Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Linoelaidic acid?

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What functions are associated with Linoelaidic acid?


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What lipids are associated with Linoelaidic acid?

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What genes are associated with Linoelaidic acid?

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What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

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All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Kapich A et al. Coupling of manganese peroxidase-mediated lipid peroxidation with destruction of nonphenolic lignin model compounds and 14C-labeled lignins. 1999 Biochem. Biophys. Res. Commun. pmid:10334942
Sakurada K et al. cis-9,10-Methylenehexadecanoic acid inhibits contractility and actomyosin ATPase activity of guinea pig myocardium. 2000 Biochem. Biophys. Res. Commun. pmid:10913372
Takahashi K et al. Ester-exchange catalyzed by lipase modified with polyethylene glycol. 1985 Biochem. Biophys. Res. Commun. pmid:4052065
Nakagawa Y and Waku K Selective inhibition of free arachidonic acid production in activated alveolar macrophages by calmodulin antagonists. 1988 Biochem. Biophys. Res. Commun. pmid:3142466
Blee E and Schuber F Enantioselectivity of the hydrolysis of linoleic acid monoepoxides catalyzed by soybean fatty acid epoxide hydrolase. 1992 Biochem. Biophys. Res. Commun. pmid:1520297
Tripathi AK et al. A physiochemical mechanism of hemozoin (beta-hematin) synthesis by malaria parasite. 2002 Biochem. Biophys. Res. Commun. pmid:11779214
Breton M et al. Linoleate incorporation into rat liver membranes phospholipids: effect on plasma membrane ATPase activities and physical properties. 1983 Biochem. Biophys. Res. Commun. pmid:6230079
Nagao K et al. The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty rats. 2003 Biochem. Biophys. Res. Commun. pmid:12788078
Klein A et al. The effect of linoleic acid on the sensitivity of human lymphocytes to cortisol and their capacity to catabolize the steroid. 1987 Biochem. Cell Biol. pmid:3620157
Usha S et al. Mitogenic stimulation of primary cultures of lung epithelial cells by linoleic acid. 1996 Biochem. Cell Biol. pmid:9213439
Sharpe M et al. Ligation, inhibition, and activation of cytochrome c oxidase by fatty acids. 1997 Biochem. Cell Biol. pmid:9192076
Howie A et al. Effects of cholesterol on viability and (n - 6) fatty acid metabolism in cultured human monocyte-like cells (U937). 1992 Biochem. Cell Biol. pmid:1335730
Stewart JM et al. Comparisons of the effects of temperature on the liver fatty acid binding proteins from hibernator and nonhibernator mammals. 1998 Biochem. Cell Biol. pmid:10099779
Geer BW et al. The effect of dietary ethanol on the composition of lipids of Drosophila melanogaster larvae. 1986 Biochem. Genet. pmid:2938574
Weber EJ Variation in corn (Zea mays L.) for fatty acid compositions of triglycerides and phospholipids. 1983 Biochem. Genet. pmid:6838482
Fletcher JE et al. Fatty acid uptake and catecholamine-stimulated phospholipid metabolism in immortalized airway epithelial cells established from primary cultures. 1990 Biochem. Int. pmid:2241999
Marra CA and de Alaniz MJ Mineralocorticoids modify rat liver delta 6 desaturase activity and other parameters of lipid metabolism. 1990 Biochem. Int. pmid:1981670
Pal S and Davis PJ Effects of different types of polyunsaturated fatty acids on cholesterol esterification in human fibroblasts. 1991 Biochem. Int. pmid:1789795
Byczkowski JZ et al. Proline hydroxylation by soybean lipoxygenase. 1991 Biochem. Int. pmid:1815499
Poirier H et al. Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine. 2001 Biochem. J. pmid:11284737
MAHADEVAN S et al. STUDIES ON METABOLISM OF VITAMIN A. 3. THE MODE OF ABSORPTION OF VITAMIN A ESTERS IN THE LIVING RAT. 1963 Biochem. J. pmid:14071526
MAHADEVAN S et al. STUDIES ON METABOLISM OF VITAMIN A. 4. STUDIES ON THE MODE OF ABSORPTION OF VITAMIN A BY RAT INTESTINE IN VITRO. 1963 Biochem. J. pmid:14071527
