Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Acidosis D000138 13 associated lipids
Acne Vulgaris D000152 35 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Adenocarcinoma D000230 166 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Alcoholism D000437 27 associated lipids
Alopecia D000505 14 associated lipids
Alzheimer Disease D000544 76 associated lipids
Aneurysm D000783 2 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Hypoxia D000860 23 associated lipids
Aortic Diseases D001018 11 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Ascites D001201 25 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Biliary Atresia D001656 4 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

Download all related citations
Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
Kim SY et al. S-adenosyl methionine prevents endothelial dysfunction by inducing heme oxygenase-1 in vascular endothelial cells. 2013 Mol. Cells pmid:24046187
Ivan M et al. Rumen fermentation and microbial population in lactating dairy cows receiving diets containing oilseeds rich in C-18 fatty acids. 2013 Br. J. Nutr. pmid:22850225
Alvheim AR et al. Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon (Salmo salar L.) and mice, and induces weight gain and inflammation in mice. 2013 Br. J. Nutr. pmid:22883314
Otte KB et al. Synthesis of 9-oxononanoic acid, a precursor for biopolymers. 2013 ChemSusChem pmid:23934656
Cheng G et al. Relative validity of a 3 d estimated food record in German toddlers. 2013 Public Health Nutr pmid:22874634
McGowan MM et al. A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue. 2013 Breast Cancer Res. Treat. pmid:23417336
Girgih AT et al. Reverse-phase HPLC separation of hemp seed (Cannabis sativa L.) protein hydrolysate produced peptide fractions with enhanced antioxidant capacity. 2013 Plant Foods Hum Nutr pmid:23417711
Mabalirajan U et al. Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. 2013 Sci Rep pmid:23443229
Tokede OA et al. Plasma phospholipid trans fatty acids and risk of heart failure. 2013 Am. J. Clin. Nutr. pmid:23446892
Zuo R et al. Effects of conjugated linoleic acid on growth, non-specific immunity, antioxidant capacity, lipid deposition and related gene expression in juvenile large yellow croaker (Larmichthys crocea) fed soyabean oil-based diets. 2013 Br. J. Nutr. pmid:23452520
Schneider MR et al. Differentially regulated microRNAs during human sebaceous lipogenesis. 2013 J. Dermatol. Sci. pmid:23452545
Kirpich IA et al. Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. 2013 Alcohol pmid:23453163
Lind PM et al. An environmental wide association study (EWAS) approach to the metabolic syndrome. 2013 Environ Int pmid:23454278
Emery JA et al. Δ-6 Desaturase substrate competition: dietary linoleic acid (18:2n-6) has only trivial effects on α-linolenic acid (18:3n-3) bioconversion in the teleost rainbow trout. 2013 PLoS ONE pmid:23460861
Suardíaz R et al. An insight into the regiospecificity of linoleic acid peroxidation catalyzed by mammalian 15-lipoxygenases. 2013 J Phys Chem B pmid:23496802
Cardoso S et al. UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats. 2013 J. Bioenerg. Biomembr. pmid:23504111
Stamey Lanier J et al. Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. 2013 Lipids pmid:23504269
Shen W et al. Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice. 2013 J. Lipid Res. pmid:23401602
Saubeau G et al. Differential induction of oxylipin pathway in potato and tobacco cells by bacterial and oomycete elicitors. 2013 Plant Cell Rep. pmid:23479199
Godinot N et al. Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice. 2013 Neuroscience pmid:23831422
Lai MC et al. The natural PPAR agonist linoleic acid stimulated insulin release in the rat pancreas. 2013 J. Vet. Med. Sci. pmid:23832628
Bartók T et al. ESI-MS and MS/MS identification of the first ceramide analogues of fumonisin B₁ mycotoxin from a Fusarium verticillioides culture following RP-HPLC separation. 2013 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:23837460
