| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
Linoelaidic acid
Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
Cross Reference
Introduction
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoelaidic acid?
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoelaidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Linoelaidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (1)
- Am. J. Physiol., Cell Physiol. (1)
- Hypertension (1)
- Others (3)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol., Cell Physiol. (1)
- Plant Cell (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoelaidic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoelaidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shin SC et al. | Development and biopharmaceutical evaluation of quinupramine-EVA matrix containing penetration enhancer for the enhanced transdermal absorption in rats. | 2007 | Pharm Dev Technol | pmid:17963142 |
| Yildiztekin F et al. | Antioxidant, anticholinesterase and tyrosinase inhibition activities, and fatty acids of Crocus mathewii - A forgotten endemic angiosperm of Turkey. | 2016 | Pharm Biol | pmid:26810584 |
| Tattersall AL and Wilkins RJ | Effects of hexosamines and omega-3/omega-6 fatty acids on pH regulation by interleukin 1-treated isolated bovine articular chondrocytes. | 2008 | Pflugers Arch. | pmid:18204856 |
| Saxena NC | Inhibition of GABA(A) receptor (GABAR) currents by arachidonic acid in HEK 293 cells stably transfected with alpha1beta2gamma2 GABAR subunits. | 2000 | Pflugers Arch. | pmid:10954324 |
| Retamal MA et al. | Biphasic effect of linoleic acid on connexin 46 hemichannels. | 2011 | Pflugers Arch. | pmid:21360038 |
| Cheguru P et al. | Adipocyte differentiation-specific gene transcriptional response to C18 unsaturated fatty acids plus insulin. | 2012 | Pflugers Arch. | pmid:22218833 |
| Bueno AA et al. | Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue. | 2008 | Pflugers Arch. | pmid:17717684 |
| Yu T et al. | Activation of oral trigeminal neurons by fatty acids is dependent upon intracellular calcium. | 2012 | Pflugers Arch. | pmid:22644615 |
| Yehuda S et al. | Fatty acids and brain peptides. | 1998 | Peptides | pmid:9493877 |
| Chirkov VA et al. | [Correction of intracellular metabolism in acute pneumonia in young children]. | 1985 | Pediatriia | pmid:4047863 |
| Derambure S et al. | [Platelet aggregation and platelet and plasma fatty acid levels in the child with migraine. Apropos of 40 case reports]. | 1983 | Pediatrie | pmid:6674921 |
| Fuchs GJ et al. | Effect of dietary fat on cardiovascular risk factors in infancy. | 1994 | Pediatrics | pmid:8165074 |
| Montalto MB et al. | Nutrient intakes of formula-fed infants and infants fed cow's milk. | 1985 | Pediatrics | pmid:3969338 |
| de Meijer VE et al. | Parenteral fish oil as monotherapy for patients with parenteral nutrition-associated liver disease. | 2009 | Pediatr. Surg. Int. | pmid:18828026 |
| Llanos A et al. | Infants with intrauterine growth restriction have impaired formation of docosahexaenoic acid in early neonatal life: a stable isotope study. | 2005 | Pediatr. Res. | pmid:16189202 |
| Parsons HG et al. | Supplemental calories improve essential fatty acid deficiency in cystic fibrosis patients. | 1988 | Pediatr. Res. | pmid:3211621 |
| Larqué E et al. | Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats. | 2000 | Pediatr. Res. | pmid:10674359 |
| Cogo PE et al. | Simultaneous measurement of the rates of appearance of palmitic and linoleic acid in critically ill infants. | 1997 | Pediatr. Res. | pmid:9029635 |
| Rogiers V et al. | Abnormal fatty acid turnover in the phospholipids of the red blood cell membranes of cystic fibrosis patients (in vitro study). | 1984 | Pediatr. Res. | pmid:6472942 |
| Spitz DR et al. | The effect of monosaturated and polyunsaturated fatty acids on oxygen toxicity in cultured cells. | 1992 | Pediatr. Res. | pmid:1408477 |
| Cogo PE et al. | Endogenous surfactant metabolism in critically ill infants measured with stable isotope labeled fatty acids. | 1999 | Pediatr. Res. | pmid:10022597 |
