Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Encopresis D004688 1 associated lipids
Enuresis D004775 1 associated lipids
Onchocerciasis D009855 1 associated lipids
Malaria, Cerebral D016779 1 associated lipids
Liposarcoma D008080 1 associated lipids
Gastroschisis D020139 1 associated lipids
Fat Necrosis D005218 1 associated lipids
Facial Nerve Diseases D005155 1 associated lipids
Child Nutrition Disorders D015362 1 associated lipids
Refeeding Syndrome D055677 1 associated lipids
Pellagra D010383 1 associated lipids
Refractive Errors D012030 1 associated lipids
Carcinoma, Krebs 2 D002287 1 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Circoviridae Infections D018173 2 associated lipids
Leptospirosis D007922 2 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Lymphopenia D008231 2 associated lipids
Lactose Intolerance D007787 2 associated lipids
Disease D004194 2 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

Download all related citations
Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
Wu D et al. Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. 2009 Anal. Chim. Acta pmid:19185115
Moodley R et al. Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. 2012 Anal. Chim. Acta pmid:22632042
Zeng YX et al. Comparative analysis of volatile components from Clematis species growing in China. 2007 Anal. Chim. Acta pmid:17606017
P Wrobel T et al. Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis. 2011 Analyst pmid:22007352
Tavilani H et al. Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. 2006 Andrologia pmid:16961570
Kreich M and Claus P Direct conversion of linoleic acid over silver catalysts in the presence of H2: an unusual way towards conjugated linoleic acids. 2005 Angew. Chem. Int. Ed. Engl. pmid:16315163
O'Quinn PR et al. Conjugated linoleic acid. 2000 Anim Health Res Rev pmid:11706843
McNamara S et al. Effect of offering rumen-protected fat supplements on fertility and performance in spring-calving Holstein-Friesian cows. 2003 Anim. Reprod. Sci. pmid:12853178
Kawahara S et al. Effects of dietary supplementation with conjugated linoleic acid on fatty acid composition and lipid oxidation in chicken breast meat. 2009 Anim. Sci. J. pmid:20163609
Shibata H et al. Effect of supplementation of soy sauce oil and Ca salts of fatty acids on rumen fermentation, milk production and conjugated linoleic acid in milk of dairy cows. 2011 Anim. Sci. J. pmid:21794014
Guo J et al. Selective transport of long-chain fatty acids by FAT/CD36 in skeletal muscle of broilers. 2013 Animal pmid:23031491
Men XM et al. Age-related changes and nutritional regulation of myosin heavy-chain composition in longissimus dorsi of commercial pigs. 2013 Animal pmid:23764195
Smink W et al. Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. 2012 Animal pmid:22436184
Zened A et al. In vitro study of dietary factors affecting the biohydrogenation shift from trans-11 to trans-10 fatty acids in the rumen of dairy cows. 2012 Animal pmid:22436225
Stachowska E et al. Is conjugated linoleic acid (CLA) a protective factor in atherosclerosis? Study with the use of neural networks. 2005 Ann Acad Med Stetin pmid:16519093
GHOSH A and GHOSH JJ EFFECT OF NYSTATIN AND AMPHOTERICIN B ON THE GROWTH OF CANDIDA ALBICANS. 1963 Ann Biochem Exp Med pmid:14060842
GHOSH A and GHOSH JJ RELEASE OF INTRACELLULAR CONSTITUENTS OF CANDIDA ALBICANS IN PRESENCE OF POLYENE ANTIBIOTICS. 1963 Ann Biochem Exp Med pmid:14154207
GHOSH A and GHOSH JJ ABSORPTION OF AMPHOTERICIN B BY CANDIDA ALBICANS. 1963 Ann Biochem Exp Med pmid:14154206
SOIVA K and CASTREN O Analysis of the lipids from ovarian tumours. 1963 Ann Med Exp Biol Fenn pmid:13989890
MARTINET M [Embryonic hemorrhages caused by deficiency in linoleic acid]. 1952 Ann Med Interne (Paris) pmid:14952971
Yen CH et al. Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. 2008 Ann. Allergy Asthma Immunol. pmid:18254485