HORGAN VJ et al. Toxicity of autoxidized squalene and linoleic acid, and of simpler peroxides, in relation to toxicity of radiation. 1957 Biochem. J. pmid:13488907
López-Nicolás JM et al. Use of 'soluble lipids' for biochemical processes: linoleic acid-cyclodextrin inclusion complexes in aqueous solutions. 1995 Biochem. J. pmid:7755559
LEAT WM FATTY ACID COMPOSITION OF THE SERUM LIPIDS OF PIGS GIVEN DIFFERENT AMOUNTS OF LINOLEIC ACID. 1963 Biochem. J. pmid:14097364
Enser M and Roberts JL The regulation of hepatic stearoyl-coenzyme A desaturase in obese-hyperglycaemic (ob/ob) mice by food intake and the fatty acid composition of the diet. 1982 Biochem. J. pmid:6128973
Schlame M and Rüstow B Lysocardiolipin formation and reacylation in isolated rat liver mitochondria. 1990 Biochem. J. pmid:2268287
HARRIS RV and JAMES AT CONVERSION OF OLEIC ACID INTO LINOLEIC ACID BY A SUBCELLULAR SYSTEM OF CHLORELLA VULGARIS. 1965 Biochem. J. pmid:14346083
Jones AL et al. Rapid induction of microsomal delta 12(omega 6)-desaturase activity in chilled Acanthamoeba castellanii. 1993 Biochem. J. pmid:8250841
Moore JP et al. The predominant polyphenol in the leaves of the resurrection plant Myrothamnus flabellifolius, 3,4,5 tri-O-galloylquinic acid, protects membranes against desiccation and free radical-induced oxidation. 2005 Biochem. J. pmid:15355309
Carpenter KL et al. Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper. 1994 Biochem. J. pmid:7999000
Clouet P et al. Pathway of alpha-linolenic acid through the mitochondrial outer membrane in the rat liver and influence on the rate of oxidation. Comparison with linoleic and oleic acids. 1989 Biochem. J. pmid:2597132
FRAENKEL G and BLEWETT M The role of linoleic acid, alpha-tocopherol and other fat-soluble substances in the nutrition of an insect (Ephestia kuehniella Lep.). 1946 Biochem. J. pmid:20989456
Williams JP et al. The role of phosphatidylcholine in fatty acid exchange and desaturation in Brassica napus L. leaves. 2000 Biochem. J. pmid:10861220
Stymne S and Stobart AK Biosynthesis of gamma-linolenic acid in cotyledons and microsomal preparations of the developing seeds of common borage (Borago officinalis). 1986 Biochem. J. pmid:3028375
Lang I et al. A lipoxygenase with linoleate diol synthase activity from Nostoc sp. PCC 7120. 2008 Biochem. J. pmid:18031288
Reid JC and Husbands DR Oxidative metabolism of long-chain fatty acids in mitochondria from sheep and rat liver. Evidence that sheep conserve linoleate by limiting its oxidation. 1985 Biochem. J. pmid:3977825
Patel RP et al. Reduction of Cu(II) by lipid hydroperoxides: implications for the copper-dependent oxidation of low-density lipoprotein. 1997 Biochem. J. pmid:9065759
Butler M et al. Unsaturated fatty acids enhance cell yields and perturb the energy metabolism of an antibody-secreting hybridoma. 1997 Biochem. J. pmid:9065785
Swida A et al. Redox state of quinone affects sensitivity of Acanthamoeba castellanii mitochondrial uncoupling protein to purine nucleotides. 2008 Biochem. J. pmid:18402555
Babizhayev MA et al. L-carnosine (beta-alanyl-L-histidine) and carcinine (beta-alanylhistamine) act as natural antioxidants with hydroxyl-radical-scavenging and lipid-peroxidase activities. 1994 Biochem. J. pmid:7998987
JAMES AT et al. THE BIOSYNTHESIS OF RICINOLEIC ACID. 1965 Biochem. J. pmid:14340094
Thuillier P et al. Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors. 2002 Biochem. J. pmid:12069687
Calder PC et al. Triacylglycerol metabolism by lymphocytes and the effect of triacylglycerols on lymphocyte proliferation. 1994 Biochem. J. pmid:8141773
Schaloske R et al. Fatty acids induce release of Ca2+ from acidosomal stores and activate capacitative Ca2+ entry in Dictyostelium discoideum. 1998 Biochem. J. pmid:9601085
Hughes RK et al. Characterization of authentic recombinant pea-seed lipoxygenases with distinct properties and reaction mechanisms. 1998 Biochem. J. pmid:9639559
Finn RD et al. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. 2009 Biochem. J. pmid:18778245
Naval J et al. Alternative route for the biosynthesis of polyunsaturated fatty acids in K562 cells. 1993 Biochem. J. pmid:8489510
