Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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O'Quinn PR et al. | Effects of modified tall oil versus a commercial source of conjugated linoleic acid and increasing levels of modified tall oil on growth performance and carcass characteristics of growing-finishing pigs. | 2000 | J. Anim. Sci. | pmid:10985411 |
Hover CG and Kulkarni AP | Human term placental lipoxygenase-mediated N-demethylation of phenothiazines and insecticides in the presence of linoleic acid. | 2000 | Placenta | pmid:10985967 |
Meinelt T et al. | Correlation of diets high in n-6 polyunsaturated fatty acids with high growth rate in zebrafish (Danio rerio). | 2000 | Comp. Med. | pmid:10987667 |
Simopoulos AP | Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10991765 |
Galli C | Commentary on the workshop statement. Essentiality of and recommended dietary intake of Omega-6 and Omega-3 fatty acids. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10991767 |
Crawford MA | Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10991768 |
Cunnane SC | Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10991770 |
Horrobin DF | Commentary on the workshop statement: are we really sure that arachidonic acid and linoleic acid are bad things? | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10991771 |
Kim SJ et al. | Improvement of oxidative stability of conjugated linoleic acid (CLA) by microencapsulation in cyclodextrins. | 2000 | J. Agric. Food Chem. | pmid:10995292 |
Antony SM et al. | Antioxidative effect of maillard reaction products formed from honey at different reaction times. | 2000 | J. Agric. Food Chem. | pmid:10995301 |
Livisay SA et al. | Impact of dietary conjugated linoleic acid on the oxidative stability of rat liver microsomes and skeletal muscle homogenates. | 2000 | J. Agric. Food Chem. | pmid:10995331 |
Han KH et al. | Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor gamma. | 2000 | J. Clin. Invest. | pmid:10995790 |
Schaffrath U et al. | Characterization of RCI-1, a chloroplastic rice lipoxygenase whose synthesis is induced by chemical plant resistance activators. | 2000 | Eur. J. Biochem. | pmid:10998053 |
Jones DF et al. | Short communication: influence of dietary tallow and fish oil on milk fat composition. | 2000 | J. Dairy Sci. | pmid:11003234 |
Morales MS et al. | Effects of fat source and copper on unsaturation of blood and milk triacylglycerol fatty acids in Holstein and Jersey cows. | 2000 | J. Dairy Sci. | pmid:11003244 |
Sol Morales M et al. | Milk fat composition of Holstein and Jersey cows with control or depleted copper status and fed whole soybeans or tallow. | 2000 | J. Dairy Sci. | pmid:11003245 |
DeLany JP et al. | Differential oxidation of individual dietary fatty acids in humans. | 2000 | Am. J. Clin. Nutr. | pmid:11010930 |
Lucchi L et al. | Changes in conjugated linoleic acid and its metabolites in patients with chronic renal failure. | 2000 | Kidney Int. | pmid:11012903 |
Petrik MB et al. | Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice. | 2000 | J. Nutr. | pmid:11015469 |
West DB et al. | Conjugated linoleic acid persistently increases total energy expenditure in AKR/J mice without increasing uncoupling protein gene expression. | 2000 | J. Nutr. | pmid:11015475 |
Kelavkar UP et al. | Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging. | 2000 | Carcinogenesis | pmid:11023533 |
Qian SY et al. | EPR detection of lipid-derived free radicals from PUFA, LDL, and cell oxidations. | 2000 | Free Radic. Biol. Med. | pmid:11025200 |
Van de Velde M et al. | Effects of lipids on the functional and metabolic recovery from global myocardial stunning in isolated rabbit hearts. | 2000 | Cardiovasc. Res. | pmid:11033115 |
Meaney CM and O'Driscoll CM | A comparison of the permeation enhancement potential of simple bile salt and mixed bile salt:fatty acid micellar systems using the CaCo-2 cell culture model. | 2000 | Int J Pharm | pmid:11036226 |
Smith HL et al. | Development of a serum-free system for the in vitro cultivation of Brugia malayi infective-stage larvae. | 2000 | Exp. Parasitol. | pmid:11038308 |
French SJ et al. | The effects of intestinal infusion of long-chain fatty acids on food intake in humans. | 2000 | Gastroenterology | pmid:11040181 |
