Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Takase S and Hosoya N | Effect of dietary medium chain triglyceride on lipogenic enzyme activity in rat liver. | 1986 | J. Nutr. Sci. Vitaminol. | pmid:3761045 |
Kanazawa K et al. | The effect of orally administered secondary autoxidation products of linoleic acid on the activity of detoxifying enzymes in the rat liver. | 1986 | Biochim. Biophys. Acta | pmid:3768385 |
Montalto MB and Benson JD | Nutrient intakes of older infants: effect of different milk feedings. | 1986 | J Am Coll Nutr | pmid:3771945 |
Feingold KR et al. | Effect of essential fatty acid deficiency on cutaneous sterol synthesis. | 1986 | J. Invest. Dermatol. | pmid:3772153 |
Jensen GE and Clausen J | Glutathione peroxidase activity, associated enzymes and substrates in blood cells from patients with multiple sclerosis--effects of antioxidant supplementation. | 1986 | Acta Pharmacol Toxicol (Copenh) | pmid:3776606 |
Kapoulas VM and Andrikopoulos NK | Detection of olive oil adulteration with linoleic acid-rich oils by reversed-phase high-performance liquid chromatography. | 1986 | J. Chromatogr. | pmid:3782323 |
Willett WC et al. | Dietary fat and the risk of breast cancer. | 1987 | N. Engl. J. Med. | pmid:3785347 |
Roguet R et al. | In vivo distribution of linoleic acid in hairless rat skin following topical administration. | 1986 | Arch. Dermatol. Res. | pmid:3789807 |
Caponnetto A et al. | [Polyunsaturated fatty acids (omega-6) in tissues: variations induced by supplementation with linoleic acid and alloxan]. | 1986 | Boll. Soc. Ital. Biol. Sper. | pmid:3790314 |
Jensen E et al. | Cell-density-dependent uptake of chylomicron remnants in rat hepatocyte monolayers. Effects of compactin and mevalonic acid. | 1987 | Biochim. Biophys. Acta | pmid:3790613 |
Lee SH and Clandinin MT | Effect of dietary fat on the utilization of fatty acids by myocardial tissue in the rat. | 1986 | J. Nutr. | pmid:3794820 |
Nassar BA et al. | The influence of dietary manipulation with n-3 and n-6 fatty acids on liver and plasma phospholipid fatty acids in rats. | 1986 | Lipids | pmid:3796229 |
de Gomez Dumm IN et al. | Effect of malonyl-CoA on delta 6 desaturation activity of rat liver microsomes. | 1986 | Lipids | pmid:3796237 |
Effect of age on the linoleate content of skin acylglucosylceramide in mice. | 1986 | Nutr. Rev. | pmid:3796906 | |
Utermohlen V and Tucker MA | Possible effects of dietary n-6 series polyunsaturated fatty acids on the development of immune dysfunction and infection. | 1986 | Proc Nutr Soc | pmid:3797410 |
Takagi M et al. | Effects of lipophilic derivatives of L-ascorbic acid and dehydro-L-ascorbic acid on the peroxidation of linoleic acid in neutral phosphate buffer containing alcohol. | 1986 | J. Nutr. Sci. Vitaminol. | pmid:3806253 |
Tilvis RS et al. | Serum lipids and fatty acids in ischemic strokes. | 1987 | Am. Heart J. | pmid:3812213 |
Masuda Y et al. | The mode of enhanced enteral absorption of macromolecules by lipid-surfactant mixed micelles. I. | 1986 | J. Pharmacobio-dyn. | pmid:3820056 |
Thomson AB et al. | A high linoleic acid diet diminishes enhanced intestinal uptake of sugars in diabetic rats. | 1987 | Am. J. Physiol. | pmid:3826353 |
Simpson RJ and Peters TJ | Transport of Fe2+ across lipid bilayers: possible role of free fatty acids. | 1987 | Biochim. Biophys. Acta | pmid:3828339 |
Levinson S et al. | Comparison of intraluminal and intravenous mediators of colonic response to eating. | 1985 | Dig. Dis. Sci. | pmid:3838089 |
Burton AF and Anderson FH | Increased cholesteryl ester content in liver of mice fed lipid emulsion diets high in polyunsaturated fats. | 1985 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:3839859 |
Kort WJ et al. | Spontaneous tumor incidence in female brown Norway rats after lifelong diets high and low in linoleic acid. | 1985 | J. Natl. Cancer Inst. | pmid:3856059 |