Okada Y et al. Wing (Ib) cells in frog taste discs detect dietary unsaturated fatty acids. 2013 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:23872318
Van Ba H et al. Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems. 2013 Meat Sci. pmid:23632107
Al-Taan O et al. Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. 2013 Lipids Health Dis pmid:23648075
Nakagawa Y [Metabolism and biological function of cardiolipin]. 2013 Yakugaku Zasshi pmid:23649397
Fairfield K ACP Journal Club. Review: replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality. 2013 Ann. Intern. Med. pmid:23689785
Giua L et al. Oxidative modifications of conjugated and unconjugated linoleic acid during heating. 2013 Food Chem pmid:23692753
Liu Q et al. Nonsense-mediated mRNA degradation of CtFAD2-1 and development of a perfect molecular marker for olol mutation in high oleic safflower (Carthamus tinctorius L.). 2013 Theor. Appl. Genet. pmid:23695179
Khalil WA et al. Protective effects of antioxidants on linoleic acid-treated bovine oocytes during maturation and subsequent embryo development. 2013 Theriogenology pmid:23683689
Le Maux S et al. β-Lactoglobulin-linoleate complexes: In vitro digestion and the role of protein in fatty acid uptake. 2013 J. Dairy Sci. pmid:23684041
Saín J et al. Effects of trans-fatty acids on liver lipid metabolism in mice fed on diets showing different fatty acid composition. 2013 Ann. Nutr. Metab. pmid:23594856
Nørskov NP et al. Multicompartmental nontargeted LC-MS metabolomics: explorative study on the metabolic responses of rye fiber versus refined wheat fiber intake in plasma and urine of hypercholesterolemic pigs. 2013 J. Proteome Res. pmid:23596967
Jung CH et al. The preventive effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of phosphatidylinositol 3-kinase/Akt signaling pathway. 2013 Metab. Clin. Exp. pmid:23639572
Hand KV et al. Examining acute and chronic effects of short- and long-chain fatty acids on peptide YY (PYY) gene expression, cellular storage and secretion in STC-1 cells. 2013 Eur J Nutr pmid:22926626
Cedernaes J et al. Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. 2013 Lipids Health Dis pmid:23298201
Kälber T et al. Effect of feeding buckwheat and chicory silages on fatty acid profile and cheese-making properties of milk from dairy cows. 2013 J. Dairy Res. pmid:23253429
Gillingham LG et al. Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. 2013 Am. J. Clin. Nutr. pmid:23221573
Carro M et al. Linoleic acid stimulates neutral lipid accumulation in lipid droplets of maturing bovine oocytes. 2013 Theriogenology pmid:23273433
Nelson RH et al. Kinetics of saturated, monounsaturated, and polyunsaturated fatty acids in humans. 2013 Diabetes pmid:23274886
Gage SH et al. Functionalization of monodisperse iron oxide NPs and their properties as magnetically recoverable catalysts. 2013 Langmuir pmid:23234434
Khan AA et al. Anticancer efficacy of a novel propofol-linoleic acid-loaded escheriosomal formulation against murine hepatocellular carcinoma. 2013 Nanomedicine (Lond) pmid:23311988
Graves JP et al. Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily. 2013 Drug Metab. Dispos. pmid:23315644
Carey AN et al. The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. 2013 Nutr Neurosci pmid:23321679
Ramsden CE et al. Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. 2013 BMJ pmid:23386268
Calder PC Old study sheds new light on the fatty acids and cardiovascular health debate. 2013 BMJ pmid:23386269
Gousiadou C et al. Minor iridoids from Scutellaria albida ssp. albida. Inhibitory potencies on lipoxygenase, linoleic acid lipid peroxidation and antioxidant activity of iridoids from Scutellaria sp. 2013 J Enzyme Inhib Med Chem pmid:22630074
Serna-Marquez N et al. Role of LOXs and COX-2 on FAK activation and cell migration induced by linoleic acid in MDA-MB-231 breast cancer cells. 2013 Cell Oncol (Dordr) pmid:23179791
Gámez-Meza N et al. Chemical characterisation of kernels, kernel meals and oils from Jatropha cordata and Jatropha cardiophylla seeds. 2013 J. Sci. Food Agric. pmid:23180465
