Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hepatolenticular Degeneration D006527 3 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Verwoert I et al. The molecular basis of the high linoleic acid content in Petunia seed oil: analysis of a seed-specific linoleic acid mutant. 2000 Biochem. Soc. Trans. pmid:11171150
Kamisaka Y and Noda N Intracellular transport of phosphatidic acid and phosphatidylcholine into lipid bodies: use of fluorescent lipids to study lipid-body formation in an oleaginous fungus. 2000 Biochem. Soc. Trans. pmid:11171185
Bailey JM et al. Dietary linoleic acid in alcohol-induced liver cirrhosis. 1995 Biochem. Soc. Trans. pmid:7672270
Grechkin AN et al. Lipoxygenase pathway in tulip: biosynthesis of ketols. 2000 Biochem. Soc. Trans. pmid:11171230
Kashulin PA et al. Extremely rapid effects of polyunsaturated fatty acids and N-acetylglucosamine on free-radical metabolism in cultured potato plant cells. 2000 Biochem. Soc. Trans. pmid:11171236
Nuñez A et al. Anaerobic lipoxygenase activity from Chlorella pyrenoidosa. 2000 Biochem. Soc. Trans. pmid:11171268
Kaushik N and Agnihotri A GLC analysis of Indian rapeseed-mustard to study the variability of fatty acid composition. 2000 Biochem. Soc. Trans. pmid:11171132
Avery SV et al. Low temperature-induced adaptations in lipid metabolism and physiological function in Acanthamoeba castellanii cultures of different ages. 1994 Biochem. Soc. Trans. pmid:7821519
Oliver MF Linoleic acid, antioxidants and coronary heart disease. 1990 Biochem. Soc. Trans. pmid:2088801
Das I et al. Effects of aspirin and garlic on cyclooxygenase-induced chemiluminescence in human term placenta. 1997 Biochem. Soc. Trans. pmid:9056997
Colquhoun A and Curi R Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. 1997 Biochem. Soc. Trans. pmid:9450108
Lloyd D et al. Adaptive changes in yeast membranes: catabolite repression and oxygen. 1983 Biochem. Soc. Trans. pmid:6617968
Kaushik N and Vir S Variations in fatty acid composition of neem seeds collected from the Rajasthan state of India. 2000 Biochem. Soc. Trans. pmid:11171243
Clouet P et al. Mitochondrial respiration on rumenic and linoleic acids. 2001 Biochem. Soc. Trans. pmid:11356175
Liu Q et al. Genetic modification of cotton seed oil using inverted-repeat gene-silencing techniques. 2000 Biochem. Soc. Trans. pmid:11288706
Devery R et al. Conjugated linoleic acid and oxidative behaviour in cancer cells. 2001 Biochem. Soc. Trans. pmid:11356179
Mogul R and Holman TR Inhibition studies of soybean and human 15-lipoxygenases with long-chain alkenyl sulfate substrates. 2001 Biochemistry pmid:11284695
Kleinfeld AM et al. Transport of long-chain native fatty acids across lipid bilayer membranes indicates that transbilayer flip-flop is rate limiting. 1997 Biochemistry pmid:9369487
Nelson MJ et al. Photolysis of "purple" lipoxygenase: implications for the structure of the chromophore. 1995 Biochemistry pmid:7742320
Surette ME et al. Relationship between arachidonate--phospholipid remodeling and apoptosis. 1996 Biochemistry pmid:8703924
Glickman MH and Klinman JP Lipoxygenase reaction mechanism: demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover. 1996 Biochemistry pmid:8841132
Jin SJ and Tserng KY Metabolic origins of urinary unsaturated dicarboxylic acids. 1990 Biochemistry pmid:2271537
Biro A et al. Complement protein C1q recognizes enzymatically modified low-density lipoprotein through unesterified fatty acids generated by cholesterol esterase. 2010 Biochemistry pmid:20166680
Pandey NR et al. Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein A-I secretion. 2008 Biochemistry pmid:18189424
SGOUTAS DS and KUMMEROW FA CHEMICAL SYNTHESIS OF TRITIUM-LABELED LINOLEIC ACID. 1964 Biochemistry pmid:14155105
