Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hepatolenticular Degeneration D006527 3 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Brodersen R et al. Multiple fatty acid binding to albumin in human blood plasma. 1990 Eur. J. Biochem. pmid:2338079
Barros H et al. Arachidonic acid absorption in human jejunum in organ culture: effects of ethanol. 1990 Eur. J. Clin. Invest. pmid:2124981
Teter BB et al. Milk fat depression in C57Bl/6J mice consuming partially hydrogenated fat. 1990 J. Nutr. pmid:2380791
DeLange RJ and Glazer AN Bile acids: antioxidants or enhancers of peroxidation depending on lipid concentration. 1990 Arch. Biochem. Biophys. pmid:2297222
Ha YL et al. Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. 1990 Cancer Res. pmid:2297758
Kawahara J et al. Dietary linoleic acid prevents the development of deoxycorticosterone acetate-salt hypertension. 1990 Hypertension pmid:2298478
Borgeson CE et al. Characterization of the delta 12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate. 1990 Biochim. Biophys. Acta pmid:2248971
Appel MJ et al. Azaserine-induced pancreatic carcinogenesis in rats: promotion by a diet rich in saturated fat and inhibition by a standard laboratory chow. 1990 Cancer Lett. pmid:2257542
Pal S and Davis PJ N-3 polyunsaturated fatty acids enhance cholesterol efflux from human fibroblasts in culture. 1990 Biochem. Biophys. Res. Commun. pmid:2260969
Butovich IA et al. [Activation of 5-lipoxygenase by lipophilic n-alkyl-containing acids--an allosteric process]. 1990 Bioorg. Khim. pmid:2344387
Singer P et al. Extreme decrease of linoleic acid in renal medulla from rats after a diet supplemented with cod liver oil. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2353033
Katan MB and van Dusseldoys M [Premenstrual syndromes]. 1990 Ned Tijdschr Geneeskd pmid:2355986
Shimizu T et al. Prostaglandin and fatty acid metabolism in patients with extrahepatic biliary atresia. 1990 J. Pediatr. Gastroenterol. Nutr. pmid:2324889
Parinandi NL et al. Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. 1990 Biochim. Biophys. Acta pmid:2123402
Hennig B et al. Effect of vitamin E on linoleic acid-mediated induction of peroxisomal enzymes in cultured porcine endothelial cells. 1990 J. Nutr. pmid:2329387
Kawada H et al. Improved maintenance of adult rat alveolar type II cell differentiation in vitro: effect of serum-free, hormonally defined medium and a reconstituted basement membrane. 1990 Am. J. Respir. Cell Mol. Biol. pmid:2363935
Lernhardt W Fatty acid requirement of B lymphocytes activated in vitro. 1990 Biochem. Biophys. Res. Commun. pmid:2302243
Galaris D et al. Ferrylmyoglobin-catalyzed linoleic acid peroxidation. 1990 Arch. Biochem. Biophys. pmid:2383021
Miller CC and Ziboh VA Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). 1990 J. Invest. Dermatol. pmid:2106562
Conquer J and Mahadevappa VG Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils. 1990 Biochem. Biophys. Res. Commun. pmid:2106881
Høy CE and Hølmer G Influence of dietary linoleic acid and trans fatty acids on the fatty acid profile of cardiolipins in rats. 1990 Lipids pmid:2215088
Buko VU Beef fat prevents alcoholic liver disease in the rat. 1990 Alcohol. Clin. Exp. Res. pmid:2221295
Opara EC et al. Enhancement of endocrine pancreatic secretions by essential fatty acids. 1990 J. Surg. Res. pmid:2187112
Dupont J and Dowd MK Icosanoid synthesis as a functional measurement of essential fatty acid requirement. 1990 J Am Coll Nutr pmid:2193052
Oliver MF Linoleic acid, antioxidants and coronary heart disease. 1990 Biochem. Soc. Trans. pmid:2088801
Bian RL et al. [Antianaphylactic components of Asarum forbsii Maxin]. 1990 Yao Xue Xue Bao pmid:2099089
Thomas CR and Lowy C The use of two in-situ simultaneously-perfused placentas to investigate the effect of carrier proteins on linoleic and palmitic acid transfer in the guinea pig. 1990 J. Dev. Physiol. pmid:2100741
