Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Tuberculosis D014376 20 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Uterine Cervical Neoplasms D002583 10 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hepatolenticular Degeneration D006527 3 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Cattle Diseases D002418 24 associated lipids
Fatty Liver D005234 48 associated lipids
Infertility, Male D007248 11 associated lipids
Varicocele D014646 4 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Foreign-Body Reaction D005549 10 associated lipids
Carcinoma D002277 18 associated lipids
Gastritis D005756 27 associated lipids
Heart Failure D006333 36 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Alopecia D000505 14 associated lipids
Liver Diseases D008107 31 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Acne Vulgaris D000152 35 associated lipids
Melanoma D008545 69 associated lipids
Kidney Diseases D007674 29 associated lipids
Weight Gain D015430 101 associated lipids
Aneurysm D000783 2 associated lipids
Acidosis D000138 13 associated lipids
Glioma D005910 112 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

Download all related citations
Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
Song E et al. Deamidated lipocalin-2 induces endothelial dysfunction and hypertension in dietary obese mice. 2014 J Am Heart Assoc pmid:24721803
Reed S et al. Dietary zinc deficiency affects blood linoleic acid: dihomo-γ-linolenic acid (LA:DGLA) ratio; a sensitive physiological marker of zinc status in vivo (Gallus gallus). 2014 Nutrients pmid:24658588
Bernhard W et al. Plasma phospholipids indicate impaired fatty acid homeostasis in preterm infants. 2014 Eur J Nutr pmid:24464176
Armstrong EH et al. Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway. 2014 J. Biol. Chem. pmid:24692551
Jacob RH et al. Phenotypic characterisation of colour stability of lamb meat. 2014 Meat Sci. pmid:23415827
Petzinger C et al. Lipid metabolic dose response to dietary alpha-linolenic acid in monk parrot (Myiopsitta monachus). 2014 Lipids pmid:24293226
Hodson L et al. Plasma and erythrocyte fatty acids reflect intakes of saturated and n-6 PUFA within a similar time frame. 2014 J. Nutr. pmid:24225449
Corrêa RC et al. Antioxidant and rheological properties of guava jam with added concentrated grape juice. 2014 J. Sci. Food Agric. pmid:23696312
Bagai S et al. Lipid-modified polyethylenimine-mediated DNA attraction evaluated by molecular dynamics simulations. 2014 J Phys Chem B pmid:24918771
Tang KS Protective effect of arachidonic acid and linoleic acid on 1-methyl-4-phenylpyridinium-induced toxicity in PC12 cells. 2014 Lipids Health Dis pmid:25522984
Qin G et al. Evolution of the aroma volatiles of pear fruits supplemented with fatty acid metabolic precursors. 2014 Molecules pmid:25474290
Ebrahimi M et al. Effects of oils rich in linoleic and α-linolenic acids on fatty acid profile and gene expression in goat meat. 2014 Nutrients pmid:25255382
Xu QY et al. Metabolomic analysis of simvastatin and fenofibrate intervention in high-lipid diet-induced hyperlipidemia rats. 2014 Acta Pharmacol. Sin. pmid:25220639
Victoria FN et al. Antioxidant and antidepressant-like activities of semi-synthetic α-phenylseleno citronellal. 2014 Eur. J. Pharmacol. pmid:25218989
Farvid MS et al. Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies. 2014 Circulation pmid:25161045
Harris WS and Shearer GC Omega-6 fatty acids and cardiovascular disease: friend, not foe? 2014 Circulation pmid:25161044
Saito HE et al. Incorporation of exogenous fatty acids protects Enterococcus faecalis from membrane-damaging agents. 2014 Appl. Environ. Microbiol. pmid:25128342
Wu JH et al. Circulating omega-6 polyunsaturated fatty acids and total and cause-specific mortality: the Cardiovascular Health Study. 2014 Circulation pmid:25124495
Phan CW et al. Intrastrain comparison of the chemical composition and antioxidant activity of an edible mushroom, Pleurotus giganteus, and its potent neuritogenic properties. 2014 ScientificWorldJournal pmid:25121118
Purushothaman D et al. Flaxseed oil supplementation alters the expression of inflammatory-related genes in dogs. 2014 Genet. Mol. Res. pmid:25078588
