Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Spirochaetales Infections D013145 2 associated lipids
Circoviridae Infections D018173 2 associated lipids
Leptospirosis D007922 2 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Lymphopenia D008231 2 associated lipids
Onchocerciasis D009855 1 associated lipids
Malaria, Cerebral D016779 1 associated lipids
Liposarcoma D008080 1 associated lipids
Gastroschisis D020139 1 associated lipids
Fat Necrosis D005218 1 associated lipids
Facial Nerve Diseases D005155 1 associated lipids
Child Nutrition Disorders D015362 1 associated lipids
Refeeding Syndrome D055677 1 associated lipids
Pellagra D010383 1 associated lipids
Refractive Errors D012030 1 associated lipids
Carcinoma, Krebs 2 D002287 1 associated lipids
Encopresis D004688 1 associated lipids
Enuresis D004775 1 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

Download all related citations
Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
Rosenthal MD and Whitehurst MC Selective effects of isomeric cis and trans fatty acids on fatty acyl delta 9 and delta 6 desaturation by human skin fibroblasts. 1983 Biochim. Biophys. Acta pmid:6615875
WEENINK RO and SHORLAND FB THE ISOLATION OF TRANS-3-HEXADECENOIC ACID FROM THE LIPIDS OF RED-CLOVER (TRIFOLIUM PRATENSE) LEAVES. 1964 Biochim. Biophys. Acta pmid:14250500
Emken EA et al. Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans. 1993 Biochim. Biophys. Acta pmid:8399342
Haas TA et al. Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity. 1990 Biochim. Biophys. Acta pmid:2155665
Melton JL et al. Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs. 1987 Biochim. Biophys. Acta pmid:3651483
Cheng Z et al. The effect of supplementation with n-6 polyunsaturated fatty acids on 1-, 2- and 3-series prostaglandin F production by ovine uterine epithelial cells. 2005 Biochim. Biophys. Acta pmid:16140575
LEVIN E et al. OCCURRENCE AND LOCALIZATION OF ALPHA-LINOLENIC ACID CONTAINING GALACTOLIPIDS IN THE PHOTOSYNTHETIC APPARATUS OF ANABAENA VARIABILLIS. 1964 Biochim. Biophys. Acta pmid:14230825
STEIN O and STEIN Y METABOLISM OF FATTY ACIDS IN THE ISOLATED PERFUSED RAT HEART. 1963 Biochim. Biophys. Acta pmid:14085937
Borgeson CE et al. Characterization of the delta 12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate. 1990 Biochim. Biophys. Acta pmid:2248971
Lam YY et al. Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21570480
Laakso S Inhibition of lipid peroxidation by casein. Evidence of molecular encapsulation of 1,4-pentadiene fatty acids. 1984 Biochim. Biophys. Acta pmid:6419780
Villasuso AL et al. Culture age and carbamoylcholine increase the incorporation of endogenously synthesized linoleic acid in lipids of Trypanosoma cruzi epimastigotes. 2005 Biochim. Biophys. Acta pmid:16024291
Grossman S et al. Methylmercuric iodide modification of lipoxygenase-1. Effects on the anaerobic reaction and pigment bleaching. 1984 Biochim. Biophys. Acta pmid:6424722
Miyashita K et al. Preferential hydrolysis of monohydroperoxides of linoleoyl and linolenoyl triacylglycerol by pancreatic lipase. 1990 Biochim. Biophys. Acta pmid:2386795
Yang XB et al. Sulfation of a polysaccharide produced by a marine filamentous fungus Phoma herbarum YS4108 alters its antioxidant properties in vitro. 2005 Biochim. Biophys. Acta pmid:16054758
Kühn H et al. The stoichiometry of oxygen uptake and conjugated diene formation during the dioxygenation of linoleic acid by the pure reticulocyte lipoxygenase. Evidence for aerobic hydroperoxidase activity. 1986 Biochim. Biophys. Acta pmid:3006782
Yamamoto T et al. Purification of the two forms of the high-molecular-weight neutral proteinase ingensin from rat liver. 1986 Biochim. Biophys. Acta pmid:3015226
Funk CD et al. Effects of selenium-deficient diets on the production of prostaglandins and other oxygenated metabolites of arachidonic acid and linoleic acid by rat and rabbit aortae. 1987 Biochim. Biophys. Acta pmid:3115301
Walstra P et al. Demonstration of a 12-lipoxygenase activity in bovine polymorphonuclear leukocytes. 1987 Biochim. Biophys. Acta pmid:3115302
Colard O et al. Hydrolysis of endogenous phospholipids by rat platelet phospholipase A2: ether or acyl bond and polar head group selectivity. 1987 Biochim. Biophys. Acta pmid:3115303