Lima ES et al. Characterization of linoleic acid nitration in human blood plasma by mass spectrometry. 2002 Biochemistry pmid:12186558
Glickman MH and Klinman JP Nature of rate-limiting steps in the soybean lipoxygenase-1 reaction. 1995 Biochemistry pmid:7578005
Nieuwenhuizen WF et al. Lipoxygenase is irreversibly inactivated by the hydroperoxides formed from the enynoic analogues of linoleic acid. 1997 Biochemistry pmid:9109655
Jones GD et al. Role of lipid hydroperoxides in the activation of 15-lipoxygenase. 1996 Biochemistry pmid:8679548
Kleinfeld AM et al. Transport of long-chain native fatty acids across human erythrocyte ghost membranes. 1998 Biochemistry pmid:9609694
Léger CL et al. Evidence for a structurally specific role of essential polyunsaturated fatty acids depending on their peculiar double-bond distribution in biomembranes. 1990 Biochemistry pmid:2169876
Wecksler AT et al. Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. 2009 Biochemistry pmid:19469483
Nelson MJ et al. Structural characterization of alkyl and peroxyl radicals in solutions of purple lipoxygenase. 1994 Biochemistry pmid:8161558
Rickert KW and Klinman JP Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects. 1999 Biochemistry pmid:10493789
Desmarais SR et al. Inhibition of soybean lipoxygenase-1 by a diaryl-N-hydroxyurea by reduction of the ferric enzyme. 1994 Biochemistry pmid:7947748
Mukherjee A et al. Molecular oxygen dependent steps in fatty acid oxidation by cyclooxygenase-1. 2007 Biochemistry pmid:17355126
Henderson WR et al. Toxoplasma gondii stimulates the release of 13- and 9-hydroxyoctadecadienoic acids by human platelets. 1992 Biochemistry pmid:1606159
BAER E and BLACKWELL J SYNTHESIS OF ALPHA-CEPHALINS BY A NEW PROCEDURE. II. DIOLEOYL AND DILINOLEOYL L-ALPHA-CEPHALINS. 1964 Biochemistry pmid:14214090
Mogul R et al. Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase. 2000 Biochemistry pmid:10769137
Widstrom RL et al. Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase. 2003 Biochemistry pmid:14529287
Arnold WR et al. Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase. 2016 Biochemistry pmid:27992998
Widstrom RL et al. Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. 2001 Biochemistry pmid:11170430
Nagler LG et al. Rate of free-radical oxidation of C18 diene and triene fatty acids in aqueous micellar solutions and effectiveness of beta-carotene as an inhibitor of their oxidation. 2003 Biochemistry Mosc. pmid:12693967
Yang J et al. Study of the inhibitory effect of fatty acids on the interaction between DNA and polymerase beta. 2009 Biochemistry Mosc. pmid:19747104
Zhan ZJ et al. Preparation and characterization of Cu,Zn-superoxide dismutase covalently modified by polyunsaturated fatty acids. 2009 Biochemistry Mosc. pmid:19916943
Chechetkin IR et al. Specificity of oxidation of linoleic acid homologs by plant lipoxygenases. 2009 Biochemistry Mosc. pmid:19817685
Lomnitski L et al. The interaction between beta-carotene and lipoxygenase in plant and animal systems. 1993 Biochim. Biophys. Acta pmid:8481396
Parinandi NL et al. Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. 1990 Biochim. Biophys. Acta pmid:2123402
Mitranic MM et al. The effect of linoleic acid and benzyl alcohol on the activity of glycosyltransferases of rat liver Golgi membranes and some soluble glycosyltransferases. 1982 Biochim. Biophys. Acta pmid:6217837
Miyashita K et al. Preferential hydrolysis of monohydroperoxides of linoleoyl and linolenoyl triacylglycerol by pancreatic lipase. 1990 Biochim. Biophys. Acta pmid:2386795
Dutta-Roy AK et al. Purification and characterization of fatty acid-binding proteins from brown adipose tissue of the rat. 1993 Biochim. Biophys. Acta pmid:8334153
Hansen HS and Jensen B Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate. 1985 Biochim. Biophys. Acta pmid:3922424
