Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Fatty Liver D005234 48 associated lipids
Fat Necrosis D005218 1 associated lipids
Facial Nerve Diseases D005155 1 associated lipids
Esophagitis, Peptic D004942 4 associated lipids
Epilepsy, Temporal Lobe D004833 4 associated lipids
Enuresis D004775 1 associated lipids
Encopresis D004688 1 associated lipids
Embolism, Fat D004620 4 associated lipids
Edema D004487 152 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Sauerwald TU et al. Polyunsaturated fatty acid supply with human milk. Physiological aspects and in vivo studies of metabolism. 2000 Adv. Exp. Med. Biol. pmid:11065079
Del Prado M et al. Contribution of dietary and newly formed arachidonic acid to milk secretion in women on low fat diets. 2000 Adv. Exp. Med. Biol. pmid:11065105
Lance A et al. 13C-linoleic acid oxidation and transfer into milk in lactating women with contrasting body mass index. 2000 Adv. Exp. Med. Biol. pmid:11065106
Egashira Y et al. Dietary linoleic acid suppresses gene expression of rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) and increases quinolinic acid in serum. 2003 Adv. Exp. Med. Biol. pmid:15206789
Sharma HM et al. Effect of MAK-4 and MAK-5 on endothelial cell and soyabean lipoxygenase-induced LDL oxidation. 1994 Adv. Exp. Med. Biol. pmid:7771286
Brash AR et al. Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues. 1999 Adv. Exp. Med. Biol. pmid:10667314
Buchanan MR Linoleic acid metabolites in health and disease. 1999 Adv. Exp. Med. Biol. pmid:10667369
Greene JF and Hammock BD Toxicity of linoleic acid metabolites. 1999 Adv. Exp. Med. Biol. pmid:10667370
Jira W and Spiteller G Dramatic increase of linoleic acid peroxidation products by aging, atherosclerosis, and rheumatoid arthritis. 1999 Adv. Exp. Med. Biol. pmid:10667371
Tanaka R et al. Prenylated acylphloroglucinol derivatives: isoprenomics-based design, syntheses and antioxidative activities. 2012 Adv. Exp. Med. Biol. pmid:22259110
Louw L et al. Impairment in the fatty acid composition of keloids. 1997 Adv. Exp. Med. Biol. pmid:9547645
Louw L et al. Linoleic acid levels in cutaneous tumors with different growth patterns as an additional sensitive diagnostic feature. 1997 Adv. Exp. Med. Biol. pmid:9547646
Louw L et al. The importance of linoleic acid in the total fatty acid compositions of benign and malignant neuroglial tumors. 1997 Adv. Exp. Med. Biol. pmid:9547647
Agostoni C et al. Long-chain polyunsaturated fatty acid concentrations in human hindmilk are constant throughout twelve months of lactation. 2001 Adv. Exp. Med. Biol. pmid:11787678
Demmelmair H et al. Investigation of long-chain polyunsaturated fatty acid metabolism in lactating women by means of stable isotope techniques. 2001 Adv. Exp. Med. Biol. pmid:11787680
Fidler N et al. Fat content and fatty acid composition of fresh, pasteurized, or sterilized human milk. 2001 Adv. Exp. Med. Biol. pmid:11787720
Kinsella JE Alpha-linolenic acid: functions and effects on linoleic acid metabolism and eicosanoid-mediated reactions. 1991 Adv. Food Nutr. Res. pmid:1681826
Hoffmann P and Förster W Influence of dietary linoleic acid content on blood pressure regulation in salt-loaded rats (with special reference to the prostaglandin system). 1981 Adv. Lipid Res. pmid:6798829
Ringertz B et al. High dietary linoleic acid content modulates neutrophil function in rats. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960199
Eling TE et al. Modulation of EGF cell signaling tyrosine phosphorylation by linoleic acid metabolites. 1995 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7537437
