Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Insulin Resistance D007333 99 associated lipids
Weight Gain D015430 101 associated lipids
Glioma D005910 112 associated lipids
Hypertension D006973 115 associated lipids
Inflammation D007249 119 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Edema D004487 152 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

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What functions are associated with Linoelaidic acid?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Volpe JJ and Obert KA Coordinate regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A synthase but not 3-hydroxy-3-methylglutaryl coenzyme A reductase in C-6 glia. 1981 Arch. Biochem. Biophys. pmid:6118099
Garcia Zevallos M and Farkas T Manipulation of plasma membrane physical state affects desaturase activity in rat lymphocytes. 1989 Arch. Biochem. Biophys. pmid:2786374
Glasgow WC and Eling TE Structure-activity relationship for potentiation of EGF-dependent mitogenesis by oxygenated metabolites of linoleic acid. 1994 Arch. Biochem. Biophys. pmid:8203891
KLEIN PD Linoleic acid and cholesterol metabolism in the rat. I. The effect of dietary fat and linoleic acid levels on the content and composition of cholesterol esters in liver and plasma. 1958 Arch. Biochem. Biophys. pmid:13560012
Jernerén F et al. Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus. 2010 Arch. Biochem. Biophys. pmid:20043865
Palmieri-Thiers C et al. Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies. 2011 Arch. Biochem. Biophys. pmid:21345329
Winterbourn CC et al. Chlorohydrin formation from unsaturated fatty acids reacted with hypochlorous acid. 1992 Arch. Biochem. Biophys. pmid:1321589
Ashida H et al. Effect of orally administered secondary autoxidation products of linoleic acid on carbohydrate metabolism in rat liver. 1987 Arch. Biochem. Biophys. pmid:3688880
Hennig B et al. Linoleic acid hydroperoxide increases the transfer of albumin across cultured endothelial monolayers. 1986 Arch. Biochem. Biophys. pmid:3729421
Wennman A et al. Kinetic investigation of the rate-limiting step of manganese- and iron-lipoxygenases. 2014 Arch. Biochem. Biophys. pmid:24857825
Behrends W et al. The glyoxysomal beta-oxidation system in cucumber seedlings: identification of enzymes required for the degradation of unsaturated fatty acids. 1988 Arch. Biochem. Biophys. pmid:3369861
Duthie GG et al. Lipid peroxidation, antioxidant concentrations, and fatty acid contents of muscle tissue from malignant hyperthermia-susceptible swine. 1992 Arch. Biochem. Biophys. pmid:1632646
KHAN NA Biological oxidation. I. The infrared studies on the lipoxidasecatalyzed oxidation of linoleic acid. 1953 Arch. Biochem. Biophys. pmid:13058378
TAPPEL AL The mechanism of the oxidation of unsaturated fatty acids catalyzed by hematin compounds. 1953 Arch. Biochem. Biophys. pmid:13058395
Kawajiri H et al. Arachidonic and linoleic acid metabolism in mouse intestinal tissue: evidence for novel lipoxygenase activity. 2002 Arch. Biochem. Biophys. pmid:11811948
SWELL L et al. ROLE OF THE LIVER IN THE METABOLISM OF EXOGENOUS CHOLESTEROL ESTERS. 1964 Arch. Biochem. Biophys. pmid:14236640
Fukuzawa K et al. Site-specific induction of lipid peroxidation by iron in charged micelles. 1988 Arch. Biochem. Biophys. pmid:2829725
Olveira G et al. Fatty acid supplements improve respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis. 2010 Arch. Bronconeumol. pmid:20045240
Ando H et al. Linoleic acid and alpha-linolenic acid lightens ultraviolet-induced hyperpigmentation of the skin. 1998 Arch. Dermatol. Res. pmid:9749992
Roguet R et al. In vivo distribution of linoleic acid in hairless rat skin following topical administration. 1986 Arch. Dermatol. Res. pmid:3789807
Vicanová J et al. Incorporation of linoleic acid by cultured human keratinocytes. 1999 Jul-Aug Arch. Dermatol. Res. pmid:10482010