| Hoving EB et al. | Gestational age dependency of essential fatty acids in cord plasma cholesterol esters and triglycerides. | 1994 | Pediatr. Res. | pmid:8047383 |
| Cetin I et al. | Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal-maternal relationships. | 2002 | Pediatr. Res. | pmid:12409524 |
| Farrell PM et al. | Fatty acid abnormalities in cystic fibrosis. | 1985 | Pediatr. Res. | pmid:3918287 |
| Carnielli VP et al. | The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. | 1996 | Pediatr. Res. | pmid:8798265 |
| Szitanyi P et al. | Metabolism of 13C-labeled linoleic acid in newborn infants during the first week of life. | 1999 | Pediatr. Res. | pmid:10231862 |
| Olivi O et al. | [A new and original therapy for seborrheic dermatitis]. | 1986 May-Jun | Pediatr Med Chir | pmid:2947051 |
| Rotta AT et al. | Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems. | 2003 | Pediatr Crit Care Med | pmid:12749658 |
| Louw L and van der Westhuizen JP | Correlation between histopathology and linoleic acid levels in five meningioma types. | 1993 | Pathol. Res. Pract. | pmid:8321745 |
| Yamaki T et al. | Acute and reversible fatty metamorphosis of cultured rat hepatocytes. | 1997 Feb-Mar | Pathol. Int. | pmid:9088028 |
| Ohmori H et al. | Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and metastases via the expression of high-mobility group box 1. | 2010 | Pathobiology | pmid:20616616 |
| Ohmori H et al. | Linoleic-acid-induced growth suppression induces quiescent cancer cell nests in nude mice. | 2008 | Pathobiology | pmid:18580068 |
| Thornhill JA et al. | Pathways for the influx of molecules into cercariae of Schistosoma mansoni during skin penetration. | 2010 | Parasitology | pmid:20128942 |
| Henderson WR and Chi EY | Cytotoxic activity of 13-hydroxyoctadecadienoic acid against Toxoplasma gondii. | 1992 | Parasitology | pmid:1461675 |
| Rahuman AA et al. | Mosquito larvicidal activity of oleic and linoleic acids isolated from Citrullus colocynthis (Linn.) Schrad. | 2008 | Parasitol. Res. | pmid:18688644 |
| Sabolovic D et al. | Alterations of uninfected red blood cells in malaria. | 1994 | Parasitol. Res. | pmid:8153129 |
| Perumalsamy H et al. | Larvicidal activity and possible mode of action of four flavonoids and two fatty acids identified in Millettia pinnata seed toward three mosquito species. | 2015 | Parasit Vectors | pmid:25928224 |
| Champakaew D et al. | Assessment of Angelica sinensis (Oliv.) Diels as a repellent for personal protection against mosquitoes under laboratory and field conditions in northern Thailand. | 2016 | Parasit Vectors | pmid:27357395 |
| Neri S et al. | Association of alpha-interferon and acetyl cysteine in patients with chronic C hepatitis. | 2000 | Panminerva Med | pmid:11218623 |
| Steinberg WM et al. | Cerulein induces hyperplasia of the pancreas in a rat model of chronic pancreatic insufficiency. | 1987 | Pancreas | pmid:3628223 |
| Kataoka K et al. | Pathophysiologic studies of experimental chronic pancreatitis in rats induced by injection of zein-oleic acid-linoleic acid solution into the pancreatic duct. | 1998 | Pancreas | pmid:9548669 |
| Ben Bacha A et al. | Proteolytic cleavage of ostrich and turkey pancreatic lipases: production of an active N-terminal domain. | 2007 | Pancreas | pmid:17895836 |
| Littman ED et al. | Role of protein kinase C isoenzymes in fatty acid stimulation of insulin secretion. | 2000 | Pancreas | pmid:10766451 |
| Morita Y et al. | Involvement of lipid peroxidation in free fatty acid-induced isolated rat pancreatic acinar cell injury. | 1998 | Pancreas | pmid:9821180 |
| Ruparel S et al. | Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation. | 2012 | Pain | pmid:22633978 |
| Green DP et al. | Role of endogenous TRPV1 agonists in a postburn pain model of partial-thickness injury. | 2013 | Pain | pmid:23891895 |
| Ruparel S et al. | Oxidized linoleic acid metabolite-cytochrome P450 system (OLAM-CYP) is active in biopsy samples from patients with inflammatory dental pain. | 2013 | Pain | pmid:23867730 |
| Jarvis MF | Cytochrome P450 mediated linoleic acid metabolism in peripheral inflammatory nociception. | 2012 | Pain | pmid:22681878 |
