Linoelaidic acid
Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
Cross Reference
Introduction
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoelaidic acid?
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoelaidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Linoelaidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (1)
- Am. J. Physiol., Cell Physiol. (1)
- Hypertension (1)
- Others (3)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol., Cell Physiol. (1)
- Plant Cell (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoelaidic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoelaidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kageyama K et al. | Synergistic inhibition of DNA synthesis in Ehrlich ascites tumour cells by a combination of unsaturated fatty acids and hyperthermia. | 1989 | J Appl Toxicol | pmid:2926093 |
| Booker ML et al. | Effect of dietary cholesterol on phosphatidylcholines and phosphatidylethanolamines in bile and gallbladder mucosa in the prairie dog. | 1989 | Gastroenterology | pmid:2507386 |
| Garcia Zevallos M and Farkas T | Manipulation of plasma membrane physical state affects desaturase activity in rat lymphocytes. | 1989 | Arch. Biochem. Biophys. | pmid:2786374 |
| Fuse K et al. | Effects of pectin on fatty acid and glucose absorption and on thickness of unstirred water layer in rat and human intestine. | 1989 | Dig. Dis. Sci. | pmid:2545425 |
| Bates D | Lipids and multiple sclerosis. | 1989 | Biochem. Soc. Trans. | pmid:2546837 |
| Huang YS et al. | Fatty acid changes in liver choline and ethanolamine glycerophospholipids in aspirin-treated rats fed linoleate, gamma-linolenate and fish oil. | 1989 | Clin Physiol Biochem | pmid:2547543 |
| Loesberg C et al. | Membrane fluidity of guinea pig lymphocytes and the dysfunction of the respiratory airway and lymphocyte beta-adrenergic systems of the guinea pig. | 1989 | Life Sci. | pmid:2554081 |
| Sawazaki S et al. | Comparison of the increment in plasma eicosapentaenoate concentrations by fish oil intake between young and middle-aged volunteers. | 1989 | J. Nutr. Sci. Vitaminol. | pmid:2555467 |
| Mcgregor L et al. | Effects of dietary linoleic acid and gamma linolenic acid on platelets of patients with multiple sclerosis. | 1989 | Acta Neurol. Scand. | pmid:2782038 |
| Meikle AW et al. | Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells. | 1989 | Am. J. Physiol. | pmid:2558577 |
| Hennig B and Watkins BA | Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. | 1989 | Am. J. Clin. Nutr. | pmid:2563626 |
| Madison KC et al. | Murine keratinocyte cultures grown at the air/medium interface synthesize stratum corneum lipids and "recycle" linoleate during differentiation. | 1989 | J. Invest. Dermatol. | pmid:2473131 |
| Kurganov BI et al. | Kinetics of soybean lipoxygenase reaction in hydrated reversed micelles. | 1989 | Biochimie | pmid:2474334 |
| Zawadzki W | [Effect of short-time intra-ruminal infusions of linoleic and cis-oleic acids on methane level in the blood of sheep]. | 1989 | Pol Arch Weter | pmid:2486864 |
| Kaduce TL et al. | Formation of 9-hydroxyoctadecadienoic acid from linoleic acid in endothelial cells. | 1989 | J. Biol. Chem. | pmid:2496121 |
| Hamazaki S et al. | Oxygen reduction and lipid peroxidation by iron chelates with special reference to ferric nitrilotriacetate. | 1989 | Arch. Biochem. Biophys. | pmid:2500058 |
| Imaizumi K et al. | Effect of phosphatidylethanolamine and its constituent base on the metabolism of linoleic acid in rat liver. | 1989 | Biochim. Biophys. Acta | pmid:2508745 |
| Buchanan MR et al. | Vessel wall reactivity and 13-hydroxy-octadecadienoic acid synthesis. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526487 |
| Lokesh BR et al. | The suppression of eicosanoid synthesis by peritoneal macrophages is influenced by the ratio of dietary docosahexaenoic acid to linoleic acid. | 1989 | Lipids | pmid:2528666 |
| Matsuzaki A et al. | Mechanism of selective killing by dilinoleoylglycerol of cells transformed by the E1A gene of adenovirus type 12. | 1989 | Cancer Res. | pmid:2529026 |