Igarashi M and Miyazawa T The growth inhibitory effect of conjugated linoleic acid on a human hepatoma cell line, HepG2, is induced by a change in fatty acid metabolism, but not the facilitation of lipid peroxidation in the cells. 2001 Biochim. Biophys. Acta pmid:11239819
Zhou L et al. Tissue uptake and interconversion of plasma unesterified 14C linoleic acid in the guinea pig. 1997 Biochim. Biophys. Acta pmid:9434134
Hagve TA and Christophersen BO In vitro effects of alpha-bromopalmitate on metabolism of essential fatty acids studied in isolated rat hepatocytes: sex differences. 1987 Biochim. Biophys. Acta pmid:3099848
López-Nicolás JM et al. Kinetic characteristics of the enzymatic conversion in presence of cyclodextrins: study of the oxidation of polyunsaturated fatty acids by lipoxygenase. 1997 Biochim. Biophys. Acta pmid:9295158
Brasitus TA and Dudeja PK Effect of hypothyroidism on the lipid composition and fluidity of rat colonic apical plasma membranes. 1988 Biochim. Biophys. Acta pmid:3128322
BENNETT JR THE ESTERIFICATION OF CHOLESTEROL BY RAT-LIVER PREPARATIONS. 1963 Biochim. Biophys. Acta pmid:14067620
Jernerén F et al. Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus. 2010 Biochim. Biophys. Acta pmid:20045744
Liffmann SM and Lynch RD Incorporation of [3H]acetate into L-cell lipids. Dependence on method of linoleate administration and timing of the pulse label. 1981 Biochim. Biophys. Acta pmid:7295748
Fitch CD et al. A role for linoleic acid in erythrocytes infected with Plasmodium berghei. 2000 Biochim. Biophys. Acta pmid:11113630
Leekumjorn S et al. The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes. 2009 Biochim. Biophys. Acta pmid:19371719
Park Y and Pariza MW The effects of dietary conjugated nonadecadienoic acid on body composition in mice. 2001 Biochim. Biophys. Acta pmid:11731328
Peters JM et al. Influence of conjugated linoleic acid on body composition and target gene expression in peroxisome proliferator-activated receptor alpha-null mice. 2001 Biochim. Biophys. Acta pmid:11731333
Mizushina Y et al. Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro. 1996 Biochim. Biophys. Acta pmid:8809118
Memoli S et al. Diffusible melanin-related metabolites are potent inhibitors of lipid peroxidation. 1997 Biochim. Biophys. Acta pmid:9187303
Nijssen JG and van den Bosch H Cytosol-stimulated remodeling of phosphatidylcholine in rat lung microsomes. 1986 Biochim. Biophys. Acta pmid:3947653
Kryvi H et al. Effects of essential fatty acid deficiency on mitochondria and peroxisomes in rat hepatocytes with special reference to a partially hydrogenated fish oil diet. 1986 Biochim. Biophys. Acta pmid:3947675
De Villiers M and Lochner A Mitochondrial Ca2+ fluxes: role of free fatty acids, acyl-CoA and acylcarnitine. 1986 Biochim. Biophys. Acta pmid:3955069
HEALD PJ et al. LIPID METABOLISM AND THE LAYING HEN. II. THE NATURE AND QUANTITIES OF THE FREE FATTY ACIDS OF THE PLASMA DURING THE ONSET OF LAYING. 1964 Biochim. Biophys. Acta pmid:14124752
Minich DM et al. Bile diversion in rats leads to a decreased plasma concentration of linoleic acid which is not due to decreased net intestinal absorption of dietary linoleic acid. 1999 Biochim. Biophys. Acta pmid:10216285
van Kuiken BA and Behnke WD The activation of porcine pancreatic lipase by cis-unsaturated fatty acids. 1994 Biochim. Biophys. Acta pmid:7918595
Roy P et al. Superoxide generation by lipoxygenase in the presence of NADH and NADPH. 1994 Biochim. Biophys. Acta pmid:7918597
Bakken AM et al. The activities of acyl-CoA hydrolase in lysate and subcellular fractions of human blood platelets in relation to activities of acyl-CoA:1-acyl-lysophospholipid acyltransferase. 1994 Biochim. Biophys. Acta pmid:7918598
del Carmen Boyano-Adánez M et al. Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. 1994 Biochim. Biophys. Acta pmid:7918608
Yu Y et al. Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. 2002 Biochim. Biophys. Acta pmid:12020636
Earles SM et al. Metabolism of oxidized linoleic acid: characterization of 13-hydroxyoctadecadienoic acid dehydrogenase activity from rat colonic tissue. 1991 Biochim. Biophys. Acta pmid:1998735
Schick PK et al. Arachidonate synthesis and uptake in isolated guinea-pig megakaryocytes and platelets. 1984 Biochim. Biophys. Acta pmid:6433984
Garg ML et al. Desaturation of linoleic acid in the small bowel is increased by short-term fasting and by dietary content of linoleic acid. 1992 Biochim. Biophys. Acta pmid:1606171