Moilanen T et al. | Atherosclerosis precursors in Finnish children and adolescents. V. Fatty acid composition of serum cholesteryl esters: regional differences in Finland. | 1985 | Acta Paediatr Scand Suppl | pmid:3867222 |
Jäntti J et al. | Linoleic acid treatment in inflammatory arthritis. | 1985 | Int J Clin Pharmacol Ther Toxicol | pmid:3886567 |
Calderbank J et al. | Plasma-membrane phospholipid unsaturation affects expression of the general amino-acid permease in Saccharomyces cerevisiae Y185. | 1985 | J. Gen. Microbiol. | pmid:3886834 |
Allen RE et al. | Effect of insulin and linoleic acid on satellite cell differentiation. | 1985 | J. Anim. Sci. | pmid:3894312 |
Vergroesen AJ | Effects of dietary lipid composition on serum lipoproteins. | 1985 | Prog. Clin. Biol. Res. | pmid:3903769 |
Margetts BM et al. | Blood pressure and dietary polyunsaturated and saturated fats: a controlled trial. | 1985 | Clin. Sci. | pmid:3905211 |
Allen RE et al. | A serum-free medium that supports the growth of cultured skeletal muscle satellite cells. | 1985 | In Vitro Cell. Dev. Biol. | pmid:3905759 |
Carroll KK | Dietary fat in relation to mammary carcinogenesis. | 1985 | Int. Symp. Princess Takamatsu Cancer Res. Fund | pmid:3916197 |
Fusco AC et al. | Schistosoma mansoni: eicosanoid production by cercariae. | 1985 | Exp. Parasitol. | pmid:3917929 |
Farrell PM et al. | Fatty acid abnormalities in cystic fibrosis. | 1985 | Pediatr. Res. | pmid:3918287 |
Boberg M et al. | Platelet fatty acid composition in relation to fatty acid composition in plasma and to serum lipoprotein lipids in healthy subjects with special reference to the linoleic acid pathway. | 1985 | Clin. Sci. | pmid:3919990 |
Ip C et al. | Requirement of essential fatty acid for mammary tumorigenesis in the rat. | 1985 | Cancer Res. | pmid:3921234 |
Stumpf DA | The inherited ataxias. | 1985 | Neurol Clin | pmid:3921817 |
Charnock JS et al. | Changes in fatty acid composition of the cardiac phospholipids of the cotton-eared marmoset (Callithrix jacchus) after feeding different lipid supplements. | 1985 | Ann. Nutr. Metab. | pmid:3922279 |
Hansen HS and Jensen B | Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate. | 1985 | Biochim. Biophys. Acta | pmid:3922424 |
Nugteren DH et al. | Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat. | 1985 | Biochim. Biophys. Acta | pmid:3922425 |
Isseroff RR et al. | Alterations in fatty acid composition of murine keratinocytes with in vitro cultivation. | 1985 | J. Invest. Dermatol. | pmid:3926903 |
Cooke RJ et al. | Safflower oil emulsion administration during parenteral nutrition in the preterm infant. 1. Effect on essential fatty acid status. | 1985 | J. Pediatr. Gastroenterol. Nutr. | pmid:3930688 |
Jones PJ et al. | Whole body oxidation of dietary fatty acids: implications for energy utilization. | 1985 | Am. J. Clin. Nutr. | pmid:3933323 |
Lankin VZ et al. | On the nature of the stimulation of the lipoxygenase from rabbit reticulocytes by biological membranes. | 1985 | Biomed. Biochim. Acta | pmid:3933493 |
Salzmann-Reinhardt U et al. | Metabolism of polyunsaturated fatty acids by rabbit reticulocytes. | 1985 | Eur. J. Biochem. | pmid:3933978 |
Buchanan MR et al. | 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX. | 1985 | J. Biol. Chem. | pmid:3934168 |
Andersen GE et al. | Fatty acid changes in plasma lipids and lymphocyte phospholipids after infusion of intralipid to newborn infants. | 1985 Nov-Dec | JPEN J Parenter Enteral Nutr | pmid:3934403 |
Wolff JA et al. | The role of lipid in the management of methylmalonic acidaemia: administration of linoleic acid does not increase excretion of methylmalonic acid. | 1985 | J. Inherit. Metab. Dis. | pmid:3939583 |
Youyou A et al. | Recovery of altered fatty acid composition induced by a diet devoid of n-3 fatty acids in myelin, synaptosomes, mitochondria, and microsomes of developing rat brain. | 1986 | J. Neurochem. | pmid:3940283 |
van Staveren WA et al. | Validity of the fatty acid composition of subcutaneous fat tissue microbiopsies as an estimate of the long-term average fatty acid composition of the diet of separate individuals. | 1986 | Am. J. Epidemiol. | pmid:3946391 |
