Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Fat Necrosis D005218 1 associated lipids
Facial Nerve Diseases D005155 1 associated lipids
Child Nutrition Disorders D015362 1 associated lipids
Refeeding Syndrome D055677 1 associated lipids
Pellagra D010383 1 associated lipids
Carcinoma, Krebs 2 D002287 1 associated lipids
Refractive Errors D012030 1 associated lipids
Encopresis D004688 1 associated lipids
Enuresis D004775 1 associated lipids
Malaria, Cerebral D016779 1 associated lipids
Onchocerciasis D009855 1 associated lipids
Liposarcoma D008080 1 associated lipids
Gastroschisis D020139 1 associated lipids
Hypokinesia D018476 2 associated lipids
Darier Disease D007644 2 associated lipids
Aneurysm D000783 2 associated lipids
Circoviridae Infections D018173 2 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Lymphopenia D008231 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Kang J et al. Identification of three genes encoding microsomal oleate desaturases (FAD2) from the oilseed crop Camelina sativa. 2011 Plant Physiol. Biochem. pmid:21215650
Jump DB et al. Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. 2011 Biochem. Pharmacol. pmid:21184748
Penumetcha M et al. Modulation of leptin levels by oxidized linoleic acid: a connection to atherosclerosis? 2011 J Med Food pmid:21186986
Park HG et al. Production of conjugated linoleic acid (CLA) by Bifidobacterium breve LMC520 and its compatibility with CLA-producing rumen bacteria. 2011 J. Agric. Food Chem. pmid:21192703
Loizzo MR et al. In vitro antioxidant and hypoglycemic activities of Ethiopian spice blend Berbere. 2011 Int J Food Sci Nutr pmid:21599464
Kruska N and Reiser G Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40. 2011 Neurobiol. Dis. pmid:21570468
Shirakawa J et al. Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. 2011 J. Biol. Chem. pmid:21613229
Labayen I et al. Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. 2011 Atherosclerosis pmid:21550607
Monfregola L et al. Physical and water sorption properties of chemically modified pectin with an environmentally friendly process. 2011 Biomacromolecules pmid:21553919
Márquez-Castillo A and Vidal-Quintanar RL Improvements in the shelf life of commercial corn dry masa flour (CMF) by reducing lipid oxidation. 2011 J. Food Sci. pmid:21535741
Shin D et al. Dietary combination effects of conjugated linoleic acid and flaxseed or fish oil on the concentration of linoleic and arachidonic acid in poultry meat. 2011 Poult. Sci. pmid:21597077
Yepuri G et al. Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. 2011 Br. J. Nutr. pmid:21281526
Wang L et al. Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+]i increase in pancreatic islet {alpha}-cells. 2011 J. Endocrinol. pmid:21565851
Nigam S et al. On mechanism of quorum sensing in Candida albicans by 3(R)-hydroxy-tetradecaenoic acid. 2011 Curr. Microbiol. pmid:20509029
de Lima-Salgado TM et al. Molecular mechanisms by which saturated fatty acids modulate TNF-α expression in mouse macrophage lineage. 2011 Cell Biochem. Biophys. pmid:20809180
Liu SJ et al. Effect of ruminal pulse dose of polyunsaturated fatty acids on ruminal microbial populations and duodenal flow and milk profiles of fatty acids. 2011 J. Dairy Sci. pmid:21605768
Palmieri-Thiers C et al. Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies. 2011 Arch. Biochem. Biophys. pmid:21345329
Kishino S et al. Linoleic acid isomerase in Lactobacillus plantarum AKU1009a proved to be a multi-component enzyme system requiring oxidoreduction cofactors. 2011 Biosci. Biotechnol. Biochem. pmid:21307591
McFarland DC et al. Effect of lipids on avian satellite cell proliferation, differentiation and heparan sulfate proteoglycan expression. 2011 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:21356326
Retamal MA et al. Biphasic effect of linoleic acid on connexin 46 hemichannels. 2011 Pflugers Arch. pmid:21360038
Maqbool A et al. The skinny on tuna fat: health implications. 2011 Public Health Nutr pmid:21324226
