Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Lasa A et al. | Effects of high-fat high-sucrose feeding, energy restriction, and trans-10,cis-12 conjugated linoleic acid on visfatin and apelin in hamsters. | 2009 | J Am Coll Nutr | pmid:20516262 |
Liavonchanka A et al. | On the mechanism of a polyunsaturated fatty acid double bond isomerase from Propionibacterium acnes. | 2009 | J. Biol. Chem. | pmid:19164287 |
Ibrahim A et al. | Impact of maternal dietary fatty acid composition on glucose and lipid metabolism in male rat offspring aged 105 d. | 2009 | Br. J. Nutr. | pmid:19166630 |
Calder PC | Early life programming of immune and lung function: can we now exclude a role of arachidonic acid exposure? | 2009 | Br. J. Nutr. | pmid:19166631 |
Oku H et al. | The effects of 2-bromopalmitate on the fatty acid composition in differentiating adipocytes of red sea bream (Pagrus major). | 2009 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:19166960 |
Schwartz J et al. | Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 long-chain polyunsaturated fatty acid synthesis in healthy infants: a double blinded randomised controlled trial. | 2009 | Arch. Dis. Child. | pmid:19193660 |
Uygun DA et al. | A novel support for antibody purification: fatty acid attached chitosan beads. | 2009 | Colloids Surf B Biointerfaces | pmid:19196498 |
Carlotti ME et al. | Role of particle coating in controlling skin damage photoinduced by titania nanoparticles. | 2009 | Free Radic. Res. | pmid:19199115 |
Devillard E et al. | Differences between human subjects in the composition of the faecal bacterial community and faecal metabolism of linoleic acid. | 2009 | Microbiology (Reading, Engl.) | pmid:19202099 |
Torrecilla JS et al. | Self-organizing maps and learning vector quantization networks as tools to identify vegetable oils. | 2009 | J. Agric. Food Chem. | pmid:19267437 |
Yazawa H et al. | Production of polyunsaturated fatty acids in yeast Saccharomyces cerevisiae and its relation to alkaline pH tolerance. | 2009 | Yeast | pmid:19243079 |
Niisuke K et al. | Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis. | 2009 | J. Lipid Res. | pmid:19244216 |
Parnas M et al. | Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels. | 2009 | J. Neurosci. | pmid:19244513 |
Wu D et al. | Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. | 2009 | Anal. Chim. Acta | pmid:19185115 |
Sahoo RR and Biswas SK | Frictional response of fatty acids on steel. | 2009 | J Colloid Interface Sci | pmid:19232636 |
Hennessy AA et al. | Optimization of a reconstituted skim milk based medium for enhanced CLA production by bifidobacteria. | 2009 | J. Appl. Microbiol. | pmid:19187142 |
MartÃnez-Force E et al. | Influence of specific fatty acids on the asymmetric distribution of saturated fatty acids in sunflower (Helianthus annuus L.) triacylglycerols. | 2009 | J. Agric. Food Chem. | pmid:19166295 |
Zhao Z et al. | Biodegradable nanoparticles based on linoleic acid and poly(beta-malic acid) double grafted chitosan derivatives as carriers of anticancer drugs. | 2009 | Biomacromolecules | pmid:19175304 |
Eriksson S et al. | Fatty acid pattern in serum is associated with bone mineralisation in healthy 8-year-old children. | 2009 | Br. J. Nutr. | pmid:19175947 |
Wempe MF et al. | Investigating idebenone and idebenone linoleate metabolism: in vitro pig ear and mouse melanocyte studies. | 2009 | J Cosmet Dermatol | pmid:19250169 |
Kim MH et al. | Linoleic acid induces mouse embryonic stem cell proliferation via Ca2+/PKC, PI3K/Akt, and MAPKs. | 2009 | Cell. Physiol. Biochem. | pmid:19255500 |
HÃ¥versen L et al. | Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. | 2009 | Atherosclerosis | pmid:18599066 |
Ishitsuka Y et al. | Effects of bolus injection of soybean-based fat emulsion and fatty acids on pulmonary gas exchange function. | 2009 | Biol. Pharm. Bull. | pmid:19252304 |
de Meijer VE et al. | Parenteral fish oil as monotherapy for patients with parenteral nutrition-associated liver disease. | 2009 | Pediatr. Surg. Int. | pmid:18828026 |