Nijssen JG and van den Bosch H | Cytosol-stimulated remodeling of phosphatidylcholine in rat lung microsomes. | 1986 | Biochim. Biophys. Acta | pmid:3947653 |
Kryvi H et al. | Effects of essential fatty acid deficiency on mitochondria and peroxisomes in rat hepatocytes with special reference to a partially hydrogenated fish oil diet. | 1986 | Biochim. Biophys. Acta | pmid:3947675 |
De Villiers M and Lochner A | Mitochondrial Ca2+ fluxes: role of free fatty acids, acyl-CoA and acylcarnitine. | 1986 | Biochim. Biophys. Acta | pmid:3955069 |
Fressinaud C et al. | Fatty acid composition of endoneurium and perineurium from adult rat sciatic nerve. | 1986 | J. Neurochem. | pmid:3958717 |
Becker W and Bruce A | Retention of linoleic acid in carcass lipids of rats fed different levels of essential fatty acids. | 1986 | Lipids | pmid:3959773 |
Otsuki T et al. | Two geometrical isomers of linoleic acid: improved total syntheses. | 1986 | Lipids | pmid:3959777 |
Kort WJ et al. | Influence of the linoleic acid content of the diet on tumor growth in transplantable rat tumor models. | 1986 | Ann. Nutr. Metab. | pmid:3963748 |
Howard-Williams J et al. | Polyunsaturated fatty acids and diabetic retinopathy. | 1985 | Br J Ophthalmol | pmid:3965024 |
Montalto MB et al. | Nutrient intakes of formula-fed infants and infants fed cow's milk. | 1985 | Pediatrics | pmid:3969338 |
Reid JC and Husbands DR | Oxidative metabolism of long-chain fatty acids in mitochondria from sheep and rat liver. Evidence that sheep conserve linoleate by limiting its oxidation. | 1985 | Biochem. J. | pmid:3977825 |
Canfield LM et al. | Anti-oxidant/pro-oxidant reactions of vitamin K. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3985964 |
Koletzko B et al. | Fatty acid composition of plasma lipids in acrodermatitis enteropathica before and after zinc supplementation. | 1985 | Eur. J. Pediatr. | pmid:3987733 |
Sugita A et al. | [Serum long chain fatty acids in the patients with inflammatory bowel disease]. | 1985 | Nihon Shokakibyo Gakkai Zasshi | pmid:3990036 |
Adam O et al. | Prostaglandin formation and platelet aggregation during fasting and linoleic acid intake. | 1985 | Res Exp Med (Berl) | pmid:3992060 |
Válek J et al. | Serum linoleic acid and cardiovascular death in postinfarction middle-aged men. | 1985 | Atherosclerosis | pmid:3994777 |
Tsuchida M et al. | Fluorescent substances in mouse and human sera as a parameter of in vivo lipid peroxidation. | 1985 | Biochim. Biophys. Acta | pmid:3995061 |
Bowser PA et al. | Identification, isolation and characterization of epidermal lipids containing linoleic acid. | 1985 | Biochim. Biophys. Acta | pmid:3995076 |
Demant EJ and Wassermann K | Doxorubicin induced alterations in lipid metabolism of cultured myocardial cells. | 1985 | Biochem. Pharmacol. | pmid:4004891 |
Robinson M et al. | Acylation of lysophospholipids by rabbit alveolar macrophages. Specificities of CoA-dependent and CoA-independent reactions. | 1985 | J. Biol. Chem. | pmid:4008481 |
McMaster JD et al. | Incorporation in vitro of 14C fatty acids into bovine sebaceous gland and dermal lipids. | 1985 | Res. Vet. Sci. | pmid:4012036 |
Noble RC et al. | Synthesis of C20 and C22 polyunsaturated fatty acids by the placenta of the sheep. | 1985 | Biol. Neonate | pmid:4027296 |
Goldstein R et al. | Increased maternal-fetal transport of fat in diabetes assessed by polyunsaturated fatty acid content in fetal lipids. | 1985 | Biol. Neonate | pmid:4027297 |
Jett M et al. | Metabolic fate of liposomal phosphatidylinositol in murine tumor cells: implications for the mechanism of tumor cell cytotoxicity. | 1985 | Cancer Res. | pmid:4027970 |
Takada K et al. | Promotion of the selective lymphatic delivery of cyclosporin A by lipid-surfactant mixed micelles. | 1985 | J. Pharmacobio-dyn. | pmid:4032221 |
Kanazawa K et al. | Uptake of secondary autoxidation products of linoleic acid by the rat. | 1985 | Lipids | pmid:4033361 |