van Schalkwijk DB et al. Dietary medium chain fatty acid supplementation leads to reduced VLDL lipolysis and uptake rates in comparison to linoleic acid supplementation. 2014 PLoS ONE pmid:25049048
Woyda-Ploszczyca AM and Jarmuszkiewicz W Different effects of guanine nucleotides (GDP and GTP) on protein-mediated mitochondrial proton leak. 2014 PLoS ONE pmid:24904988
Maruyama H et al. Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells. 2014 Lipids Health Dis pmid:24885871
Nosaka S and Miyazawa M Characterization of volatile components and odor-active compounds in the oil of edible mushroom Boletopsis leucomelas. 2014 J Oleo Sci pmid:24881770
Chilton FH et al. Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. 2014 Nutrients pmid:24853887
Saito H and Ishikawa S Lipid classes and fatty acid profile of cultured and wild black rockfish, Sebastes schlegeli. 2014 J Oleo Sci pmid:24829130
Morris JB et al. Flavonol content, oil%, and fatty acid composition variability in seeds of Teramnus labialis and T. uncinatus accessions with nutraceutical potential. 2014 J Diet Suppl pmid:25054688
Verlotta A and Trono D Expression, purification and refolding of active durum wheat (Triticum durum Desf.) secretory phospholipase A2 from inclusion bodies of Escherichia coli. 2014 Protein Expr. Purif. pmid:24925645
Yang B et al. Synthesis of conjugated linoleic acid by the linoleate isomerase complex in food-derived lactobacilli. 2014 J. Appl. Microbiol. pmid:24750362
Mouokeu RS et al. Antifungal and antioxidant activity of Crassocephalum bauchiense (Hutch.) Milne-Redh ethyl acetate extract and fractions (Asteraceae). 2014 BMC Res Notes pmid:24742210
Buehlmann C et al. Desert ants locate food by combining high sensitivity to food odors with extensive crosswind runs. 2014 Curr. Biol. pmid:24726153
Arcan I and YemenicioÄŸlu A Controlled release properties of zein-fatty acid blend films for multiple bioactive compounds. 2014 J. Agric. Food Chem. pmid:25025594
Buček A et al. Δ12-Fatty acid desaturase from Candida parapsilosis is a multifunctional desaturase producing a range of polyunsaturated and hydroxylated fatty acids. 2014 PLoS ONE pmid:24681902
Rodriguez MA et al. Concordance analysis between estimation methods of milk fatty acid content. 2014 Food Chem pmid:24629954
Spartano NL et al. Linoleic acid suppresses cholesterol efflux and ATP-binding cassette transporters in murine bone marrow-derived macrophages. 2014 Lipids pmid:24595513
Scalerandi MV et al. Effect of conjugated linoleic acid mixtures and different edible oils in body composition and lipid regulation in mice. 2014 Nutr Hosp pmid:24559004
Asselin C et al. Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure. 2014 Redox Biol pmid:24494189
Mouradian M et al. Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth. 2014 Prostaglandins Leukot. Essent. Fatty Acids pmid:24374147
Nehdi IA et al. Chamaerops humilis L. var. argentea André date palm seed oil: a potential dietetic plant product. 2014 J. Food Sci. pmid:24666023
Santos S et al. Fatty acids derived from a food frequency questionnaire and measured in the erythrocyte membrane in relation to adiponectin and leptin concentrations. 2014 Eur J Clin Nutr pmid:24642786
Negrini R et al. Influence of electrostatic interactions on the release of charged molecules from lipid cubic phases. 2014 Langmuir pmid:24673189
Choi JI et al. Development of microalga Scenedesmus dimorphus mutant with higher lipid content by radiation breeding. 2014 Bioprocess Biosyst Eng pmid:24871276
Wright CR and Setzer WN Chemical composition of volatiles from Opuntia littoralis, Opuntia ficus-indica, and Opuntia prolifera growing on Catalina Island, California. 2014 Nat. Prod. Res. pmid:24354326
Guo HH et al. XsFAD2 gene encodes the enzyme responsible for the high linoleic acid content in oil accumulated in Xanthoceras sorbifolia seeds. 2014 J. Sci. Food Agric. pmid:23775588
Radice M et al. Chemical characterization and antioxidant activity of Amazonian (Ecuador) Caryodendron orinocense Karst. and Bactris gasipaes Kunth seed oils. 2014 J Oleo Sci pmid:25391685
Garrel G et al. Unsaturated fatty acids disrupt Smad signaling in gonadotrope cells leading to inhibition of FSHβ gene expression. 2014 Endocrinology pmid:24248462
