Linoelaidic acid
Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
Cross Reference
Introduction
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoelaidic acid?
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoelaidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Linoelaidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (1)
- Am. J. Physiol., Cell Physiol. (1)
- Hypertension (1)
- Others (3)
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol., Cell Physiol. (1)
- Plant Cell (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoelaidic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoelaidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brodersen R et al. | Multiple fatty acid binding to albumin in human blood plasma. | 1990 | Eur. J. Biochem. | pmid:2338079 |
| Barros H et al. | Arachidonic acid absorption in human jejunum in organ culture: effects of ethanol. | 1990 | Eur. J. Clin. Invest. | pmid:2124981 |
| Parinandi NL et al. | Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. | 1990 | Biochim. Biophys. Acta | pmid:2123402 |
| Jin SJ and Tserng KY | Metabolic origins of urinary unsaturated dicarboxylic acids. | 1990 | Biochemistry | pmid:2271537 |
| Hamberg M and Hamberg G | Hydroperoxide-dependent epoxidation of unsaturated fatty acids in the broad bean (Vicia faba L.). | 1990 | Arch. Biochem. Biophys. | pmid:2275553 |
| Ohtani H et al. | Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism. | 1990 | J. Lipid Res. | pmid:2280182 |
| Lefkowith J et al. | Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes. | 1990 | J. Exp. Med. | pmid:2307932 |
| Buckman DK et al. | Modulation of mouse mammary tumor growth and linoleate enhanced metastasis by oleate. | 1990 | J. Nutr. | pmid:2313378 |
| MacIver DH et al. | The effect of short chain fatty acid supplementation on membrane electrolyte transport and blood pressure. | 1990 | J Hum Hypertens | pmid:2283638 |
| Jakobsson A et al. | Metabolism of fatty acids and their incorporation into phospholipids of the mitochondria and endoplasmic reticulum in isolated hepatocytes determined by isolation of fluorescence derivatives. | 1990 | Biochim. Biophys. Acta | pmid:2223867 |
| Buset M et al. | Injury induced by fatty acids or bile acid in isolated human colonocytes prevented by calcium. | 1990 | Cancer Lett. | pmid:2322935 |
| Katzenellenbogen BS and Norman MJ | Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen. | 1990 | Endocrinology | pmid:2404751 |
| Jensen MD et al. | Measurement of non-steady-state free fatty acid turnover. | 1990 | Am. J. Physiol. | pmid:2405695 |
| Kawada H et al. | Improved maintenance of adult rat alveolar type II cell differentiation in vitro: effect of serum-free, hormonally defined medium and a reconstituted basement membrane. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2363935 |
| Miller CC and Ziboh VA | Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). | 1990 | J. Invest. Dermatol. | pmid:2106562 |
| Okuyama H | [Does food affect brain functions?]. | 1990 | Tanpakushitsu Kakusan Koso | pmid:1970438 |
| elAttar TM et al. | Comparison of the inhibitory effect of polyunsaturated fatty acids on prostaglandin synthesis. II. Fibroblasts. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1971442 |
| Kitagawa S et al. | Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. | 1990 | Biochim. Biophys. Acta | pmid:2166588 |
| Anel A et al. | Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. | 1990 | Biochim. Biophys. Acta | pmid:2114179 |
| Moch D et al. | The linoleic acid metabolite 9DS-hydroxy-10,12(E,Z)-octadecadienoic acid is a strong proinflammatory mediator in an experimental wound healing model of the rat. | 1990 | Biomed. Biochim. Acta | pmid:2169722 |
| Léger CL et al. | Evidence for a structurally specific role of essential polyunsaturated fatty acids depending on their peculiar double-bond distribution in biomembranes. | 1990 | Biochemistry | pmid:2169876 |
| Fletcher MP and Ziboh VA | Effects of dietary supplementation with eicosapentaenoic acid or gamma-linolenic acid on neutrophil phospholipid fatty acid composition and activation responses. | 1990 | Inflammation | pmid:2174410 |
| Kulkarni AP et al. | Hydrogen peroxide: a potent activator of dioxygenase activity of soybean lipoxygenase. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2105721 |