Schwartz J et al. Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 long-chain polyunsaturated fatty acid synthesis in healthy infants: a double blinded randomised controlled trial. 2009 Arch. Dis. Child. pmid:19193660
MARTINET M [Vitamin F deficiency and hemorrhages in the rat embryo]. 1953 Arch. Fr. Pediatr. pmid:13058451
Ridsdill-Smith J et al. Induced responses in clover to an herbaceous mite. 2002 Arch. Insect Biochem. Physiol. pmid:12432518
Buckner JS and Hagen MM Triacylglycerol and phospholipid fatty acids of the silverleaf whitefly: composition and biosynthesis. 2003 Arch. Insect Biochem. Physiol. pmid:12761874
Narce M et al. [Chronologic studies of the effects of a hypoproteinic diet followed by an equilibrated diet on delta-6 and delta-5 desaturations of linoleic acid in liver microsomes in the rat]. 1986 Arch. Int. Physiol. Biochim. pmid:2430531
Laaksonen DE et al. Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. 2005 Arch. Intern. Med. pmid:15668366
Rasic-Milutinovic Z et al. Lower serum paraoxonase-1 activity is related to linoleic and docosahexanoic fatty acids in type 2 diabetic patients. 2012 Arch. Med. Res. pmid:22222492
Paraszkiewicz K et al. Lipid peroxidation in the fungus Curvularia lunata exposed to nickel. 2010 Arch. Microbiol. pmid:20047047
Gustafsson MC et al. Fatty-acid-displaced transcriptional repressor, a conserved regulator of cytochrome P450 102 transcription in Bacillus species. 2001 Arch. Microbiol. pmid:11734890
Rashid S et al. Topical omega-3 and omega-6 fatty acids for treatment of dry eye. 2008 Arch. Ophthalmol. pmid:18268213
Seddon JM et al. Dietary fat and risk for advanced age-related macular degeneration. 2001 Arch. Ophthalmol. pmid:11483088
Prout RE and Odutuga AA Fatty acid composition of neutral lipids and phospholipids of enamel and dentine from human molars. 1974 Arch. Oral Biol. pmid:12692911
Huang CB et al. Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms. 2010 Arch. Oral Biol. pmid:20541177
Siguel EN et al. Monitoring the optimal infusion of intravenous lipids. Detection of essential fatty acid deficiency. 1986 Arch. Pathol. Lab. Med. pmid:2875703
Vukovic N et al. An efficient synthesis and antioxidant properties of novel imino and amino derivatives of 4-hydroxy coumarins. 2010 Arch. Pharm. Res. pmid:20191339
Gwak HS and Chun IK Effect of vehicles and enhancers on the in vitro skin penetration of aspalatone and its enzymatic degradation across rat skins. 2001 Arch. Pharm. Res. pmid:11794538
Canetti L et al. Linoleic and alpha linolenic acids ameliorate streptozotocin-induced diabetes in mice. 2014 Arch. Physiol. Biochem. pmid:24320056
Heiskanen KM et al. Effect of linoleic acid, linoleic acid anilide, and arachidonic acid on the expression of adhesion molecules on human neutrophils. 1997 Arch. Toxicol. pmid:9332699
Sakai K et al. Fatty acid compositions of plasma lipids in atopic dermatitis/asthma patients. 1994 Arerugi pmid:8147707
Hashimoto A et al. [Effect of dietary alpha-linolenate/linoleate balance on the formation of leukotrienes in rat polymorphonuclear leukocytes]. 1988 Arerugi pmid:2901255
Bonanome A et al. Effect of dietary monounsaturated and polyunsaturated fatty acids on the susceptibility of plasma low density lipoproteins to oxidative modification. 1992 Arterioscler. Thromb. pmid:1558840
Reaven PD et al. Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans. 1994 Arterioscler. Thromb. pmid:8148354
Ettinger WH et al. Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells. 1994 Arterioscler. Thromb. pmid:8274481
Won JC et al. Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19965780
Belkner J et al. Expression of 12/15-lipoxygenase attenuates intracellular lipid deposition during in vitro foam cell formation. 2005 Arterioscler. Thromb. Vasc. Biol. pmid:15681297
Nagelin MH et al. 12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1. 2008 Arterioscler. Thromb. Vasc. Biol. pmid:18635820