Martinez GA et al. | Nutrient intakes of American infants and children fed cow's milk or infant formula. | 1985 | Am. J. Dis. Child. | pmid:4036886 |
Roshanai F and Sanders TA | Influence of different supplements of N-3 polyunsaturated fatty acids on blood and tissue lipids in rats receiving high intakes of linoleic acid. | 1985 | Ann. Nutr. Metab. | pmid:4037727 |
Becker W and MÃ¥nsson JE | Incorporation of 14C into tissue lipids after oral administration of [1-14C]linoleic acid in rats fed different levels of essential fatty acids. | 1985 | J. Nutr. | pmid:4045568 |
Chirkov VA et al. | [Correction of intracellular metabolism in acute pneumonia in young children]. | 1985 | Pediatriia | pmid:4047863 |
Charnock JS et al. | Altered levels of n-6/n-3 fatty acids in rat heart and storage fat following variable dietary intake of linoleic acid. | 1985 | Ann. Nutr. Metab. | pmid:4051450 |
Charnock JS et al. | Diet and cardiac arrhythmia: effects of lipids on age-related changes in myocardial function in the rat. | 1985 | Ann. Nutr. Metab. | pmid:4051452 |
Takahashi K et al. | Ester-exchange catalyzed by lipase modified with polyethylene glycol. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4052065 |
Hennig B et al. | Exposure to fatty acid increases human low density lipoprotein transfer across cultured endothelial monolayers. | 1985 | Circ. Res. | pmid:4053308 |
Hagve TA et al. | Norflurazon--an inhibitor of essential fatty acid desaturation in isolated liver cells. | 1985 | Lipids | pmid:4058269 |
Barclay LR et al. | The antioxidant activity of alpha-tocopherol-bovine serum albumin complex in micellar and liposome autoxidations. | 1985 | J. Biol. Chem. | pmid:4066696 |
Mathias MM and Dupont J | Quantitative relationships between dietary linoleate and prostaglandin (eicosanoid) biosynthesis. | 1985 | Lipids | pmid:4068908 |
Potter LM and McCarthy JP | Varying fat and protein in diets of growing large white turkeys. | 1985 | Poult. Sci. | pmid:4070128 |
Clark DL and Queener SF | Effects of diabetes mellitus on renal fatty acid activation and desaturation. | 1985 | Biochem. Pharmacol. | pmid:4074391 |
Giamalva D et al. | A comparison of the rates of ozonation of biological antioxidants and oleate and linoleate esters. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4084297 |
Ford GL | Semi-preparative isolation of crepenynic acid, a potential inhibitor of essential fatty acid metabolism. | 1985 | J. Chromatogr. | pmid:4086624 |
Salo MK et al. | Platelet aggregation in Finnish men and its relation to fatty acids in platelets, plasma and adipose tissue. | 1985 | Thromb. Haemost. | pmid:4089791 |
Adam O et al. | [The effect of linoleic acid intake on its concentration and resultant products in individual plasma lipids in humans]. | 1985 | Z Ernahrungswiss | pmid:4096032 |
Kabara JJ et al. | Fatty acids and derivatives as antimicrobial agents. | 1972 | Antimicrob. Agents Chemother. | pmid:4670656 |
Enig MG et al. | Trans-unsaturated fatty acids in margarines and human subcutaneous fat in Israel. | 1984 | Hum Nutr Clin Nutr | pmid:6086551 |
Reuter W and Heybey U | [Dietary fat analysis--a contribution to the problem of nutrition and aging]. | 1984 May-Jun | Z Alternsforsch | pmid:6087576 |
Yorek MA et al. | Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. | 1984 | Biochim. Biophys. Acta | pmid:6089899 |
Furukawa M et al. | Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. | 1984 | Biochim. Biophys. Acta | pmid:6089906 |
Curnutte JT et al. | Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate. | 1984 | J. Biol. Chem. | pmid:6090448 |
Johnston DV and Marshall LA | Dietary fat, prostaglandins and the immune response. | 1984 | Prog Food Nutr Sci | pmid:6091179 |
Brush MG et al. | Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. | 1984 | Am. J. Obstet. Gynecol. | pmid:6091462 |
Hagve TA and Christophersen BO | Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. | 1984 | Biochim. Biophys. Acta | pmid:6093889 |