Saitou K et al. | Contribution of gustation to the palatability of linoleic acid. | 2009 | Physiol. Behav. | pmid:18835400 |
RodrÃguez-Cruz M et al. | Effect of dietary levels of corn oil on maternal arachidonic acid synthesis and fatty acid composition in lactating rats. | 2009 | Nutrition | pmid:18849148 |
Bannenberg G et al. | Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana. | 2009 | Lipids | pmid:18949503 |
Saez G et al. | Hepatic metabolism of glucose and linoleic acid varies in relation to susceptibility to fatty liver in ad libitum-fed Muscovy and Pekin ducks. | 2009 | Br. J. Nutr. | pmid:18616836 |
Lapenna D et al. | Inhibitory activity of salicylic acid on lipoxygenase-dependent lipid peroxidation. | 2009 | Biochim. Biophys. Acta | pmid:18950686 |
Garscha U and Oliw EH | Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity. | 2009 | J. Biol. Chem. | pmid:19289462 |
Yang L et al. | Oxidative stability of conjugated linolenic acids. | 2009 | J. Agric. Food Chem. | pmid:19368396 |
Leekumjorn S et al. | The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes. | 2009 | Biochim. Biophys. Acta | pmid:19371719 |
Wang S et al. | In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation. | 2009 | Br. J. Nutr. | pmid:19660150 |
Roche M et al. | Olive phenols efficiently inhibit the oxidation of serum albumin-bound linoleic acid and butyrylcholine esterase. | 2009 | Biochim. Biophys. Acta | pmid:19714864 |
Pianaro A et al. | Stingless bees: chemical differences and potential functions in Nannotrigona testaceicornis and Plebeia droryana males and workers. | 2009 | J. Chem. Ecol. | pmid:19730955 |
Jirovetz L et al. | Chemical composition, olfactory evaluation and antioxidant effects of essential oil from Mentha canadensis. | 2009 | Nat Prod Commun | pmid:19731614 |
de Castro J et al. | Platelet linoleic acid is a potential biomarker of advanced non-small cell lung cancer. | 2009 | Exp. Mol. Pathol. | pmid:19733167 |
Pandey NR et al. | An induction in hepatic HDL secretion associated with reduced ATPase expression. | 2009 | Am. J. Pathol. | pmid:19717637 |
Radunz AE et al. | Effects of dietary polyunsaturated fatty acid supplementation on fatty acid composition in muscle and subcutaneous adipose tissue of lambs. | 2009 | J. Anim. Sci. | pmid:19717771 |
Taylor WA and Hatch GM | Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1). | 2009 | J. Biol. Chem. | pmid:19737925 |
Iwamoto N et al. | Antioxidative capacities of durum wheat flour and its components on linoleic acid. | 2009 | J Oleo Sci | pmid:19745581 |
Queirós B et al. | In search of synergistic effects in antioxidant capacity of combined edible mushrooms. | 2009 | Int J Food Sci Nutr | pmid:19746297 |
Zhang Y and Wang ZZ | Phenolic composition and antioxidant activities of two Phlomis species: A correlation study. | 2009 | C. R. Biol. | pmid:19748456 |
Simopoulos AP | Evolutionary aspects of the dietary omega-6:omega-3 fatty acid ratio: medical implications. | 2009 | World Rev Nutr Diet | pmid:19696523 |
Wecksler AT et al. | Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1. | 2009 | Bioorg. Med. Chem. | pmid:19716306 |
Takasuka N et al. | Promotion of mouse two-stage skin carcinogenesis by diacylglycerol-rich edible oil. | 2009 | Cancer Lett. | pmid:19028010 |
Malhotra S et al. | Antioxidant activity of citrus cultivars and chemical composition of Citrus karna essential oil. | 2009 | Planta Med. | pmid:19031367 |
Lee CM et al. | SPION-loaded chitosan-linoleic acid nanoparticles to target hepatocytes. | 2009 | Int J Pharm | pmid:19138733 |
Tan YL and Liu CG | Self-aggregated nanoparticles from linoleic acid modified carboxymethyl chitosan: Synthesis, characterization and application in vitro. | 2009 | Colloids Surf B Biointerfaces | pmid:19124228 |
Staiger H et al. | Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans. | 2009 | Diabetes | pmid:19074989 |
Sánchez-Campillo M et al. | Rosmarinic acid, a photo-protective agent against UV and other ionizing radiations. | 2009 | Food Chem. Toxicol. | pmid:19084569 |