Kang JX et al. The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells. 1992 Biochem. J. pmid:1323271
Koshiishi I et al. Radical scavenger can scavenge lipid allyl radicals complexed with lipoxygenase at lower oxygen content. 2006 Biochem. J. pmid:16396633
Luévano-Martínez LA et al. A critical tyrosine residue determines the uncoupling protein-like activity of the yeast mitochondrial oxaloacetate carrier. 2012 Biochem. J. pmid:22236206
Arslan P et al. cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes. 1984 Biochem. J. pmid:6696740
Rayner BS et al. Regio- and stereo-chemical oxidation of linoleic acid by human myoglobin and hydrogen peroxide: Tyr(103) affects rate and product distribution. 2004 Biochem. J. pmid:15035657
Stymne S and Stobart AK The biosynthesis of triacylglycerols in microsomal preparations of developing cotyledons of sunflower (Helianthus annuus L.). 1984 Biochem. J. pmid:6743281
Gavigan SJ and Knight BL The effects of low-density lipoprotein and cholesterol on acyl-coenzyme A: cholesterol acyltransferase activity in membranes from cultured human fibroblasts. 1983 Biochem. J. pmid:6651782
O'donnell VB and Kühn H Co-oxidation of NADH and NADPH by a mammalian 15-lipoxygenase: inhibition of lipoxygenase activity at near-physiological NADH concentrations. 1997 Biochem. J. pmid:9355754
Haines KA et al. The leukotriene B4 paradox: neutrophils can, but will not, respond to ligand-receptor interactions by forming leukotriene B4 or its omega-metabolites. 1987 Biochem. J. pmid:3032161
Griffiths G et al. Delta 6- and delta 12-desaturase activities and phosphatidic acid formation in microsomal preparations from the developing cotyledons of common borage (Borago officinalis). 1988 Biochem. J. pmid:3421914
FRAENKEL G and BLEWETT M The effect of linoleic acid and arachidonic acid on the development of the flour moth, Ephestia kuehniella. 1947 Biochem. J. pmid:20343449
Jones AL et al. Temperature-induced membrane-lipid adaptation in Acanthamoeba castellanii. 1993 Biochem. J. pmid:8439295
Fraenkel G and Blewett M Linoleic acid and arachidonic acid in the metabolism of two insects, Ephestia kuehniella (Lep.) and Tenebrio molitor (Col.). 1947 Biochem. J. pmid:16748194
Ando H et al. Intracellular composition of fatty acid affects the processing and function of tyrosinase through the ubiquitin-proteasome pathway. 2006 Biochem. J. pmid:16232122
Brodhun F et al. PpoC from Aspergillus nidulans is a fusion protein with only one active haem. 2010 Biochem. J. pmid:19878096
Grechkin AN et al. The lipoxygenase pathway in tulip (Tulipa gesneriana): detection of the ketol route. 2000 Biochem. J. pmid:11085944
Huang YS et al. Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. 1994 Biochem. Med. Metab. Biol. pmid:7910749
Poisson JP et al. Effect of salt-loading and spontaneous hypertension on in vitro metabolism of [1-14C]linoleic and [2-14C]dihomo-gamma-linolenic acids. 1993 Biochem. Med. Metab. Biol. pmid:8382502
Maehira F Inhibitory effect of lipid hydroperoxide on cholesteryl esterases. 1994 Biochem. Mol. Biol. Int. pmid:8019427
Oulhaj H et al. Synthesis and distribution of rat Sertoli cell proteoglycans are modulated by linoleate and vitamin E. 1993 Biochem. Mol. Biol. Int. pmid:8275018
Romanini D et al. Absorption and fluorescence spectra of polyene antibiotics in the presence of human serum albumin. 1998 Biochem. Mol. Biol. Int. pmid:9556221
Jump DB et al. Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. 2011 Biochem. Pharmacol. pmid:21184748
Murphy MG et al. Effects of membrane polyunsaturated fatty acids on opiate peptide inhibition of basal and prostaglandin E1-stimulated cyclic AMP formation in intact N1E-115 neuroblastoma cells. 1987 Biochem. Pharmacol. pmid:2825714
Bomalaski JS et al. Alteration of uptake and distribution of eicosanoid precursor fatty acids by aspirin. 1987 Biochem. Pharmacol. pmid:3117063
Medini L et al. Diets rich in n-9, n-6 and n-3 fatty acids differentially affect the generation of inositol phosphates and of thromboxane by stimulated platelets, in the rabbit. 1990 Biochem. Pharmacol. pmid:2105092
Demant EJ and Wassermann K Doxorubicin induced alterations in lipid metabolism of cultured myocardial cells. 1985 Biochem. Pharmacol. pmid:4004891
