Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Brodersen R et al. | Multiple fatty acid binding to albumin in human blood plasma. | 1990 | Eur. J. Biochem. | pmid:2338079 |
Sams GH et al. | Isolation and characterization of a fatty acid binding protein in adipose tissue of Gallus domesticus. | 1990 | Comp. Biochem. Physiol., B | pmid:1697230 |
Girón MD et al. | Changes in lipid composition and desaturase activities of duodenal mucosa induced by dietary fat. | 1990 | Biochim. Biophys. Acta | pmid:2369586 |
Barros H et al. | Arachidonic acid absorption in human jejunum in organ culture: effects of ethanol. | 1990 | Eur. J. Clin. Invest. | pmid:2124981 |
Teter BB et al. | Milk fat depression in C57Bl/6J mice consuming partially hydrogenated fat. | 1990 | J. Nutr. | pmid:2380791 |
DeLange RJ and Glazer AN | Bile acids: antioxidants or enhancers of peroxidation depending on lipid concentration. | 1990 | Arch. Biochem. Biophys. | pmid:2297222 |
Ha YL et al. | Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. | 1990 | Cancer Res. | pmid:2297758 |
Kawahara J et al. | Dietary linoleic acid prevents the development of deoxycorticosterone acetate-salt hypertension. | 1990 | Hypertension | pmid:2298478 |
Parinandi NL et al. | Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. | 1990 | Biochim. Biophys. Acta | pmid:2123402 |
MacIver DH et al. | The effect of short chain fatty acid supplementation on membrane electrolyte transport and blood pressure. | 1990 | J Hum Hypertens | pmid:2283638 |
Jakobsson A et al. | Metabolism of fatty acids and their incorporation into phospholipids of the mitochondria and endoplasmic reticulum in isolated hepatocytes determined by isolation of fluorescence derivatives. | 1990 | Biochim. Biophys. Acta | pmid:2223867 |
Buset M et al. | Injury induced by fatty acids or bile acid in isolated human colonocytes prevented by calcium. | 1990 | Cancer Lett. | pmid:2322935 |
Kawada H et al. | Improved maintenance of adult rat alveolar type II cell differentiation in vitro: effect of serum-free, hormonally defined medium and a reconstituted basement membrane. | 1990 | Am. J. Respir. Cell Mol. Biol. | pmid:2363935 |
Lernhardt W | Fatty acid requirement of B lymphocytes activated in vitro. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2302243 |
Galaris D et al. | Ferrylmyoglobin-catalyzed linoleic acid peroxidation. | 1990 | Arch. Biochem. Biophys. | pmid:2383021 |
Miller CC and Ziboh VA | Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). | 1990 | J. Invest. Dermatol. | pmid:2106562 |
Okuyama H | [Does food affect brain functions?]. | 1990 | Tanpakushitsu Kakusan Koso | pmid:1970438 |
elAttar TM et al. | Comparison of the inhibitory effect of polyunsaturated fatty acids on prostaglandin synthesis. II. Fibroblasts. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1971442 |
Kestin M et al. | n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. | 1990 | Am. J. Clin. Nutr. | pmid:1971991 |
Watanabe S et al. | Effect of dietary alpha-linolenate/linoleate balance on crescent type-anti-glomerular basement membrane nephritis in rats. | 1990 | Lipids | pmid:1972260 |
Singer P et al. | Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension. | 1990 | J Hum Hypertens | pmid:1972963 |
Lipids and multiple sclerosis. | 1990 | Lancet | pmid:1973215 | |
Oxholm A et al. | Abnormal essential fatty acid metabolism in Darier's disease. | 1990 | Arch Dermatol | pmid:1977367 |
Lester DS | In vitro linoleic acid activation of protein kinase C. | 1990 | Biochim. Biophys. Acta | pmid:2207179 |
Høy CE and Hølmer G | Influence of dietary linoleic acid and trans fatty acids on the fatty acid profile of cardiolipins in rats. | 1990 | Lipids | pmid:2215088 |
Buko VU | Beef fat prevents alcoholic liver disease in the rat. | 1990 | Alcohol. Clin. Exp. Res. | pmid:2221295 |
Opara EC et al. | Enhancement of endocrine pancreatic secretions by essential fatty acids. | 1990 | J. Surg. Res. | pmid:2187112 |
Dupont J and Dowd MK | Icosanoid synthesis as a functional measurement of essential fatty acid requirement. | 1990 | J Am Coll Nutr | pmid:2193052 |