Moran JH et al. | Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s. | 2000 | Toxicol. Appl. Pharmacol. | pmid:11042099 |
Soriano CR et al. | Cutaneous application of vegetable oil as a coadjutant in the nutritional management of preterm infants. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:11045835 |
Steinkamp G et al. | Energy supplements rich in linoleic acid improve body weight and essential fatty acid status of cystic fibrosis patients. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:11045840 |
Whigham LD et al. | Conjugated linoleic acid: implications for human health. | 2000 | Pharmacol. Res. | pmid:11058400 |
Surai PF et al. | Effect of long-term supplementation with arachidonic or docosahexaenoic acids on sperm production in the broiler chicken. | 2000 | J. Reprod. Fertil. | pmid:11058441 |
Cunnane SC et al. | Specific linoleate deficiency in the rat does not prevent substantial carbon recycling from [(14)C]linoleate into sterols. | 2000 | J. Lipid Res. | pmid:11060350 |
Ferry DR et al. | A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. | 2000 | Ann. Oncol. | pmid:11061613 |
French P et al. | Fatty acid composition, including conjugated linoleic acid, of intramuscular fat from steers offered grazed grass, grass silage, or concentrate-based diets. | 2000 | J. Anim. Sci. | pmid:11063308 |
Brynes AE et al. | Diet-induced change in fatty acid composition of plasma triacylglycerols is not associated with change in glucagon-like peptide 1 or insulin sensitivity in people with type 2 diabetes. | 2000 | Am. J. Clin. Nutr. | pmid:11063437 |
Granot E et al. | Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. | 2000 | Am. J. Clin. Nutr. | pmid:11063450 |
Sauerwald TU et al. | Polyunsaturated fatty acid supply with human milk. Physiological aspects and in vivo studies of metabolism. | 2000 | Adv. Exp. Med. Biol. | pmid:11065079 |
Del Prado M et al. | Contribution of dietary and newly formed arachidonic acid to milk secretion in women on low fat diets. | 2000 | Adv. Exp. Med. Biol. | pmid:11065105 |
Lance A et al. | 13C-linoleic acid oxidation and transfer into milk in lactating women with contrasting body mass index. | 2000 | Adv. Exp. Med. Biol. | pmid:11065106 |
Cahoon EB et al. | Formation of conjugated delta8,delta10-double bonds by delta12-oleic-acid desaturase-related enzymes: biosynthetic origin of calendic acid. | 2001 | J. Biol. Chem. | pmid:11067856 |
Hochi S et al. | Nuclear transfer in cattle : effect of linoleic acid-albumin on freezing sensitivity of enucleated oocytes. | 2000 | J. Vet. Med. Sci. | pmid:11073086 |
Grechkin AN et al. | The lipoxygenase pathway in tulip (Tulipa gesneriana): detection of the ketol route. | 2000 | Biochem. J. | pmid:11085944 |
Lehtinen P and Laakso S | Inhibition of linoleic acid oxidation by interaction with a protein-rich oat fraction. | 2000 | J. Agric. Food Chem. | pmid:11087534 |
Louw L and Dannhauser A | Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090250 |
Louw L | Keloids in rural black South Africans. Part 3: a lipid model for the prevention and treatment of keloid formations. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090251 |
Mizushina Y et al. | Structural homology between DNA binding sites of DNA polymerase beta and DNA topoisomerase II. | 2000 | J. Mol. Biol. | pmid:11090281 |
Ueno S et al. | Polymorphism of linoleic acid (cis-9, cis-12-octadecadienoic acid) and alpha-linolenic acid (cis-9, cis-12, cis-15-octadecatrienoic acid). | 2000 | Chem. Phys. Lipids | pmid:11090846 |
Kwok CF et al. | Linoleic acid and oleic acid increase the endothelin-1 binding and action in cultured rat aortic smooth muscle cells. | 2000 | Metab. Clin. Exp. | pmid:11092498 |
Minich DM et al. | Intestinal absorption and postabsorptive metabolism of linoleic acid in rats with short-term bile duct ligation. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11093947 |
Kim YJ et al. | Effect of linoleic acid concentration on conjugated linoleic acid production by Butyrivibrio fibrisolvens A38. | 2000 | Appl. Environ. Microbiol. | pmid:11097894 |