Popescu FD et al. Effects of season and reproductive state on lipid intake and fatty acid composition of gastrointestinal tract contents in the European hare. 2011 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:21328065
Lee MJ et al. The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. 2011 Mol. Cells pmid:21331775
Andreu I et al. Probing lipid peroxidation by using linoleic acid and benzophenone. 2011 Chemistry pmid:21793062
Shibata H et al. Effect of supplementation of soy sauce oil and Ca salts of fatty acids on rumen fermentation, milk production and conjugated linoleic acid in milk of dairy cows. 2011 Anim. Sci. J. pmid:21794014
Cunnane SC and Guesnet P Linoleic acid recommendations--A house of cards. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21963263
Prasad A and Pospíšil P Linoleic acid-induced ultra-weak photon emission from Chlamydomonas reinhardtii as a tool for monitoring of lipid peroxidation in the cell membranes. 2011 PLoS ONE pmid:21799835
P Wrobel T et al. Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis. 2011 Analyst pmid:22007352
Li YC et al. Effects of conjugated linoleic acid on cleavage of amyloid precursor protein via PPARγ. 2011 Neurol. Sci. pmid:21800078
Baâtour O et al. Salt effects on Origanum majorana fatty acid and essential oil composition. 2011 J. Sci. Food Agric. pmid:21800320
Lebold KM et al. Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). 2011 J. Nutr. pmid:22013196
Nishioka N et al. Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1. 2011 Br. J. Cancer pmid:22015554
Toledo L et al. Substrate binding to mammalian 15-lipoxygenase. 2011 J. Comput. Aided Mol. Des. pmid:21861154
Vedtofte MS et al. Dietary α-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease. 2011 Am. J. Clin. Nutr. pmid:21865326
Amtul Z et al. Additive effects of fatty acid mixtures on the levels and ratio of amyloid β40/42 peptides differ from the effects of individual fatty acids. 2011 J. Neurosci. Res. pmid:21748777
Ilić M et al. Thrombin inhibitors with lipid peroxidation and lipoxygenase inhibitory activities. 2011 Bioorg. Med. Chem. Lett. pmid:21757348
Mito F et al. Oxygen concentration dependence of lipid peroxidation and lipid-derived radical generation: application of profluorescent nitroxide switch. 2011 Free Radic. Res. pmid:21736483
Ranchordas MK et al. A-z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--part 23. 2011 Br J Sports Med pmid:21743106
Kikalishvili BIu et al. [The most biological important constances of Rkatsiteli grape oil and its effect as a 5% and 10% food-additive]. 2011 Georgian Med News pmid:21778549
Mahmmoud YA and Christensen SB Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. 2011 Biochim. Biophys. Acta pmid:21767529
Khadake R et al. Functional and bioinformatic characterisation of sequence variants of Fad3 gene from flax. 2011 J. Sci. Food Agric. pmid:21769878
Banta JP et al. Effects of prepartum supplementation of linoleic and mid-oleic sunflower seed on cow performance, cow reproduction, and calf performance from birth through slaughter, and effects on intake and digestion in steers. 2011 J. Anim. Sci. pmid:21788431
Končić MZ et al. Antiradical, chelating and antioxidant activities of hydroxamic acids and hydroxyureas. 2011 Molecules pmid:21788931
Danish HH et al. Hydrogen tunneling steps in cyclooxygenase-2 catalysis. 2011 J. Am. Chem. Soc. pmid:21902213
Bowden JA et al. Electrospray ionization tandem mass spectrometry of sodiated adducts of cholesteryl esters. 2011 Lipids pmid:21904795
Shchepinov MS et al. Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease. 2011 Toxicol. Lett. pmid:21906664
Aktumsek A et al. Screening for in vitro antioxidant properties and fatty acid profiles of five Centaurea L. species from Turkey flora. 2011 Food Chem. Toxicol. pmid:21878362
Guesnet P et al. α-Linolenate reduces the dietary requirement for linoleate in the growing rat. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21880475