| Hicks M et al. | Increase in crosslinking of nonenzymatically glycosylated collagen induced by products of lipid peroxidation. | 1989 | Arch. Biochem. Biophys. | pmid:2492180 |
| Hansen O | Characterization of fatty acid interaction with ouabain and vanadate binding to (Na+ + K+)-activated ATPase. | 1989 | Biochim. Biophys. Acta | pmid:2554979 |
| D'Aquino M et al. | Vitamin A and glutathione-mediated free radical damage: competing reactions with polyunsaturated fatty acids and vitamin C. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2568114 |
| Stammers JP et al. | High arachidonic acid levels in the cord blood of infants of mothers on vegetarian diets. | 1989 | Br. J. Nutr. | pmid:2493804 |
| Blond JP et al. | Effect of fenofibrate treatment on linoleic acid desaturation in liver of obese Zucker rats. | 1989 | Biochem. Pharmacol. | pmid:2764996 |
| Hrboticky N et al. | Effect of linoleic acid-rich infant formula feeding on brain synaptosomal lipid accretion and enzyme thermotropic behavior in the piglet. | 1989 | J. Lipid Res. | pmid:2769072 |
| Zhu YP et al. | Growth-inhibition effects of oleic acid, linoleic acid, and their methyl esters on transplanted tumors in mice. | 1989 | J. Natl. Cancer Inst. | pmid:2769782 |
| Hrelia S et al. | Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2570573 |
| Bolton-Smith C et al. | The effect of dietary linoleic acid on rat platelet sialic acid. | 1989 | Biochim. Biophys. Acta | pmid:2775771 |
| Rosing U and Olund A | Endometrial content of prostaglandin precursors during the menstrual cycle. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2780764 |
| Blanken R et al. | Effect of mineral oil and linoleic-acid-containing emulsions on the skin vapour loss of sodium-lauryl-sulphate-induced irritant skin reactions. | 1989 | Contact Derm. | pmid:2706971 |
| Zevenbergen JL and Houtsmuller UM | Effect of dietary fats on linoleic acid metabolism. A radiolabel study in rats. | 1989 | Biochim. Biophys. Acta | pmid:2713382 |
| Ling KY et al. | Mechanisms of linoleic acid uptake by rabbit small intestinal brush border membrane vesicles. | 1989 | Lipids | pmid:2747430 |
| Levay-Young BK and Nandi S | Spermidine is necessary for, but not the only mediator of, linoleic acid-stimulated alpha-casein accumulation in mouse mammary epithelial cells. | 1989 | Endocrinology | pmid:2759031 |
| Berlin E et al. | Dietary fat and hormonal effects on erythrocyte membrane fluidity and lipid composition in adult women. | 1989 | Metab. Clin. Exp. | pmid:2761416 |
| Furr HC et al. | The effect of dietary fatty acid composition on liver retinyl ester (vitamin A ester) composition in the rat. | 1989 | J. Nutr. | pmid:2703916 |
| Klein A et al. | The effect of fatty acids on the vulnerability of lymphocytes to cortisol. | 1989 | Metab. Clin. Exp. | pmid:2537454 |
| Christon R et al. | Modification of fluidity and lipid-protein relationships in pig intestinal brush-border membrane by dietary essential fatty acid deficiency. | 1989 | Biochim. Biophys. Acta | pmid:2538158 |
| Chen Q et al. | Hydrolysis of triacylglycerol arachidonic and linoleic acid ester bonds by human pancreatic lipase and carboxyl ester lipase. | 1989 | Biochim. Biophys. Acta | pmid:2503032 |
| Shires SE et al. | Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. | 1989 | Biochim. Biophys. Acta | pmid:2493807 |
| Hamazaki T et al. | Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake. | 1989 | Prostaglandins | pmid:2503856 |
| Szamel M et al. | Activation signals in human lymphocytes. Incorporation of polyunsaturated fatty acids into plasma membrane phospholipids regulates IL-2 synthesis via sustained activation of protein kinase C. | 1989 | J. Immunol. | pmid:2530278 |
| Brestel EP and Koes MT | Heparin inhibits the "quasi-lipoxygenase" activity of hemoglobin toward linoleic acid by oxidant scavenging. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2500671 |
| Mohsenin V and Gee JL | Oxidation of alpha 1-protease inhibitor: role of lipid peroxidation products. | 1989 | J. Appl. Physiol. | pmid:2787317 |