Ranganath LR et al. Increased mean platelet volume after oestrogen replacement therapy. 1996 Ann. Clin. Biochem. pmid:8937589
Taylor AJ Erythrocyte membrane fatty acid composition in hypercholesterolaemia. 1994 Ann. Clin. Biochem. pmid:7979101
Fairfield K ACP Journal Club. Review: replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality. 2013 Ann. Intern. Med. pmid:23689785
Davis PA et al. A linoleate-enriched cheese product reduces low-density lipoprotein in moderately hypercholesterolemic adults. 1993 Ann. Intern. Med. pmid:8363165
Kankaanpää P et al. Dietary fatty acids and allergy. 1999 Ann. Med. pmid:10480759
Chopra M et al. Free radical scavenging of lutein in vitro. 1993 Ann. N. Y. Acad. Sci. pmid:8129303
Thompson RL et al. Cigarette smoking, polyunsaturated fats, and coronary heart disease. 1993 Ann. N. Y. Acad. Sci. pmid:8512244
Sugano M and Koba K Dietary protein and lipid metabolism: a multifunctional effect. 1993 Ann. N. Y. Acad. Sci. pmid:8489133
Merendino N et al. Induction of apoptosis in human pancreatic cancer cells by docosahexaenoic acid. 2003 Ann. N. Y. Acad. Sci. pmid:15033753
Schlame M et al. Deficiency of tetralinoleoyl-cardiolipin in Barth syndrome. 2002 Ann. Neurol. pmid:12112112
Sakai T et al. Chorea-acanthocytosis: abnormal composition of covalently bound fatty acids of erythrocyte membrane proteins. 1991 Ann. Neurol. pmid:1832532
Charnock JS et al. Changes in fatty acid composition of the cardiac phospholipids of the cotton-eared marmoset (Callithrix jacchus) after feeding different lipid supplements. 1985 Ann. Nutr. Metab. pmid:3922279
Babin F et al. Plasma fatty acid composition and lipid peroxide levels in children with paucity of interlobular bile ducts. 1988 Ann. Nutr. Metab. pmid:3195990
Carreau JP et al. Cholesterol synthesis in the liver, kidneys and brain after injection of uniformly 14C-labeled oleic or linoleic acid to developing rats. 1982 Ann. Nutr. Metab. pmid:6814348
Romijn D et al. A linoleic acid enriched diet increases serum cholesterol esterification by lecithin:cholesterol acyltransferase in meal-fed rats. 1998 Ann. Nutr. Metab. pmid:9745111
Choi YS and Sugano M Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. 1988 Ann. Nutr. Metab. pmid:2903713
Mogenson GJ and Box BM Physiological effects of varying dietary linoleic acid in spontaneously hypertensive rats. 1982 Ann. Nutr. Metab. pmid:7137945
Adam O et al. Prostaglandin formation in man during intake of different amounts of linoleic acid in formula diets. 1982 Ann. Nutr. Metab. pmid:7137955
Fuhrmann H and Sallmann HP Alpha-tocopherol and phospholipase A2 in liver and brain of chicks posthatching: the influence of dietary fat and vitamin E. 1995 Ann. Nutr. Metab. pmid:8585700
Saito M and Yamaguchi M Liver microsomal mixed-function oxidases in response to dietary n-3 fatty acid levels in rats. 1994 Ann. Nutr. Metab. pmid:7832581
Saín J et al. Effects of trans-fatty acids on liver lipid metabolism in mice fed on diets showing different fatty acid composition. 2013 Ann. Nutr. Metab. pmid:23594856
Boissonneault GA et al. Oxidized low-density lipoproteins delay endothelial wound healing: lack of effect of vitamin E. 1995 Ann. Nutr. Metab. pmid:7872651
Santos MJ et al. Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. 1995 Ann. Nutr. Metab. pmid:7872656
Lohner S et al. Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. 2013 Ann. Nutr. Metab. pmid:23327902
Kort WJ et al. Influence of the linoleic acid content of the diet on tumor growth in transplantable rat tumor models. 1986 Ann. Nutr. Metab. pmid:3963748
Roshanai F and Sanders TA Influence of different supplements of N-3 polyunsaturated fatty acids on blood and tissue lipids in rats receiving high intakes of linoleic acid. 1985 Ann. Nutr. Metab. pmid:4037727