Singer P et al. A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. 1990 Atherosclerosis pmid:2146966
Kitagawa S et al. Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. 1990 Biochim. Biophys. Acta pmid:2166588
Anel A et al. Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. 1990 Biochim. Biophys. Acta pmid:2114179
van Doormaal JJ Linoleic acid metabolism in diabetes mellitus. 1990 Neth J Med pmid:2074912
Ando H et al. Protein kinase C and linoleic acid-induced inhibition of melanogenesis. 1990 Pigment Cell Res. pmid:2077533
Newman MJ Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2371287
Gyllenhammar H et al. Dietary linoleate supplementation modulates formyl-peptide receptor expression and functional responses of rat neutrophils. 1990 J. Lab. Clin. Med. pmid:2157784
Kawashima Y et al. Peroxisome proliferators enhance linoleic acid metabolism in rat liver. Increased biosynthesis of omega 6 polyunsaturated fatty acids. 1990 J. Biol. Chem. pmid:2160962
Bedotti R et al. Stimulatory effect of serum albumin on the proliferation of serum-free SV40-transformed Balb/c 3T3 cells. 1990 Biochim. Biophys. Acta pmid:2163687
Akamatsu H et al. Suppressive effects of linoleic acid on neutrophil oxygen metabolism and phagocytosis. 1990 J. Invest. Dermatol. pmid:2143521
Piché LA and Mahadevappa VG Modification of rat platelet fatty acid composition by dietary lipids of animal and vegetable origin. 1990 J. Nutr. pmid:2111377
Weaver BJ et al. Dietary canola oil: effect on the accumulation of eicosapentaenoic acid in the alkenylacyl fraction of human platelet ethanolamine phosphoglyceride. 1990 Am. J. Clin. Nutr. pmid:2181858
Renner HW Anticlastogenic dietary factors assessed in mammalian assays. 1990 Basic Life Sci. pmid:2183774
Farnworth ER and Kramer JK Fat supplementation to the gestation diet of older sows and its effect on maternal and fetal fat metabolism. 1990 Reprod. Nutr. Dev. pmid:1981311
Marra CA and de Alaniz MJ Mineralocorticoids modify rat liver delta 6 desaturase activity and other parameters of lipid metabolism. 1990 Biochem. Int. pmid:1981670
Byczkowski JZ and Kulkarni AP Lipid peroxidation and benzo(a)pyrene derivative co-oxygenation by environmental pollutants. 1990 Bull Environ Contam Toxicol pmid:2176112
Mullarkey CJ et al. Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. 1990 Biochem. Biophys. Res. Commun. pmid:2176495
Stocker R et al. Antioxidant activities of bile pigments: biliverdin and bilirubin. 1990 Meth. Enzymol. pmid:2233302
Glasgow WC and Eling TE Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts. 1990 Mol. Pharmacol. pmid:2233691
Abraham RD et al. Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. 1990 Atherosclerosis pmid:2112389
Field CJ et al. Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals. 1990 J. Biol. Chem. pmid:2113530
Kim D and Duff RA Regulation of K+ channels in cardiac myocytes by free fatty acids. 1990 Circ. Res. pmid:2119911
Hori T et al. Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid. 1990 Biochem. Biophys. Res. Commun. pmid:2114113
Hjelte L et al. Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats. 1990 Am. J. Physiol. pmid:2115302
Bell JG and Raynard RS Effects of a high linoleic acid diet on the fatty acid composition of leucocytes from Atlantic salmon (Salmo salar). 1990 Biochem. Soc. Trans. pmid:2083726
Palmblad J Eicosanoids and modulation of inflammatory and immune responses. 1990 Scand. J. Clin. Lab. Invest. Suppl. pmid:1963704
Zakhariv OIa et al. [Metabolism of linoleic acid given with the feed in the calf liver]. 1990 Jan-Feb Ukr. Biokhim. Zh. pmid:2336726
Shultz TD Physiological free fatty acid concentrations do not increase free estradiol in plasma. 1991 J. Clin. Endocrinol. Metab. pmid:1986028