Ek BA et al. Fatty acid binding proteins reduce 15-lipoxygenase-induced oxygenation of linoleic acid and arachidonic acid. 1997 Biochim. Biophys. Acta pmid:9187305
Hansen O Characterization of fatty acid interaction with ouabain and vanadate binding to (Na+ + K+)-activated ATPase. 1989 Biochim. Biophys. Acta pmid:2554979
Mahmmoud YA and Christensen SB Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. 2011 Biochim. Biophys. Acta pmid:21767529
Regdel D et al. On the reaction specificity of the lipoxygenase from tomato fruits. 1994 Biochim. Biophys. Acta pmid:7905748
Hulea SA et al. Bilirubin sensitized photooxidation of human plasma low density lipoprotein. 1996 Biochim. Biophys. Acta pmid:8982266
Bull AW et al. Conjugation of the linoleic acid oxidation product, 13-oxooctadeca-9,11-dienoic acid, a bioactive endogenous substrate for mammalian glutathione transferase. 2002 Biochim. Biophys. Acta pmid:12031293
Gargouri M and Legoy MD The kinetic behaviour of a two-enzyme system in biphasic media: coupling hydrolysis and lipoxygenation. 1997 Biochim. Biophys. Acta pmid:9048899
Hansen HS et al. Apparent in vivo retroconversion of dietary arachidonic to linoleic acid in essential fatty acid-deficient rats. 1986 Biochim. Biophys. Acta pmid:3092868
Bolton-Smith C et al. The effect of dietary linoleic acid on rat platelet sialic acid. 1989 Biochim. Biophys. Acta pmid:2775771
Chambaz J et al. Essential fatty acid uptake and esterification in primary culture of rat hepatocytes. 1986 Biochim. Biophys. Acta pmid:3092869
Kitagawa S et al. Activation of bovine platelets induced by long-chain unsaturated fatty acids at just below their lytic concentrations, and its mechanism. 1984 Biochim. Biophys. Acta pmid:6435686
Zevenbergen JL and Houtsmuller UM Effect of dietary fats on linoleic acid metabolism. A radiolabel study in rats. 1989 Biochim. Biophys. Acta pmid:2713382
Hu ZY et al. cAMP inhibits linoleic acid-induced growth by antagonizing p27(kip1) depletion, but not interfering with the extracellular signal-regulated kinase or AP-1 activities. 1998 Biochim. Biophys. Acta pmid:9784625
Kanazawa K et al. The effect of orally administered secondary autoxidation products of linoleic acid on the activity of detoxifying enzymes in the rat liver. 1986 Biochim. Biophys. Acta pmid:3768385
Byczkowski JZ and Kulkarni AP Vanadium redox cycling, lipid peroxidation and co-oxygenation of benzo(a)pyrene-7,8-dihydrodiol. 1992 Biochim. Biophys. Acta pmid:1315157
DeMar JC et al. Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult rats. 2006 Biochim. Biophys. Acta pmid:16920015
Urquhart P et al. The effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells. 2002 Biochim. Biophys. Acta pmid:11880240
Yorek MA et al. Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. 1984 Biochim. Biophys. Acta pmid:6089899
Loidl-Stahlhofen A et al. Generation of alpha-hydroxyaldehydic compounds in the course of lipid peroxidation. 1994 Biochim. Biophys. Acta pmid:8025124
Ramanadham S et al. Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations. 2002 Biochim. Biophys. Acta pmid:11923099
Pirtle IL et al. Molecular cloning and functional expression of the gene for a cotton Delta-12 fatty acid desaturase (FAD2). 2001 Biochim. Biophys. Acta pmid:11750064
Hajarine M and Lagarde M Studies on polyenoic acid incorporation into human platelet lipid stores: interactions with linoleic and arachidonic acids. 1986 Biochim. Biophys. Acta pmid:3719006
Christon R et al. Modification of fluidity and lipid-protein relationships in pig intestinal brush-border membrane by dietary essential fatty acid deficiency. 1989 Biochim. Biophys. Acta pmid:2538158
Macías P et al. Hemin and hemeprotein bleaching during linoleic acid oxidation by lipoxygenases. 1991 Biochim. Biophys. Acta pmid:1903070
Simpson RJ and Peters TJ Transport of Fe2+ across lipid bilayers: possible role of free fatty acids. 1987 Biochim. Biophys. Acta pmid:3828339
Chen Q et al. Hydrolysis of triacylglycerol arachidonic and linoleic acid ester bonds by human pancreatic lipase and carboxyl ester lipase. 1989 Biochim. Biophys. Acta pmid:2503032
Thomson AB et al. Feeding rats a diet enriched with saturated fatty acids prevents the inhibitory effects of acute and chronic ethanol exposure on the in vitro uptake of hexoses and lipids. 1991 Biochim. Biophys. Acta pmid:1854796
