Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Duckett SK et al. | Effect of high-oil corn or added corn oil on ruminal biohydrogenation of fatty acids and conjugated linoleic acid formation in beef steers fed finishing diets. | 2002 | J. Anim. Sci. | pmid:12542177 |
Martin SA and Jenkins TC | Factors affecting conjugated linoleic acid and trans-C18:1 fatty acid production by mixed ruminal bacteria. | 2002 | J. Anim. Sci. | pmid:12542176 |
Vos E and Cunnane SC | Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality. | 2003 | Am. J. Clin. Nutr. | pmid:12540417 |
Innis SM and Elias SL | Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. | 2003 | Am. J. Clin. Nutr. | pmid:12540410 |
Pasqualini ME et al. | Association between E-cadherin expression by human colon, bladder and breast cancer cells and the 13-HODE:15-HETE ratio. A possible role of their metastatic potential. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538085 |
Hubbard NE et al. | Effect of separate conjugated linoleic acid isomers on murine mammary tumorigenesis. | 2003 | Cancer Lett. | pmid:12536072 |
Goodfriend TL et al. | Oxidized products of linoleic acid stimulate adrenal steroidogenesis. | 2002 | Endocr. Res. | pmid:12530633 |
Yang M and Cook ME | Dietary conjugated linoleic acid decreased cachexia, macrophage tumor necrosis factor-alpha production, and modifies splenocyte cytokines production. | 2003 | Exp. Biol. Med. (Maywood) | pmid:12524473 |
Cohen LA et al. | Effect of soy protein isolate and conjugated linoleic acid on the growth of Dunning R-3327-AT-1 rat prostate tumors. | 2003 | Prostate | pmid:12518321 |
Rodriguez M et al. | Plasma fatty acids and [13C]linoleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides. | 2003 | J. Lipid Res. | pmid:12518021 |
Vaughan JE and Walsh SW | Oxidative stress reproduces placental abnormalities of preeclampsia. | 2002 | Hypertens Pregnancy | pmid:12517328 |
Belury MA et al. | The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. | 2003 | J. Nutr. | pmid:12514304 |
Chen BQ et al. | Inhibition of conjugated linoleic acid on mouse forestomach neoplasia induced by benzo (a) pyrene and chemopreventive mechanisms. | 2003 | World J. Gastroenterol. | pmid:12508349 |
Yamasaki M et al. | Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets. | 2003 | Nutrition | pmid:12507636 |
Kanicky JR and Shah DO | Effect of degree, type, and position of unsaturation on the pKa of long-chain fatty acids. | 2002 | J Colloid Interface Sci | pmid:12505514 |
de Kok TM et al. | Analysis of oxidative DNA damage after human dietary supplementation with linoleic acid. | 2003 | Food Chem. Toxicol. | pmid:12504167 |
Fukuda S et al. | Production of conjugated linoleic acid by intestinal bacteria in dogs and cats. | 2002 | J. Vet. Med. Sci. | pmid:12499682 |
Ishiguro K et al. | Effects of conjugated linoleic acid on anaphylaxis and allergic pruritus. | 2002 | Biol. Pharm. Bull. | pmid:12499660 |
Su BN et al. | Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. | 2002 | Planta Med. | pmid:12494342 |
Hou WC et al. | Yam (Dioscorea batatas) tuber mucilage exhibited antioxidant activities in vitro. | 2002 | Planta Med. | pmid:12494332 |
López-López A et al. | Fatty acid and sn-2 fatty acid composition in human milk from Granada (Spain) and in infant formulas. | 2002 | Eur J Clin Nutr | pmid:12494309 |
Wachira AM et al. | Effects of dietary fat source and breed on the carcass composition, n-3 polyunsaturated fatty acid and conjugated linoleic acid content of sheep meat and adipose tissue. | 2002 | Br. J. Nutr. | pmid:12493092 |
Ostrowska E et al. | Effects of dietary fat and conjugated linoleic acid on plasma metabolite concentrations and metabolic responses to homeostatic signals in pigs. | 2002 | Br. J. Nutr. | pmid:12493084 |
Coakley M et al. | Conjugated linoleic acid biosynthesis by human-derived Bifidobacterium species. | 2003 | J. Appl. Microbiol. | pmid:12492934 |
French MA et al. | Cholesterolaemic effect of palmitic acid in relation to other dietary fatty acids. | 2002 | Asia Pac J Clin Nutr | pmid:12492626 |
