid:3117063 |
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Effect of parenteral linoleate on fatty acid composition of infant brain and liver. | 1987 | Nutr. Rev. | pmid:3114686 | |
McLennan PL et al. | Dietary lipid modulation of myocardial beta-adrenergic mechanisms, Ca2+-dependent automaticity, and arrhythmogenesis in the marmoset. | 1987 | J. Cardiovasc. Pharmacol. | pmid:2444777 |
Gibian MJ and Vandenberg P | Product yield in oxygenation of linoleate by soybean lipoxygenase: the value of the molar extinction coefficient in the spectrophotometric assay. | 1987 | Anal. Biochem. | pmid:3116881 |
Ludwig P et al. | A kinetic model for lipoxygenases based on experimental data with the lipoxygenase of reticulocytes. | 1987 | Eur. J. Biochem. | pmid:3117544 |
Cook HW and Spence MW | Studies of the modulation of essential fatty acid metabolism by fatty acids in cultured neuroblastoma and glioma cells. | 1987 | Biochim. Biophys. Acta | pmid:3105586 |
Ha YL et al. | Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid. | 1987 | Carcinogenesis | pmid:3119246 |
Stocker R et al. | Bilirubin is an antioxidant of possible physiological importance. | 1987 | Science | pmid:3029864 |
Griffin JF et al. | Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in biopsy material. | 1987 | Clin. Chim. Acta | pmid:3568417 |
Huang YS et al. | Protective effect of gamma-linolenic acid on aspirin-induced gastric hemorrhage in rats. | 1987 | Digestion | pmid:3030865 |
Tay SK et al. | Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in exfoliated cells. | 1987 | Clin. Chim. Acta | pmid:3568418 |
Horrobin DF | Essential fatty acids, prostaglandins, and alcoholism: an overview. | 1987 | Alcohol. Clin. Exp. Res. | pmid:3032012 |
Popp-Snijders C et al. | Dietary supplementation of omega-3 polyunsaturated fatty acids improves insulin sensitivity in non-insulin-dependent diabetes. | 1987 | Diabetes Res. | pmid:3038454 |
Quik M | Evidence for an involvement of membrane lipids in the control of neuronal nicotinic receptor function using bungarotoxin II-S1. | 1987 | J. Neurochem. | pmid:3106571 |
Bandyopadhyay GK et al. | Linoleate metabolites enhance the in vitro proliferative response of mouse mammary epithelial cells to epidermal growth factor. | 1987 | J. Biol. Chem. | pmid:3102474 |
Kaneko T et al. | Lethal effects of a linoleic acid hydroperoxide and its autoxidation products, unsaturated aliphatic aldehydes, on human diploid fibroblasts. | 1987 | Chem. Biol. Interact. | pmid:3664790 |
Das UN et al. | Uptake and distribution of cis-unsaturated fatty acids and their effect on free radical generation in normal and tumor cells in vitro. | 1987 | Free Radic. Biol. Med. | pmid:3040539 |
Fisher M et al. | Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients. | 1987 | Acta Neurol. Scand. | pmid:3687373 |
Ashida H et al. | Effect of orally administered secondary autoxidation products of linoleic acid on carbohydrate metabolism in rat liver. | 1987 | Arch. Biochem. Biophys. | pmid:3688880 |
Willett WC et al. | Dietary fat and the risk of breast cancer. | 1987 | N. Engl. J. Med. | pmid:3785347 |
Jensen E et al. | Cell-density-dependent uptake of chylomicron remnants in rat hepatocyte monolayers. Effects of compactin and mevalonic acid. | 1987 | Biochim. Biophys. Acta | pmid:3790613 |
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Simpson RJ and Peters TJ | Transport of Fe2+ across lipid bilayers: possible role of free fatty acids. | 1987 | Biochim. Biophys. Acta | pmid:3828339 |
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Kovár J | Hybridoma cultivation in defined serum-free media: growth-supporting substances. IV. Lipids and serum albumin. | 1987 | Folia Biol. (Praha) | pmid:3436465 |
McIntosh GH et al. | The influence of linoleate and vitamin E from sunflower seed oil on platelet function and prostaglandin production in the common marmoset monkey. | 1987 | J. Nutr. Sci. Vitaminol. | pmid:3437342 |
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Wickwire MA et al. | Effect of maternal dietary linoleic acid and trans-octadecenoic acid on the fatty acid composition and prostaglandin content of rat milk. | 1987 | J. Nutr. | pmid:3470441 |
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Cohen LA | Fat and endocrine-responsive cancer in animals. | 1987 | Prev Med | pmid:3476922 |
Ito Y et al. | A low protein-high linoleate diet increases glomerular PGE2 and protects renal function in rats with reduced renal mass. | 1987 | Prostaglandins Leukot Med | pmid:3477824 |
Yamamoto N et al. | Effect of dietary alpha-linolenate/linoleate balance on brain lipid compositions and learning ability of rats. | 1987 | J. Lipid Res. | pmid:2883248 |
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Croft KD et al. | Differential inhibition of thromboxane B2 and leukotriene B4 biosynthesis by two naturally occurring acetylenic fatty acids. | 1987 | Biochim. Biophys. Acta | pmid:2822134 |
Tischinger-Wagner H et al. | [Oxidative degradation of linoleic acid methyl ester in suspensions of inorganic excipients. 1. Auto-oxidation in the presence of silicic acid products and aluminum oxide]. | 1987 | Pharmazie | pmid:2823296 |
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Berge RK et al. | Effect of a high-fat diet with partially hydrogenated fish oil on long-chain fatty acid metabolizing enzymes in subcellular fractions of rat liver. | 1987 | Arch. Biochem. Biophys. | pmid:2880562 |
Clementz T et al. | Membrane potential, lipid regulation and adenylate energy charge in acyl chain modified Acholeplasma laidlawii. | 1987 | Biochim. Biophys. Acta | pmid:3567184 |
Strannegård IL et al. | Essential fatty acids in serum lecithin of children with atopic dermatitis and in umbilical cord serum of infants with high or low IgE levels. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3570505 |
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Heifets M et al. | Effect of dietary lipids on renal function in rats with subtotal nephrectomy. | 1987 | Kidney Int. | pmid:3669493 |
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Hubbard NE and Erickson KL | Enhancement of metastasis from a transplantable mouse mammary tumor by dietary linoleic acid. | 1987 | Cancer Res. | pmid:3677068 |
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Sanders TA and Rana SK | Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. | 1987 | Ann. Nutr. Metab. | pmid:2892461 |
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Loesberg C et al. | Effects of dietary poly-unsaturated fatty acids on tracheal histaminergic and cholinergic responsiveness in experimental models of bronchial hypersensitivity and hyperreactivity. | 1987 | Agents Actions | pmid:2895570 |
Perez RV et al. | The effect of donor specific transfusions and dietary fatty acids on rat cardiac allograft survival. | 1987 | J. Surg. Res. | pmid:3553741 |
Berry EM et al. | Dietary fat, plasma lipoproteins, and immune function in middle-aged American men. | 1987 | Nutr Cancer | pmid:3562291 |
Nugteren DH and Kivits GA | Conversion of linoleic acid and arachidonic acid by skin epidermal lipoxygenases. | 1987 | Biochim. Biophys. Acta | pmid:3113487 |
Arca M et al. | Erythrocyte fatty acid composition and gallstone disease: results of an epidemiological survey. | 1987 | Am. J. Clin. Nutr. | pmid:3604961 |