Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Acidosis D000138 13 associated lipids
Acne Vulgaris D000152 35 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Adenocarcinoma D000230 166 associated lipids
Alcoholic Intoxication D000435 15 associated lipids
Alcoholism D000437 27 associated lipids
Alopecia D000505 14 associated lipids
Alzheimer Disease D000544 76 associated lipids
Aneurysm D000783 2 associated lipids
Anorexia D000855 8 associated lipids
Olfaction Disorders D000857 17 associated lipids
Hypoxia D000860 23 associated lipids
Aortic Diseases D001018 11 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Ascites D001201 25 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Biliary Atresia D001656 4 associated lipids
Birth Weight D001724 23 associated lipids
Body Weight D001835 333 associated lipids
Brain Edema D001929 20 associated lipids
Breast Neoplasms D001943 24 associated lipids
Cachexia D002100 21 associated lipids
Carcinoma D002277 18 associated lipids
Carcinoma, Krebs 2 D002287 1 associated lipids
Cattle Diseases D002418 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Cholestasis D002779 23 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Constipation D003248 8 associated lipids
Coronary Disease D003327 70 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Deficiency Diseases D003677 12 associated lipids
Demyelinating Diseases D003711 15 associated lipids
Dermatitis D003872 30 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Disease D004194 2 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Edema D004487 152 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

Download all related citations
Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
Del Prado M et al. Contribution of dietary and newly formed arachidonic acid to milk secretion in women on low fat diets. 2000 Adv. Exp. Med. Biol. pmid:11065105
Lance A et al. 13C-linoleic acid oxidation and transfer into milk in lactating women with contrasting body mass index. 2000 Adv. Exp. Med. Biol. pmid:11065106
Kelavkar U et al. 15-lipoxygenase-1 overexpression in prostate adenocarcinoma. 2002 Adv. Exp. Med. Biol. pmid:12664577
Brash AR et al. Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues. 1999 Adv. Exp. Med. Biol. pmid:10667314
Buchanan MR Linoleic acid metabolites in health and disease. 1999 Adv. Exp. Med. Biol. pmid:10667369
Greene JF and Hammock BD Toxicity of linoleic acid metabolites. 1999 Adv. Exp. Med. Biol. pmid:10667370
Jira W and Spiteller G Dramatic increase of linoleic acid peroxidation products by aging, atherosclerosis, and rheumatoid arthritis. 1999 Adv. Exp. Med. Biol. pmid:10667371
Camacho M et al. IL-1 increases the ability of human endothelial cells to transform linoleic acid into monohydroxy-isomers and their incorporation into cell lipids. 1997 Adv. Exp. Med. Biol. pmid:9547616
Louw L et al. Impairment in the fatty acid composition of keloids. 1997 Adv. Exp. Med. Biol. pmid:9547645
Louw L et al. Linoleic acid levels in cutaneous tumors with different growth patterns as an additional sensitive diagnostic feature. 1997 Adv. Exp. Med. Biol. pmid:9547646
Brister SJ and Buchanan MR Effects of linoleic acid and/or marine fish oil supplements on vessel wall thromboresistance in patients undergoing cardiac surgery. 1997 Adv. Exp. Med. Biol. pmid:9561151
Giménez-Arnau A et al. Effects of linoleic acid supplements on atopic dermatitis. 1997 Adv. Exp. Med. Biol. pmid:9561153
Horrobin DF and Ziboh VA The importance of linoleic acid metabolites in cancer metastasis and in the synthesis and actions of 13-HODE. 1997 Adv. Exp. Med. Biol. pmid:9561154
Eling TE et al. Modulation of epidermal growth factor signal transduction by linoleic acid metabolites. 1997 Adv. Exp. Med. Biol. pmid:9321970
Asakawa T et al. Ca2+-activated, fatty acid-dependent guanylate cyclase in synaptic plasma membranes and its requirement for Ca2+ and Mg-GTP in the activation. 1984 Adv. Exp. Med. Biol. pmid:6149673
Louw L et al. Keloids: peripheral and central differences in cell morphology and fatty acid compositions of lipids. 1997 Adv. Exp. Med. Biol. pmid:9322000
Kinsella JE Alpha-linolenic acid: functions and effects on linoleic acid metabolism and eicosanoid-mediated reactions. 1991 Adv. Food Nutr. Res. pmid:1681826
Hoffmann P and Förster W Influence of dietary linoleic acid content on blood pressure regulation in salt-loaded rats (with special reference to the prostaglandin system). 1981 Adv. Lipid Res. pmid:6798829
Ringertz B et al. High dietary linoleic acid content modulates neutrophil function in rats. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960199