Hargrave KM et al. | Adipose depletion and apoptosis induced by trans-10, cis-12 conjugated linoleic Acid in mice. | 2002 | Obes. Res. | pmid:12490673 |
Rajakangas J et al. | Effects of conjugated linoleic acid on adenoma formation in the ApcMin mouse. | 2002 | IARC Sci. Publ. | pmid:12484222 |
Bougnoux P et al. | n-3 fatty acids and breast cancer. | 2002 | IARC Sci. Publ. | pmid:12484201 |
Chajès V et al. | Conjugated linoleic acid and the risk of breast cancer. | 2002 | IARC Sci. Publ. | pmid:12484165 |
Gabriëls M et al. | Improved thin-layer chromatographic method for the separation of cholesterol, egg phosphatidylcholine, and their degradation products. | 2002 Nov-Dec | J AOAC Int | pmid:12477189 |
Kristinsson HG | Acid-induced unfolding of flounder hemoglobin: evidence for a molten globular state with enhanced pro-oxidative activity. | 2002 | J. Agric. Food Chem. | pmid:12475287 |
Cooper DJ et al. | Role of beer lipid-binding proteins in preventing lipid destabilization of foam. | 2002 | J. Agric. Food Chem. | pmid:12475284 |
Zhang Y et al. | Cyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa. | 2002 | J. Agric. Food Chem. | pmid:12475274 |
Bassaganya-Riera J et al. | Colonic anti-inflammatory mechanisms of conjugated linoleic acid. | 2002 | Clin Nutr | pmid:12468364 |
Iwakiri Y et al. | Suppression of cyclooxygenase-2 and inducible nitric oxide synthase expression by conjugated linoleic acid in murine macrophages. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468265 |
Rainio A et al. | Cell-adhered conjugated linoleic acid regulates isomerization of linoleic acid by resting cells of Propionibacterium freudenreichii. | 2002 | Appl. Microbiol. Biotechnol. | pmid:12466891 |
Rossetto M et al. | Synergistic antioxidant effect of catechin and malvidin 3-glucoside on free radical-initiated peroxidation of linoleic acid in micelles. | 2002 | Arch. Biochem. Biophys. | pmid:12464277 |
Mir PS et al. | Growth, carcass characteristics, muscle conjugated linoleic acid (CLA) content, and response to intravenous glucose challenge in high percentage Wagyu, Wagyu x Limousin, and Limousin steers fed sunflower oil-containing diet. | 2002 | J. Anim. Sci. | pmid:12462269 |
Higashi-Okai K et al. | Potent suppressive activity of fresh and dried peels from Satsuma mandarin Citrus unshiu (Marcorv.) on hydroperoxide generation from oxidized linoleic acid. | 2002 | Phytother Res | pmid:12458489 |
Demizieux L et al. | Conjugated linoleic acid isomers in mitochondria: evidence for an alteration of fatty acid oxidation. | 2002 | J. Lipid Res. | pmid:12454273 |
Makristathis A et al. | Fatty acid composition and preservation of the Tyrolean Iceman and other mummies. | 2002 | J. Lipid Res. | pmid:12454266 |
Tischendorf F et al. | Effect of dietary conjugated linoleic acids on the distribution of fatty acids in serum lipoprotein fractions and different tissues of growing pigs. | 2002 | J Anim Physiol Anim Nutr (Berl) | pmid:12452973 |
Rosa A et al. | Antioxidant activity of capsinoids. | 2002 | J. Agric. Food Chem. | pmid:12452665 |
Liu Y et al. | [Chemical constituents analysis on anticonvulsive effect of three extracts from radix bupleuri]. | 2002 | Zhong Yao Cai | pmid:12451973 |
Kishino S et al. | Ricinoleic acid and castor oil as substrates for conjugated linoleic acid production by washed cells of Lactobacillus plantarum. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12450151 |
Belury M | Not all trans-fatty acids are alike: what consumers may lose when we oversimplify nutrition facts. | 2002 | J Am Diet Assoc | pmid:12449281 |
Taylor LJ et al. | Effect of occlusion on the percutaneous penetration of linoleic acid and glycerol. | 2002 | Int J Pharm | pmid:12433444 |
Ridsdill-Smith J et al. | Induced responses in clover to an herbaceous mite. | 2002 | Arch. Insect Biochem. Physiol. | pmid:12432518 |
Takahashi Y et al. | Dietary conjugated linoleic acid reduces body fat mass and affects gene expression of proteins regulating energy metabolism in mice. | 2002 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:12431407 |
Cardador-MartÃnez A et al. | Antioxidant activity in common beans (Phaseolus vulgaris L.). | 2002 | J. Agric. Food Chem. | pmid:12428946 |