Buchanan MR et al. Vessel wall reactivity and 13-hydroxy-octadecadienoic acid synthesis. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2526487
Eling TE and Glasgow WC Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism. 1991 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:1825423
Gyllenhammar H et al. Dietary essential fatty acid deficiency in rats is accompanied by impairments in neutrophil function and leukotriene B4 generation. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2823572
Loesberg C et al. Superoxide anion production by alveolar macrophages of guinea pigs fed different diets in a model of atopy. 1988 Agents Actions pmid:2833083
Iversen L et al. Linoleic acid and dihomogammalinolenic acid inhibit leukotriene B4 formation and stimulate the formation of their 15-lipoxygenase products by human neutrophils in vitro. Evidence of formation of antiinflammatory compounds. 1991 Agents Actions pmid:1659156
Loesberg C et al. Effects of dietary poly-unsaturated fatty acids on tracheal histaminergic and cholinergic responsiveness in experimental models of bronchial hypersensitivity and hyperreactivity. 1987 Agents Actions pmid:2895570
Kramer HJ et al. The role of renal prostaglandins in the regulation of renal sodium excretion. 1987 Agents Actions Suppl. pmid:3481214
Henricks PA et al. Epithelium-derived linoleic acid metabolites modulate airway smooth muscle function. 1990 Agents Actions Suppl. pmid:2080762
Pamplona R et al. Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse. 1999 Aging (Milano) pmid:10337442
Kirpich IA et al. Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. 2013 Alcohol pmid:23453163
Pirozhkov SV et al. Effect of chronic consumption of ethanol and vitamin E on fatty acid composition and lipid peroxidation in rat heart tissue. 1992 Jul-Aug Alcohol pmid:1637499
Horrobin DF Essential fatty acids, prostaglandins, and alcoholism: an overview. 1987 Alcohol. Clin. Exp. Res. pmid:3032012
Buko VU Beef fat prevents alcoholic liver disease in the rat. 1990 Alcohol. Clin. Exp. Res. pmid:2221295
Tsukamoto S et al. Effects of bezafibrate on ethanol oxidation in rats. 1996 Alcohol. Clin. Exp. Res. pmid:8986210
Cunnane SC Hepatic triacylglycerol accumulation induced by ethanol and carbon tetrachloride: interactions with essential fatty acids and prostaglandins. 1987 Alcohol. Clin. Exp. Res. pmid:3032013
Szebeni J et al. Plasma fatty acid pattern including diene-conjugated linoleic acid in ethanol users and patients with ethanol-related liver disease. 1986 Alcohol. Clin. Exp. Res. pmid:3101533
Uden S et al. Antioxidant therapy for recurrent pancreatitis: biochemical profiles in a placebo-controlled trial. 1992 Aliment. Pharmacol. Ther. pmid:1600043
Belluzzi A et al. Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease. 1994 Aliment. Pharmacol. Ther. pmid:8186338
Kelly GS Conjugated linoleic acid: a review. 2001 Altern Med Rev pmid:11578253
Poole E and McQueen CE Conjugated linoleic acid. 2006 Am J Health Syst Pharm pmid:17057041
Block RC et al. Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes? 2008 Am. Heart J. pmid:19033007
Tilvis RS et al. Serum lipids and fatty acids in ischemic strokes. 1987 Am. Heart J. pmid:3812213
McDaniel HG et al. Glucose-insulin-potassium induced alterations in individual plasma free fatty acids in patients with acute myocardial infarction. 1981 Am. Heart J. pmid:6787909
Magsino CH et al. Nadolol inhibits reactive oxygen species generation by leukocytes and linoleic acid oxidation. 2000 Am. J. Cardiol. pmid:10946040
Siguel EN and Ratnayake WM Trans-fatty acid patterns in patients with demonstrated coronary artery disease. 1995 Am. J. Cardiol. pmid:7856548
