Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Refeeding Syndrome D055677 1 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Mucositis D052016 7 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Atherosclerosis D050197 85 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Coronary Restenosis D023903 10 associated lipids
Parkinsonian Disorders D020734 20 associated lipids
Muscular Dystrophy, Duchenne D020388 11 associated lipids
Choroidal Neovascularization D020256 5 associated lipids
Gastroschisis D020139 1 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Endotoxemia D019446 27 associated lipids
Wasting Syndrome D019282 3 associated lipids
Anemia, Iron-Deficiency D018798 6 associated lipids
Hypokinesia D018476 2 associated lipids
Circoviridae Infections D018173 2 associated lipids
Glucose Intolerance D018149 13 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Myocardial Stunning D017682 10 associated lipids
Hyperpigmentation D017495 11 associated lipids
Dermatitis, Phototoxic D017484 4 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Mitochondrial Myopathies D017240 13 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Malaria, Cerebral D016779 1 associated lipids
Malaria, Falciparum D016778 22 associated lipids
Critical Illness D016638 13 associated lipids
Helicobacter Infections D016481 21 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Weight Loss D015431 56 associated lipids
Weight Gain D015430 101 associated lipids
Reperfusion Injury D015427 65 associated lipids
Child Nutrition Disorders D015362 1 associated lipids
Dry Eye Syndromes D015352 10 associated lipids
Wounds, Penetrating D014950 10 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Varicose Ulcer D014647 4 associated lipids
Varicocele D014646 4 associated lipids
Tuberculosis D014376 20 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

Download all related citations
Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
Kim SY et al. S-adenosyl methionine prevents endothelial dysfunction by inducing heme oxygenase-1 in vascular endothelial cells. 2013 Mol. Cells pmid:24046187
Otte KB et al. Synthesis of 9-oxononanoic acid, a precursor for biopolymers. 2013 ChemSusChem pmid:23934656
McGowan MM et al. A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue. 2013 Breast Cancer Res. Treat. pmid:23417336
Girgih AT et al. Reverse-phase HPLC separation of hemp seed (Cannabis sativa L.) protein hydrolysate produced peptide fractions with enhanced antioxidant capacity. 2013 Plant Foods Hum Nutr pmid:23417711
Mabalirajan U et al. Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. 2013 Sci Rep pmid:23443229
Tokede OA et al. Plasma phospholipid trans fatty acids and risk of heart failure. 2013 Am. J. Clin. Nutr. pmid:23446892
Zuo R et al. Effects of conjugated linoleic acid on growth, non-specific immunity, antioxidant capacity, lipid deposition and related gene expression in juvenile large yellow croaker (Larmichthys crocea) fed soyabean oil-based diets. 2013 Br. J. Nutr. pmid:23452520
Schneider MR et al. Differentially regulated microRNAs during human sebaceous lipogenesis. 2013 J. Dermatol. Sci. pmid:23452545
Kirpich IA et al. Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. 2013 Alcohol pmid:23453163
Lind PM et al. An environmental wide association study (EWAS) approach to the metabolic syndrome. 2013 Environ Int pmid:23454278
Van Ba H et al. Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems. 2013 Meat Sci. pmid:23632107
Al-Taan O et al. Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. 2013 Lipids Health Dis pmid:23648075
Nakagawa Y [Metabolism and biological function of cardiolipin]. 2013 Yakugaku Zasshi pmid:23649397
Fairfield K ACP Journal Club. Review: replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality. 2013 Ann. Intern. Med. pmid:23689785
Giua L et al. Oxidative modifications of conjugated and unconjugated linoleic acid during heating. 2013 Food Chem pmid:23692753
Liu Q et al. Nonsense-mediated mRNA degradation of CtFAD2-1 and development of a perfect molecular marker for olol mutation in high oleic safflower (Carthamus tinctorius L.). 2013 Theor. Appl. Genet. pmid:23695179
Khalil WA et al. Protective effects of antioxidants on linoleic acid-treated bovine oocytes during maturation and subsequent embryo development. 2013 Theriogenology pmid:23683689
