Linoelaidic acid
Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
Cross Reference
Introduction
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoelaidic acid?
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoelaidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Linoelaidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoelaidic acid?
Related references are published most in these journals:
- J. Lipid Res. (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (1)
- Others (3)
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol., Cell Physiol. (1)
- Plant Cell (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoelaidic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoelaidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pirozhkov SV et al. | Effect of chronic consumption of ethanol and vitamin E on fatty acid composition and lipid peroxidation in rat heart tissue. | 1992 Jul-Aug | Alcohol | pmid:1637499 |
| Pamplona R et al. | Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse. | 1999 | Aging (Milano) | pmid:10337442 |
| Kramer HJ et al. | The role of renal prostaglandins in the regulation of renal sodium excretion. | 1987 | Agents Actions Suppl. | pmid:3481214 |
| Henricks PA et al. | Epithelium-derived linoleic acid metabolites modulate airway smooth muscle function. | 1990 | Agents Actions Suppl. | pmid:2080762 |
| Loesberg C et al. | Superoxide anion production by alveolar macrophages of guinea pigs fed different diets in a model of atopy. | 1988 | Agents Actions | pmid:2833083 |
| Iversen L et al. | Linoleic acid and dihomogammalinolenic acid inhibit leukotriene B4 formation and stimulate the formation of their 15-lipoxygenase products by human neutrophils in vitro. Evidence of formation of antiinflammatory compounds. | 1991 | Agents Actions | pmid:1659156 |
| Loesberg C et al. | Effects of dietary poly-unsaturated fatty acids on tracheal histaminergic and cholinergic responsiveness in experimental models of bronchial hypersensitivity and hyperreactivity. | 1987 | Agents Actions | pmid:2895570 |
| Ringertz B et al. | High dietary linoleic acid content modulates neutrophil function in rats. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960199 |
| Eling TE et al. | Modulation of EGF cell signaling tyrosine phosphorylation by linoleic acid metabolites. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7537437 |
| Buchanan MR et al. | Vessel wall reactivity and 13-hydroxy-octadecadienoic acid synthesis. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526487 |
| Eling TE and Glasgow WC | Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825423 |
| Gyllenhammar H et al. | Dietary essential fatty acid deficiency in rats is accompanied by impairments in neutrophil function and leukotriene B4 generation. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2823572 |
| Hoffmann P and Förster W | Influence of dietary linoleic acid content on blood pressure regulation in salt-loaded rats (with special reference to the prostaglandin system). | 1981 | Adv. Lipid Res. | pmid:6798829 |
| Kinsella JE | Alpha-linolenic acid: functions and effects on linoleic acid metabolism and eicosanoid-mediated reactions. | 1991 | Adv. Food Nutr. Res. | pmid:1681826 |
| Sauerwald TU et al. | Polyunsaturated fatty acid supply with human milk. Physiological aspects and in vivo studies of metabolism. | 2000 | Adv. Exp. Med. Biol. | pmid:11065079 |
| Del Prado M et al. | Contribution of dietary and newly formed arachidonic acid to milk secretion in women on low fat diets. | 2000 | Adv. Exp. Med. Biol. | pmid:11065105 |
| Lance A et al. | 13C-linoleic acid oxidation and transfer into milk in lactating women with contrasting body mass index. | 2000 | Adv. Exp. Med. Biol. | pmid:11065106 |
| Kelavkar U et al. | 15-lipoxygenase-1 overexpression in prostate adenocarcinoma. | 2002 | Adv. Exp. Med. Biol. | pmid:12664577 |
| Egashira Y et al. | Dietary linoleic acid suppresses gene expression of rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) and increases quinolinic acid in serum. | 2003 | Adv. Exp. Med. Biol. | pmid:15206789 |
| Sharma HM et al. | Effect of MAK-4 and MAK-5 on endothelial cell and soyabean lipoxygenase-induced LDL oxidation. | 1994 | Adv. Exp. Med. Biol. | pmid:7771286 |
| Brash AR et al. | Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues. | 1999 | Adv. Exp. Med. Biol. | pmid:10667314 |
| Buchanan MR | Linoleic acid metabolites in health and disease. | 1999 | Adv. Exp. Med. Biol. | pmid:10667369 |