Dailey MJ et al. Jejunal linoleic acid infusions require GLP-1 receptor signaling to inhibit food intake: implications for the effectiveness of Roux-en-Y gastric bypass. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21917638
Lee YJ and Jenkins TC Identification of enriched conjugated linoleic acid isomers in cultures of ruminal microorganisms after dosing with 1-(13)C-linoleic acid. 2011 J. Microbiol. pmid:21887646
Beker BY et al. Antioxidant protective effect of flavonoids on linoleic acid peroxidation induced by copper(II)/ascorbic acid system. 2011 Chem. Phys. Lipids pmid:21925488
Ogawa E et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. 2011 J. Invest. Dermatol. pmid:21068754
Arciniega JC et al. Effects of free fatty acids on meibomian lipid films. 2011 Exp. Eye Res. pmid:21718696
Odabasoglu F et al. α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations. 2011 Br. J. Nutr. pmid:21073761
Akrout A et al. Antioxidant and antitumor activities of Artemisia campestris and Thymelaea hirsuta from southern Tunisia. 2011 Food Chem. Toxicol. pmid:21075159
Cheng TM et al. Haemoglobin-induced oxidative stress is associated with both endogenous peroxidase activity and H2O2 generation from polyunsaturated fatty acids. 2011 Free Radic. Res. pmid:21034361
Lin YH et al. Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. 2011 J. Nutr. Biochem. pmid:21111595
Vinaixa M et al. Metabolomics reveals reduction of metabolic oxidation in women with polycystic ovary syndrome after pioglitazone-flutamide-metformin polytherapy. 2011 PLoS ONE pmid:22194988
Lam WM et al. In Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement. 2011 J. Biomed. Mater. Res. Part B Appl. Biomater. pmid:21053263
Yang Y et al. Synthesis and antioxidant capacities of hydroxyl derivatives of cinnamoylphenethylamine in protecting DNA and scavenging radicals. 2011 Free Radic. Res. pmid:21128731
Hubert DJ et al. In vitro hepatoprotective and antioxidant activities of crude extract and isolated compounds from Ficus gnaphalocarpa. 2011 Inflammopharmacology pmid:21088994
Morganti P et al. Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre-randomized trial. 2011 Int J Cosmet Sci pmid:21668835
Narwaley M et al. Drug-induced protein free radical formation is attenuated by unsaturated fatty acids by scavenging drug-derived phenyl radical metabolites. 2011 Chem. Res. Toxicol. pmid:21671642
Göçer H and Gülçin I Caffeic acid phenethyl ester (CAPE): correlation of structure and antioxidant properties. 2011 Int J Food Sci Nutr pmid:21631390
Lautenslager GT et al. Effects of nonenzymatic glycation and fatty acids on functional properties of human albumin. 2011 Metab. Clin. Exp. pmid:21632076
Blaul B and Ruther J How parasitoid females produce sexy sons: a causal link between oviposition preference, dietary lipids and mate choice in Nasonia. 2011 Proc. Biol. Sci. pmid:21429922
Gibson RA et al. Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. 2011 Matern Child Nutr pmid:21366864
Lauritzen L and Carlson SE Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. 2011 Matern Child Nutr pmid:21366866
Brenna JT Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. 2011 Matern Child Nutr pmid:21366867
Briend A et al. Fatty acid status in early life in low-income countries--overview of the situation, policy and research priorities. 2011 Matern Child Nutr pmid:21366873
Blasbalg TL et al. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. 2011 Am. J. Clin. Nutr. pmid:21367944
Aewsiri T et al. Surface activity and molecular characteristics of cuttlefish skin gelatin modified by oxidized linoleic acid. 2011 Int. J. Biol. Macromol. pmid:21334373
You Q et al. Purification, immobilization and characterization of linoleic acid isomerase on modified palygorskite. 2011 Bioprocess Biosyst Eng pmid:21340675
Rybicka M et al. Comparative effects of conjugated linoleic acid (CLA) and linoleic acid (LA) on the oxidoreduction status in THP-1 macrophages. 2011 J. Agric. Food Chem. pmid:21391598
