Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Decsi T et al. | Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17321122 |
Okita M et al. | Effect of arachidonic acid-rich oil on lipids and arachidonate metabolites in ethanol- treated rats. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418023 |
Abeywardena MY et al. | Dietary n-3 and n-6 polyunsaturated oils and airway contractility. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418024 |
Gueck T et al. | Effects of essential fatty acids on mediators of mast cells in culture. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711248 |
Angela Liou Y and Innis SM | Dietary linoleic acid has no effect on arachidonic acid, but increases n-6 eicosadienoic acid, and lowers dihomo-gamma-linolenic and eicosapentaenoic acid in plasma of adult men. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19356914 |
Cunnane SC and Guesnet P | Linoleic acid recommendations--A house of cards. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21963263 |
Ramsden CE et al. | Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22959954 |
Perkins DM and Duncan JR | The effect of gamma-linolenic acid and zinc supplementation on the growth of normal and tumour cells in vitro. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1881941 |
Turpeinen AM et al. | A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9844997 |
Singer P et al. | Defective desaturation and elongation of n-6 and n-3 fatty acids in hypertensive patients. | 1984 | Prostaglandins Leukot Med | pmid:6387718 |
Kher V et al. | Protective effect of polyunsaturated fatty acid supplementation in apoferritin induced murine glomerulonephritis. | 1986 | Prostaglandins Leukot Med | pmid:3014561 |
Huang YS et al. | Effect of dietary depletion and repletion of linoleic acid on renal fatty acid composition and urinary prostaglandin excretion. | 1984 | Prostaglandins Leukot Med | pmid:6593743 |
Strong AM et al. | Prostaglandin precursors in plasma phospholipids of patients with psoriasis: effects of treatment with coal tar. | 1984 | Prostaglandins Leukot Med | pmid:6588390 |
Ito Y et al. | A low protein-high linoleate diet increases glomerular PGE2 and protects renal function in rats with reduced renal mass. | 1987 | Prostaglandins Leukot Med | pmid:3477824 |
Hoffmann P et al. | Augmented acute hypotensive effect of dihydralazine and clonidine after linoleic acid rich diet in normotensive conscious rats. | 1982 | Prostaglandins Leukot Med | pmid:6955801 |
Sullivan LM and Mathias MM | Eicosanoid production in rat blood as affected by fasting and dietary fat. | 1982 | Prostaglandins Leukot Med | pmid:6956928 |
Abeywardena MY et al. | Effects of variable linoleate intake on aortic PGI2-like activity and fatty acid composition: difference between rat and marmoset (Callithrix jacchus). | 1986 | Prostaglandins Leukot Med | pmid:3103139 |
Hoffmann P et al. | Circadian rhythm of eicosanoid formation as affected by dietary linoleate. | 1986 | Prostaglandins Leukot Med | pmid:3547416 |
Sakuma S et al. | Effect of 13-hydroperoxyoctadecadienoic acid on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex. | 1993 | Prostaglandins | pmid:8210445 |
Lewis MG et al. | Effect of essential polyunsaturated fatty acid modifications on prostaglandin production by MDCK canine kidney cells. | 1981 | Prostaglandins | pmid:6799988 |
Bonacossa A et al. | Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. | 1982 | Prostaglandins | pmid:6278538 |
Needleman SW et al. | Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. | 1982 | Prostaglandins | pmid:6819602 |
Hashimoto A et al. | Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats. | 1988 | Prostaglandins | pmid:2459732 |