Grechkin AN et al. | Role of structure and pH in cyclization of allene oxide fatty acids: implications for the reaction mechanism. | 2002 | Chem. Phys. Lipids | pmid:12426078 |
Craven J et al. | Does the rate of fat deposition influence the pharmacokinetic disposition of subcutaneously administered moxidectin and ivermectin in pigs? | 2002 | J. Vet. Pharmacol. Ther. | pmid:12423225 |
Demaree SR et al. | Conjugated linoleic acid differentially modifies fatty acid composition in subcellular fractions of muscle and adipose tissue but not adiposity of postweaning pigs. | 2002 | J. Nutr. | pmid:12421839 |
Lee JY and Hwang DH | Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12419306 |
Perfield JW et al. | Effects of dietary supplementation of rumen-protected conjugated linoleic acid in dairy cows during established lactation. | 2002 | J. Dairy Sci. | pmid:12416815 |
da Costa M et al. | Incorporation of [1-14C]-linoleic acid by LLC-WRC256 tumour cells. | 2002 | Cell Biochem. Funct. | pmid:12415566 |
RamÃrez-Expósito MJ et al. | Effects of exogenous fatty acids and cholesterol on aminopeptidase activities in rat astroglia. | 2002 | Cell Biochem. Funct. | pmid:12415561 |
Cherian G et al. | Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs. | 2002 | Poult. Sci. | pmid:12412926 |
Cetin I et al. | Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal-maternal relationships. | 2002 | Pediatr. Res. | pmid:12409524 |
Yamasaki M et al. | Potent cytotoxic effect of the trans10, cis12 isomer of conjugated linoleic acid on rat hepatoma dRLh-84 cells. | 2002 | Cancer Lett. | pmid:12406562 |
Minemoto Y et al. | Oxidation of linoleic acid encapsulated with soluble soybean polysaccharide by spray-drying. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12400679 |
Petkova-Andonova M et al. | CYP92B1, A cytochrome P450, expressed in petunia flower buds, that catalyzes monooxidation of long-chain fatty acids. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12400678 |
Freese R et al. | High intakes of vegetables, berries, and apples combined with a high intake of linoleic or oleic acid only slightly affect markers of lipid peroxidation and lipoprotein metabolism in healthy subjects. | 2002 | Am. J. Clin. Nutr. | pmid:12399265 |
Toyosaki T | Antioxidant effect of beta-carotene on lipid peroxidation and synergism with tocopherol in an emulsified linoleic acid model system. | 2002 | Int J Food Sci Nutr | pmid:12396467 |
Reed DW et al. | Mechanism of 1,4-dehydrogenation catalyzed by a fatty acid (1,4)-desaturase of Calendula officinalis. | 2002 | Eur. J. Biochem. | pmid:12383261 |
Fahey J et al. | Effects of calcium salts of fatty acids and calcium salt of methionine hydroxy analogue on plasma prostaglandin F2alpha metabolite and milk fatty acid profiles in late lactation Holstein-Friesian cows. | 2002 | Theriogenology | pmid:12374118 |
Cherian G et al. | Dietary CLA alters yolk and tissue FA composition and hepatic histopathology of laying hens. | 2002 | Lipids | pmid:12371745 |
Emken EA et al. | Effect of dietary conjugated linoleic acid (CLA) on metabolism of isotope-labeled oleic, linoleic, and CLA isomers in women. | 2002 | Lipids | pmid:12371744 |
Gatlin LA et al. | Conjugated linoleic acid in combination with supplemental dietary fat alters pork fat quality. | 2002 | J. Nutr. | pmid:12368402 |
Belury MA | Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action. | 2002 | J. Nutr. | pmid:12368384 |
Parmentier HK et al. | Different sources of dietary n-6 polyunsaturated fatty acids and their effects on antibody responses in chickens. | 2002 | Br. Poult. Sci. | pmid:12365510 |
Korotkova M et al. | Leptin levels in rat offspring are modified by the ratio of linoleic to alpha-linolenic acid in the maternal diet. | 2002 | J. Lipid Res. | pmid:12364559 |
Hulbert AJ et al. | Acyl composition of muscle membranes varies with body size in birds. | 2002 | J. Exp. Biol. | pmid:12364409 |
Mashek DG et al. | Metabolic fate of long-chain unsaturated fatty acids and their effects on palmitic acid metabolism and gluconeogenesis in bovine hepatocytes. | 2002 | J. Dairy Sci. | pmid:12362461 |