Rakib MA et al. Preventive effect of t,t-conjugated linoleic acid on 12-O-tetradecanoylphorbol-13-acetate-induced inhibition of gap junctional intercellular communication in human mammary epithelial MCF-10A cells. 2011 J. Agric. Food Chem. pmid:21391601
Tuei VC et al. Effects of human serum albumin complexed with free fatty acids on cell viability and insulin secretion in the hamster pancreatic β-cell line HIT-T15. 2011 Life Sci. pmid:21396379
Mihaljević B et al. Linoleic acid peroxidation vs. isomerization: a biomimetic model of free radical reactivity in the presence of thiols. 2011 Org. Biomol. Chem. pmid:21442126
Blum JL et al. Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. 2011 Toxicol In Vitro pmid:21443943
Edris AE The chemical composition and the content of volatile oil: potential factors that can contribute to the oxidative stability of Nigella sativa L. crude oil. 2011 J Diet Suppl pmid:22432633
Salem N and Kuratko CN Lack of evidence for increased α-linolenic acid metabolism in vegetarians. 2011 Am. J. Clin. Nutr. pmid:21430120
Sala-Vila A et al. Inverse association between serum phospholipid oleic acid and insulin resistance in subjects with primary dyslipidaemia. 2011 Clin Nutr pmid:21458117
Li M et al. Isolation of a novel C18-Δ9 polyunsaturated fatty acid specific elongase gene from DHA-producing Isochrysis galbana H29 and its use for the reconstitution of the alternative Δ8 pathway in Saccharomyces cerevisiae. 2011 Biotechnol. Lett. pmid:21538137
Ueda Y et al. Effect of dietary lipids on longevity and memory in the SAMP8 mice. 2011 J. Nutr. Sci. Vitaminol. pmid:21512289
Pi F et al. Solid-state low temperature→middle temperature phase transition of linoleic acid studied by FTIR spectroscopy. 2011 J Phys Chem B pmid:21520953
Hasegawa T et al. Constituents of the green tea seeds of Camellia sinensis. 2011 Nat Prod Commun pmid:21485277
Atri MS et al. Structure and stability analysis of cytotoxic complex of camel α-lactalbumin and unsaturated fatty acids produced at high temperature. 2011 J. Biomol. Struct. Dyn. pmid:21469752
Carrillo C et al. Oleic acid versus linoleic and α-linolenic acid. different effects on Ca2+ signaling in rat thymocytes. 2011 Cell. Physiol. Biochem. pmid:21471726
Subbaiah PV et al. Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. 2011 Biochim. Biophys. Acta pmid:20920595
Wong WT et al. Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. 2011 Nutr Metab Cardiovasc Dis pmid:20005687
Alloatti A and Uttaro AD Highly specific methyl-end fatty-acid desaturases of trypanosomatids. 2011 Mol. Biochem. Parasitol. pmid:20974196
Figueras M et al. Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status. 2011 Obesity (Silver Spring) pmid:20885391
Konkel A and Schunck WH Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. 2011 Biochim. Biophys. Acta pmid:20869469
Liou AP et al. The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. 2011 Gastroenterology pmid:20955703
White HM et al. Differential regulation of bovine pyruvate carboxylase promoters by fatty acids and peroxisome proliferator-activated receptor-α agonist. 2011 J. Dairy Sci. pmid:21700028
Siddique BM et al. Chemical composition and antioxidant properties of candlenut oil extracted by supercritical CO2. 2011 J. Food Sci. pmid:22417332
Chen HH and Chiu TH Phytochemicals characterization of solvent extracts from taro-scented japonica rice bran. 2011 J. Food Sci. pmid:22417350
Turk HF et al. Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. 2011 Int. J. Cancer pmid:20232381
Rosberg-Cody E et al. Recombinant lactobacilli expressing linoleic acid isomerase can modulate the fatty acid composition of host adipose tissue in mice. 2011 Microbiology (Reading, Engl.) pmid:21178166
Tuo Y et al. Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways. 2011 Endocrine pmid:21161439
Hamberg M Stereochemistry of hydrogen removal during oxygenation of linoleic acid by singlet oxygen and synthesis of 11(S)-deuterium-labeled linoleic acid. 2011 Lipids pmid:21161604