Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Kim SY et al. | S-adenosyl methionine prevents endothelial dysfunction by inducing heme oxygenase-1 in vascular endothelial cells. | 2013 | Mol. Cells | pmid:24046187 |
Otte KB et al. | Synthesis of 9-oxononanoic acid, a precursor for biopolymers. | 2013 | ChemSusChem | pmid:23934656 |
Chukir T et al. | Shared retronasal identifications of vapor-phase 18-carbon fatty acids. | 2013 | Chem. Senses | pmid:23424022 |
Anton SD et al. | Differential effects of adulterated versus unadulterated forms of linoleic acid on cardiovascular health. | 2013 | J Integr Med | pmid:23464640 |
Zhang J et al. | Characteristics of fatty acid distribution is associated with colorectal cancer prognosis. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23465412 |
Moon C et al. | Modeling sulfate removal by inhibited mesophilic mixed anaerobic communities using a statistical approach. | 2013 | Water Res. | pmid:23466036 |
Sy C et al. | Inhibition of iron-induced lipid peroxidation by newly identified bacterial carotenoids in model gastric conditions: comparison with common carotenoids. | 2013 | Food Funct | pmid:23411789 |
Salama el-S et al. | Biomass, lipid content, and fatty acid composition of freshwater Chlamydomonas mexicana and Scenedesmus obliquus grown under salt stress. | 2013 | Bioprocess Biosyst Eng | pmid:23411874 |
Bae WK et al. | Docetaxel-loaded thermoresponsive conjugated linoleic acid-incorporated poloxamer hydrogel for the suppression of peritoneal metastasis of gastric cancer. | 2013 | Biomaterials | pmid:23174142 |
McGowan MM et al. | A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue. | 2013 | Breast Cancer Res. Treat. | pmid:23417336 |
Girgih AT et al. | Reverse-phase HPLC separation of hemp seed (Cannabis sativa L.) protein hydrolysate produced peptide fractions with enhanced antioxidant capacity. | 2013 | Plant Foods Hum Nutr | pmid:23417711 |
Lin KH et al. | Antioxidant activity of herbaceous plant extracts protect against hydrogen peroxide-induced DNA damage in human lymphocytes. | 2013 | BMC Res Notes | pmid:24279749 |
Mabalirajan U et al. | Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. | 2013 | Sci Rep | pmid:23443229 |
Tokede OA et al. | Plasma phospholipid trans fatty acids and risk of heart failure. | 2013 | Am. J. Clin. Nutr. | pmid:23446892 |
Zuo R et al. | Effects of conjugated linoleic acid on growth, non-specific immunity, antioxidant capacity, lipid deposition and related gene expression in juvenile large yellow croaker (Larmichthys crocea) fed soyabean oil-based diets. | 2013 | Br. J. Nutr. | pmid:23452520 |
Schneider MR et al. | Differentially regulated microRNAs during human sebaceous lipogenesis. | 2013 | J. Dermatol. Sci. | pmid:23452545 |
Kirpich IA et al. | Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. | 2013 | Alcohol | pmid:23453163 |
Lind PM et al. | An environmental wide association study (EWAS) approach to the metabolic syndrome. | 2013 | Environ Int | pmid:23454278 |
Wei J et al. | Linoleic acid attenuates endothelium-derived relaxing factor production by suppressing cAMP-hydrolyzing phosphodiesterase activity. | 2013 | Circ. J. | pmid:23883876 |
Moloney AP et al. | Colour of fat, and colour, fatty acid composition and sensory characteristics of muscle from heifers offered alternative forages to grass silage in a finishing ration. | 2013 | Meat Sci. | pmid:23806853 |
Lagarde M et al. | Lipidomics of essential fatty acids and oxygenated metabolites. | 2013 | Mol Nutr Food Res | pmid:23818385 |
Falavigna C et al. | Fatty acid esters of fumonisins: first evidence of their presence in maize. | 2013 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:23819788 |
Zhao X et al. | Analysis of fatty acids and phytosterols in ethanol extracts of Nelumbo nucifera seeds and rhizomes by GC-MS. | 2013 | J. Agric. Food Chem. | pmid:23742045 |
Kikalishvili BIu et al. | [The fatty acid composition of peach oil and its biological activity]. | 2013 | Georgian Med News | pmid:23787514 |
Renner L et al. | Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid, linoleic acid, phytanic acid and the combination of various fatty acids on proliferation and cytokine expression of bovine peripheral blood mononuclear cells. | 2013 | Nutrients | pmid:23857174 |