AbuGhazaleh AA et al. | Fatty acid profiles of milk and rumen digesta from cows fed fish oil, extruded soybeans or their blend. | 2002 | J. Dairy Sci. | pmid:12362459 |
Peterson DG et al. | Analysis of variation in cis-9, trans-11 conjugated linoleic acid (CLA) in milk fat of dairy cows. | 2002 | J. Dairy Sci. | pmid:12362448 |
Baumgard LH et al. | trans-10, cis-12 conjugated linoleic acid decreases lipogenic rates and expression of genes involved in milk lipid synthesis in dairy cows. | 2002 | J. Dairy Sci. | pmid:12362447 |
Rahman SM et al. | Short-term administration of conjugated linoleic acid reduces liver triglyceride concentration and phosphatidate phosphohydrolase activity in OLETF rats. | 2002 | J. Biochem. Mol. Biol. | pmid:12359092 |
Hornung E et al. | Formation of conjugated Delta11Delta13-double bonds by Delta12-linoleic acid (1,4)-acyl-lipid-desaturase in pomegranate seeds. | 2002 | Eur. J. Biochem. | pmid:12354116 |
Shimada Y et al. | Effects of Lentinus edodes on fatty acid and molecular species profiles of phosphatidylcholine in rats fed different levels of corn oil. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12353643 |
Itoh A et al. | Identification of a jasmonate-regulated allene oxide synthase that metabolizes 9-hydroperoxides of linoleic and linolenic acids. | 2002 | J. Biol. Chem. | pmid:12351632 |
Voorrips LE et al. | Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer. | 2002 | Am. J. Clin. Nutr. | pmid:12324303 |
Baylin A et al. | Adipose tissue biomarkers of fatty acid intake. | 2002 | Am. J. Clin. Nutr. | pmid:12324287 |
Goodfriend TL et al. | An oxidized derivative of linoleic acid affects aldosterone secretion by adrenal cells in vitro. | 2002 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12324236 |
O'Rourke K | Natural antimicrobials look promising. | 2002 | J. Am. Vet. Med. Assoc. | pmid:12322907 |
Fang JG et al. | Antioxidant effects of resveratrol and its analogues against the free-radical-induced peroxidation of linoleic acid in micelles. | 2002 | Chemistry | pmid:12298009 |
Yang L et al. | Production of conjugated linoleic acids through KOH-catalyzed dehydration of ricinoleic acid. | 2002 | Chem. Phys. Lipids | pmid:12270670 |
Du M et al. | Quality characteristics of irradiated ready-to-eat breast rolls from turkeys fed conjugated linoleic acid. | 2002 | Poult. Sci. | pmid:12269620 |
Harrell MD and Stimers JR | Differential effects of linoleic Acid metabolites on cardiac sodium current. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12235270 |
Newman JW et al. | The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. | 2002 | J. Lipid Res. | pmid:12235189 |
Blank C et al. | Optimizing DHA levels in piglets by lowering the linoleic acid to alpha-linolenic acid ratio. | 2002 | J. Lipid Res. | pmid:12235186 |
Clément L et al. | Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. | 2002 | J. Lipid Res. | pmid:12235171 |
Bouthegourd JC et al. | A CLA mixture prevents body triglyceride accumulation without affecting energy expenditure in Syrian hamsters. | 2002 | J. Nutr. | pmid:12221229 |
Gulcin I et al. | On the in vitro antioxidative properties of melatonin. | 2002 | J. Pineal Res. | pmid:12220332 |
Hayman A et al. | High intake, but not low intake, of CLA impairs weight gain in growing mice. | 2002 | Lipids | pmid:12216840 |
Corl BA et al. | Trans-7,cis-9 CLA is synthesized endogenously by delta9-desaturase in dairy cows. | 2002 | Lipids | pmid:12216839 |
Coles B et al. | Nitrolinoleate inhibits superoxide generation, degranulation, and integrin expression by human neutrophils: novel antiinflammatory properties of nitric oxide-derived reactive species in vascular cells. | 2002 | Circ. Res. | pmid:12215485 |
Freedman JE | Nitrated lipids: defining their bioactivity. | 2002 | Circ. Res. | pmid:12215483 |
Giesy JG et al. | Effect of dose of calcium salts of conjugated linoleic acid (CLA) on percentage and fatty acid content of milk fat in midlactation holstein cows. | 2002 | J. Dairy Sci. | pmid:12214995 |
Göbel C et al. | Oxylipin profiling in pathogen-infected potato leaves. | 2002 | Biochim. Biophys. Acta | pmid:12213493 |