Kitagawa S et al. | Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. | 1990 | Biochim. Biophys. Acta | pmid:2166588 |
Umeda F et al. | Modification of prostacyclin-stimulatory activity in sera by glucose, insulin, low density lipoprotein, linoleic acid and linoleic acid hydroperoxide. | 1990 | Diabetes Res. Clin. Pract. | pmid:2106424 |
Lasekan JB et al. | Dietary olive and safflower oils in promotion of DMBA-induced mammary tumorigenesis in rats. | 1990 | Nutr Cancer | pmid:2106675 |
Tonogai Y and Tai HH | Quantitation of 13-hydroxyoctadecadienoic acid (13-HODE) by radioimmunoassay. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2111553 |
Moore SA et al. | Role of the blood-brain barrier in the formation of long-chain omega-3 and omega-6 fatty acids from essential fatty acid precursors. | 1990 | J. Neurochem. | pmid:2115069 |
Newman MJ | Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2371287 |
Gyllenhammar H et al. | Dietary linoleate supplementation modulates formyl-peptide receptor expression and functional responses of rat neutrophils. | 1990 | J. Lab. Clin. Med. | pmid:2157784 |
Chatterjee S and Ghosh N | Phosphatidylcholine stimulates the activity of UDP-Gal beta 1-4 galactosyltransferase in normal human kidney proximal tumour cells. | 1990 | Indian J. Biochem. Biophys. | pmid:2129343 |
Kawashima Y et al. | Peroxisome proliferators enhance linoleic acid metabolism in rat liver. Increased biosynthesis of omega 6 polyunsaturated fatty acids. | 1990 | J. Biol. Chem. | pmid:2160962 |
Bedotti R et al. | Stimulatory effect of serum albumin on the proliferation of serum-free SV40-transformed Balb/c 3T3 cells. | 1990 | Biochim. Biophys. Acta | pmid:2163687 |
Koba K and Sugano M | Dietary protein influences polyunsaturated fatty acid patterns of rat tissue lipids. | 1990 | J. Nutr. Sci. Vitaminol. | pmid:2130152 |
Akamatsu H et al. | Suppressive effects of linoleic acid on neutrophil oxygen metabolism and phagocytosis. | 1990 | J. Invest. Dermatol. | pmid:2143521 |
Yashiro K et al. | [Changes in the free fatty acid composition of rat salivary glands induced by chronic administration of isoproterenol]. | 1990 | Gifu Shika Gakkai Zasshi | pmid:2133668 |
Weaver BJ et al. | Dietary canola oil: effect on the accumulation of eicosapentaenoic acid in the alkenylacyl fraction of human platelet ethanolamine phosphoglyceride. | 1990 | Am. J. Clin. Nutr. | pmid:2181858 |
Renner HW | Anticlastogenic dietary factors assessed in mammalian assays. | 1990 | Basic Life Sci. | pmid:2183774 |
Farnworth ER and Kramer JK | Fat supplementation to the gestation diet of older sows and its effect on maternal and fetal fat metabolism. | 1990 | Reprod. Nutr. Dev. | pmid:1981311 |
Marra CA and de Alaniz MJ | Mineralocorticoids modify rat liver delta 6 desaturase activity and other parameters of lipid metabolism. | 1990 | Biochem. Int. | pmid:1981670 |
Byczkowski JZ and Kulkarni AP | Lipid peroxidation and benzo(a)pyrene derivative co-oxygenation by environmental pollutants. | 1990 | Bull Environ Contam Toxicol | pmid:2176112 |
Mullarkey CJ et al. | Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2176495 |
Stocker R et al. | Antioxidant activities of bile pigments: biliverdin and bilirubin. | 1990 | Meth. Enzymol. | pmid:2233302 |
Glasgow WC and Eling TE | Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts. | 1990 | Mol. Pharmacol. | pmid:2233691 |
Hernández-Caselles T et al. | Stability of liposomes on long term storage. | 1990 | J. Pharm. Pharmacol. | pmid:1979618 |
Field CJ et al. | Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals. | 1990 | J. Biol. Chem. | pmid:2113530 |
Kim D and Duff RA | Regulation of K+ channels in cardiac myocytes by free fatty acids. | 1990 | Circ. Res. | pmid:2119911 |
Palmblad J | Eicosanoids and modulation of inflammatory and immune responses. | 1990 | Scand. J. Clin. Lab. Invest. Suppl. | pmid:1963704 |
Zakhariv OIa et al. | [Metabolism of linoleic acid given with the feed in the calf liver]. | 1990 Jan-Feb | Ukr. Biokhim. Zh. | pmid:2336726 |