Kim JY et al. Role of moisture on the lipid oxidation determined by D(2)O in a linoleic acid model system. 2014 Food Chem pmid:24176324
Usami A et al. Characteristic odorants from bailingu oyster mushroom (Pleurotus eryngii var. tuoliensis) and summer oyster mushroom (Pleurotus cystidiosus). 2014 J Oleo Sci pmid:24919476
Sponton OE et al. Effect of limited enzymatic hydrolysis on linoleic acid binding properties of β-lactoglobulin. 2014 Food Chem pmid:24176383
Dal Bosco A et al. Effect of dietary alfalfa on the fatty acid composition and indexes of lipid metabolism of rabbit meat. 2014 Meat Sci. pmid:24036258
Alvheim AR et al. Dietary linoleic acid elevates the endocannabinoids 2-AG and anandamide and promotes weight gain in mice fed a low fat diet. 2014 Lipids pmid:24081493
Su MH et al. Chemical composition of seed oils in native Taiwanese Camellia species. 2014 Food Chem pmid:24629982
Bakır T et al. Antioxidant/prooxidant effects of α-tocopherol, quercetin and isorhamnetin on linoleic acid peroxidation induced by Cu(II) and H2O2. 2014 Int J Food Sci Nutr pmid:24152374
Yavin E et al. Metabolic conversion of intra-amniotically-injected deuterium-labeled essential fatty acids by fetal rats following maternal n-3 fatty acid deficiency. 2014 Biochim. Biophys. Acta pmid:24960100
Huang FC et al. Expression and characterization of CYP52 genes involved in the biosynthesis of sophorolipid and alkane metabolism from Starmerella bombicola. 2014 Appl. Environ. Microbiol. pmid:24242247
Yang Q et al. Anti-thrombotic effects of α-linolenic acid isolated from Zanthoxylum bungeanum Maxim seeds. 2014 BMC Complement Altern Med pmid:25252789
Shimizu N et al. De novo biosynthesis of linoleic acid and its conversion to the hydrocarbon (Z,Z)-6,9-heptadecadiene in the astigmatid mite, Carpoglyphus lactis: incorporation experiments with 13C-labeled glucose. 2014 Insect Biochem. Mol. Biol. pmid:24333472
Wu MH et al. A novel sodium N-fatty acyl amino acid surfactant using silkworm pupae as stock material. 2014 Sci Rep pmid:24651079
Reiner WB et al. Fatty acids in mountain gorilla diets: implications for primate nutrition and health. 2014 Am. J. Primatol. pmid:24243235
Bonferoni MC et al. Ionic polymeric micelles based on chitosan and fatty acids and intended for wound healing. Comparison of linoleic and oleic acid. 2014 Eur J Pharm Biopharm pmid:24384070
Stoffel W et al. Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency. 2014 EMBO Rep. pmid:24378641
González-Abuín N et al. Grape-seed procyanidins modulate cellular membrane potential and nutrient-induced GLP-1 secretion in STC-1 cells. 2014 Am. J. Physiol., Cell Physiol. pmid:24371039
Öztürk M et al. The fatty acid compositions of several plant seed oils belong to Leguminosae and Umbelliferae families. 2014 Environ Monit Assess pmid:24357269
Choi JS et al. In vivo hair growth-promoting effect of rice bran extract prepared by supercritical carbon dioxide fluid. 2014 Biol. Pharm. Bull. pmid:24389480
Chevrot M et al. Obesity interferes with the orosensory detection of long-chain fatty acids in humans. 2014 Am. J. Clin. Nutr. pmid:24522446
Barua P et al. Seed oils from non-conventional sources in north-east India: potential feedstock for production of biodiesel. 2014 Nat. Prod. Res. pmid:24483850
Cho Y et al. Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation. 2014 Exp. Biol. Med. (Maywood) pmid:24495951
Matthaus B and Özcan MM Fatty acid and tocopherol contents of several soybean oils. 2014 Nat. Prod. Res. pmid:24499198
Dailey MJ et al. Nutrient-specific feeding and endocrine effects of jejunal infusions in obese animals. 2014 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24452547
Shen J et al. A 13-lipoxygenase, TomloxC, is essential for synthesis of C5 flavour volatiles in tomato. 2014 J. Exp. Bot. pmid:24453226
Mulligan CM et al. Inhibition of delta-6 desaturase reverses cardiolipin remodeling and prevents contractile dysfunction in the aged mouse heart without altering mitochondrial respiratory function. 2014 J. Gerontol. A Biol. Sci. Med. Sci. pmid:24418793
Paulsen SJ et al. Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion. 2014 PLoS ONE pmid:24520357