Beneytout JL et al. | Effect of isoquinoline alkaloids on soybean lipoxygenase activity in vitro. | 1986 | Prostaglandins | pmid:3086939 |
Engels F et al. | Preferential formation of 13-hydroxylinoleic acid by human peripheral blood eosinophils. | 1996 | Prostaglandins | pmid:8880897 |
Engels F et al. | Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. | 1991 | Prostaglandins | pmid:1662406 |
Bull AW et al. | Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. | 1991 | Prostaglandins | pmid:2020745 |
Bronstein JC and Bull AW | The correlation between 13-hydroxyoctadecadienoate dehydrogenase (13-HODE dehydrogenase) and intestinal cell differentiation. | 1993 | Prostaglandins | pmid:8278616 |
Andersen BR et al. | The effects of arachidonic and other fatty acids on canine neutrophil metabolism. | 1981 | Prostaglandins | pmid:6795686 |
Hamazaki T et al. | Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake. | 1989 | Prostaglandins | pmid:2503856 |
Singer P et al. | Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. | 1984 | Prostaglandins | pmid:6328578 |
Murphy MG | Increasing membrane polyunsaturated fatty-acid content augments cyclic AMP formation and prostaglandin production in NIE-115 neuroblastoma. | 1984 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:6099586 |
Frankel EN | Chemistry of free radical and singlet oxidation of lipids. | 1984 | Prog. Lipid Res. | pmid:6100997 |
Cunnane SC | Problems with essential fatty acids: time for a new paradigm? | 2003 | Prog. Lipid Res. | pmid:14559071 |
Cunnane SC | Differential regulation of essential fatty acid metabolism to the prostaglandins: possible basis for the interaction of zinc and copper in biological systems. | 1982 | Prog. Lipid Res. | pmid:7051042 |
Dwyer LA and Blomquist GJ | Biosynthesis of linoleic acid in the American cockroach. | 1981 | Prog. Lipid Res. | pmid:7342085 |
Launay M et al. | Control of replication by dietary lipids and namely by linoleic acid in liver and adipose tissue of developing rats. | 1981 | Prog. Lipid Res. | pmid:7342098 |
Houtsmuller AJ et al. | Favorable influences of linoleic acid on the progression of diabetic micro- and macroangiopathy in adult onset diabetes mellitus. | 1981 | Prog. Lipid Res. | pmid:7342100 |
Cunnane SC | Zinc and copper interact antagonistically in the regulation of linoleic acid metabolism. | 1981 | Prog. Lipid Res. | pmid:7342114 |
Lynn WS et al. | Linoleic acid: a specific cytotaxin for macrophages. | 1981 | Prog. Lipid Res. | pmid:7342119 |
Kitada S et al. | Characterization of a lipid mobilizing factor from tumors. | 1981 | Prog. Lipid Res. | pmid:7342133 |
Houtsmuller UM and van der Beek A | Effects of topical application of fatty acids. | 1981 | Prog. Lipid Res. | pmid:6804961 |
Frankel EN | Volatile lipid oxidation products. | 1983 | Prog. Lipid Res. | pmid:6306693 |
Holman RT | Nutritional and biochemical evidences of acyl interaction with respect to essential polyunsaturated fatty acids. | 1986 | Prog. Lipid Res. | pmid:3423089 |
Burr GO | The essential fatty acids fifty years ago. | 1981 | Prog. Lipid Res. | pmid:7043474 |
Spector AA et al. | Essential fatty acid availability and prostacyclin production by cultured human endothelial cells. | 1981 | Prog. Lipid Res. | pmid:7043481 |
Agradi E et al. | Dietary linoleic acid, accumulation of arachidonic acid in tissue lipids and production of TXB2 and PGI2 in the cardiovascular system. | 1981 | Prog. Lipid Res. | pmid:7043483 |
Mercuri O and De Tomás ME | Early steps on the in vivo incorporation of [1-14C]linoleic acid into liver lipids of protein deficient pregnant rats. | 1981 | Prog. Lipid Res. | pmid:6804968 |
Rey HG et al. | Two-sided functional Na,K-ATPase-liposomes for characterizing the permeability and side of action of pump inhibitors. | 1988 | Prog. Clin. Biol. Res. | pmid:2906133 |