van Dijk K and Nelson EB | Fatty acid competition as a mechanism by which Enterobacter cloacae suppresses Pythium ultimum sporangium germination and damping-off. | 2000 | Appl. Environ. Microbiol. | pmid:11097912 |
Gardner HW et al. | Biotransformation of linoleic acid by Clavibacter sp. ALA2: heterocyclic and heterobicyclic fatty acids. | 2000 | Lipids | pmid:11104009 |
Kelley DS et al. | Dietary conjugated linoleic acid did not alter immune status in young healthy women. | 2000 | Lipids | pmid:11104011 |
Ostrowska E et al. | Comparison of silver-ion high-performance liquid chromatographic quantification of free and methylated conjugated linoleic acids. | 2000 | Lipids | pmid:11104021 |
Bauman DE et al. | Technical note: production of butter with enhanced conjugated linoleic acid for use in biomedical studies with animal models. | 2000 | J. Dairy Sci. | pmid:11104258 |
Thuillier P et al. | Activators of peroxisome proliferator-activated receptor-alpha partially inhibit mouse skin tumor promotion. | 2000 | Mol. Carcinog. | pmid:11108658 |
Blankson H et al. | Conjugated linoleic acid reduces body fat mass in overweight and obese humans. | 2000 | J. Nutr. | pmid:11110851 |
Bee G | Dietary conjugated linoleic acid consumption during pregnancy and lactation influences growth and tissue composition in weaned pigs. | 2000 | J. Nutr. | pmid:11110857 |
Innis SM | The role of dietary n-6 and n-3 fatty acids in the developing brain. | 2000 Sep-Dec | Dev. Neurosci. | pmid:11111165 |
Fitch CD et al. | A role for linoleic acid in erythrocytes infected with Plasmodium berghei. | 2000 | Biochim. Biophys. Acta | pmid:11113630 |
Bemelmans WJ et al. | Associations of alpha-linolenic acid and linoleic acid with risk factors for coronary heart disease. | 2000 | Eur J Clin Nutr | pmid:11114683 |
Yamasaki M et al. | Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague-Dawley rat spleen lymphocytes. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11129589 |
Masuda A et al. | Study of lipid in the ear canal in canine otitis externa with Malassezia pachydermatis. | 2000 | J. Vet. Med. Sci. | pmid:11129861 |
MarÃn MC et al. | Dietary long-chain fatty acids and visual response in malnourished nursing infants. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133176 |
Kontush A et al. | Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma. | 2001 | Free Radic. Biol. Med. | pmid:11134902 |
Kawai T et al. | Chronic effects of different fatty acids and leptin in INS-1 cells. | 2001 | Diabetes Res. Clin. Pract. | pmid:11137176 |
Scimeca JA and Miller GD | Potential health benefits of conjugated linoleic acid. | 2000 | J Am Coll Nutr | pmid:11153468 |
Shureiqi I et al. | 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. | 2000 | Cancer Res. | pmid:11156377 |
Sakuma S et al. | The effects of fatty acyl CoA esters on the formation of prostaglandin and arachidonoyl-CoA formed from arachidonic acid in rabbit kidney medulla microsomes. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161586 |
Soppela P and Nieminen M | The effect of wintertime undernutrition on the fatty acid composition of leg bone marrow fats in reindeer (Rangifer tarandus tarandus L.). | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11163305 |
Dikalov SI and Mason RP | Spin trapping of polyunsaturated fatty acid-derived peroxyl radicals: reassignment to alkoxyl radical adducts. | 2001 | Free Radic. Biol. Med. | pmid:11163536 |
RamÃrez-Expósito MJ et al. | Oleate, linoleate and cholesterol differently modify aspartyl- and glutamyl-aminopeptidase activities in primary cultures of rat astrocytes. | 2001 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:11166679 |
Widstrom RL et al. | Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. | 2001 | Biochemistry | pmid:11170430 |
Rival SG et al. | Caseins and casein hydrolysates. 2. Antioxidative properties and relevance to lipoxygenase inhibition. | 2001 | J. Agric. Food Chem. | pmid:11170591 |
López-Nicolás JM et al. | Eggplant lipoxygenase (Solanum melongena): product characterization and effect of physicochemical properties of linoleic acid on the enzymatic activity. | 2001 | J. Agric. Food Chem. | pmid:11170610 |
Kaushik N and Agnihotri A | GLC analysis of Indian rapeseed-mustard to study the variability of fatty acid composition. | 2000 | Biochem. Soc. Trans. | pmid:11171132 |