Hrboticky N et al. Retina fatty acid composition of piglets fed from birth with a linoleic acid-rich vegetable-oil formula for infants. 1991 Am. J. Clin. Nutr. pmid:1989416
Kearns EV et al. The role of cytochrome b5 in delta 12 desaturation of oleic acid by microsomes of safflower (Carthamus tinctorius L.). 1991 Arch. Biochem. Biophys. pmid:1989527
Hou SY et al. Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and x-ray diffraction. 1991 J. Invest. Dermatol. pmid:1991982
Muakkassa FF et al. Effect of dietary fish oil on plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha levels in septic rats. 1991 Arch Surg pmid:1992995
Earles SM et al. Metabolism of oxidized linoleic acid: characterization of 13-hydroxyoctadecadienoic acid dehydrogenase activity from rat colonic tissue. 1991 Biochim. Biophys. Acta pmid:1998735
Hubbard NE and Erickson KL Role of dietary oleic acid in linoleic acid-enhanced metastasis of a mouse mammary tumor. 1991 Cancer Lett. pmid:1998946
Kim RS and Zaborniak CL The aldehydic metabolites of linoleic acid are cytotoxic against human breast cancer cells. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1946549
Martin JC et al. Essential fatty acid composition of human colostrum triglycerides: its relationship with adipose tissue composition. 1991 Am. J. Clin. Nutr. pmid:1951153
Seidell JC et al. Polyunsaturated fatty acids in adipose tissue in European men aged 38 years in relation to serum lipids, smoking habits, and fat distribution. 1991 Am. J. Epidemiol. pmid:1951263
Andrianarison RH et al. Oxodiene formation during the Vicia sativa lipoxygenase-catalyzed reaction: occurrence of dioxygenase and fatty acid lyase activities associated in a single protein. 1991 Biochem. Biophys. Res. Commun. pmid:1953704
Pettersen J and Opstvedt J Trans fatty acids. 4. Effects on fatty acid composition of colostrum and milk. 1991 Lipids pmid:1762516
Stroh S and Elmadfa I [In vitro studies of the effect of different mixture proportions of omega-3 and omega-6 fatty acids on thrombocyte aggregation and thromboxane synthesis in human thrombocytes]. 1991 Z Ernahrungswiss pmid:1763556
Wright S and Sanders TA Adipose tissue essential fatty acid composition in patients with atopic eczema. 1991 Eur J Clin Nutr pmid:1782921
Venkatraman JT et al. Influence of genotype on diet-induced changes in membrane phosphatidylcholine and phosphatidylethanolamine composition of splenocytes, liver nuclear envelope and liver mitochondria. 1991 Lipids pmid:2046486
Rubinstein A et al. Fatty acid composition of adipose tissue in Ethiopian immigrants: a prospective study during their first year in Israel. 1991 Isr. J. Med. Sci. pmid:2050506
Holman RT Highpoints in an affair with polyunsaturated fatty acids. 1991 World Rev Nutr Diet pmid:2053355
Stein Y et al. Metabolism of 3-[3H]sphingosine sphingomyelin labeled with [14C]palmitic or [14C]linoleic acid by Hep G2 cells and rat liver in vivo. 1991 Biochim. Biophys. Acta pmid:2054378
Reaven P et al. Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. 1991 Am. J. Clin. Nutr. pmid:1897476
Leyton J et al. Effects of type of dietary fat on phorbol ester-elicited tumor promotion and other events in mouse skin. 1991 Cancer Res. pmid:1899048
Iacono JM and Dougherty RM Lack of effect of linoleic acid on the high-density-lipoprotein-cholesterol fraction of plasma lipoproteins. 1991 Am. J. Clin. Nutr. pmid:1900384
Macías P et al. Hemin and hemeprotein bleaching during linoleic acid oxidation by lipoxygenases. 1991 Biochim. Biophys. Acta pmid:1903070
Schmitz PG et al. Glomerular hemodynamic effects of dietary polyunsaturated fatty acid supplementation. 1991 J. Lab. Clin. Med. pmid:1856576
Kinsella JE Alpha-linolenic acid: functions and effects on linoleic acid metabolism and eicosanoid-mediated reactions. 1991 Adv. Food Nutr. Res. pmid:1681826