Vergroesen AJ | Effects of dietary lipid composition on serum lipoproteins. | 1985 | Prog. Clin. Biol. Res. | pmid:3903769 |
Jones R et al. | Monitoring changes in the blood of patients with multiple sclerosis. | 1983 | Prog. Brain Res. | pmid:6665128 |
Champe SP et al. | Sexual sporulation. | 1994 | Prog Ind Microbiol | pmid:7765136 |
Johnston DV and Marshall LA | Dietary fat, prostaglandins and the immune response. | 1984 | Prog Food Nutr Sci | pmid:6091179 |
REISER R | Conjugated linoleic acid in rat tissue lipids after ingestion as free acid and as triglyceride. | 1950 | Proc. Soc. Exp. Biol. Med. | pmid:14781143 |
STEIN O and STEIN Y | FATTY ACID METABOLISM BY IN VIVO LABELED ADIPOSE TISSUE IN ESSENTIAL FATTY ACID DEFICIENT RATS. | 1965 | Proc. Soc. Exp. Biol. Med. | pmid:14264515 |
SWELL L et al. | ESTERIFICATION OF CHOLESTEROL BY CANINE ADRENAL CELL FRACTIONS. | 1965 | Proc. Soc. Exp. Biol. Med. | pmid:14297887 |
Watkins BA et al. | Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes. | 1996 | Proc. Soc. Exp. Biol. Med. | pmid:8650253 |
KRITCHEVSKY D and TEPPER SA | AUTOXIDATION OF METHYL LINOLEATE: EFFECT OF SEX HORMONES AND OF NICOTINIC ACID AND RELATED COMPOUNDS. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14155843 |
WALKER BL and KUMMEROW FA | ERYTHROCYTE FATTY ACID COMPOSITION AND APPARENT PERMEABILITY TO NON-ELECTROLYTES. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14166569 |
TUREEN LL et al. | EFFECT OF HIGH LINOLEIC ACID AND ANTIOXIDANT DEFICIENT DIET ON BLOOD SERUM PROTEINS IN CHICKS. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14121629 |
DESAI ID et al. | PEROXIDATION AND LYSOSOMES IN NUTRITIONAL MUSCULAR DYSTROPHY OF CHICKS. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14121639 |
HOPKINS DT et al. | A RESPIRATORY DISEASE SYNDROME IN CHICKENS FED ESSENTIAL FATTY ACID DEFICIENT DIETS. | 1963 | Proc. Soc. Exp. Biol. Med. | pmid:14076921 |
SWELL L et al. | Influence of a family diet pattern high in linoleic acid on serum cholesterol level: one year study. | 1962 | Proc. Soc. Exp. Biol. Med. | pmid:13979681 |
HOLMAN RT | Metabolism of isomers of linoleic and linolenic acids. | 1951 | Proc. Soc. Exp. Biol. Med. | pmid:14816402 |
GORDON S and MEAD JF | CONVERSION OF LINOLEIC-1-C14 ACID TO ARACHIDONIC ACID IN THE GERBIL. | 1964 | Proc. Soc. Exp. Biol. Med. | pmid:14194646 |
Izumi Y et al. | Effects of dietary linoleic acid on blood pressure and renal function in subtotally nephrectomized rats. | 1986 | Proc. Soc. Exp. Biol. Med. | pmid:3532127 |
Wieland E et al. | Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation? | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8327462 |
Levay-Young BK et al. | Linoleic acid, but not cortisol, stimulates accumulation of casein by mouse mammary epithelial cells in serum-free collagen gel culture. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3317407 |
Yehuda S and Carasso RL | Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7901853 |
Baker PR et al. | Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15273286 |
Whittle EJ et al. | Revealing the catalytic potential of an acyl-ACP desaturase: tandem selective oxidation of saturated fatty acids. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18796606 |
Jiang Q et al. | gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15596715 |
Asaoka Y et al. | Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8099446 |
Saeki K et al. | Functional expression of a Delta12 fatty acid desaturase gene from spinach in transgenic pigs. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15067141 |
Kliewer SA et al. | Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8041794 |