| Umeda F et al. | Modification of prostacyclin-stimulatory activity in sera by glucose, insulin, low density lipoprotein, linoleic acid and linoleic acid hydroperoxide. | 1990 | Diabetes Res. Clin. Pract. | pmid:2106424 |
| Lasekan JB et al. | Dietary olive and safflower oils in promotion of DMBA-induced mammary tumorigenesis in rats. | 1990 | Nutr Cancer | pmid:2106675 |
| Tonogai Y and Tai HH | Quantitation of 13-hydroxyoctadecadienoic acid (13-HODE) by radioimmunoassay. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2111553 |
| Fletcher JE et al. | Fatty acid uptake and catecholamine-stimulated phospholipid metabolism in immortalized airway epithelial cells established from primary cultures. | 1990 | Biochem. Int. | pmid:2241999 |
| Mimouni V and Poisson JP | Spontaneous diabetes in BB rats: evidence for insulin dependent liver microsomal delta 6 and delta 5 desaturase activities. | 1990 | Horm. Metab. Res. | pmid:2227799 |
| Pariza MW and Ha YL | Conjugated dienoic derivatives of linoleic acid: a new class of anticarcinogens. | 1990 | Med Oncol Tumor Pharmacother | pmid:2232933 |
| Moore SA et al. | Role of the blood-brain barrier in the formation of long-chain omega-3 and omega-6 fatty acids from essential fatty acid precursors. | 1990 | J. Neurochem. | pmid:2115069 |
| Nikolaev V et al. | Stereochemical nature of the products of linoleic acid oxidation catalyzed by lipoxygenases from potato and soybean. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2116790 |
| Mensink RP et al. | Effect of a monounsaturated diet vs. a polyunsaturated fatty acid-enriched diet on blood pressure in normotensive women and men. | 1990 | Eur. J. Clin. Invest. | pmid:2121507 |
| Newman MJ | Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2371287 |
| Gyllenhammar H et al. | Dietary linoleate supplementation modulates formyl-peptide receptor expression and functional responses of rat neutrophils. | 1990 | J. Lab. Clin. Med. | pmid:2157784 |
| Chatterjee S and Ghosh N | Phosphatidylcholine stimulates the activity of UDP-Gal beta 1-4 galactosyltransferase in normal human kidney proximal tumour cells. | 1990 | Indian J. Biochem. Biophys. | pmid:2129343 |
| Kawashima Y et al. | Peroxisome proliferators enhance linoleic acid metabolism in rat liver. Increased biosynthesis of omega 6 polyunsaturated fatty acids. | 1990 | J. Biol. Chem. | pmid:2160962 |
| Bedotti R et al. | Stimulatory effect of serum albumin on the proliferation of serum-free SV40-transformed Balb/c 3T3 cells. | 1990 | Biochim. Biophys. Acta | pmid:2163687 |
| Koba K and Sugano M | Dietary protein influences polyunsaturated fatty acid patterns of rat tissue lipids. | 1990 | J. Nutr. Sci. Vitaminol. | pmid:2130152 |
| Akamatsu H et al. | Suppressive effects of linoleic acid on neutrophil oxygen metabolism and phagocytosis. | 1990 | J. Invest. Dermatol. | pmid:2143521 |
| Piché LA and Mahadevappa VG | Modification of rat platelet fatty acid composition by dietary lipids of animal and vegetable origin. | 1990 | J. Nutr. | pmid:2111377 |
| Weaver BJ et al. | Dietary canola oil: effect on the accumulation of eicosapentaenoic acid in the alkenylacyl fraction of human platelet ethanolamine phosphoglyceride. | 1990 | Am. J. Clin. Nutr. | pmid:2181858 |
| Renner HW | Anticlastogenic dietary factors assessed in mammalian assays. | 1990 | Basic Life Sci. | pmid:2183774 |
| Field CJ et al. | Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals. | 1990 | J. Biol. Chem. | pmid:2113530 |
| Kim D and Duff RA | Regulation of K+ channels in cardiac myocytes by free fatty acids. | 1990 | Circ. Res. | pmid:2119911 |
| Hori T et al. | Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2114113 |
| Molina MT et al. | Caecal and colonic uptake of both linoleic acid and cholesterol in rats following intestinal resection. | 1990 | Lipids | pmid:2079865 |
| Hjelte L et al. | Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats. | 1990 | Am. J. Physiol. | pmid:2115302 |
| Corner EJ et al. | Accumulation of eicosapentaenoic acid in plasma phospholipids of subjects fed canola oil. | 1990 | Lipids | pmid:2079866 |
| Henricks PA et al. | Epithelium-derived linoleic acid metabolites modulate airway smooth muscle function. | 1990 | Agents Actions Suppl. | pmid:2080762 |