Fidler N et al. Oxidation of an oil rich in docosahexaenoic acid compared to linoleic acid in lactating women. 1999 Ann. Nutr. Metab. pmid:10725767
Charnock JS et al. Altered levels of n-6/n-3 fatty acids in rat heart and storage fat following variable dietary intake of linoleic acid. 1985 Ann. Nutr. Metab. pmid:4051450
Adam O Linoleic acid - the fall of an angel? 1999 Ann. Nutr. Metab. pmid:10725772
Charnock JS et al. Diet and cardiac arrhythmia: effects of lipids on age-related changes in myocardial function in the rat. 1985 Ann. Nutr. Metab. pmid:4051452
Soltysova T and Bellisle F Nutrition in ten-year-old children of the Liberec area (Czech Republic). 1994 Ann. Nutr. Metab. pmid:7979168
Pascaud M and Strouve-Vallet C Desaturation of 14C linoleic acid by the rat fetus. 1985 Ann. Nutr. Metab. pmid:2983600
Roth HP and Kirchgessner M [Effect of various unsaturated fatty acids on the stability of the erythrocyte membrane in the rat]. 1992 Ann. Nutr. Metab. pmid:1354951
Aziz AA et al. Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. 2010 Ann. Nutr. Metab. pmid:20714137
Jensen MM et al. Intestinal absorption of octanoic, decanoic, and linoleic acids: effect of triglyceride structure. 1994 Ann. Nutr. Metab. pmid:8067685
Heine RJ et al. The effect of dietary linoleic acid and pectin on lipoprotein and apolipoprotein A1 concentrations in rhesus monkeys. 1984 Ann. Nutr. Metab. pmid:6476785
de Deckere EA et al. Hepatic de novo fatty acid synthesis in the rat. 1993 Ann. Nutr. Metab. pmid:8215236
Katan MB et al. Biological markers of dietary intake, with emphasis on fatty acids. 1991 Ann. Nutr. Metab. pmid:1776820
Xiang M et al. Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects. 2006 Ann. Nutr. Metab. pmid:16988497
Decsi T and Koletzko B Do trans fatty acids impair linoleic acid metabolism in children? 1995 Ann. Nutr. Metab. pmid:7872654
De Vriese SR et al. Estimation of dietary fat intake of Belgian pregnant women. Comparison of two methods. 2001 Ann. Nutr. Metab. pmid:11786650
Black JM and Kinsella JE Dietary n-3 fatty acids alter murine peritoneal macrophage cytotoxicity. 1993 Ann. Nutr. Metab. pmid:8373135
Adam O et al. Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers. 2003 Ann. Nutr. Metab. pmid:12624485
Leat WM et al. Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. 1986 Ann. Nutr. Metab. pmid:2872851
Sanders TA and Rana SK Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. 1987 Ann. Nutr. Metab. pmid:2892461
Jakobsen K et al. Heat production and quantitative oxidation of nutrients by physical activity in pigs. 1994 Ann. Nutr. Metab. pmid:8185282
Ferry DR et al. A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. 2000 Ann. Oncol. pmid:11061613
Polesel J et al. Linoleic acid, vitamin D and other nutrient intakes in the risk of non-Hodgkin lymphoma: an Italian case-control study. 2006 Ann. Oncol. pmid:16556850
Alexander JW et al. The importance of lipid type in the diet after burn injury. 1986 Ann. Surg. pmid:3015058
Franco-Pons N et al. Fat necrosis generates proinflammatory halogenated lipids during acute pancreatitis. 2013 Ann. Surg. pmid:22964727
Singer S et al. Correlation of lipid content and composition with liposarcoma histology and grade. 1997 Oct-Nov Ann. Surg. Oncol. pmid:9367021
Belury MA Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action. 2002 Annu. Rev. Nutr. pmid:12055356
Bauman DE and Griinari JM Nutritional regulation of milk fat synthesis. 2003 Annu. Rev. Nutr. pmid:12626693
Lipkin M et al. Dietary factors in human colorectal cancer. 1999 Annu. Rev. Nutr. pmid:10448536
Tsubura A et al. Anticancer effects of garlic and garlic-derived compounds for breast cancer control. 2011 Anticancer Agents Med Chem pmid:21269259
Schønberg S and Krokan HE The inhibitory effect of conjugated dienoic derivatives (CLA) of linoleic acid on the growth of human tumor cell lines is in part due to increased lipid peroxidation. 1995 Jul-Aug Anticancer Res. pmid:7654003