Tsimikas S et al. LDL isolated from Greek subjects on a typical diet or from American subjects on an oleate-supplemented diet induces less monocyte chemotaxis and adhesion when exposed to oxidative stress. 1999 Arterioscler. Thromb. Vasc. Biol. pmid:9888874
Salomaa VV et al. Association of the fatty acid composition of serum phospholipids with hemostatic factors. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9157941
Mennen L et al. Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9555866
Chancharme L et al. Cholesteryl ester hydroperoxide lability is a key feature of the oxidative susceptibility of small, dense LDL. 1999 Arterioscler. Thromb. Vasc. Biol. pmid:10073990
Augé N et al. Uptake of 13-hydroperoxylinoleic acid by cultured cells. 1999 Arterioscler. Thromb. Vasc. Biol. pmid:10195919
Gniwotta C et al. Prostaglandin F2-like compounds, F2-isoprostanes, are present in increased amounts in human atherosclerotic lesions. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9409317
Rodríguez-Lee M et al. Fatty acids cause alterations of human arterial smooth muscle cell proteoglycans that increase the affinity for low-density lipoprotein. 2006 Arterioscler. Thromb. Vasc. Biol. pmid:16239593
Natarajan R and Nadler JL Lipid inflammatory mediators in diabetic vascular disease. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15166011
Loscalzo J et al. Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. 1987 Sep-Oct Arteriosclerosis pmid:3675304
Hennig B et al. Exposure to free fatty acid increases the transfer of albumin across cultured endothelial monolayers. 1984 Sep-Oct Arteriosclerosis pmid:6477300
Rationale of the diet-heart statement of the American Heart Association. Report of the AHA nutrition committee. 1982 Mar-Apr Arteriosclerosis pmid:7039581
Goodnight SH et al. Polyunsaturated fatty acids, hyperlipidemia, and thrombosis. 1982 Mar-Apr Arteriosclerosis pmid:7039582
Kaduce TL et al. Linoleic acid metabolism and prostaglandin production by cultured bovine pulmonary artery endothelial cells. 1982 Sep-Oct Arteriosclerosis pmid:6751307
Nicolosi RJ et al. Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. 1997 Artery pmid:9209699
Timur S et al. An enzyme electrode based on lipoxygenase immobilized in gelatin for selective determination of essential fatty acids. 2003 Artif Cells Blood Substit Immobil Biotechnol pmid:12906313
Lucchi L et al. Changes in conjugated linoleic acid and palmitoleic acid are correlated to retinol levels in chronic renal failure in both hemodialysis and conservative treatment patients. 2005 Artif Organs pmid:15854218
Canudas N et al. Photodegradation of bezafibrate in aqueous media. Studies of its in vitro phototoxicity. 1996 Arzneimittelforschung pmid:8842340
Canudas N et al. Photosensitizing properties of Actarit, an antirheumatic drug. 2008 Arzneimittelforschung pmid:18540480
Arutselvan N et al. Antioxidative activity of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid. 1999 Arzneimittelforschung pmid:10514898
JUNG A [Experimental basis of therapy with essential, highly unsaturated fatty acids]. 1949-1950 Arztl Monatshefte Berufl Fortbild pmid:24541383
French MA et al. Cholesterolaemic effect of palmitic acid in relation to other dietary fatty acids. 2002 Asia Pac J Clin Nutr pmid:12492626
Daud AZ et al. The trans fatty acid content in human milk and its association with maternal diet among lactating mothers in Malaysia. 2013 Asia Pac J Clin Nutr pmid:23945414
Liu Q et al. Dietary n-6:n-3 ratio and Vitamin E improve motility characteristics in association with membrane properties of boar spermatozoa. 2017 Mar-Apr Asian J. Androl. pmid:26763547
Turci F et al. Free-radical chemistry as a means to evaluate lunar dust health hazard in view of future missions to the moon. 2015 Astrobiology pmid:25946080
Tilvis RS et al. Fatty acids of plasma lipids, red cells and platelets in Alzheimer's disease and vascular dementia. 1987 Atherosclerosis pmid:3619988
Sneddon AA et al. Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants. 2003 Atherosclerosis pmid:14642406