Hou SY et al. | Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and x-ray diffraction. | 1991 | J. Invest. Dermatol. | pmid:1991982 |
Muakkassa FF et al. | Effect of dietary fish oil on plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha levels in septic rats. | 1991 | Arch Surg | pmid:1992995 |
Earles SM et al. | Metabolism of oxidized linoleic acid: characterization of 13-hydroxyoctadecadienoic acid dehydrogenase activity from rat colonic tissue. | 1991 | Biochim. Biophys. Acta | pmid:1998735 |
Hubbard NE and Erickson KL | Role of dietary oleic acid in linoleic acid-enhanced metastasis of a mouse mammary tumor. | 1991 | Cancer Lett. | pmid:1998946 |
Kim RS and Zaborniak CL | The aldehydic metabolites of linoleic acid are cytotoxic against human breast cancer cells. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1946549 |
Martin JC et al. | Essential fatty acid composition of human colostrum triglycerides: its relationship with adipose tissue composition. | 1991 | Am. J. Clin. Nutr. | pmid:1951153 |
Seidell JC et al. | Polyunsaturated fatty acids in adipose tissue in European men aged 38 years in relation to serum lipids, smoking habits, and fat distribution. | 1991 | Am. J. Epidemiol. | pmid:1951263 |
Andrianarison RH et al. | Oxodiene formation during the Vicia sativa lipoxygenase-catalyzed reaction: occurrence of dioxygenase and fatty acid lyase activities associated in a single protein. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1953704 |
Kanazawa K | Hepatic dysfunction caused by dietary products of lipid peroxidation. | 1991 | Int J Tissue React | pmid:1955295 |
Takamura H et al. | Inhibition by lipoxygenase-3 of n-hexanal generation in soybeans. | 1991 | FEBS Lett. | pmid:1959624 |
Boor PJ et al. | Synergistic vascular toxicity and fatty acid anilides in the toxic oil syndrome. | 1991 | J. Am. Coll. Cardiol. | pmid:1960335 |
Kühn H et al. | Formation of ketodienoic fatty acids by the pure pea lipoxygenase-1. | 1991 | Eicosanoids | pmid:1905562 |
Beyers EC and Emken EA | Metabolites of cis,trans, and trans,cis isomers of linoleic acid in mice and incorporation into tissue lipids. | 1991 | Biochim. Biophys. Acta | pmid:2029547 |
Pettersen J and Opstvedt J | Trans fatty acids. 4. Effects on fatty acid composition of colostrum and milk. | 1991 | Lipids | pmid:1762516 |
Stroh S and Elmadfa I | [In vitro studies of the effect of different mixture proportions of omega-3 and omega-6 fatty acids on thrombocyte aggregation and thromboxane synthesis in human thrombocytes]. | 1991 | Z Ernahrungswiss | pmid:1763556 |
Wright S and Sanders TA | Adipose tissue essential fatty acid composition in patients with atopic eczema. | 1991 | Eur J Clin Nutr | pmid:1782921 |
Butovich IA et al. | The unusual action of (R,S)-2-hydroxy-2-trifluoromethyl-trans-n-octadec-4-enoic acid on 5-lipoxygenase from potato tubers. | 1991 | Eur. J. Biochem. | pmid:2065670 |
Schreiner GF | Dietary treatment of immunologically mediated renal disease. | 1991 | Kidney Int. Suppl. | pmid:2046271 |
Venkatraman JT et al. | Influence of genotype on diet-induced changes in membrane phosphatidylcholine and phosphatidylethanolamine composition of splenocytes, liver nuclear envelope and liver mitochondria. | 1991 | Lipids | pmid:2046486 |
Rubinstein A et al. | Fatty acid composition of adipose tissue in Ethiopian immigrants: a prospective study during their first year in Israel. | 1991 | Isr. J. Med. Sci. | pmid:2050506 |
Holman RT | Highpoints in an affair with polyunsaturated fatty acids. | 1991 | World Rev Nutr Diet | pmid:2053355 |
Stein Y et al. | Metabolism of 3-[3H]sphingosine sphingomyelin labeled with [14C]palmitic or [14C]linoleic acid by Hep G2 cells and rat liver in vivo. | 1991 | Biochim. Biophys. Acta | pmid:2054378 |
Uchida Y et al. | Enhancement of keratin synthesis induced by lipokeratinogenoside, N-(O-linoleoyl)-omega-hydroxy fatty acyl sphingosyl glucose, in association with alteration of the intracellular Ca(2+)-content and protein kinase in cultured keratinocytes (FRSK). | 1991 | J. Biochem. | pmid:1715342 |