Yavin E et al. Metabolic conversion of intra-amniotically-injected deuterium-labeled essential fatty acids by fetal rats following maternal n-3 fatty acid deficiency. 2014 Biochim. Biophys. Acta pmid:24960100
KHAN NA Infrared studies on initiation of the autoxidation of some fatty acid esters with and without light-sensitized chlorophyll, ultraviolet light and lipoxidase. 1955 Biochim. Biophys. Acta pmid:14363243
Minich DM et al. Biliary phospholipid secretion is not required for intestinal absorption and plasma status of linoleic acid in mice. 1999 Biochim. Biophys. Acta pmid:10526224
Hayakawa F et al. DNA cleavage reaction and linoleic acid peroxidation induced by tea catechins in the presence of cupric ion. 1997 Biochim. Biophys. Acta pmid:9305782
Mizushina Y et al. The inhibitory action of fatty acids on DNA polymerase beta. 1997 Biochim. Biophys. Acta pmid:9367179
Schieberle P et al. A study of oxygen isotope scrambling in the enzymic and non-enzymic oxidation of linoleic acid. 1981 Biochim. Biophys. Acta pmid:6798993
Doderer A et al. Purification and characterization of two lipoxygenase isoenzymes from germinating barley. 1992 Biochim. Biophys. Acta pmid:1554746
Croft KD et al. Differential inhibition of thromboxane B2 and leukotriene B4 biosynthesis by two naturally occurring acetylenic fatty acids. 1987 Biochim. Biophys. Acta pmid:2822134
Dufour C and Loonis M Flavonoids and their oxidation products protect efficiently albumin-bound linoleic acid in a model of plasma oxidation. 2007 Biochim. Biophys. Acta pmid:17428609
Stimers JR et al. Effects of linoleic acid metabolites on electrical activity in adult rat ventricular myocytes. 1999 Biochim. Biophys. Acta pmid:10366778
Gaquerel E et al. Evidence for oxylipin synthesis and induction of a new polyunsaturated fatty acid hydroxylase activity in Chondrus crispus in response to methyljasmonate. 2007 Biochim. Biophys. Acta pmid:17428728
Subbaiah PV et al. Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. 2011 Biochim. Biophys. Acta pmid:20920595
Zhou L and Nilsson A Fasting increases tissue uptake and interconversion of plasma unesterified linoleic acid in guinea pigs. 1999 Biochim. Biophys. Acta pmid:9989279
Barceló-Coblijn G et al. Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. 2003 Biochim. Biophys. Acta pmid:12782153
Sasaki T et al. Effects of dietary docosahexaenoic acid on surface molecules involved in T cell proliferation. 1999 Biochim. Biophys. Acta pmid:9989281
Konkel A and Schunck WH Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. 2011 Biochim. Biophys. Acta pmid:20869469
Lodge JK et al. Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopy. 1995 Biochim. Biophys. Acta pmid:7766690
Spiteller P et al. Aldehydic lipid peroxidation products derived from linoleic acid. 2001 Biochim. Biophys. Acta pmid:11325611
Coté GG and Brody S Circadian rhythms in Neurospora crassa: a clock mutant, prd-1, is altered in membrane fatty acid composition. 1987 Biochim. Biophys. Acta pmid:2889471
Jaudszus A et al. Cis-9,trans-11-CLA exerts anti-inflammatory effects in human bronchial epithelial cells and eosinophils: comparison to trans-10,cis-12-CLA and to linoleic acid. 2005 Biochim. Biophys. Acta pmid:16303327
Chander A and Fisher AB Choline-phosphate cytidyltransferase activity and phosphatidylcholine synthesis in rat granular pneumocytes are increased with exogenous fatty acids. 1988 Biochim. Biophys. Acta pmid:2893643
Cominacini L et al. Determination of lipid hydroperoxides in native low-density lipoprotein by a chemiluminescent flow-injection assay. 1993 Biochim. Biophys. Acta pmid:8418885
de Athayde Moncorvo Collado A et al. Cholesterol induces surface localization of polyphenols in model membranes thus enhancing vesicle stability against lysozyme, but reduces protection of distant double bonds from reactive-oxygen species. 2016 Biochim. Biophys. Acta pmid:27063609
Christophersen BO et al. Studies on the regulation of arachidonic acid synthesis in isolated rat liver cells. 1982 Biochim. Biophys. Acta pmid:6812639
Bordet JC et al. Hydroperoxides produced by n-6 lipoxygenation of arachidonic and linoleic acids potentiate synthesis of prostacyclin related compounds. 1988 Biochim. Biophys. Acta pmid:3124885
Tabachnick M and Korcek L Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. 1986 Biochim. Biophys. Acta pmid:2869786