Labayen I et al. Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. 2011 Atherosclerosis pmid:21550607
Huang YS et al. Most biological effects of zinc deficiency corrected by gamma-linolenic acid (18: 3 omega 6) but not by linoleic acid (18: 2 omega 6). 1982 Atherosclerosis pmid:6279122
Garelnabi M et al. Dietary oxidized linoleic acid lowers triglycerides via APOA5/APOClll dependent mechanisms. 2008 Atherosclerosis pmid:18243209
Allman-Farinelli MA et al. Comparison of the effects of two low fat diets with different alpha-linolenic:linoleic acid ratios on coagulation and fibrinolysis. 1999 Atherosclerosis pmid:9920517
HÃ¥versen L et al. Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. 2009 Atherosclerosis pmid:18599066
Ramasamy S et al. Oxidized lipid-mediated alterations in proteoglycan metabolism in cultured pulmonary endothelial cells. 1996 Atherosclerosis pmid:8645361
van Greevenbroek MM et al. Effects of saturated, mono-, and polyunsaturated fatty acids on the secretion of apo B containing lipoproteins by Caco-2 cells. 1996 Atherosclerosis pmid:8678919
Jones PJ et al. High-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humans. 2015 Atherosclerosis pmid:25528432
Válek J et al. Serum linoleic acid and cardiovascular death in postinfarction middle-aged men. 1985 Atherosclerosis pmid:3994777
Benadé AJ et al. Plasma low density lipoprotein composition in relation to atherosclerosis in nutritionally defined Vervet monkeys. 1988 Atherosclerosis pmid:3145748
Waddington EI et al. Fatty acid oxidation products in human atherosclerotic plaque: an analysis of clinical and histopathological correlates. 2003 Atherosclerosis pmid:12618275
Weldon S et al. Conjugated linoleic acid and atherosclerosis: no effect on molecular markers of cholesterol homeostasis in THP-1 macrophages. 2004 Atherosclerosis pmid:15136056
Naqvi AZ et al. Dietary fatty acids and peripheral artery disease in adults. 2012 Atherosclerosis pmid:22552117
Ohrvall M et al. Malondialdehyde concentration in plasma is inversely correlated to the proportion of linoleic acid in serum lipoprotein lipids. 1994 Atherosclerosis pmid:7980703
Lee KN et al. Conjugated linoleic acid and atherosclerosis in rabbits. 1994 Atherosclerosis pmid:7980704
Kurushima H et al. Comparison of hypocholesterolemic effects induced by dietary linoleic acid and oleic acid in hamsters. 1995 Atherosclerosis pmid:7605390
Singer P et al. A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. 1990 Atherosclerosis pmid:2146966
Shiina T et al. Eicosapentaenoic acid and docosahexaenoic acid suppress the proliferation of vascular smooth muscle cells. 1993 Atherosclerosis pmid:8141854
Liu SX et al. Oxidized cholesterol in oxidized low density lipoprotein may be responsible for the inhibition of LPS-induced nitric oxide production in macrophages. 1998 Atherosclerosis pmid:9544730
Fuhrman B et al. Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties. 1994 Atherosclerosis pmid:7840815
Ramasamy S et al. Proteoglycans and endothelial barrier function: effect of linoleic acid exposure to porcine pulmonary artery endothelial cells. 1993 Atherosclerosis pmid:8292102
Lux CA et al. Hypersusceptibility of neutrophil granulocytes towards lethal action of free fatty acids contained in enzyme-modified atherogenic low density lipoprotein. 2009 Atherosclerosis pmid:19423111
Abraham RD et al. Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. 1990 Atherosclerosis pmid:2112389
Fei J et al. ω-6 lipids regulate PPAR turnover via reciprocal switch between PGC-1 alpha and ubiquitination. 2012 Atherosclerosis pmid:22464285
Litvinov D et al. Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice. 2010 Atherosclerosis pmid:19880116
Artwohl M et al. Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure. 2009 Atherosclerosis pmid:18597758
Lecerf J et al. Variations in the fatty acid composition of lipid classes from lipoproteins in elderly women. 1993 Atherosclerosis pmid:8457263