Van Ba H et al. | Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems. | 2013 | Meat Sci. | pmid:23632107 |
Al-Taan O et al. | Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. | 2013 | Lipids Health Dis | pmid:23648075 |
Nakagawa Y | [Metabolism and biological function of cardiolipin]. | 2013 | Yakugaku Zasshi | pmid:23649397 |
Fairfield K | ACP Journal Club. Review: replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality. | 2013 | Ann. Intern. Med. | pmid:23689785 |
Giua L et al. | Oxidative modifications of conjugated and unconjugated linoleic acid during heating. | 2013 | Food Chem | pmid:23692753 |
Liu Q et al. | Nonsense-mediated mRNA degradation of CtFAD2-1 and development of a perfect molecular marker for olol mutation in high oleic safflower (Carthamus tinctorius L.). | 2013 | Theor. Appl. Genet. | pmid:23695179 |
Khalil WA et al. | Protective effects of antioxidants on linoleic acid-treated bovine oocytes during maturation and subsequent embryo development. | 2013 | Theriogenology | pmid:23683689 |
Le Maux S et al. | β-Lactoglobulin-linoleate complexes: In vitro digestion and the role of protein in fatty acid uptake. | 2013 | J. Dairy Sci. | pmid:23684041 |
Hand KV et al. | Examining acute and chronic effects of short- and long-chain fatty acids on peptide YY (PYY) gene expression, cellular storage and secretion in STC-1 cells. | 2013 | Eur J Nutr | pmid:22926626 |
Zeng G et al. | Kinetics of heterogeneous reaction of ozone with linoleic acid and its dependence on temperature, physical state, RH, and ozone concentration. | 2013 | J Phys Chem A | pmid:23347186 |
Raatz SK et al. | Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially. | 2013 | J Acad Nutr Diet | pmid:23351633 |
Lohner S et al. | Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. | 2013 | Ann. Nutr. Metab. | pmid:23327902 |
MacIntosh BA et al. | Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. | 2013 | Br. J. Nutr. | pmid:23328113 |
Soto-Guzman A et al. | Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23332799 |
Poudyal H et al. | Responses to oleic, linoleic and α-linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. | 2013 | J. Nutr. Biochem. | pmid:23333092 |
Zamora-Rojas E et al. | Prediction of fatty acids content in pig adipose tissue by near infrared spectroscopy: at-line versus in-situ analysis. | 2013 | Meat Sci. | pmid:23793086 |
Fijlstra M et al. | Reduced absorption of long-chain fatty acids during methotrexate-induced gastrointestinal mucositis in the rat. | 2013 | Clin Nutr | pmid:23102689 |
Warstedt K and Duchén K | Increased linoleic acid/α-linolenic acid ratio in Swedish cord blood samples collected between 1985 and 2005. | 2013 | Eur J Nutr | pmid:22584414 |
Patarra RF et al. | Fatty acid composition of selected macrophytes. | 2013 | Nat. Prod. Res. | pmid:22591127 |
Zlatanov MD et al. | Lipid composition of Castanea sativa Mill. and Aesculus hippocastanum fruit oils. | 2013 | J. Sci. Food Agric. | pmid:23174908 |
Gousiadou C et al. | Minor iridoids from Scutellaria albida ssp. albida. Inhibitory potencies on lipoxygenase, linoleic acid lipid peroxidation and antioxidant activity of iridoids from Scutellaria sp. | 2013 | J Enzyme Inhib Med Chem | pmid:22630074 |
McPherson PA et al. | Mechanism for the enhanced peroxidation of linoleic acid by a titanium dioxide/hypochlorite system. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23178466 |
Serna-Marquez N et al. | Role of LOXs and COX-2 on FAK activation and cell migration induced by linoleic acid in MDA-MB-231 breast cancer cells. | 2013 | Cell Oncol (Dordr) | pmid:23179791 |
Gámez-Meza N et al. | Chemical characterisation of kernels, kernel meals and oils from Jatropha cordata and Jatropha cardiophylla seeds. | 2013 | J. Sci. Food Agric. | pmid:23180465 |
Toral PG et al. | Effect of the inclusion of quebracho tannins in a diet rich in linoleic acid on milk fatty acid composition in dairy ewes. | 2013 | J. Dairy Sci. | pmid:23164228 |
Yang Z and Huffman SL | Modelling linoleic acid and α-linolenic acid requirements for infants and young children in developing countries. | 2013 | Matern Child Nutr | pmid:23167585 |