| Emken EA et al. | Metabolism in vivo of deuterium-labelled linolenic and linoleic acids in humans. | 1990 | Biochem. Soc. Trans. | pmid:2083671 |
| James SR et al. | Linoleic acid increases cytosolic Ca2+ in lymphocytes. | 1990 | Biochem. Soc. Trans. | pmid:2083720 |
| Bell JG and Raynard RS | Effects of a high linoleic acid diet on the fatty acid composition of leucocytes from Atlantic salmon (Salmo salar). | 1990 | Biochem. Soc. Trans. | pmid:2083726 |
| Palmblad J | Eicosanoids and modulation of inflammatory and immune responses. | 1990 | Scand. J. Clin. Lab. Invest. Suppl. | pmid:1963704 |
| Zakhariv OIa et al. | [Metabolism of linoleic acid given with the feed in the calf liver]. | 1990 Jan-Feb | Ukr. Biokhim. Zh. | pmid:2336726 |
| Saddik M and Lopaschuk GD | The fate of arachidonic acid and linoleic acid in isolated working rat hearts containing normal or elevated levels of coenzyme A. | 1991 | Biochim. Biophys. Acta | pmid:1932104 |
| Shultz TD | Physiological free fatty acid concentrations do not increase free estradiol in plasma. | 1991 | J. Clin. Endocrinol. Metab. | pmid:1986028 |
| Hrboticky N et al. | Retina fatty acid composition of piglets fed from birth with a linoleic acid-rich vegetable-oil formula for infants. | 1991 | Am. J. Clin. Nutr. | pmid:1989416 |
| Kearns EV et al. | The role of cytochrome b5 in delta 12 desaturation of oleic acid by microsomes of safflower (Carthamus tinctorius L.). | 1991 | Arch. Biochem. Biophys. | pmid:1989527 |
| Hou SY et al. | Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and x-ray diffraction. | 1991 | J. Invest. Dermatol. | pmid:1991982 |
| Muakkassa FF et al. | Effect of dietary fish oil on plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha levels in septic rats. | 1991 | Arch Surg | pmid:1992995 |
| Earles SM et al. | Metabolism of oxidized linoleic acid: characterization of 13-hydroxyoctadecadienoic acid dehydrogenase activity from rat colonic tissue. | 1991 | Biochim. Biophys. Acta | pmid:1998735 |
| Hubbard NE and Erickson KL | Role of dietary oleic acid in linoleic acid-enhanced metastasis of a mouse mammary tumor. | 1991 | Cancer Lett. | pmid:1998946 |
| Kim RS and Zaborniak CL | The aldehydic metabolites of linoleic acid are cytotoxic against human breast cancer cells. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1946549 |
| Martin JC et al. | Essential fatty acid composition of human colostrum triglycerides: its relationship with adipose tissue composition. | 1991 | Am. J. Clin. Nutr. | pmid:1951153 |
| Seidell JC et al. | Polyunsaturated fatty acids in adipose tissue in European men aged 38 years in relation to serum lipids, smoking habits, and fat distribution. | 1991 | Am. J. Epidemiol. | pmid:1951263 |
| Pettersen J and Opstvedt J | Trans fatty acids. 4. Effects on fatty acid composition of colostrum and milk. | 1991 | Lipids | pmid:1762516 |
| Stroh S and Elmadfa I | [In vitro studies of the effect of different mixture proportions of omega-3 and omega-6 fatty acids on thrombocyte aggregation and thromboxane synthesis in human thrombocytes]. | 1991 | Z Ernahrungswiss | pmid:1763556 |
| Wright S and Sanders TA | Adipose tissue essential fatty acid composition in patients with atopic eczema. | 1991 | Eur J Clin Nutr | pmid:1782921 |
| Butovich IA et al. | The unusual action of (R,S)-2-hydroxy-2-trifluoromethyl-trans-n-octadec-4-enoic acid on 5-lipoxygenase from potato tubers. | 1991 | Eur. J. Biochem. | pmid:2065670 |
| Rose DP and Connolly JM | Effects of fatty acids and eicosanoid synthesis inhibitors on the growth of two human prostate cancer cell lines. | 1991 | Prostate | pmid:2020620 |
| Engels F et al. | Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. | 1991 | Prostaglandins | pmid:1662406 |
| Bull AW et al. | Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. | 1991 | Prostaglandins | pmid:2020745 |
| Lee JH et al. | Dietary cholesterol influences on various lipid indices and eicosanoid production in rats fed dietary fat desirable for the protection of ischemic heart disease. | 1991 | J. Nutr. Sci. Vitaminol. | pmid:1765843 |
| Rainey PM et al. | Biochemical and molecular characterization of Leishmania pifanoi amastigotes in continuous axenic culture. | 1991 | Mol. Biochem. Parasitol. | pmid:1775152 |
| Katan MB et al. | Biological markers of dietary intake, with emphasis on fatty acids. | 1991 | Ann. Nutr. Metab. | pmid:1776820 |