Marina AM et al. | Antioxidant capacity and phenolic acids of virgin coconut oil. | 2009 | Int J Food Sci Nutr | pmid:19115123 |
Walsh SW | Plasma from preeclamptic women stimulates transendothelial migration of neutrophils. | 2009 | Reprod Sci | pmid:19087976 |
Minto RE et al. | Atypical biosynthetic properties of a Delta 12/nu+3 desaturase from the model basidiomycete Phanerochaete chrysosporium. | 2009 | Appl. Environ. Microbiol. | pmid:19088315 |
Gemeinhardt A et al. | The influence of linoleic and linolenic acid on the activity and intracellular localisation of phospholipase D in COS-1 cells. | 2009 | Biol. Chem. | pmid:19090716 |
Blask DE | Melatonin, sleep disturbance and cancer risk. | 2009 | Sleep Med Rev | pmid:19095474 |
Yuan X et al. | Identification of an endogenous ligand bound to a native orphan nuclear receptor. | 2009 | PLoS ONE | pmid:19440305 |
Robinson NJ et al. | A potential role for free fatty acids in the pathogenesis of preeclampsia. | 2009 | J. Hypertens. | pmid:19462499 |
Adiguzel A et al. | Antimicrobial and antioxidant activity of the essential oil and methanol extract of Nepeta cataria. | 2009 | Pol. J. Microbiol. | pmid:19469289 |
Wecksler AT et al. | Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. | 2009 | Biochemistry | pmid:19469483 |
Jeng JY et al. | Linoleic acid promotes mitochondrial biogenesis and maintains mitochondrial structure for prevention of streptozotocin damage in RIN-m5F cells. | 2009 | Biosci. Biotechnol. Biochem. | pmid:19502730 |
Pinho RS et al. | Potential oilseed crops from the semiarid region of northeastern Brazil. | 2009 | Bioresour. Technol. | pmid:19577461 |
Guyenet SJ | High-fat diets: details matter. | 2009 | Obesity (Silver Spring) | pmid:19553921 |
Zhang HM et al. | Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation. | 2009 | PLoS ONE | pmid:19557129 |
Sarikurkcu C et al. | Studies on the antioxidant activity of essential oil and different solvent extracts of Vitexagnuscastus L. fruits from Turkey. | 2009 | Food Chem. Toxicol. | pmid:19595732 |
Shah KB et al. | The cardioprotective effects of fish oil during pressure overload are blocked by high fat intake: role of cardiac phospholipid remodeling. | 2009 | Hypertension | pmid:19597033 |
Hernández ML et al. | Expression analysis identifies FAD2-2 as the olive oleate desaturase gene mainly responsible for the linoleic acid content in virgin olive oil. | 2009 | J. Agric. Food Chem. | pmid:19601663 |
Marosvölgyi T et al. | Trans isomeric and LCPUFA are inversely correlated in erythrocyte membrane lipids at mid-gestation. | 2009 | Adv. Exp. Med. Biol. | pmid:19536675 |
Zhu X et al. | Mass spectrometric characterization of protein modification by the products of nonenzymatic oxidation of linoleic acid. | 2009 | Chem. Res. Toxicol. | pmid:19537826 |
Gursoy N et al. | Antioxidant activities, metal contents, total phenolics and flavonoids of seven Morchella species. | 2009 | Food Chem. Toxicol. | pmid:19563856 |
Goupy P et al. | Antioxidant activity of wine pigments derived from anthocyanins: hydrogen transfer reactions to the dpph radical and inhibition of the heme-induced peroxidation of linoleic acid. | 2009 | J. Agric. Food Chem. | pmid:19566083 |
Quintana N et al. | Phytotoxic compounds from roots of Centaurea diffusa Lam. | 2009 | Plant Signal Behav | pmid:19568334 |
Silva-Queiroz SR et al. | PHA(MCL) biosynthesis systems in Pseudomonas aeruginosa and Pseudomonas putida strains show differences on monomer specificities. | 2009 | J. Biotechnol. | pmid:19540884 |
Lausada N et al. | Effect of cyclosporine and sirolimus on fatty acid desaturase activities in cultured HEPG2 cells. | 2009 | Transplant. Proc. | pmid:19545746 |
Tesoriere L et al. | Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes. | 2009 | Free Radic. Res. | pmid:19548153 |
Alves BN et al. | Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs). | 2009 | Cell Biochem. Funct. | pmid:19548271 |
Miranda J et al. | Hepatomegaly induced by trans-10,cis-12 conjugated linoleic acid in adult hamsters fed an atherogenic diet is not associated with steatosis. | 2009 | J Am Coll Nutr | pmid:19571159 |