Sentex E et al. Is the cytoprotective effect of trimetazidine associated with lipid metabolism? 1998 Am. J. Cardiol. pmid:9737482
Kim JB et al. Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins. 2013 Am. J. Cardiol. pmid:24050409
Wu MJ et al. Antioxidant activity of Porcelainberry (Ampelopsis brevipedunculata (Maxim.) Trautv.). 2004 Am. J. Chin. Med. pmid:15633804
Cho EJ et al. The inhibitory effects of 12 medicinal plants and their component compounds on lipid peroxidation. 2003 Am. J. Chin. Med. pmid:14992543
Tokede OA et al. Plasma phospholipid trans fatty acids and risk of heart failure. 2013 Am. J. Clin. Nutr. pmid:23446892
Bjerve KS et al. Alpha-linolenic acid deficiency in man: effect of ethyl linolenate on plasma and erythrocyte fatty acid composition and biosynthesis of prostanoids. 1987 Am. J. Clin. Nutr. pmid:3310599
Kark JD et al. Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids. 2003 Am. J. Clin. Nutr. pmid:12663274
Djoussé L et al. Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. 2003 Am. J. Clin. Nutr. pmid:12663278
Routi T et al. Effects of prospective, randomized cholesterol-lowering dietary intervention and apolipoprotein E phenotype on serum lipoprotein(a) concentrations of infants aged 7-24 mo. 1996 Am. J. Clin. Nutr. pmid:8602597
Anderson RL Quantitation of the effects of trans isomers of linoleic acid on the metabolism of linoleic acid. 1982 Am. J. Clin. Nutr. pmid:7081132
Turpeinen AM et al. Bioconversion of vaccenic acid to conjugated linoleic acid in humans. 2002 Am. J. Clin. Nutr. pmid:12197992
Hennig B and Watkins BA Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. 1989 Am. J. Clin. Nutr. pmid:2563626
Anderson GJ and Connor WE On the demonstration of omega-3 essential-fatty-acid deficiency in humans. 1989 Am. J. Clin. Nutr. pmid:2494878
Jannace PW et al. Effects of oral soy phosphatidylcholine on phagocytosis, arachidonate concentrations, and killing by human polymorphonuclear leukocytes. 1992 Am. J. Clin. Nutr. pmid:1323926
Bradbury KE et al. The serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations. 2010 Am. J. Clin. Nutr. pmid:19955401
Erickson KL Is there a relation between dietary linoleic acid and cancer of the breast, colon, or prostate? 1998 Am. J. Clin. Nutr. pmid:9665090
Vedtofte MS et al. Dietary α-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease. 2011 Am. J. Clin. Nutr. pmid:21865326
Zock PL and Katan MB Linoleic acid intake and cancer risk: a review and meta-analysis. 1998 Am. J. Clin. Nutr. pmid:9665108
Kestin M et al. n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. 1990 Am. J. Clin. Nutr. pmid:1971991
HOLMAN RT et al. ESTIMATION OF LINOLEATE INTAKE OF MEN FROM SERUM LIPID ANALYSIS. 1964 Am. J. Clin. Nutr. pmid:14142377
MACDONALD I and BARRY PJ CHANGES IN THE FATTY ACID PATTERN OF THE ADIPOSE TISSUE OF OBESE SUBJECTS WHILE ON A REDUCING REGIMEN. 1964 Am. J. Clin. Nutr. pmid:14212750
PINTER KG et al. FAT ABSORPTION STUDIES IN VARIOUS FORMS OF STEATORRHEA. 1964 Am. J. Clin. Nutr. pmid:14220479
Cleland LG et al. Linoleate inhibits EPA incorporation from dietary fish-oil supplements in human subjects. 1992 Am. J. Clin. Nutr. pmid:1310374
Green P et al. Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study. 1990 Am. J. Clin. Nutr. pmid:2239789
Meerarani P et al. Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. 2000 Am. J. Clin. Nutr. pmid:10617950
Sanders TA Polyunsaturated fatty acids in the food chain in Europe. 2000 Am. J. Clin. Nutr. pmid:10617968
Uauy R and Hoffman DR Essential fat requirements of preterm infants. 2000 Am. J. Clin. Nutr. pmid:10617979
Gibson RA and Makrides M n-3 polyunsaturated fatty acid requirements of term infants. 2000 Am. J. Clin. Nutr. pmid:10617980