| Schneider YJ | Optimisation of hybridoma cell growth and monoclonal antibody secretion in a chemically defined, serum- and protein-free culture medium. | 1989 | J. Immunol. Methods | pmid:2644356 |
| Watkins BA | Influences of biotin deficiency and dietary trans-fatty acids on tissue lipids in chickens. | 1989 | Br. J. Nutr. | pmid:2923859 |
| Bourre JM et al. | Composition of nerve biomembranes and nutritional fatty acids. | 1989 Jul-Aug | Nutrition | pmid:2577681 |
| Kamano K et al. | Effects of a high-linoleate and a high-alpha-linolenate diet on spontaneous mammary tumourigenesis in mice. | 1989 Nov-Dec | Anticancer Res. | pmid:2627137 |
| Buko VU et al. | [Changes in the fatty acid composition of erythrocyte membranes in patients with chronic alcoholism under the effect of a diet enriched with linoleic acid]. | 1989 Nov-Dec | Vopr Pitan | pmid:2629246 |
| Brodersen R et al. | Multiple fatty acid binding to albumin in human blood plasma. | 1990 | Eur. J. Biochem. | pmid:2338079 |
| Sams GH et al. | Isolation and characterization of a fatty acid binding protein in adipose tissue of Gallus domesticus. | 1990 | Comp. Biochem. Physiol., B | pmid:1697230 |
| Girón MD et al. | Changes in lipid composition and desaturase activities of duodenal mucosa induced by dietary fat. | 1990 | Biochim. Biophys. Acta | pmid:2369586 |
| Barros H et al. | Arachidonic acid absorption in human jejunum in organ culture: effects of ethanol. | 1990 | Eur. J. Clin. Invest. | pmid:2124981 |
| Teter BB et al. | Milk fat depression in C57Bl/6J mice consuming partially hydrogenated fat. | 1990 | J. Nutr. | pmid:2380791 |
| DeLange RJ and Glazer AN | Bile acids: antioxidants or enhancers of peroxidation depending on lipid concentration. | 1990 | Arch. Biochem. Biophys. | pmid:2297222 |
| Ha YL et al. | Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. | 1990 | Cancer Res. | pmid:2297758 |
| Kawahara J et al. | Dietary linoleic acid prevents the development of deoxycorticosterone acetate-salt hypertension. | 1990 | Hypertension | pmid:2298478 |
| Borgeson CE et al. | Characterization of the delta 12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate. | 1990 | Biochim. Biophys. Acta | pmid:2248971 |
| Appel MJ et al. | Azaserine-induced pancreatic carcinogenesis in rats: promotion by a diet rich in saturated fat and inhibition by a standard laboratory chow. | 1990 | Cancer Lett. | pmid:2257542 |
| Pal S and Davis PJ | N-3 polyunsaturated fatty acids enhance cholesterol efflux from human fibroblasts in culture. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2260969 |
| Butovich IA et al. | [Activation of 5-lipoxygenase by lipophilic n-alkyl-containing acids--an allosteric process]. | 1990 | Bioorg. Khim. | pmid:2344387 |
| Singer P et al. | Extreme decrease of linoleic acid in renal medulla from rats after a diet supplemented with cod liver oil. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2353033 |
| Katan MB and van Dusseldoys M | [Premenstrual syndromes]. | 1990 | Ned Tijdschr Geneeskd | pmid:2355986 |
| Shimizu T et al. | Prostaglandin and fatty acid metabolism in patients with extrahepatic biliary atresia. | 1990 | J. Pediatr. Gastroenterol. Nutr. | pmid:2324889 |
| Parinandi NL et al. | Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. | 1990 | Biochim. Biophys. Acta | pmid:2123402 |
| Hennig B et al. | Effect of vitamin E on linoleic acid-mediated induction of peroxisomal enzymes in cultured porcine endothelial cells. | 1990 | J. Nutr. | pmid:2329387 |
| Miller CC and Ziboh VA | Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). | 1990 | J. Invest. Dermatol. | pmid:2106562 |
| Conquer J and Mahadevappa VG | Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2106881 |
| Oxholm A et al. | Abnormal essential fatty acid metabolism in Darier's disease. | 1990 | Arch Dermatol | pmid:1977367 |
| Lester DS | In vitro linoleic acid activation of protein kinase C. | 1990 | Biochim. Biophys. Acta | pmid:2207179 |
| Høy CE and Hølmer G | Influence of dietary linoleic acid and trans fatty acids on the fatty acid profile of cardiolipins in rats. | 1990 | Lipids | pmid:2215088 |