Nugteren DH et al. Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat. 1985 Biochim. Biophys. Acta pmid:3922425
Kitagawa S et al. Effects of four types of reagents on ADP-induced aggregation and Ca2+ mobilization of bovine blood platelets. 1984 Biochim. Biophys. Acta pmid:6324876
Simon I et al. Electron-spin resonance studies of lipid-modified microsomes from Friend erythroleukemia cells. 1984 Biochim. Biophys. Acta pmid:6326852
Gavigan SJ and Knight BL Catabolism of low-density lipoprotein by fibroblasts cultured in medium supplemented with saturated or unsaturated free fatty acids. 1981 Biochim. Biophys. Acta pmid:6271233
Greenspan MD et al. Studies on the in vivo synthesis of triacylglycerol in mouse liver. 1982 Biochim. Biophys. Acta pmid:7055591
Okano G and Shimojo T Utilization of long-chain free fatty acids in white and red muscle of rats. 1982 Biochim. Biophys. Acta pmid:7066350
Deva R et al. Arachidonic acid stimulates cell growth and forms a novel oxygenated metabolite in Candida albicans. 2000 Biochim. Biophys. Acta pmid:10903481
Lapenna D et al. Inhibitory activity of salicylic acid on lipoxygenase-dependent lipid peroxidation. 2009 Biochim. Biophys. Acta pmid:18950686
Quoc KP and Dubacq JP Effect of growth temperature on the biosynthesis of eukaryotic lipid molecular species by the cyanobacterium Spirulina platensis. 1997 Biochim. Biophys. Acta pmid:9219908
Seeley SK et al. Metabolism of oxidized linoleic acid by glutathione transferases: peroxidase activity toward 13-hydroperoxyoctadecadienoic acid. 2006 Biochim. Biophys. Acta pmid:16624487
Gardner HW Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. 1989 Biochim. Biophys. Acta pmid:2492826
Gurvitz A et al. Degradation of conjugated linoleic acid isomers in the yeast Saccharomyces cerevisiae. 2001 Biochim. Biophys. Acta pmid:11566445
Woldseth B and Christophersen BO Biosynthesis of phospholipid molecular species in isolated liver cells studied by combining fatty acid substrates esterified in the sn-1 and sn-2 positions. 1994 Biochim. Biophys. Acta pmid:8011678
Moghaddam M et al. Novel metabolic pathways for linoleic and arachidonic acid metabolism. 1996 Biochim. Biophys. Acta pmid:8765137
Hrboticky N et al. Linoleic acid esterified in low density lipoprotein serves as substrate for increased arachidonic acid synthesis in differentiating monocytic cells. 1996 Biochim. Biophys. Acta pmid:8765140
Msika O et al. NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. 2012 Biochim. Biophys. Acta pmid:22564256
van Haaster CM et al. Formation of prostanoids and hydroxy fatty acids by stimulated peritoneal mast cells: role of the dietary fat type in rat. 1993 Biochim. Biophys. Acta pmid:8466942
Wenli Y and Yaping Z Chemiluminescence evaluation of oxidative damage to biomolecules induced by singlet oxygen and the protective effects of antioxidants. 2005 Biochim. Biophys. Acta pmid:15936152
Meuillet EJ et al. Incorporation of exogenous lipids modulates insulin signaling in the hepatoma cell line, HepG2. 1999 Biochim. Biophys. Acta pmid:10354513
SCHLENK H et al. INTERCONVERSION OF LONG-CHAIN FATTY ACIDS IN THE RAT. 1963 Biochim. Biophys. Acta pmid:14102761
Beyers EC and Emken EA Metabolites of cis,trans, and trans,cis isomers of linoleic acid in mice and incorporation into tissue lipids. 1991 Biochim. Biophys. Acta pmid:2029547
GOODMAN DW and SHIRATORI T THE TURNOVER OF INDIVIDUAL CHOLESTEROL ESTERS IN HUMAN AND RAT PLASMA. 1964 Biochim. Biophys. Acta pmid:14129407
Ghafoorunissa A et al. Substituting dietary linoleic acid with alpha-linolenic acid improves insulin sensitivity in sucrose fed rats. 2005 Biochim. Biophys. Acta pmid:15801047
Kanter JE et al. Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages. 2012 Biochim. Biophys. Acta pmid:22020260