| Virtanen JK et al. | Dietary intake of polyunsaturated fatty acids and risk of hip fracture in men and women. | 2012 | Osteoporos Int | pmid:22270860 |
| Jacquot C et al. | Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases. | 2008 | Org. Biomol. Chem. | pmid:18972057 |
| Joshi S et al. | Synthesis, antibacterial activity and mode of action of novel linoleic acid-dipeptide-spermidine conjugates. | 2012 | Org. Biomol. Chem. | pmid:22986997 |
| Mihaljević B et al. | Linoleic acid peroxidation vs. isomerization: a biomimetic model of free radical reactivity in the presence of thiols. | 2011 | Org. Biomol. Chem. | pmid:21442126 |
| Akeo K et al. | Effects of superoxide dismutase and catalase on growth of retinal pigment epithelial cells in vitro following addition of linoleic acid or linoleic acid hydroperoxide. | 1996 | Ophthalmic Res. | pmid:8726672 |
| Trimborn M et al. | Linoleic acid cytotoxicity to bovine lens epithelial cells: influence of albumin on linoleic acid uptake and cytotoxicity. | 2000 Mar-Jun | Ophthalmic Res. | pmid:10754440 |
| Schumann T et al. | Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment. | 2015 | Oncotarget | pmid:25968567 |
| Noguchi M et al. | Effects of eicosapentaenoic and docosahexaenoic acid on cell growth and prostaglandin E and leukotriene B production by a human breast cancer cell line (MDA-MB-231). | 1995 Nov-Dec | Oncology | pmid:7478431 |
| Noguchi M et al. | The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. | 1995 Jul-Aug | Oncology | pmid:7777237 |
| Zuo X et al. | Oxidative metabolism of linoleic acid modulates PPAR-beta/delta suppression of PPAR-gamma activity. | 2006 | Oncogene | pmid:16288226 |
| Herrera JA et al. | Prevention of preeclampsia by linoleic acid and calcium supplementation: a randomized controlled trial. | 1998 | Obstet Gynecol | pmid:9540946 |
| Dailey MJ et al. | Nutrient specific feeding and endocrine effects of jejunal infusions. | 2010 | Obesity (Silver Spring) | pmid:20134410 |
| Pinnick KE et al. | Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. | 2008 | Obesity (Silver Spring) | pmid:18239594 |
| Alvheim AR et al. | Dietary linoleic acid elevates endogenous 2-AG and anandamide and induces obesity. | 2012 | Obesity (Silver Spring) | pmid:22334255 |
| Guyenet SJ | High-fat diets: details matter. | 2009 | Obesity (Silver Spring) | pmid:19553921 |
| Figueras M et al. | Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status. | 2011 | Obesity (Silver Spring) | pmid:20885391 |
| Hargrave KM et al. | Adipose depletion and apoptosis induced by trans-10, cis-12 conjugated linoleic Acid in mice. | 2002 | Obes. Res. | pmid:12490673 |
| Thurmond DC et al. | Time-dependent effects of progressive gamma-linolenate feeding on hyperphagia, weight gain, and erythrocyte fatty acid composition during growth of Zucker obese rats. | 1993 | Obes. Res. | pmid:16353349 |
| Miner JL et al. | Conjugated linoleic acid (CLA), body fat, and apoptosis. | 2001 | Obes. Res. | pmid:11316347 |
| Hargrave KM et al. | Influence of dietary conjugated linoleic Acid and fat source on body fat and apoptosis in mice. | 2004 | Obes. Res. | pmid:15483208 |
| Lasa A et al. | Effects of trans-10,cis-12 CLA on liver size and fatty acid oxidation under energy restriction conditions in hamsters. | 2011 | Nutrition | pmid:20619605 |
| Ghosh S et al. | Role of dietary fatty acids and acute hyperglycemia in modulating cardiac cell death. | 2004 | Nutrition | pmid:15474882 |
| Jory J | Abnormal fatty acids in Canadian children with autism. | 2016 | Nutrition | pmid:26746679 |
| Aronis A et al. | Lipotoxic effects of triacylglycerols in J774.2 macrophages. | 2008 | Nutrition | pmid:18165129 |
| Bourre JM et al. | Composition of nerve biomembranes and nutritional fatty acids. | 1989 Jul-Aug | Nutrition | pmid:2577681 |
| RodrÃguez-Cruz M et al. | Effect of dietary levels of corn oil on maternal arachidonic acid synthesis and fatty acid composition in lactating rats. | 2009 | Nutrition | pmid:18849148 |