Youn K et al. Oleic acid and linoleic acid from Tenebrio molitor larvae inhibit BACE1 activity in vitro: molecular docking studies. 2014 J Med Food pmid:24548007
Ambrozova JV et al. Influence of extractive solvents on lipid and fatty acids content of edible freshwater algal and seaweed products, the green Microalga Chlorella kessleri and the Cyanobacterium Spirulina platensis. 2014 Molecules pmid:24566307
Bazongo P et al. Characteristics, composition and oxidative stability of Lannea microcarpa seed and seed oil. 2014 Molecules pmid:24566330
Kwon B et al. Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. 2014 Biochim. Biophys. Acta pmid:24732014
Breiden B and Sandhoff K The role of sphingolipid metabolism in cutaneous permeability barrier formation. 2014 Biochim. Biophys. Acta pmid:23954553
Darling RA et al. Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors. 2014 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24760994
Nardi F et al. Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A. 2014 PLoS ONE pmid:24632852
Mahendran Y et al. Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes. 2014 Am. J. Clin. Nutr. pmid:24153340
Hall TD et al. Changes during leaf expansion of ΦPSII temperature optima in Gossypium hirsutum are associated with the degree of fatty acid lipid saturation. 2014 J. Plant Physiol. pmid:24594393
Ogorodnikova AV et al. Screening of divinyl ether synthase activity in nonphotosynthetic tissue of asparagales. 2013 Mar-Apr Dokl. Biochem. Biophys. pmid:23657662
Thomas CP et al. Steric analysis of epoxyalcohol and trihydroxy derivatives of 9-hydroperoxy-linoleic acid from hematin and enzymatic synthesis. 2013 Feb-Mar Chem. Phys. Lipids pmid:23352713
Ivan M et al. Rumen fermentation and microbial population in lactating dairy cows receiving diets containing oilseeds rich in C-18 fatty acids. 2013 Br. J. Nutr. pmid:22850225
Alvheim AR et al. Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon (Salmo salar L.) and mice, and induces weight gain and inflammation in mice. 2013 Br. J. Nutr. pmid:22883314
Godinot N et al. Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice. 2013 Neuroscience pmid:23831422
Lai MC et al. The natural PPAR agonist linoleic acid stimulated insulin release in the rat pancreas. 2013 J. Vet. Med. Sci. pmid:23832628
Kälber T et al. Effect of feeding buckwheat and chicory silages on fatty acid profile and cheese-making properties of milk from dairy cows. 2013 J. Dairy Res. pmid:23253429
Gillingham LG et al. Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. 2013 Am. J. Clin. Nutr. pmid:23221573
Carro M et al. Linoleic acid stimulates neutral lipid accumulation in lipid droplets of maturing bovine oocytes. 2013 Theriogenology pmid:23273433
Khan AA et al. Anticancer efficacy of a novel propofol-linoleic acid-loaded escheriosomal formulation against murine hepatocellular carcinoma. 2013 Nanomedicine (Lond) pmid:23311988
Graves JP et al. Characterization of four new mouse cytochrome P450 enzymes of the CYP2J subfamily. 2013 Drug Metab. Dispos. pmid:23315644
Carey AN et al. The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. 2013 Nutr Neurosci pmid:23321679
Guo J et al. Selective transport of long-chain fatty acids by FAT/CD36 in skeletal muscle of broilers. 2013 Animal pmid:23031491
Kiernan M et al. The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. 2013 Reprod. Fertil. Dev. pmid:23036717
Han L et al. Hydroxyl radical induced by lipid in Maillard reaction model system promotes diet-derived N(ε)-carboxymethyllysine formation. 2013 Food Chem. Toxicol. pmid:23959106
Aboshi T et al. Biosynthesis of linoleic acid in Tyrophagus mites (Acarina: Acaridae). 2013 Insect Biochem. Mol. Biol. pmid:23973745
Hashim A et al. Antioxidant and α -amylase inhibitory property of phyllanthus virgatus L.: an in vitro and molecular interaction study. 2013 Biomed Res Int pmid:23957001
Navarro-Guillén C et al. Interaction between dietary levels of LC-PUFA and vegetable oil sources in Senegalese sole (Solea senegalensis) post-larvae: puzzling results suggesting complete biosynthesis pathway from C18 PUFA to DHA. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141696
Okada Y et al. Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization. 2013 Clin. Exp. Immunol. pmid:24028683