Crawford M Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. 2000 Am. J. Clin. Nutr. pmid:10617983
Adam O and Wolfram G Effect of different linoleic acid intakes on prostaglandin biosynthesis and kidney function in man. 1984 Am. J. Clin. Nutr. pmid:6486083
Dutta-Roy AK Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. 2000 Am. J. Clin. Nutr. pmid:10617989
Ziboh VA et al. Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. 2000 Am. J. Clin. Nutr. pmid:10617998
Horrobin DF Essential fatty acid metabolism and its modification in atopic eczema. 2000 Am. J. Clin. Nutr. pmid:10617999
Weaver BJ et al. Dietary canola oil: effect on the accumulation of eicosapentaenoic acid in the alkenylacyl fraction of human platelet ethanolamine phosphoglyceride. 1990 Am. J. Clin. Nutr. pmid:2181858
Kalivianakis M et al. Fat malabsorption in cystic fibrosis patients receiving enzyme replacement therapy is due to impaired intestinal uptake of long-chain fatty acids. 1999 Am. J. Clin. Nutr. pmid:9925134
SINGLETON WS CHARACTERIZED OILS FOR USE IN INTRAVENOUS FAT EMULSIONS. 1965 Am. J. Clin. Nutr. pmid:14262113
Hodgson JM et al. Can linoleic acid contribute to coronary artery disease? 1993 Am. J. Clin. Nutr. pmid:8192728
Truswell AS Can linoleic acid contribute to coronary artery disease? 1994 Am. J. Clin. Nutr. pmid:8198070
Innis SM and Hansen JW Plasma fatty acid responses, metabolic effects, and safety of microalgal and fungal oils rich in arachidonic and docosahexaenoic acids in healthy adults. 1996 Am. J. Clin. Nutr. pmid:8694015
Cosgrove MC et al. Dietary nutrient intakes and skin-aging appearance among middle-aged American women. 2007 Am. J. Clin. Nutr. pmid:17921406
Jones PJ et al. Whole body oxidation of dietary fatty acids: implications for energy utilization. 1985 Am. J. Clin. Nutr. pmid:3933323
Blasbalg TL et al. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. 2011 Am. J. Clin. Nutr. pmid:21367944
Asciutti-Moura LS et al. Fatty acid composition of serum lipids and its relation to diet in an elderly institutionalized population. 1988 Am. J. Clin. Nutr. pmid:3421207
Cunnane SC Diodoquin and linoleic acid absorption in zinc deficiency. 1981 Am. J. Clin. Nutr. pmid:6792900
Salem N and Kuratko CN Lack of evidence for increased α-linolenic acid metabolism in vegetarians. 2011 Am. J. Clin. Nutr. pmid:21430120
Chevrot M et al. Obesity interferes with the orosensory detection of long-chain fatty acids in humans. 2014 Am. J. Clin. Nutr. pmid:24522446
Goyens PL et al. Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio. 2006 Am. J. Clin. Nutr. pmid:16825680
Abbey M et al. Oxidation of low-density lipoproteins: intraindividual variability and the effect of dietary linoleate supplementation. 1993 Am. J. Clin. Nutr. pmid:8438773
Makrides M et al. Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. 1994 Am. J. Clin. Nutr. pmid:7913291
Seidelin KN et al. Percentage distribution of fatty acids in subcutaneous adipose tissue of patients with peptic ulcer disease. 1993 Am. J. Clin. Nutr. pmid:8416668
OLSON FE et al. The use of diets containing large amounts of linoleic acid. 1958 Nov-Dec Am. J. Clin. Nutr. pmid:13594895
Chan JK et al. Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. 1991 Am. J. Clin. Nutr. pmid:1673589
Nestel PJ et al. Effect of a stearic acid-rich, structured triacylglycerol on plasma lipid concentrations. 1998 Am. J. Clin. Nutr. pmid:9846846
Hodge AM et al. Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid. 2007 Am. J. Clin. Nutr. pmid:17616780
Arca M et al. Erythrocyte fatty acid composition and gallstone disease: results of an epidemiological survey. 1987 Am. J. Clin. Nutr. pmid:3604961