Le Maux S et al. β-Lactoglobulin-linoleate complexes: In vitro digestion and the role of protein in fatty acid uptake. 2013 J. Dairy Sci. pmid:23684041
Hand KV et al. Examining acute and chronic effects of short- and long-chain fatty acids on peptide YY (PYY) gene expression, cellular storage and secretion in STC-1 cells. 2013 Eur J Nutr pmid:22926626
Soto-Guzman A et al. Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23332799
Poudyal H et al. Responses to oleic, linoleic and α-linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. 2013 J. Nutr. Biochem. pmid:23333092
Warstedt K and Duchén K Increased linoleic acid/α-linolenic acid ratio in Swedish cord blood samples collected between 1985 and 2005. 2013 Eur J Nutr pmid:22584414
Patarra RF et al. Fatty acid composition of selected macrophytes. 2013 Nat. Prod. Res. pmid:22591127
Zlatanov MD et al. Lipid composition of Castanea sativa Mill. and Aesculus hippocastanum fruit oils. 2013 J. Sci. Food Agric. pmid:23174908
Gousiadou C et al. Minor iridoids from Scutellaria albida ssp. albida. Inhibitory potencies on lipoxygenase, linoleic acid lipid peroxidation and antioxidant activity of iridoids from Scutellaria sp. 2013 J Enzyme Inhib Med Chem pmid:22630074
McPherson PA et al. Mechanism for the enhanced peroxidation of linoleic acid by a titanium dioxide/hypochlorite system. 2013 Biochem. Biophys. Res. Commun. pmid:23178466
Serna-Marquez N et al. Role of LOXs and COX-2 on FAK activation and cell migration induced by linoleic acid in MDA-MB-231 breast cancer cells. 2013 Cell Oncol (Dordr) pmid:23179791
Gámez-Meza N et al. Chemical characterisation of kernels, kernel meals and oils from Jatropha cordata and Jatropha cardiophylla seeds. 2013 J. Sci. Food Agric. pmid:23180465
Toral PG et al. Effect of the inclusion of quebracho tannins in a diet rich in linoleic acid on milk fatty acid composition in dairy ewes. 2013 J. Dairy Sci. pmid:23164228
Yang Z and Huffman SL Modelling linoleic acid and α-linolenic acid requirements for infants and young children in developing countries. 2013 Matern Child Nutr pmid:23167585
Fedor DM et al. The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. 2013 Metab Syndr Relat Disord pmid:23170930
Jemia MB et al. Studies on the antioxidant activity of the essential oil and extract of Tunisian Tetraclinis articulata (Vahl) Mast. (Cupressaceae). 2013 Nat. Prod. Res. pmid:23082942
Bakır T et al. Polar paradox revisited: analogous pairs of hydrophilic and lipophilic antioxidants in linoleic acid emulsion containing Cu(II). 2013 J. Sci. Food Agric. pmid:23520052
Godovikova TS et al. Ligand-directed acid-sensitive amidophosphate 5-trifluoromethyl-2'-deoxyuridine conjugate as a potential theranostic agent. 2013 Bioconjug. Chem. pmid:23521072
Høstmark AT and Haug A Percentage oleic acid is inversely related to percentage arachidonic acid in total lipids of rat serum. 2013 Lipids Health Dis pmid:23521743
Fujii M et al. Deficiency of n-6 polyunsaturated fatty acids is mainly responsible for atopic dermatitis-like pruritic skin inflammation in special diet-fed hairless mice. 2013 Exp. Dermatol. pmid:23528213
Shimomura S et al. Stereoselective synthesis of a promising flower-inducing KODA analog, (9R,12S,13R,15Z)-9-hydroxy-12,13-methylene-10-oxooctadec-15-enoic acid. 2013 Biosci. Biotechnol. Biochem. pmid:23748793
Poon JF et al. In search of catalytic antioxidants--(alkyltelluro)phenols, (alkyltelluro)resorcinols, and bis(alkyltelluro)phenols. 2013 J. Org. Chem. pmid:23701313
Chodok P et al. Identification and functional characterization of two Δ12-fatty acid desaturases associated with essential linoleic acid biosynthesis in Physcomitrella patens. 2013 J. Ind. Microbiol. Biotechnol. pmid:23702573
Benjakul S et al. Antioxidant activity and inhibitory effects of lead (Leucaena leucocephala) seed extracts against lipid oxidation in model systems. 2013 Food Sci Technol Int pmid:23729420
de Goede J et al. N-6 and N-3 fatty acid cholesteryl esters in relation to fatal CHD in a Dutch adult population: a nested case-control study and meta-analysis. 2013 PLoS ONE pmid:23741290
Katan MB [Linoleic acid and heart infarct]. 2013 Ned Tijdschr Geneeskd pmid:23714298
Özcan T Accumulation patterns of some seed oil components from wild sources of Turkey. 2013 Nat. Prod. Res. pmid:22233192
Herrera-Meza MS et al. Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats. 2013 Int J Food Sci Nutr pmid:23360131