MacÃas P et al. | Hemin and hemeprotein bleaching during linoleic acid oxidation by lipoxygenases. | 1991 | Biochim. Biophys. Acta | pmid:1903070 |
Iwahashi H et al. | Isolation and identification of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenase. | 1991 | Arch. Biochem. Biophys. | pmid:1846731 |
Thomson AB et al. | Feeding rats a diet enriched with saturated fatty acids prevents the inhibitory effects of acute and chronic ethanol exposure on the in vitro uptake of hexoses and lipids. | 1991 | Biochim. Biophys. Acta | pmid:1854796 |
Bellomonte G et al. | Quantitative determination of linoleic acid in infant formulas. | 1991 | Int J Vitam Nutr Res | pmid:1856052 |
Schmitz PG et al. | Glomerular hemodynamic effects of dietary polyunsaturated fatty acid supplementation. | 1991 | J. Lab. Clin. Med. | pmid:1856576 |
Kinsella JE | Alpha-linolenic acid: functions and effects on linoleic acid metabolism and eicosanoid-mediated reactions. | 1991 | Adv. Food Nutr. Res. | pmid:1681826 |
Eling TE and Glasgow WC | Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism. | 1991 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:1825423 |
Ramasamy S et al. | Linoleic acid-induced endothelial cell injury: role of membrane-bound enzyme activities and lipid oxidation. | 1991 | J. Biochem. Toxicol. | pmid:1831858 |
Ledwozyw A et al. | [Surfactant lipids of bovine lungs]. | 1991 | Pol Arch Weter | pmid:1842618 |
Semplicini A et al. | Effects of linoleic acid supplementation on blood pressure and kinetics of red cell sodium transport: the Piove di Sacco Study. | 1991 | J Hypertens Suppl | pmid:1818979 |
Rose DP et al. | Effect of dietary fat on human breast cancer growth and lung metastasis in nude mice. | 1991 | J. Natl. Cancer Inst. | pmid:1920496 |
Batres-Cerezo R et al. | Studies of women eating diets with different fatty acid composition. III. Fatty acids and prostaglandin synthesis by platelets and cultured human endothelial cells. | 1991 | J Am Coll Nutr | pmid:1894889 |
Burri BJ et al. | Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid. | 1991 | Am. J. Clin. Nutr. | pmid:1858699 |
Ikeda I et al. | Lymphatic absorption of structured glycerolipids containing medium-chain fatty acids and linoleic acid, and their effect on cholesterol absorption in rats. | 1991 | Lipids | pmid:1895884 |
Bell JG et al. | High dietary linoleic acid affects the fatty acid compositions of individual phospholipids from tissues of Atlantic salmon (Salmo salar): association with stress susceptibility and cardiac lesion. | 1991 | J. Nutr. | pmid:1861166 |
DaTorre SD and Creer MH | Differential turnover of polyunsaturated fatty acids in plasmalogen and diacyl glycerophospholipids of isolated cardiac myocytes. | 1991 | J. Lipid Res. | pmid:1940640 |
Byczkowski JZ et al. | Proline hydroxylation by soybean lipoxygenase. | 1991 | Biochem. Int. | pmid:1815499 |
Hiramatsu N et al. | Effects of dietary pantethine levels on contents of fatty acids and thiobarbituric acid reactive substances in the liver of rats orally administered varying amounts of autoxidized linoleate. | 1991 | J. Nutr. Sci. Vitaminol. | pmid:1880633 |
Laganiere S and Fernandes G | Study on the lipid composition of aging Fischer-344 rat lymphoid cells: effect of long-term calorie restriction. | 1991 | Lipids | pmid:1881243 |
Perkins DM and Duncan JR | The effect of gamma-linolenic acid and zinc supplementation on the growth of normal and tumour cells in vitro. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1881941 |
Huynh S et al. | Metabolic utilization of linoleate and alpha-linolenate in cultured Sertoli cells. | 1991 | Comp. Biochem. Physiol., B | pmid:1684926 |
de Tomás ME et al. | Metabolic transformation of intracraneally injected [1-14C]linoleic and [1-14C]alpha-linolenic acids in malnourished developing rats. | 1991 | Lipids | pmid:1687158 |
Witte-Foster SR et al. | Lipid profiles, serum immunoglobulins, dietary intake, and drug use of older rural Iowa women. | 1991 | J Am Diet Assoc | pmid:2040782 |