Fedor DM et al. | The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. | 2013 | Metab Syndr Relat Disord | pmid:23170930 |
Jemia MB et al. | Studies on the antioxidant activity of the essential oil and extract of Tunisian Tetraclinis articulata (Vahl) Mast. (Cupressaceae). | 2013 | Nat. Prod. Res. | pmid:23082942 |
Mujtaba SF et al. | Singlet oxygen mediated apoptosis by anthrone involving lysosomes and mitochondria at ambient UV exposure. | 2013 | J. Hazard. Mater. | pmid:23542321 |
Wardhani DH et al. | Inhibition kinetics of lipid oxidation of model foods by using antioxidant extract of fermented soybeans. | 2013 | Food Chem | pmid:23561179 |
Garofalo JM et al. | Mouse mammary gland is refractory to the effects of ethanol after natural lactation. | 2013 | Comp. Med. | pmid:23561936 |
Hein LK et al. | Selective reduction of bis(monoacylglycero)phosphate ameliorates the storage burden in a THP-1 macrophage model of Gaucher disease. | 2013 | J. Lipid Res. | pmid:23564732 |
Zhao Y et al. | Linoleic acid stimulates [Ca2+]i increase in rat pancreatic beta-cells through both membrane receptor- and intracellular metabolite-mediated pathways. | 2013 | PLoS ONE | pmid:23565210 |
Bakır T et al. | Polar paradox revisited: analogous pairs of hydrophilic and lipophilic antioxidants in linoleic acid emulsion containing Cu(II). | 2013 | J. Sci. Food Agric. | pmid:23520052 |
Godovikova TS et al. | Ligand-directed acid-sensitive amidophosphate 5-trifluoromethyl-2'-deoxyuridine conjugate as a potential theranostic agent. | 2013 | Bioconjug. Chem. | pmid:23521072 |
Høstmark AT and Haug A | Percentage oleic acid is inversely related to percentage arachidonic acid in total lipids of rat serum. | 2013 | Lipids Health Dis | pmid:23521743 |
Fujii M et al. | Deficiency of n-6 polyunsaturated fatty acids is mainly responsible for atopic dermatitis-like pruritic skin inflammation in special diet-fed hairless mice. | 2013 | Exp. Dermatol. | pmid:23528213 |
Shimomura S et al. | Stereoselective synthesis of a promising flower-inducing KODA analog, (9R,12S,13R,15Z)-9-hydroxy-12,13-methylene-10-oxooctadec-15-enoic acid. | 2013 | Biosci. Biotechnol. Biochem. | pmid:23748793 |
Poon JF et al. | In search of catalytic antioxidants--(alkyltelluro)phenols, (alkyltelluro)resorcinols, and bis(alkyltelluro)phenols. | 2013 | J. Org. Chem. | pmid:23701313 |
Chodok P et al. | Identification and functional characterization of two Δ12-fatty acid desaturases associated with essential linoleic acid biosynthesis in Physcomitrella patens. | 2013 | J. Ind. Microbiol. Biotechnol. | pmid:23702573 |
Benjakul S et al. | Antioxidant activity and inhibitory effects of lead (Leucaena leucocephala) seed extracts against lipid oxidation in model systems. | 2013 | Food Sci Technol Int | pmid:23729420 |
de Goede J et al. | N-6 and N-3 fatty acid cholesteryl esters in relation to fatal CHD in a Dutch adult population: a nested case-control study and meta-analysis. | 2013 | PLoS ONE | pmid:23741290 |
Katan MB | [Linoleic acid and heart infarct]. | 2013 | Ned Tijdschr Geneeskd | pmid:23714298 |
Kummerow FA et al. | Effects of trans fats on prostacyclin production. | 2013 | Scand. Cardiovasc. J. | pmid:24228623 |
Vasudevan C et al. | The effect of parenteral lipid emulsions on pulmonary hemodynamics and eicosanoid metabolites in preterm infants: a pilot study. | 2013 | Nutr Clin Pract | pmid:24177284 |
Özcan T | Accumulation patterns of some seed oil components from wild sources of Turkey. | 2013 | Nat. Prod. Res. | pmid:22233192 |
Herrera-Meza MS et al. | Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats. | 2013 | Int J Food Sci Nutr | pmid:23360131 |
Satoh K | Linoleic acid. A novel mechanism of endothelial cell dysfunction. | 2013 | Circ. J. | pmid:24077059 |
Li KC et al. | [A preliminary study of the inhibitive efficacy of iodized linoleic acid and its fluorodeoxyuridine ester in hepatocellular cancer]. | 2013 | Zhonghua Gan Zang Bing Za Zhi | pmid:24025140 |
Kim JB et al. | Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins. | 2013 | Am. J. Cardiol. | pmid:24050409 |