Chu S et al. | Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624373 |
Wright JR et al. | Essential fatty acid deficiency prevents multiple low-dose streptozotocin-induced diabetes in CD-1 mice. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3045812 |
Newman MJ | Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2371287 |
Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
Stocker R et al. | Antioxidant activity of albumin-bound bilirubin. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3475708 |
Hill EG et al. | Perturbation of the metabolism of essential fatty acids by dietary partially hydrogenated vegetable oil. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6951178 |
Lange LG | Nonoxidative ethanol metabolism: formation of fatty acid ethyl esters by cholesterol esterase. | 1982 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6955782 |
Keler T et al. | Specific growth stimulation by linoleic acid in hepatoma cell lines transfected with the target protein of a liver carcinogen. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1594582 |
Blaul B and Ruther J | How parasitoid females produce sexy sons: a causal link between oviposition preference, dietary lipids and mate choice in Nasonia. | 2011 | Proc. Biol. Sci. | pmid:21429922 |
Utermohlen V and Tucker MA | Possible effects of dietary n-6 series polyunsaturated fatty acids on the development of immune dysfunction and infection. | 1986 | Proc Nutr Soc | pmid:3797410 |
Betteridge J | Nutrition and platelet function in atherogenesis. | 1987 | Proc Nutr Soc | pmid:2893383 |
Permiakova MD and Trufanov VA | [Effect of soybean lipoxygenae on baking properties of wheat flour]. | 2011 May-Jun | Prikl. Biokhim. Mikrobiol. | pmid:21790037 |
Dupont J | Essential fatty acids and prostaglandins. | 1987 | Prev Med | pmid:3628199 |
Cohen LA | Fat and endocrine-responsive cancer in animals. | 1987 | Prev Med | pmid:3476922 |
WAREMBOURG H et al. | [COMPARATIVE STUDY OF THE LIPID COMPOSITION OF THE PLASMA IN THE HEALTHY SUBJECT AND IN SIMPLE AND COMPLICATED DIABETES]. | 1964 | Presse Med | pmid:14214759 |
Wadekar SD et al. | Microbial synthesis of rhamnolipids by Pseudomonas aeruginosa (ATCC 10145) on waste frying oil as low cost carbon source. | 2012 | Prep. Biochem. Biotechnol. | pmid:22509850 |
TORRES LM and VOROBIOFF S | [TREATMENT OF CIRRHOSIS]. | 1963 | Prensa Med Argent | pmid:14091581 |
DUDAN A | [Essential polyunsaturated fatty acids; clinical study and therapeutic indications]. | 1956 | Praxis | pmid:13335660 |
Shin D et al. | Dietary combination effects of conjugated linoleic acid and flaxseed or fish oil on the concentration of linoleic and arachidonic acid in poultry meat. | 2011 | Poult. Sci. | pmid:21597077 |
Carrillo-DomÃnguez S et al. | Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes). | 2005 | Poult. Sci. | pmid:15685957 |
Puthpongsiriporn U and Scheideler SE | Effects of dietary ratio of linoleic to linolenic acid on performance, antibody production, and in vitro lymphocyte proliferation in two strains of leghorn pullet chicks. | 2005 | Poult. Sci. | pmid:15971520 |
Grobas S et al. | Laying hen productivity as affected by energy, supplemental fat, and linoleic acid concentration of the diet. | 1999 | Poult. Sci. | pmid:10560827 |
Vilchez C et al. | Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Coturnix coturnix japonica). 1. Reproductive performance and tissue fatty acids. | 1991 | Poult. Sci. | pmid:1784570 |
Du M et al. | Effect of dietary conjugated linoleic acid on the composition of egg yolk lipids. | 1999 | Poult. Sci. | pmid:10560841 |
Ahn DU et al. | Effect of dietary conjugated linoleic acid on the quality characteristics of chicken eggs during refrigerated storage. | 1999 | Poult. Sci. | pmid:10438141 |