Toral PG et al. Effect of the inclusion of quebracho tannins in a diet rich in linoleic acid on milk fatty acid composition in dairy ewes. 2013 J. Dairy Sci. pmid:23164228
Yang Z and Huffman SL Modelling linoleic acid and α-linolenic acid requirements for infants and young children in developing countries. 2013 Matern Child Nutr pmid:23167585
Fedor DM et al. The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. 2013 Metab Syndr Relat Disord pmid:23170930
Jemia MB et al. Studies on the antioxidant activity of the essential oil and extract of Tunisian Tetraclinis articulata (Vahl) Mast. (Cupressaceae). 2013 Nat. Prod. Res. pmid:23082942
Bin Q et al. The caspase pathway of linoelaidic acid (9t, 12t-c18:2)-induced apoptosis in human umbilical vein endothelial cells. 2013 Lipids pmid:23065354
Ghisolfi J et al. Nutrient intakes of children aged 1-2 years as a function of milk consumption, cows' milk or growing-up milk. 2013 Public Health Nutr pmid:23098567
Guo J et al. Selective transport of long-chain fatty acids by FAT/CD36 in skeletal muscle of broilers. 2013 Animal pmid:23031491
Kiernan M et al. The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. 2013 Reprod. Fertil. Dev. pmid:23036717
Høstmark AT and Haug A Percentage oleic acid is inversely related to percentage arachidonic acid in total lipids of rat serum. 2013 Lipids Health Dis pmid:23521743
Fujii M et al. Deficiency of n-6 polyunsaturated fatty acids is mainly responsible for atopic dermatitis-like pruritic skin inflammation in special diet-fed hairless mice. 2013 Exp. Dermatol. pmid:23528213
Shimomura S et al. Stereoselective synthesis of a promising flower-inducing KODA analog, (9R,12S,13R,15Z)-9-hydroxy-12,13-methylene-10-oxooctadec-15-enoic acid. 2013 Biosci. Biotechnol. Biochem. pmid:23748793
Poon JF et al. In search of catalytic antioxidants--(alkyltelluro)phenols, (alkyltelluro)resorcinols, and bis(alkyltelluro)phenols. 2013 J. Org. Chem. pmid:23701313
Chodok P et al. Identification and functional characterization of two Δ12-fatty acid desaturases associated with essential linoleic acid biosynthesis in Physcomitrella patens. 2013 J. Ind. Microbiol. Biotechnol. pmid:23702573
Benjakul S et al. Antioxidant activity and inhibitory effects of lead (Leucaena leucocephala) seed extracts against lipid oxidation in model systems. 2013 Food Sci Technol Int pmid:23729420
de Goede J et al. N-6 and N-3 fatty acid cholesteryl esters in relation to fatal CHD in a Dutch adult population: a nested case-control study and meta-analysis. 2013 PLoS ONE pmid:23741290
Katan MB [Linoleic acid and heart infarct]. 2013 Ned Tijdschr Geneeskd pmid:23714298
Franco-Pons N et al. Fat necrosis generates proinflammatory halogenated lipids during acute pancreatitis. 2013 Ann. Surg. pmid:22964727
Whelan J and Fritsche K Linoleic acid. 2013 Adv Nutr pmid:23674797
Men XM et al. Age-related changes and nutritional regulation of myosin heavy-chain composition in longissimus dorsi of commercial pigs. 2013 Animal pmid:23764195
Ndhlala AR et al. Anti-oxidative and cholinesterase inhibitory effects of leaf extracts and their isolated compounds from two closely related Croton species. 2013 Molecules pmid:23377133
Al-Bishri WM Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats. 2013 J Oleo Sci pmid:24005015
Han L et al. Hydroxyl radical induced by lipid in Maillard reaction model system promotes diet-derived N(ε)-carboxymethyllysine formation. 2013 Food Chem. Toxicol. pmid:23959106
Aboshi T et al. Biosynthesis of linoleic acid in Tyrophagus mites (Acarina: Acaridae). 2013 Insect Biochem. Mol. Biol. pmid:23973745
Luo C et al. Vegetable oil thermosets reinforced by tannin-lipid formulations. 2013 Acta Biomater pmid:22975626
Ramirez AM et al. A trichome-specific linoleate lipoxygenase expressed during pyrethrin biosynthesis in pyrethrum. 2013 Lipids pmid:23893337
Ding CH et al. [Extraction of fatty constituents from Tabanus bivittatus and their analysis by GC-MS]. 2013 Zhong Yao Cai pmid:23901639
Özcan T Accumulation patterns of some seed oil components from wild sources of Turkey. 2013 Nat. Prod. Res. pmid:22233192