Caligiuri SP et al. | Dietary linoleic acid and α-linolenic acid differentially affect renal oxylipins and phospholipid fatty acids in diet-induced obese rats. | 2013 | J. Nutr. | pmid:23902961 |
Risé P et al. | Different patterns characterize Omega 6 and Omega 3 long chain polyunsaturated fatty acid levels in blood from Italian infants, children, adults and elderly. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23910046 |
Kenny JG et al. | Mannitol utilisation is required for protection of Staphylococcus aureus from human skin antimicrobial fatty acids. | 2013 | PLoS ONE | pmid:23861785 |
Xie J et al. | A polyethylenimine-linoleic acid conjugate for antisense oligonucleotide delivery. | 2013 | Biomed Res Int | pmid:23862153 |
Xia Q et al. | Fatty acid profile, oxidative stability and toxicological safety of bayberry kernel oil. | 2013 | Food Chem. Toxicol. | pmid:23867545 |
Smink W et al. | Effect of intake of linoleic acid and α-linolenic acid levels on conversion into long-chain polyunsaturated fatty acids in backfat and in intramuscular fat of growing pigs. | 2013 | J Anim Physiol Anim Nutr (Berl) | pmid:22463497 |
Gibson RA et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22515943 |
Benbrook CM et al. | Organic production enhances milk nutritional quality by shifting fatty acid composition: a United States-wide, 18-month study. | 2013 | PLoS ONE | pmid:24349282 |
Green DP et al. | Role of endogenous TRPV1 agonists in a postburn pain model of partial-thickness injury. | 2013 | Pain | pmid:23891895 |
Steffen BT et al. | n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. | 2013 | Br. J. Nutr. | pmid:23551952 |
Ruparel S et al. | Oxidized linoleic acid metabolite-cytochrome P450 system (OLAM-CYP) is active in biopsy samples from patients with inflammatory dental pain. | 2013 | Pain | pmid:23867730 |
Shinjyo N et al. | Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. | 2013 | J. Neurosci. Res. | pmid:23633391 |
de Oliveira Otto MC et al. | Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. | 2013 | J Am Heart Assoc | pmid:24351702 |
Sisignano M et al. | Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice. | 2013 | PLoS ONE | pmid:24349046 |
Yang Y and McClements DJ | Vitamin E and vitamin E acetate solubilization in mixed micelles: physicochemical basis of bioaccessibility. | 2013 | J Colloid Interface Sci | pmid:23768725 |
Ngakegni-Limbili AC et al. | Aframomum stipulatum (Gagnep) K. Schum and Aframomum giganteum (Oliv. & Hanb) K. Schum as Aroma Tincto Oleo Crops resources: essential oil, fatty acids, sterols, tocopherols, and tocotrienols composition of different fruit parts of Congo varieties. | 2013 | J. Sci. Food Agric. | pmid:22692978 |
Li XP et al. | Linolelaidic acid induces a stronger proliferative effect on human umbilical vein smooth muscle cells compared to elaidic acid. | 2013 | Lipids | pmid:23341188 |
Del Mar Bibiloni M et al. | Dietary factors associated with subclinical inflammation among girls. | 2013 | Eur J Clin Nutr | pmid:24149444 |
Vukašinović EL et al. | Diapause induces changes in the composition and biophysical properties of lipids in larvae of the European corn borer, Ostrinia nubilalis (Lepidoptera: Crambidae). | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23701990 |
Layek B and Singh J | Cell penetrating peptide conjugated polymeric micelles as a high performance versatile nonviral gene carrier. | 2013 | Biomacromolecules | pmid:24083483 |
Luo X et al. | Comparison of enzymatic activity of two linoleic acid isomerases expressed in E. coli. | 2013 | Mol. Biol. Rep. | pmid:24062071 |
Peters BD et al. | Polyunsaturated fatty acid concentration predicts myelin integrity in early-phase psychosis. | 2013 | Schizophr Bull | pmid:22927668 |
Thomas CP et al. | Steric analysis of epoxyalcohol and trihydroxy derivatives of 9-hydroperoxy-linoleic acid from hematin and enzymatic synthesis. | 2013 Feb-Mar | Chem. Phys. Lipids | pmid:23352713 |
Ogorodnikova AV et al. | Screening of divinyl ether synthase activity in nonphotosynthetic tissue of asparagales. | 2013 Mar-Apr | Dokl. Biochem. Biophys. | pmid:23657662 |
Asselin C et al. | Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure. | 2014 | Redox Biol | pmid:24494189 |