| Christon R et al. | Effects of a low dietary linoleic acid level on intestinal morphology and enterocyte brush border membrane lipid composition. | 1991 | Reprod. Nutr. Dev. | pmid:1777061 |
| Nihro Y et al. | 3-O-alkylascorbic acids as free radical quenchers. II. Inhibitory effects on some lipid peroxidation models. | 1991 | Chem. Pharm. Bull. | pmid:1777926 |
| Sarkar G | Beneficial ghee? | 1991 | Nature | pmid:1876181 |
| Vilchez C et al. | Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Coturnix coturnix japonica). 1. Reproductive performance and tissue fatty acids. | 1991 | Poult. Sci. | pmid:1784570 |
| Pourplanche C et al. | Comparison of polarographic and chemical measurements of oxygen uptake in complex media: the example of lipoxygenase reaction. | 1991 | Anal. Biochem. | pmid:1789419 |
| Pal S and Davis PJ | Effects of different types of polyunsaturated fatty acids on cholesterol esterification in human fibroblasts. | 1991 | Biochem. Int. | pmid:1789795 |
| Reaven P et al. | Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. | 1991 | Am. J. Clin. Nutr. | pmid:1897476 |
| Uchida Y et al. | Enhancement of keratin synthesis induced by lipokeratinogenoside, N-(O-linoleoyl)-omega-hydroxy fatty acyl sphingosyl glucose, in association with alteration of the intracellular Ca(2+)-content and protein kinase in cultured keratinocytes (FRSK). | 1991 | J. Biochem. | pmid:1715342 |
| Leyton J et al. | Effects of type of dietary fat on phorbol ester-elicited tumor promotion and other events in mouse skin. | 1991 | Cancer Res. | pmid:1899048 |
| Iacono JM and Dougherty RM | Lack of effect of linoleic acid on the high-density-lipoprotein-cholesterol fraction of plasma lipoproteins. | 1991 | Am. J. Clin. Nutr. | pmid:1900384 |
| MacÃas P et al. | Hemin and hemeprotein bleaching during linoleic acid oxidation by lipoxygenases. | 1991 | Biochim. Biophys. Acta | pmid:1903070 |
| Iwahashi H et al. | Isolation and identification of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenase. | 1991 | Arch. Biochem. Biophys. | pmid:1846731 |
| Thomson AB et al. | Feeding rats a diet enriched with saturated fatty acids prevents the inhibitory effects of acute and chronic ethanol exposure on the in vitro uptake of hexoses and lipids. | 1991 | Biochim. Biophys. Acta | pmid:1854796 |
| Bellomonte G et al. | Quantitative determination of linoleic acid in infant formulas. | 1991 | Int J Vitam Nutr Res | pmid:1856052 |
| Kinsella JE | Alpha-linolenic acid: functions and effects on linoleic acid metabolism and eicosanoid-mediated reactions. | 1991 | Adv. Food Nutr. Res. | pmid:1681826 |
| Ledwozyw A et al. | [Surfactant lipids of bovine lungs]. | 1991 | Pol Arch Weter | pmid:1842618 |
| Semplicini A et al. | Effects of linoleic acid supplementation on blood pressure and kinetics of red cell sodium transport: the Piove di Sacco Study. | 1991 | J Hypertens Suppl | pmid:1818979 |
| Rose DP et al. | Effect of dietary fat on human breast cancer growth and lung metastasis in nude mice. | 1991 | J. Natl. Cancer Inst. | pmid:1920496 |
| Burri BJ et al. | Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid. | 1991 | Am. J. Clin. Nutr. | pmid:1858699 |
| Bell JG et al. | High dietary linoleic acid affects the fatty acid compositions of individual phospholipids from tissues of Atlantic salmon (Salmo salar): association with stress susceptibility and cardiac lesion. | 1991 | J. Nutr. | pmid:1861166 |
| James DR et al. | Increased susceptibility to peroxide-induced haemolysis with normal vitamin E concentrations in cystic fibrosis. | 1991 | Clin. Chim. Acta | pmid:1819470 |
| Ulmann L et al. | Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. | 1991 | Biochim. Biophys. Acta | pmid:1657182 |
| Huynh S et al. | Metabolic utilization of linoleate and alpha-linolenate in cultured Sertoli cells. | 1991 | Comp. Biochem. Physiol., B | pmid:1684926 |
| de Tomás ME et al. | Metabolic transformation of intracraneally injected [1-14C]linoleic and [1-14C]alpha-linolenic acids in malnourished developing rats. | 1991 | Lipids | pmid:1687158 |
| Okuyama H and Sakai K | Effects of dietary oils with extreme omega 3/omega 6 ratios--selective incorporation and differential catabolism. | 1991 | World Rev Nutr Diet | pmid:1675826 |