Li KC et al. [A preliminary study of the inhibitive efficacy of iodized linoleic acid and its fluorodeoxyuridine ester in hepatocellular cancer]. 2013 Zhonghua Gan Zang Bing Za Zhi pmid:24025140
Hashim A et al. Antioxidant and α -amylase inhibitory property of phyllanthus virgatus L.: an in vitro and molecular interaction study. 2013 Biomed Res Int pmid:23957001
Stelzleni AM et al. Effects of feeding extruded full-fat cottonseed pellets in place of tallow as a fat source for finishing heifers on feedlot performance, carcass characteristics, sensory traits, display color, and fatty acid profiles. 2013 J. Anim. Sci. pmid:23893987
Kim JB et al. Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins. 2013 Am. J. Cardiol. pmid:24050409
Caligiuri SP et al. Dietary linoleic acid and α-linolenic acid differentially affect renal oxylipins and phospholipid fatty acids in diet-induced obese rats. 2013 J. Nutr. pmid:23902961
Risé P et al. Different patterns characterize Omega 6 and Omega 3 long chain polyunsaturated fatty acid levels in blood from Italian infants, children, adults and elderly. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23910046
Kenny JG et al. Mannitol utilisation is required for protection of Staphylococcus aureus from human skin antimicrobial fatty acids. 2013 PLoS ONE pmid:23861785
Xie J et al. A polyethylenimine-linoleic acid conjugate for antisense oligonucleotide delivery. 2013 Biomed Res Int pmid:23862153
Xia Q et al. Fatty acid profile, oxidative stability and toxicological safety of bayberry kernel oil. 2013 Food Chem. Toxicol. pmid:23867545
Le Maux S et al. Complexes between linoleate and native or aggregated β-lactoglobulin: interaction parameters and in vitro cytotoxic effect. 2013 Food Chem pmid:23870962
Aladedunye F and Przybylski R Frying stability of high oleic sunflower oils as affected by composition of tocopherol isomers and linoleic acid content. 2013 Food Chem pmid:23870970
Chen CS et al. Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue. 2013 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24154509
Reinders I et al. Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. 2013 Eur J Clin Nutr pmid:24084512
Navarro-Guillén C et al. Interaction between dietary levels of LC-PUFA and vegetable oil sources in Senegalese sole (Solea senegalensis) post-larvae: puzzling results suggesting complete biosynthesis pathway from C18 PUFA to DHA. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141696
Li P et al. Effect of non-esterified fatty acids on fatty acid metabolism-related genes in calf hepatocytes cultured in vitro. 2013 Cell. Physiol. Biochem. pmid:24335176
Shinjyo N et al. Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. 2013 J. Neurosci. Res. pmid:23633391
de Oliveira Otto MC et al. Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. 2013 J Am Heart Assoc pmid:24351702
Sisignano M et al. Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice. 2013 PLoS ONE pmid:24349046
Ngakegni-Limbili AC et al. Aframomum stipulatum (Gagnep) K. Schum and Aframomum giganteum (Oliv. & Hanb) K. Schum as Aroma Tincto Oleo Crops resources: essential oil, fatty acids, sterols, tocopherols, and tocotrienols composition of different fruit parts of Congo varieties. 2013 J. Sci. Food Agric. pmid:22692978
Sato K et al. Selective and potent inhibitory effect of docosahexaenoic acid (DHA) on U46619-induced contraction in rat aorta. 2013 J Smooth Muscle Res pmid:24304639
De Weirdt R et al. A simulated mucus layer protects Lactobacillus reuteri from the inhibitory effects of linoleic acid. 2013 Benef Microbes pmid:24311313
Li XP et al. Linolelaidic acid induces a stronger proliferative effect on human umbilical vein smooth muscle cells compared to elaidic acid. 2013 Lipids pmid:23341188
Okada Y et al. Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization. 2013 Clin. Exp. Immunol. pmid:24028683
Yamagishi K et al. Plasma fatty acid composition and incident ischemic stroke in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. 2013 Cerebrovasc. Dis. pmid:23920478