| Greene JF and Hammock BD | Toxicity of linoleic acid metabolites. | 1999 | Adv. Exp. Med. Biol. | pmid:10667370 |
| Jira W and Spiteller G | Dramatic increase of linoleic acid peroxidation products by aging, atherosclerosis, and rheumatoid arthritis. | 1999 | Adv. Exp. Med. Biol. | pmid:10667371 |
| Gibson RA et al. | Long chain omega 3 polyunsaturates in formula-fed term infants. | 1992 | Adv. Exp. Med. Biol. | pmid:1353286 |
| Tanaka R et al. | Prenylated acylphloroglucinol derivatives: isoprenomics-based design, syntheses and antioxidative activities. | 2012 | Adv. Exp. Med. Biol. | pmid:22259110 |
| Camacho M et al. | IL-1 increases the ability of human endothelial cells to transform linoleic acid into monohydroxy-isomers and their incorporation into cell lipids. | 1997 | Adv. Exp. Med. Biol. | pmid:9547616 |
| Louw L et al. | Impairment in the fatty acid composition of keloids. | 1997 | Adv. Exp. Med. Biol. | pmid:9547645 |
| Louw L et al. | Linoleic acid levels in cutaneous tumors with different growth patterns as an additional sensitive diagnostic feature. | 1997 | Adv. Exp. Med. Biol. | pmid:9547646 |
| Louw L et al. | The importance of linoleic acid in the total fatty acid compositions of benign and malignant neuroglial tumors. | 1997 | Adv. Exp. Med. Biol. | pmid:9547647 |
| Marosvölgyi T et al. | Trans isomeric and LCPUFA are inversely correlated in erythrocyte membrane lipids at mid-gestation. | 2009 | Adv. Exp. Med. Biol. | pmid:19536675 |
| Hörnsten L et al. | Bisallylic hydroxylation of linoleic and arachidonic acids by adult and fetal human liver microsomes and a comparison with human recombinant cytochromes P450. | 1997 | Adv. Exp. Med. Biol. | pmid:9561118 |
| Riambau V et al. | Effect of linoleic acid supplements on vessel wall hyperplasia in rabbits. | 1997 | Adv. Exp. Med. Biol. | pmid:9561150 |
| Brister SJ and Buchanan MR | Effects of linoleic acid and/or marine fish oil supplements on vessel wall thromboresistance in patients undergoing cardiac surgery. | 1997 | Adv. Exp. Med. Biol. | pmid:9561151 |
| Giménez-Arnau A et al. | Effects of linoleic acid supplements on atopic dermatitis. | 1997 | Adv. Exp. Med. Biol. | pmid:9561153 |
| Horrobin DF and Ziboh VA | The importance of linoleic acid metabolites in cancer metastasis and in the synthesis and actions of 13-HODE. | 1997 | Adv. Exp. Med. Biol. | pmid:9561154 |
| Agostoni C et al. | Long-chain polyunsaturated fatty acid concentrations in human hindmilk are constant throughout twelve months of lactation. | 2001 | Adv. Exp. Med. Biol. | pmid:11787678 |
| Demmelmair H et al. | Investigation of long-chain polyunsaturated fatty acid metabolism in lactating women by means of stable isotope techniques. | 2001 | Adv. Exp. Med. Biol. | pmid:11787680 |
| Fidler N et al. | Fat content and fatty acid composition of fresh, pasteurized, or sterilized human milk. | 2001 | Adv. Exp. Med. Biol. | pmid:11787720 |
| Blask DE et al. | New insights into melatonin regulation of cancer growth. | 1999 | Adv. Exp. Med. Biol. | pmid:10810531 |
| Eling TE et al. | Modulation of epidermal growth factor signal transduction by linoleic acid metabolites. | 1997 | Adv. Exp. Med. Biol. | pmid:9321970 |
| Asakawa T et al. | Ca2+-activated, fatty acid-dependent guanylate cyclase in synaptic plasma membranes and its requirement for Ca2+ and Mg-GTP in the activation. | 1984 | Adv. Exp. Med. Biol. | pmid:6149673 |
| Louw L et al. | Keloids: peripheral and central differences in cell morphology and fatty acid compositions of lipids. | 1997 | Adv. Exp. Med. Biol. | pmid:9322000 |
| GIBSON DM and ALLMANN DW | ADAPTIVE CHANGES IN FATTY ACID BIOSYNTHESIS. | 1963 | Adv. Enzyme Regul. | pmid:14190353 |
| Cook ME | Nutritional effects on vaccination. | 1999 | Adv Vet Med | pmid:9890009 |
| Birnbaum L | Addition of conjugated linoleic acid to a herbal anticellulite pill. | 2001 Sep-Oct | Adv Ther | pmid:11783459 |
| Guyenet SJ and Carlson SE | Increase in adipose tissue linoleic acid of US adults in the last half century. | 2015 | Adv Nutr | pmid:26567191 |
| Whelan J and Fritsche K | Linoleic acid. | 2013 | Adv Nutr | pmid:23674797 |
| Ermidou-Pollet S et al. | Influence of subcutaneous injection of essential fatty acids on the stress-induced modifications of rat platelet aggregation and membrane lipid composition. | 2005 | Acta. Biol. Hung. | pmid:16196200 |
| Arawwawala M et al. | In vitro and in vivo evaluation of antioxidant activity of Trichosanthes cucumerina aerial parts. | 2011 | Acta. Biol. Hung. | pmid:21840826 |