| Buko VU | Beef fat prevents alcoholic liver disease in the rat. | 1990 | Alcohol. Clin. Exp. Res. | pmid:2221295 |
| Opara EC et al. | Enhancement of endocrine pancreatic secretions by essential fatty acids. | 1990 | J. Surg. Res. | pmid:2187112 |
| Dupont J and Dowd MK | Icosanoid synthesis as a functional measurement of essential fatty acid requirement. | 1990 | J Am Coll Nutr | pmid:2193052 |
| Oliver MF | Linoleic acid, antioxidants and coronary heart disease. | 1990 | Biochem. Soc. Trans. | pmid:2088801 |
| Bian RL et al. | [Antianaphylactic components of Asarum forbsii Maxin]. | 1990 | Yao Xue Xue Bao | pmid:2099089 |
| Thomas CR and Lowy C | The use of two in-situ simultaneously-perfused placentas to investigate the effect of carrier proteins on linoleic and palmitic acid transfer in the guinea pig. | 1990 | J. Dev. Physiol. | pmid:2100741 |
| Singer P et al. | A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. | 1990 | Atherosclerosis | pmid:2146966 |
| Kitagawa S et al. | Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. | 1990 | Biochim. Biophys. Acta | pmid:2166588 |
| Anel A et al. | Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. | 1990 | Biochim. Biophys. Acta | pmid:2114179 |
| van Doormaal JJ | Linoleic acid metabolism in diabetes mellitus. | 1990 | Neth J Med | pmid:2074912 |
| Ando H et al. | Protein kinase C and linoleic acid-induced inhibition of melanogenesis. | 1990 | Pigment Cell Res. | pmid:2077533 |
| Green P et al. | Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study. | 1990 | Am. J. Clin. Nutr. | pmid:2239789 |
| Fletcher JE et al. | Fatty acid uptake and catecholamine-stimulated phospholipid metabolism in immortalized airway epithelial cells established from primary cultures. | 1990 | Biochem. Int. | pmid:2241999 |
| Mimouni V and Poisson JP | Spontaneous diabetes in BB rats: evidence for insulin dependent liver microsomal delta 6 and delta 5 desaturase activities. | 1990 | Horm. Metab. Res. | pmid:2227799 |
| Pariza MW and Ha YL | Conjugated dienoic derivatives of linoleic acid: a new class of anticarcinogens. | 1990 | Med Oncol Tumor Pharmacother | pmid:2232933 |
| Nikolaev V et al. | Stereochemical nature of the products of linoleic acid oxidation catalyzed by lipoxygenases from potato and soybean. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2116790 |
| Mensink RP et al. | Effect of a monounsaturated diet vs. a polyunsaturated fatty acid-enriched diet on blood pressure in normotensive women and men. | 1990 | Eur. J. Clin. Invest. | pmid:2121507 |
| Newman MJ | Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2371287 |
| Gyllenhammar H et al. | Dietary linoleate supplementation modulates formyl-peptide receptor expression and functional responses of rat neutrophils. | 1990 | J. Lab. Clin. Med. | pmid:2157784 |
| Piché LA and Mahadevappa VG | Modification of rat platelet fatty acid composition by dietary lipids of animal and vegetable origin. | 1990 | J. Nutr. | pmid:2111377 |
| Abraham RD et al. | Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. | 1990 | Atherosclerosis | pmid:2112389 |
| Field CJ et al. | Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals. | 1990 | J. Biol. Chem. | pmid:2113530 |
| Kim D and Duff RA | Regulation of K+ channels in cardiac myocytes by free fatty acids. | 1990 | Circ. Res. | pmid:2119911 |
| Hori T et al. | Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2114113 |
| Hjelte L et al. | Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats. | 1990 | Am. J. Physiol. | pmid:2115302 |
| Emken EA et al. | Metabolism in vivo of deuterium-labelled linolenic and linoleic acids in humans. | 1990 | Biochem. Soc. Trans. | pmid:2083671 |
| James SR et al. | Linoleic acid increases cytosolic Ca2+ in lymphocytes. | 1990 | Biochem. Soc. Trans. | pmid:2083720 |
| Bell JG and Raynard RS | Effects of a high linoleic acid diet on the fatty acid composition of leucocytes from Atlantic salmon (Salmo salar). | 1990 | Biochem. Soc. Trans. | pmid:2083726 |
| Palmblad J | Eicosanoids and modulation of inflammatory and immune responses. | 1990 | Scand. J. Clin. Lab. Invest. Suppl. | pmid:1963704 |