Satoh K Linoleic acid. A novel mechanism of endothelial cell dysfunction. 2013 Circ. J. pmid:24077059
Li KC et al. [A preliminary study of the inhibitive efficacy of iodized linoleic acid and its fluorodeoxyuridine ester in hepatocellular cancer]. 2013 Zhonghua Gan Zang Bing Za Zhi pmid:24025140
Kim JB et al. Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins. 2013 Am. J. Cardiol. pmid:24050409
Caligiuri SP et al. Dietary linoleic acid and α-linolenic acid differentially affect renal oxylipins and phospholipid fatty acids in diet-induced obese rats. 2013 J. Nutr. pmid:23902961
Risé P et al. Different patterns characterize Omega 6 and Omega 3 long chain polyunsaturated fatty acid levels in blood from Italian infants, children, adults and elderly. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23910046
Kenny JG et al. Mannitol utilisation is required for protection of Staphylococcus aureus from human skin antimicrobial fatty acids. 2013 PLoS ONE pmid:23861785
Xie J et al. A polyethylenimine-linoleic acid conjugate for antisense oligonucleotide delivery. 2013 Biomed Res Int pmid:23862153
Xia Q et al. Fatty acid profile, oxidative stability and toxicological safety of bayberry kernel oil. 2013 Food Chem. Toxicol. pmid:23867545
Ruparel S et al. Oxidized linoleic acid metabolite-cytochrome P450 system (OLAM-CYP) is active in biopsy samples from patients with inflammatory dental pain. 2013 Pain pmid:23867730
Shinjyo N et al. Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. 2013 J. Neurosci. Res. pmid:23633391
de Oliveira Otto MC et al. Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. 2013 J Am Heart Assoc pmid:24351702
Sisignano M et al. Synthesis of lipid mediators during UVB-induced inflammatory hyperalgesia in rats and mice. 2013 PLoS ONE pmid:24349046
Ngakegni-Limbili AC et al. Aframomum stipulatum (Gagnep) K. Schum and Aframomum giganteum (Oliv. & Hanb) K. Schum as Aroma Tincto Oleo Crops resources: essential oil, fatty acids, sterols, tocopherols, and tocotrienols composition of different fruit parts of Congo varieties. 2013 J. Sci. Food Agric. pmid:22692978
Li XP et al. Linolelaidic acid induces a stronger proliferative effect on human umbilical vein smooth muscle cells compared to elaidic acid. 2013 Lipids pmid:23341188
Ramsden CE et al. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22959954
Mysiakina IS et al. [Lipid composition of fungus Mucor hiemalis mycelium grown in the presence of trehalose, triacylglycerols, and itraconazole]. 2012 Nov-Dec Mikrobiologiia pmid:23610922
Mysiakina IS et al. [Effect of biological factors on morphogenesis, growth, and lipid composition of fungus Mucor hiemalis mycelium]. 2012 Nov-Dec Mikrobiologiia pmid:23610923
Alinezhad H et al. Biochemical activities of acetone extracts of Hyssopus angustifolius. 2012 Jul-Aug Acta Pol Pharm pmid:22876603
Moghaddam AH et al. Antioxidant, antihemolytic and nephroprotective activity of aqueous extract of Diospyros lotus seeds. 2012 Jul-Aug Acta Pol Pharm pmid:22876611
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Chivandi E et al. Suppression of Caco-2 and HEK-293 cell proliferation by Kigelia africana, Mimusops zeyheri and Ximenia caffra seed oils. 2012 Jan-Feb In Vivo pmid:22210722
Fu J et al. Hypolipidemic activity in Sprague-Dawley rats and constituents of a novel natural vegetable oil from Cornus wilsoniana fruits. 2012 J. Food Sci. pmid:22747885
Virtanen JK et al. Dietary intake of polyunsaturated fatty acids and risk of hip fracture in men and women. 2012 Osteoporos Int pmid:22270860
Sabir A et al. The fatty acid and tocopherol constituents of the seed oil extracted from 21 grape varieties (Vitis spp.). 2012 J. Sci. Food Agric. pmid:22271548
Morales A et al. Quantitative analysis of hydroperoxy-, keto- and hydroxy-dienes in refined vegetable oils. 2012 J Chromatogr A pmid:22321954
Ménard N et al. Novel surfactants with diglutamic acid polar head group: drug solubilization and toxicity studies. 2012 Pharm. Res. pmid:22451248
Honkanen AM et al. Characterization of the disappearance and formation of biohydrogenation intermediates during incubations of linoleic acid with rumen fluid in vitro. 2012 J. Dairy Sci. pmid:22365221
Jadoon A et al. Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression. 2012 J Affect Disord pmid:22113178