Eling TE et al. Modulation of EGF cell signaling tyrosine phosphorylation by linoleic acid metabolites. 1995 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7537437
Buchanan MR et al. Vessel wall reactivity and 13-hydroxy-octadecadienoic acid synthesis. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2526487
Eling TE and Glasgow WC Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism. 1991 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:1825423
Gyllenhammar H et al. Dietary essential fatty acid deficiency in rats is accompanied by impairments in neutrophil function and leukotriene B4 generation. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2823572
Loesberg C et al. Superoxide anion production by alveolar macrophages of guinea pigs fed different diets in a model of atopy. 1988 Agents Actions pmid:2833083
Iversen L et al. Linoleic acid and dihomogammalinolenic acid inhibit leukotriene B4 formation and stimulate the formation of their 15-lipoxygenase products by human neutrophils in vitro. Evidence of formation of antiinflammatory compounds. 1991 Agents Actions pmid:1659156
Loesberg C et al. Effects of dietary poly-unsaturated fatty acids on tracheal histaminergic and cholinergic responsiveness in experimental models of bronchial hypersensitivity and hyperreactivity. 1987 Agents Actions pmid:2895570
Kramer HJ et al. The role of renal prostaglandins in the regulation of renal sodium excretion. 1987 Agents Actions Suppl. pmid:3481214
Henricks PA et al. Epithelium-derived linoleic acid metabolites modulate airway smooth muscle function. 1990 Agents Actions Suppl. pmid:2080762
Pamplona R et al. Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse. 1999 Aging (Milano) pmid:10337442
Kirpich IA et al. Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. 2013 Alcohol pmid:23453163
Pirozhkov SV et al. Effect of chronic consumption of ethanol and vitamin E on fatty acid composition and lipid peroxidation in rat heart tissue. 1992 Jul-Aug Alcohol pmid:1637499
Horrobin DF Essential fatty acids, prostaglandins, and alcoholism: an overview. 1987 Alcohol. Clin. Exp. Res. pmid:3032012
Buko VU Beef fat prevents alcoholic liver disease in the rat. 1990 Alcohol. Clin. Exp. Res. pmid:2221295
Tsukamoto S et al. Effects of bezafibrate on ethanol oxidation in rats. 1996 Alcohol. Clin. Exp. Res. pmid:8986210
Cunnane SC Hepatic triacylglycerol accumulation induced by ethanol and carbon tetrachloride: interactions with essential fatty acids and prostaglandins. 1987 Alcohol. Clin. Exp. Res. pmid:3032013
Szebeni J et al. Plasma fatty acid pattern including diene-conjugated linoleic acid in ethanol users and patients with ethanol-related liver disease. 1986 Alcohol. Clin. Exp. Res. pmid:3101533
Uden S et al. Antioxidant therapy for recurrent pancreatitis: biochemical profiles in a placebo-controlled trial. 1992 Aliment. Pharmacol. Ther. pmid:1600043
Belluzzi A et al. Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease. 1994 Aliment. Pharmacol. Ther. pmid:8186338
Kelly GS Conjugated linoleic acid: a review. 2001 Altern Med Rev pmid:11578253
Poole E and McQueen CE Conjugated linoleic acid. 2006 Am J Health Syst Pharm pmid:17057041
Block RC et al. Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes? 2008 Am. Heart J. pmid:19033007
Tilvis RS et al. Serum lipids and fatty acids in ischemic strokes. 1987 Am. Heart J. pmid:3812213
McDaniel HG et al. Glucose-insulin-potassium induced alterations in individual plasma free fatty acids in patients with acute myocardial infarction. 1981 Am. Heart J. pmid:6787909
Magsino CH et al. Nadolol inhibits reactive oxygen species generation by leukocytes and linoleic acid oxidation. 2000 Am. J. Cardiol. pmid:10946040
Siguel EN and Ratnayake WM Trans-fatty acid patterns in patients with demonstrated coronary artery disease. 1995 Am. J. Cardiol. pmid:7856548
Sentex E et al. Is the cytoprotective effect of trimetazidine associated with lipid metabolism? 1998 Am. J. Cardiol. pmid:9737482
Kim JB et al. Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins. 2013 Am. J. Cardiol. pmid:24050409
Wu MJ et al. Antioxidant activity of Porcelainberry (Ampelopsis brevipedunculata (Maxim.) Trautv.). 2004 Am. J. Chin. Med. pmid:15633804
Cho EJ et al. The inhibitory effects of 12 medicinal plants and their component compounds on lipid peroxidation. 2003 Am. J. Chin. Med. pmid:14992543
Turpeinen AM et al. Bioconversion of vaccenic acid to conjugated linoleic acid in humans. 2002 Am. J. Clin. Nutr. pmid:12197992