Eling TE and Glasgow WC Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism. 1991 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:1825423
Ramasamy S et al. Linoleic acid-induced endothelial cell injury: role of membrane-bound enzyme activities and lipid oxidation. 1991 J. Biochem. Toxicol. pmid:1831858
Ledwozyw A et al. [Surfactant lipids of bovine lungs]. 1991 Pol Arch Weter pmid:1842618
Semplicini A et al. Effects of linoleic acid supplementation on blood pressure and kinetics of red cell sodium transport: the Piove di Sacco Study. 1991 J Hypertens Suppl pmid:1818979
Rose DP et al. Effect of dietary fat on human breast cancer growth and lung metastasis in nude mice. 1991 J. Natl. Cancer Inst. pmid:1920496
Batres-Cerezo R et al. Studies of women eating diets with different fatty acid composition. III. Fatty acids and prostaglandin synthesis by platelets and cultured human endothelial cells. 1991 J Am Coll Nutr pmid:1894889
Burri BJ et al. Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid. 1991 Am. J. Clin. Nutr. pmid:1858699
Ikeda I et al. Lymphatic absorption of structured glycerolipids containing medium-chain fatty acids and linoleic acid, and their effect on cholesterol absorption in rats. 1991 Lipids pmid:1895884
Bell JG et al. High dietary linoleic acid affects the fatty acid compositions of individual phospholipids from tissues of Atlantic salmon (Salmo salar): association with stress susceptibility and cardiac lesion. 1991 J. Nutr. pmid:1861166
van der Schouw YT et al. Fatty acid composition of serum lipids of mothers and their babies after normal and hypertensive pregnancies. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1815240
Mayer M Linoleic-acid-dependent slowing of erythrocyte sedimentation in multiple sclerosis. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1815242
DaTorre SD and Creer MH Differential turnover of polyunsaturated fatty acids in plasmalogen and diacyl glycerophospholipids of isolated cardiac myocytes. 1991 J. Lipid Res. pmid:1940640
Nègre-Salvayre A et al. Additional antilipoperoxidant activities of alpha-tocopherol and ascorbic acid on membrane-like systems are potentiated by rutin. 1991 Pharmacology pmid:1652140
Venkatraman JT et al. Effect of dietary fat on diabetes-induced changes in liver microsomal fatty acid composition and glucose-6-phosphatase activity in rats. 1991 Lipids pmid:1652672
Krumhardt B and Dupont J The relationship between thromboxane and cytosolic calcium modifiers in rat platelets. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1652770
Julu PO and Mutamba A Comparison of short-term effects of insulin and essential fatty acids on the slowed nerve conduction of streptozotocin diabetes in rats. 1991 J. Neurol. Sci. pmid:1663993
Benmansour N et al. Effects of castration, dietary fat and adipose tissue sites on adipocyte plasma-membranes cyclic AMP phosphodiesterase activity in the pig. 1991 Int. J. Biochem. pmid:1665423
Cant A et al. The effect of maternal supplementation with linoleic and gamma-linolenic acids on the fat composition and content of human milk: a placebo-controlled trial. 1991 J. Nutr. Sci. Vitaminol. pmid:1668100
Yamamoto N et al. Effects of a high-linoleate and a high-alpha-linolenate diet on the learning ability of aged rats. Evidence against an autoxidation-related lipid peroxide theory of aging. 1991 J Gerontol pmid:1670780
Chan JK et al. Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. 1991 Am. J. Clin. Nutr. pmid:1673589
Watanabe S and Okuyama H [Physiological significance of n-3 fatty acid-containing phospholipids]. 1991 Tanpakushitsu Kakusan Koso pmid:1673799
Dyer JR and Greenwood CE Neural 22-carbon fatty acids in the weanling rat respond rapidly and specifically to a range of dietary linoleic to alpha-linolenic fatty acid ratios. 1991 J. Neurochem. pmid:1673995