Rich MR Conformational analysis of arachidonic and related fatty acids using molecular dynamics simulations. 1993 Biochim. Biophys. Acta pmid:8329458
Battu S et al. Linoleic acid peroxidation by Solanum tuberosum lipoxygenase was activated in the presence of human 5-lipoxygenase-activating protein. 1998 Biochim. Biophys. Acta pmid:9630716
Gibson RA et al. Incorporation of dietary oleate, linoleate, alpha-linolenate and eicosapentaenoate into the plasma lipid fractions of four strains of rat. 1992 Biochim. Biophys. Acta pmid:1351403
Stein Y et al. Metabolism of 3-[3H]sphingosine sphingomyelin labeled with [14C]palmitic or [14C]linoleic acid by Hep G2 cells and rat liver in vivo. 1991 Biochim. Biophys. Acta pmid:2054378
Konrad SD et al. Use of deuterium oxide to measure de novo fatty acid synthesis in normal subjects consuming different dietary fatty acid composition1. 1998 Biochim. Biophys. Acta pmid:9714781
Ryu SB and Wang X Increase in free linolenic and linoleic acids associated with phospholipase D-mediated hydrolysis of phospholipids in wounded castor bean leaves. 1998 Biochim. Biophys. Acta pmid:9714802
Mahfouz MM et al. Changes of linoleic acid metabolism and cellular phospholipid fatty acid composition in LLC-PK cells cultured at low magnesium concentrations. 1989 Biochim. Biophys. Acta pmid:2804072
Sprinz H et al. Mechanism of thiyl radical-catalyzed isomerization of unsaturated fatty acid residues in homogeneous solution and in liposomes. 2000 Biochim. Biophys. Acta pmid:10601698
Nordøy A et al. Effect of dietary (n--3) fatty acids on platelet function and lipid metabolism in rats. 1985 Biochim. Biophys. Acta pmid:2861854
Vrignaud P and Robert J Free fatty acid uptake is increased in doxorubicin-resistant rat glioblastoma cells. 1987 Biochim. Biophys. Acta pmid:2886153
Jensen E et al. Cell-density-dependent uptake of chylomicron remnants in rat hepatocyte monolayers. Effects of compactin and mevalonic acid. 1987 Biochim. Biophys. Acta pmid:3790613
Ringseis R et al. LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2. 2006 Biochim. Biophys. Acta pmid:16982210
Göbel C et al. Oxylipin profiling in pathogen-infected potato leaves. 2002 Biochim. Biophys. Acta pmid:12213493
Jyothirmayi N and Ramadoss CS Soybean lipoxygenase catalysed oxygenation of unsaturated fatty acid encapsulated in cyclodextrin. 1991 Biochim. Biophys. Acta pmid:1903659
Macrì F et al. Lipoxygenase activity associated to isolated soybean plasma membranes. 1994 Biochim. Biophys. Acta pmid:7947991
DE GIER J and VAN DEENENL A DIETARY INVESTIGATION ON THE VARIATIONS IN PHOSPHOLIPID CHARACTERISTICS OF RED-CELL MEMBRANES. 1964 Biochim. Biophys. Acta pmid:14194234
Leikin AI and Brenner RR Regulation of linoleic acid delta 6-desaturation by a cytosolic lipoprotein-like fraction in isolated rat liver microsomes. 1986 Biochim. Biophys. Acta pmid:2869785
Mizushina Y et al. Mode analysis of binding of fatty acids to mammalian DNA polymerases. 2000 Biochim. Biophys. Acta pmid:10903472
Schmitt A et al. Phospholipid hydrolysis of mildly oxidized LDL reduces their cytotoxicity to cultured endothelial cells. Potential protective role against atherogenesis. 1995 Biochim. Biophys. Acta pmid:7786889
VAN DEN BOSCH H and VAN DEENEN L THE FORMATION OF ISOMERIC LYSOLECITHINS. 1964 Biochim. Biophys. Acta pmid:14181312
Brightman AO et al. A growth factor- and hormone-stimulated NADH oxidase from rat liver plasma membrane. 1992 Biochim. Biophys. Acta pmid:1567890
Kwon B et al. Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. 2014 Biochim. Biophys. Acta pmid:24732014
Banerjee N and Rosenthal MD High-affinity incorporation of 20-carbon polyunsaturated fatty acids by human skin fibroblasts. 1985 Biochim. Biophys. Acta pmid:2990563
Breiden B and Sandhoff K The role of sphingolipid metabolism in cutaneous permeability barrier formation. 2014 Biochim. Biophys. Acta pmid:23954553