| Webb AN et al. | Tolerability and safety of olive oil-based lipid emulsion in critically ill neonates: a blinded randomized trial. | 2008 Nov-Dec | Nutrition | pmid:18619813 |
| Burke PA et al. | Conditionally essential fatty acid deficiencies in end-stage liver disease. | 1999 | Nutrition | pmid:10319364 |
| Fukushima M et al. | Effects of a mixture of organisms, Lactobacillus acidophilus or Streptococcus faecalis on delta6-desaturase activity in the livers of rats fed a fat- and cholesterol-enriched diet. | 1999 | Nutrition | pmid:10355850 |
| Hilakivi-Clarke L et al. | The influence of maternal diet on breast cancer risk among female offspring. | 1999 | Nutrition | pmid:10355854 |
| Yamasaki M et al. | Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets. | 2003 | Nutrition | pmid:12507636 |
| Cury-Boaventura MF et al. | Comparative toxicity of oleic acid and linoleic acid on Raji cells. | 2005 | Nutrition | pmid:15797684 |
| Stark KD et al. | Fatty acid compositions of serum phospholipids of postmenopausal women: a comparison between Greenland Inuit and Canadians before and after supplementation with fish oil. | 2002 Jul-Aug | Nutrition | pmid:12093443 |
| Wolfe RR et al. | Dietary fat composition alters pulmonary function in pigs. | 2002 Jul-Aug | Nutrition | pmid:12093447 |
| Ramesh G et al. | Effect of essential fatty acids on tumor cells. | 1992 Sep-Oct | Nutrition | pmid:1330107 |
| Nordenström J et al. | Metabolic effects of infusion of a structured-triglyceride emulsion in healthy subjects. | 1995 May-Jun | Nutrition | pmid:8541695 |
| Rahman SM et al. | Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats. | 2001 | Nutrition | pmid:11377131 |
| Moore CS et al. | Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women. | 2006 | Nutrition | pmid:17027436 |
| Kim KH and Park HS | Dietary supplementation of conjugated linoleic acid reduces colon tumor incidence in DMH-treated rats by increasing apoptosis with modulation of biomarkers. | 2003 | Nutrition | pmid:12921888 |
| Nagao K et al. | The 10trans, 12cis isomer of conjugated linoleic acid promotes energy metabolism in OLETF rats. | 2003 Jul-Aug | Nutrition | pmid:12831953 |
| Decsi T and Koletzko B | Effects of protein-energy malnutrition and human immunodeficiency virus-1 infection on essential fatty acid metabolism in children. | 2000 | Nutrition | pmid:10869902 |
| Peterson DB | Long-chain fatty acids and cardiovascular disease risk in non-insulin-dependent diabetes. | 1998 | Nutrition | pmid:9583379 |
| Reed S et al. | Dietary zinc deficiency affects blood linoleic acid: dihomo-γ-linolenic acid (LA:DGLA) ratio; a sensitive physiological marker of zinc status in vivo (Gallus gallus). | 2014 | Nutrients | pmid:24658588 |
| Moran LJ et al. | Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in Overweight and Obese Women Undertaking in Vitro Fertilisation. | 2016 | Nutrients | pmid:26742065 |
| Valenzuela R et al. | Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing. | 2015 | Nutrients | pmid:26247968 |
| Renner L et al. | Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid, linoleic acid, phytanic acid and the combination of various fatty acids on proliferation and cytokine expression of bovine peripheral blood mononuclear cells. | 2013 | Nutrients | pmid:23857174 |
| Ebrahimi M et al. | Effects of oils rich in linoleic and α-linolenic acids on fatty acid profile and gene expression in goat meat. | 2014 | Nutrients | pmid:25255382 |
| Chilton FH et al. | Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. | 2014 | Nutrients | pmid:24853887 |
| Fekete K and Decsi T | Long-chain polyunsaturated fatty acids in inborn errors of metabolism. | 2010 | Nutrients | pmid:22254065 |
| Cerf ME and Herrera E | High Fat Diet Administration during Specific Periods of Pregnancy Alters Maternal Fatty Acid Profiles in the Near-Term Rat. | 2016 | Nutrients | pmid:26742067 |
| Cinelli G et al. | Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile. | 2016 | Nutrients | pmid:27314385 |
| Position of double bond of trans isomers of linoleic acid affects fatty acid desaturation and elongation. | 1992 | Nutr. Rev. | pmid:1570085 |