Järvinen R et al. Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women. 2012 Eur J Clin Nutr pmid:22113249
Nandi S et al. Effect of prostaglandin producing modulators on in vitro growth of buffalo uterine epithelial cells. 2012 Theriogenology pmid:22115808
Dubé E et al. Modulation of fatty acid transport and metabolism by maternal obesity in the human full-term placenta. 2012 Biol. Reprod. pmid:22553224
O'Donnell-Megaro AM et al. Effect of linoleic acid and dietary vitamin E supplementation on sustained conjugated linoleic acid production in milk fat from dairy cows. 2012 J. Dairy Sci. pmid:23063161
Sauerwald UC et al. Effect of different levels of docosahexaenoic acid supply on fatty acid status and linoleic and α-linolenic acid conversion in preterm infants. 2012 J. Pediatr. Gastroenterol. Nutr. pmid:22008957
Krugner-Higby L et al. Ulcerative dermatitis in C57BL/6 mice lacking stearoyl CoA desaturase 1. 2012 Comp. Med. pmid:23043777
Han SN et al. Novel soybean oils differing in fatty acid composition alter immune functions of moderately hypercholesterolemic older adults. 2012 J. Nutr. pmid:23096013
Buchhaupt M et al. Synthesis of green note aroma compounds by biotransformation of fatty acids using yeast cells coexpressing lipoxygenase and hydroperoxide lyase. 2012 Appl. Microbiol. Biotechnol. pmid:21789493
Sandoval-Montemayor NE et al. Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. 2012 Molecules pmid:22992784
Nurachman Z et al. Oil from the tropical marine benthic-diatom Navicula sp. 2012 Appl. Biochem. Biotechnol. pmid:22926527
Huang FC and Schwab W Overexpression of hydroperoxide lyase, peroxygenase and epoxide hydrolase in tobacco for the biotechnological production of flavours and polymer precursors. 2012 Plant Biotechnol. J. pmid:22967031
Osuji GO et al. Molecular modeling of metabolism for allergen-free low linoleic acid peanuts. 2012 Appl. Biochem. Biotechnol. pmid:22918723
Stachowska E et al. Conjugated linoleic acid isomers may diminish human macrophages adhesion to endothelial surface. 2012 Int J Food Sci Nutr pmid:21721848
Dundar A et al. Antioxidant properties, chemical composition and nutritional value of Terfezia boudieri (Chatin) from Turkey. 2012 Food Sci Technol Int pmid:22773542
Ogawa N et al. Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain-hypothalamic neural pathways in rats. 2012 Metab. Clin. Exp. pmid:22445513
Shen J et al. Effect of essential fatty acids on glucose-induced cytotoxicity to retinal vascular endothelial cells. 2012 Lipids Health Dis pmid:22781401
Al-Said MS et al. Edible oils for liver protection: hepatoprotective potentiality of Moringa oleifera seed oil against chemical-induced hepatitis in rats. 2012 J. Food Sci. pmid:22757719
Fares M et al. ω6/ω3 Polyunsaturated fatty acid supplementations in renal cell model lead to a particular regulation through lipidome for preserved ω6/ω3 ratios. 2012 Cell. Mol. Biol. (Noisy-le-grand) pmid:22762527
Toomik P et al. The effect of tenderizing acids on linoleic acid oxidation during marination of pork. 2012 Meat Sci. pmid:22762994
Jarvis MF Cytochrome P450 mediated linoleic acid metabolism in peripheral inflammatory nociception. 2012 Pain pmid:22681878
Passos PP et al. Dopaminergic cell populations of the rat substantia nigra are differentially affected by essential fatty acid dietary restriction over two generations. 2012 J. Chem. Neuroanat. pmid:22687395
Wu J et al. Metabolite profiles of rice cultivars containing bacterial blight-resistant genes are distinctive from susceptible rice. 2012 Acta Biochim. Biophys. Sin. (Shanghai) pmid:22687573
Cerretani L et al. DSC evaluation of extra virgin olive oil stability under accelerated oxidative test: effect of fatty acid composition and phenol contents. 2012 J Oleo Sci pmid:22687775
Reynolds CM et al. Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. 2012 Mol Nutr Food Res pmid:22700321
Gull J et al. Variation in antioxidant attributes at three ripening stages of guava (Psidium guajava L.) fruit from different geographical regions of Pakistan. 2012 Molecules pmid:22418924
Santos FS et al. Status of cis and trans fatty acids in Brazilian adolescent mothers and their newborns. 2012 J Pediatr Adolesc Gynecol pmid:22840939
McPherson PA et al. A curvilinear approach to the kinetic analysis of linoleate peroxidation in aqueous liposomes by 2,2'azobis(2-amidoinopropane) dihydrochloride. 2012 Chem. Phys. Lipids pmid:22841574