Nohl H et al. Suppression of tumour-promoting factors in fat-induced colon carcinogenesis by the antioxidants caroverine and ubiquinone. 2005 Jul-Aug Anticancer Res. pmid:16080529
desBordes C and Lea MA Effects of C18 fatty acid isomers on DNA synthesis in hepatoma and breast cancer cells. 1995 Sep-Oct Anticancer Res. pmid:8572595
Kamano K et al. Effects of a high-linoleate and a high-alpha-linolenate diet on spontaneous mammary tumourigenesis in mice. 1989 Nov-Dec Anticancer Res. pmid:2627137
Cohen LA et al. The influence of different varieties of olive oil on N-methylnitrosourea(NMU)-induced mammary tumorigenesis. 2000 Jul-Aug Anticancer Res. pmid:10953289
Davidson BC et al. Individual fatty acids influence cultured human liver cells differently when compared to plant oils. 2003 Jan-Feb Anticancer Res. pmid:12680255
Gadducci A et al. Malnutrition and cachexia in ovarian cancer patients: pathophysiology and management. 2001 Jul-Aug Anticancer Res. pmid:11712791
Cunningham DC et al. Proliferative responses of normal human mammary and MCF-7 breast cancer cells to linoleic acid, conjugated linoleic acid and eicosanoid synthesis inhibitors in culture. 1997 Jan-Feb Anticancer Res. pmid:9066651
Visonneau S et al. Conjugated linoleic acid suppresses the growth of human breast adenocarcinoma cells in SCID mice. 1997 Mar-Apr Anticancer Res. pmid:9137436
Wong MW et al. Effects of dietary conjugated linoleic acid on lymphocyte function and growth of mammary tumors in mice. 1997 Mar-Apr Anticancer Res. pmid:9137439
Chew BP et al. Effects of conjugated dienoic derivatives of linoleic acid and beta-carotene in modulating lymphocyte and macrophage function. 1997 Mar-Apr Anticancer Res. pmid:9137456
Cesano A et al. Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice. 1998 May-Jun Anticancer Res. pmid:9673351
Senzaki H et al. Dietary effects of fatty acids on growth and metastasis of KPL-1 human breast cancer cells in vivo and in vitro. 1998 May-Jun Anticancer Res. pmid:9673380
Iwai K et al. Tumor targeting by arterial administration of lipids: rabbit model with VX2 carcinoma in the liver. 1987 May-Jun Anticancer Res. pmid:2820293
Shultz TD et al. Differential stimulatory and inhibitory responses of human MCF-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture. 1992 Nov-Dec Anticancer Res. pmid:1295460
Cantrill RC et al. Variations in temperature and oxygen content do not alter levels of thiobarbiturate reactive material in human breast tumour cells (ZR-75-1) incubated with gamma-linolenic acid. 1993 Sep-Oct Anticancer Res. pmid:8239521
O'Shea M et al. Antioxidant enzyme defence responses of human MCF-7 and SW480 cancer cells to conjugated linoleic acid. 1999 May-Jun Anticancer Res. pmid:10470140
De Antueno RJ et al. Metabolism of radiolabelled 18:2n-6 and 18:3n-6 by NIH-3T3 cells and the DT subclone. 1993 Jul-Aug Anticancer Res. pmid:8394680
Davidson BC et al. The influence of fatty acids on normal and transformed human liver cells in culture. 1998 Sep-Oct Anticancer Res. pmid:9858936
Cai YJ et al. The 3,4-dihydroxyl groups are important for trans-resveratrol analogs to exhibit enhanced antioxidant and apoptotic activities. 2004 Mar-Apr Anticancer Res. pmid:15161055
Kabara JJ et al. Fatty acids and derivatives as antimicrobial agents. 1972 Antimicrob. Agents Chemother. pmid:4670656
Stein CA Controversies in the cellular pharmacology of oligodeoxynucleotides. 1997 Antisense Nucleic Acid Drug Dev. pmid:9212912
Hwang YC et al. Rapid identification of inhibitors that interfere with poliovirus replication using a cell-based assay. 2008 Antiviral Res. pmid:18243348
Vidal-Mas J et al. Cloning and expression of a lipoxygenase from Pseudomonas aeruginosa 42A2. 2005 Antonie Van Leeuwenhoek pmid:15803390