Verwoert I et al. | The molecular basis of the high linoleic acid content in Petunia seed oil: analysis of a seed-specific linoleic acid mutant. | 2000 | Biochem. Soc. Trans. | pmid:11171150 |
Kamisaka Y and Noda N | Intracellular transport of phosphatidic acid and phosphatidylcholine into lipid bodies: use of fluorescent lipids to study lipid-body formation in an oleaginous fungus. | 2000 | Biochem. Soc. Trans. | pmid:11171185 |
Grechkin AN et al. | Lipoxygenase pathway in tulip: biosynthesis of ketols. | 2000 | Biochem. Soc. Trans. | pmid:11171230 |
Kashulin PA et al. | Extremely rapid effects of polyunsaturated fatty acids and N-acetylglucosamine on free-radical metabolism in cultured potato plant cells. | 2000 | Biochem. Soc. Trans. | pmid:11171236 |
Kaushik N and Vir S | Variations in fatty acid composition of neem seeds collected from the Rajasthan state of India. | 2000 | Biochem. Soc. Trans. | pmid:11171243 |
Nuñez A et al. | Anaerobic lipoxygenase activity from Chlorella pyrenoidosa. | 2000 | Biochem. Soc. Trans. | pmid:11171268 |
Whigham LD et al. | CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae. | 2001 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:11171673 |
Khosla P and Fungwe TV | Conjugated linoleic acid: effects on plasma lipids and cardiovascular function. | 2001 | Curr. Opin. Lipidol. | pmid:11176200 |
Cunnane SC | The conditional nature of the dietary need for polyunsaturates: a proposal to reclassify 'essential fatty acids' as 'conditionally-indispensable' or 'conditionally-dispensable' fatty acids. | 2000 | Br. J. Nutr. | pmid:11177196 |
Thomas Yeung CH et al. | Dietary conjugated linoleic acid mixture affects the activity of intestinal acyl coenzyme A: cholesterol acyltransferase in hamsters. | 2000 | Br. J. Nutr. | pmid:11177212 |
Hughes RK et al. | Mutagenesis and modelling of linoleate-binding to pea seed lipoxygenase. | 2001 | Eur. J. Biochem. | pmid:11179969 |
Burczynski JM et al. | Suppression of lipid peroxidation in adrenal microsomes following ACTH administration to guinea pigs. | 2001 | J. Endocrinol. | pmid:11182771 |
Dyck DJ | Dietary fat intake, supplements, and weight loss. | 2000 | Can J Appl Physiol | pmid:11187927 |
Cheon SH et al. | Effect of dietary linoleate/alpha-linolenate balance on the brain lipid composition, reproductive outcome and behavior of rats during their prenatal and postnatal development. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11193394 |
Du M et al. | Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. | 2000 | Poult. Sci. | pmid:11194037 |
Boscá F et al. | Involvement of type I and type II mechanisms in the linoleic acid peroxidation photosensitized by tiaprofenic acid. | 2000 | J. Photochem. Photobiol. B, Biol. | pmid:11195846 |
Brown JE et al. | Linoleic acid metabolism in the spontaneously diabetic rat: delta6-desaturase activity vs. product/precursor ratios. | 2000 | Lipids | pmid:11201993 |
Li Z et al. | Hepatic microsomal and peroxisomal docosahexaenoate biosynthesis during piglet development. | 2000 | Lipids | pmid:11201994 |
Carvajal O et al. | Effect of medium-chain fatty acid positional distribution in dietary triacylglycerol on lymphatic lipid transport and chylomicron composition in rats. | 2000 | Lipids | pmid:11201996 |
Jayaprakasha GK and Rao LJ | Phenolic constituents from the lichen Parmotrema stuppeum (Nyl.) Hale and their antioxidant activity. | 2000 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:11204179 |
Kajiwara T et al. | Fatty acid oxidizing activity in a red marine alga, Porphyra sp. | 2000 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:11204194 |
Lance VA et al. | Hyperlipidemia and reproductive failure in captive-reared alligators: vitamin E, vitamin A, plasma lipids, fatty acids, and steroid hormones. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11207442 |
Cavicchioli P et al. | Endogenous surfactant turnover in preterm infants with respiratory distress syndrome studied with stable isotope lipids. | 2001 | Am. J. Respir. Crit. Care Med. | pmid:11208626 |
Higashi K et al. | Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. | 2001 | Lipids | pmid:11214722 |