Deshpande GC et al. | Parenteral lipid emulsions based on olive oil compared with soybean oil in preterm (<28 weeks' gestation) neonates: a randomised controlled trial. | 2009 | J. Pediatr. Gastroenterol. Nutr. | pmid:19644398 |
Kim JI et al. | Kinetic study of the quenching reaction of singlet oxygen by common synthetic antioxidants (tert-butylhydroxyanisol, tert-di-butylhydroxytoluene, and tert-butylhydroquinone) as compared with alpha-tocopherol. | 2009 | J. Food Sci. | pmid:19646028 |
Tsuyama S et al. | Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice. | 2009 | Nutr Neurosci | pmid:19622239 |
Giroud S et al. | Dietary palmitate and linoleate oxidations, oxidative stress, and DNA damage differ according to season in mouse lemurs exposed to a chronic food deprivation. | 2009 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:19625694 |
Cheong SJ et al. | Superparamagnetic iron oxide nanoparticles-loaded chitosan-linoleic acid nanoparticles as an effective hepatocyte-targeted gene delivery system. | 2009 | Int J Pharm | pmid:19429277 |
Fukasawa R et al. | Anti-oxidative effects of rooibos tea extract on autoxidation and thermal oxidation of lipids. | 2009 | J Oleo Sci | pmid:19430189 |
Fang IM et al. | Comparative effects of fatty acids on proinflammatory gene cyclooxygenase 2 and inducible nitric oxide synthase expression in retinal pigment epithelial cells. | 2009 | Mol Nutr Food Res | pmid:19437483 |
Grasso EJ and Calderón RO | Urinary bladder membrane permeability differentially induced by membrane lipid composition. | 2009 | Mol. Cell. Biochem. | pmid:19412731 |
Yasuda M et al. | Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction. | 2009 | Carcinogenesis | pmid:19414503 |
Celia C et al. | Turbiscan lab expert analysis of the stability of ethosomes and ultradeformable liposomes containing a bilayer fluidizing agent. | 2009 | Colloids Surf B Biointerfaces | pmid:19376689 |
Evans LM et al. | Dietary stearate reduces human breast cancer metastasis burden in athymic nude mice. | 2009 | Clin. Exp. Metastasis | pmid:19267249 |
Venegas-Calerón M et al. | Effect of the ferredoxin electron donor on sunflower (Helianthus annuus) desaturases. | 2009 | Plant Physiol. Biochem. | pmid:19342250 |
Lata M et al. | Whole body protection against lethal ionizing radiation in mice by REC-2001: a semi-purified fraction of Podophyllum hexandrum. | 2009 | Phytomedicine | pmid:17574826 |
Artwohl M et al. | Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure. | 2009 | Atherosclerosis | pmid:18597758 |
Shimomura H et al. | Steroids mediate resistance to the bactericidal effect of phosphatidylcholines against Helicobacter pylori. | 2009 | FEMS Microbiol. Lett. | pmid:19843309 |
Chen Q et al. | Generation of fad2 transgenic mice that produce omega-6 fatty acids. | 2009 | Sci. China, C, Life Sci. | pmid:19937203 |
Yang J et al. | Study of the inhibitory effect of fatty acids on the interaction between DNA and polymerase beta. | 2009 | Biochemistry Mosc. | pmid:19747104 |
Detsi A et al. | Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. | 2009 | Bioorg. Med. Chem. | pmid:19853459 |
Luo J et al. | Studies on the antioxidant activity and phenolic compounds of enzyme-assisted water extracts from Du-zhong (Eucommia ulmoides Oliv.) leaves. | 2009 | J Enzyme Inhib Med Chem | pmid:19912062 |
Zhan ZJ et al. | Preparation and characterization of Cu,Zn-superoxide dismutase covalently modified by polyunsaturated fatty acids. | 2009 | Biochemistry Mosc. | pmid:19916943 |
Higashi-Okai K et al. | Potent antioxidant and radical-scavenging activity of Chenpi--compensatory and cooperative actions of ascorbic acid and citric acid. | 2009 | J. UOEH | pmid:20000005 |
Chechetkin IR et al. | Specificity of oxidation of linoleic acid homologs by plant lipoxygenases. | 2009 | Biochemistry Mosc. | pmid:19817685 |
Grossmann ME et al. | Eleostearic Acid inhibits breast cancer proliferation by means of an oxidation-dependent mechanism. | 2009 | Cancer Prev Res (Phila) | pmid:19789297 |