Kashfi K and Rigas B Non-COX-2 targets and cancer: expanding the molecular target repertoire of chemoprevention. 2005 Biochem. Pharmacol. pmid:15949789
Clark DL and Queener SF Effects of diabetes mellitus on renal fatty acid activation and desaturation. 1985 Biochem. Pharmacol. pmid:4074391
Kawashima Y et al. Reduction by clofibric acid of serum arachidonic acid in rats. Effect on the acyl composition of renal phospholipids. 1992 Biochem. Pharmacol. pmid:1610396
Blond JP et al. Effect of fenofibrate treatment on linoleic acid desaturation in liver of obese Zucker rats. 1989 Biochem. Pharmacol. pmid:2764996
Hudson EA et al. Kinetics of the inhibition of tumour growth in mice by eicosapentaenoic acid-reversal by linoleic acid. 1993 Biochem. Pharmacol. pmid:8517859
Sauer LA et al. Polyunsaturated fatty acids, melatonin, and cancer prevention. 2001 Biochem. Pharmacol. pmid:11377374
Allgayer H et al. Superoxide, hydroxyl and fatty acid radical scavenging by aminosalicylates. Direct evaluation with electron spin resonance spectroscopy. 1992 Biochem. Pharmacol. pmid:1310851
Larsen LN et al. Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. 1998 Biochem. Pharmacol. pmid:9514074
Goldmacher VS Immobilization of protein molecules on liposomes. Anchorage by artificially bound unsaturated hydrocarbon tails. 1983 Biochem. Pharmacol. pmid:6189496
Masini E et al. Histamine release from rat mast cells induced by metabolic activation of polyunsaturated fatty acids into free radicals. 1990 Biochem. Pharmacol. pmid:1690007
Vaughan PF and Ball SG The effect of unsaturated fatty acids on sodium nitroprusside stimulation of guanylate cyclase in the human astrocytoma clone, D384, and the human neuroblastoma clone, NB1-G. 1990 Biochem. Pharmacol. pmid:1968340
Castańeda-Hernández G Presence of endogenous digitalis-like activity in mammalian heart not due to fatty acids. 1987 Biochem. Pharmacol. pmid:3036154
Reynolds CH Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid. 1988 Biochem. Pharmacol. pmid:3144281
Murakami A et al. New class of linoleic acid metabolites biosynthesized by corn and rice lipoxygenases: suppression of proinflammatory mediator expression via attenuation of MAPK- and Akt-, but not PPARgamma-, dependent pathways in stimulated macrophages. 2005 Biochem. Pharmacol. pmid:16143312
Altmann R et al. 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells. 2007 Biochem. Pharmacol. pmid:17604003
Verwoert I et al. The molecular basis of the high linoleic acid content in Petunia seed oil: analysis of a seed-specific linoleic acid mutant. 2000 Biochem. Soc. Trans. pmid:11171150
Kamisaka Y and Noda N Intracellular transport of phosphatidic acid and phosphatidylcholine into lipid bodies: use of fluorescent lipids to study lipid-body formation in an oleaginous fungus. 2000 Biochem. Soc. Trans. pmid:11171185
Grechkin AN et al. Lipoxygenase pathway in tulip: biosynthesis of ketols. 2000 Biochem. Soc. Trans. pmid:11171230
Kashulin PA et al. Extremely rapid effects of polyunsaturated fatty acids and N-acetylglucosamine on free-radical metabolism in cultured potato plant cells. 2000 Biochem. Soc. Trans. pmid:11171236
Nuñez A et al. Anaerobic lipoxygenase activity from Chlorella pyrenoidosa. 2000 Biochem. Soc. Trans. pmid:11171268
Bates D Lipids and multiple sclerosis. 1989 Biochem. Soc. Trans. pmid:2546837
Sanderson P et al. Dietary fish oil diminishes the antigen presentation activity of rat dendritic cells. 1997 Biochem. Soc. Trans. pmid:9191396
Campbell FM and Dutta-Roy AK Asymmetric distribution of the plasma membrane fatty acid-binding protein (FABPpm) in the human placenta. 1996 Biochem. Soc. Trans. pmid:8736907
Chaloner C et al. Effect of oral supplementation with micronutrient antioxidants on trans fatty acid content of lipoproteins in healthy humans. 1996 Biochem. Soc. Trans. pmid:8736849
Colquhoun A and Curi R Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. 1997 Biochem. Soc. Trans. pmid:9450108
Lloyd D et al. Adaptive changes in yeast membranes: catabolite repression and oxygen. 1983 Biochem. Soc. Trans. pmid:6617968