| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Diabetic Ketoacidosis | D016883 | 16 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Hepatolenticular Degeneration | D006527 | 3 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
Linoelaidic acid
Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
Cross Reference
Introduction
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoelaidic acid?
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoelaidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Linoelaidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (1)
- Am. J. Physiol., Cell Physiol. (1)
- Hypertension (1)
- Others (3)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol., Cell Physiol. (1)
- Plant Cell (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoelaidic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoelaidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Avellini L et al. | Linoleic acid passage through the blood-brain barrier and a possible effect of age. | 1994 | Neurochem. Res. | pmid:8183422 |
| Salvati S et al. | Stimulation of myelin proteolipid protein gene expression by eicosapentaenoic acid in C6 glioma cells. | 2004 | Neurochem. Int. | pmid:14643750 |
| Kruska N and Reiser G | Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40. | 2011 | Neurobiol. Dis. | pmid:21570468 |
| van Doormaal JJ | Linoleic acid metabolism in diabetes mellitus. | 1990 | Neth J Med | pmid:2074912 |
| Kher V et al. | Effects of dietary linoleic acid enrichment on induction of immune complex nephritis in mice. | 1985 | Nephron | pmid:3156280 |
| Kakita N et al. | Induction of gelatinolytic neutral proteinase secretion by lipid peroxide in cultured mesangial cells. | 1993 | Nephron | pmid:8446258 |
| Huang X et al. | Serum and adipose tissue fatty acid composition as biomarkers of habitual dietary fat intake in elderly men with chronic kidney disease. | 2014 | Nephrol. Dial. Transplant. | pmid:23229929 |
| Messa P et al. | Abnormal arachidonic acid content of red blood cell membranes and main lithogenic factors in stone formers. | 2000 | Nephrol. Dial. Transplant. | pmid:10978396 |
| Maher ER et al. | Increased free-radical activity during haemodialysis? | 1987 | Nephrol. Dial. Transplant. | pmid:3114676 |
| Kelavkar UP et al. | Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice. | 2004 Nov-Dec | Neoplasia | pmid:15720809 |
| Katan MB and van Dusseldoys M | [Premenstrual syndromes]. | 1990 | Ned Tijdschr Geneeskd | pmid:2355986 |
| Katan MB | [Linoleic acid and heart infarct]. | 2013 | Ned Tijdschr Geneeskd | pmid:23714298 |
| Naber FB et al. | [Effect of short-term use of omega-3-type polyunsaturated fatty acids in subjects with hypertriglyceridemia]. | 1992 | Ned Tijdschr Geneeskd | pmid:1495569 |
| BUSINCO L | [Vitamin F in therapy of allergic syndromes and liver diseases]. | 1954 | Ned Tijdschr Geneeskd | pmid:13203632 |
| Romero MM et al. | The conjugated linoleic acid ester of estrone induces the mobilisation of fat in male Wistar rats. | 2007 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:17387456 |
| SCHULER W and MEIER R | [Effects of sex hormones on the cortisone catalyzed linoleic acid oxidation in vitro]. | 1956 | Naunyn Schmiedebergs Arch Exp Pathol Pharmakol | pmid:13348673 |
| Ma C et al. | NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. | 2016 | Nature | pmid:26934227 |
| BERGSTROM S | Autoxidation of linoleic acid. | 1945 | Nature | pmid:21007623 |
| BERGSTROM S and HOLMAN RT | Total conjugation of linoleic acid in oxidation with lipoxidase. | 1948 | Nature | pmid:18899663 |
| Sarkar G | Beneficial ghee? | 1991 | Nature | pmid:1876181 |
| HORVAT RJ et al. | SATURATED HYDROCARBONS FROM AUTOXIDIZING METHYL LINOLEATE. | 1964 | Nature | pmid:14202378 |
| Chyb S et al. | Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. | 1999 | Nature | pmid:9930700 |
| Lawrence JF et al. | An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection. | 1994 | Nat. Toxins | pmid:7866668 |
| Li Y et al. | Molecular recognition of nitrated fatty acids by PPAR gamma. | 2008 | Nat. Struct. Mol. Biol. | pmid:18604218 |
| Kiliç T et al. | Fatty acid composition of seeds of some species of Nepeta L. | 2007 | Nat. Prod. Res. | pmid:17487620 |
| Bentrad N et al. | Identification and evaluation of antibacterial agents present in lipophilic fractions isolated from sub-products of Phoenix dactilyfera. | 2017 | Nat. Prod. Res. | pmid:28403631 |
| Ozcan MM et al. | Characteristics of grape seed and oil from nine Turkish cultivars. | 2012 | Nat. Prod. Res. | pmid:22132714 |
| Patarra RF et al. | Fatty acid composition of selected macrophytes. | 2013 | Nat. Prod. Res. | pmid:22591127 |
| Jemia MB et al. | Studies on the antioxidant activity of the essential oil and extract of Tunisian Tetraclinis articulata (Vahl) Mast. (Cupressaceae). | 2013 | Nat. Prod. Res. | pmid:23082942 |
| Arfaoui MO et al. | Variation in oil content, fatty acid and phytosterols profile of Onopordum acanthium L. during seed development. | 2014 | Nat. Prod. Res. | pmid:25103576 |
| Yumrutas O et al. | Phenolic acid contents, essential oil compositions and antioxidant activities of two varieties of Salvia euphratica from Turkey. | 2012 | Nat. Prod. Res. | pmid:21995274 |
| Saracoglu HT et al. | Evaluation of oil content and fatty acid composition of five endemic Bupleurum species growing in the Central Anatolia region of Turkey. | 2012 | Nat. Prod. Res. | pmid:21870933 |
| Wright CR and Setzer WN | Chemical composition of volatiles from Opuntia littoralis, Opuntia ficus-indica, and Opuntia prolifera growing on Catalina Island, California. | 2014 | Nat. Prod. Res. | pmid:24354326 |
| Özcan T | Accumulation patterns of some seed oil components from wild sources of Turkey. | 2013 | Nat. Prod. Res. | pmid:22233192 |
| Beevi SS et al. | Polyphenolics profile and antioxidant properties of Raphanus sativus L. | 2012 | Nat. Prod. Res. | pmid:21714734 |
| Zengin G et al. | Composition of essential oil and antioxidant capacity of Centaurea drabifolia Sm. subsp. detonsa (Bornm.) Wagenitz, endemic to Turkey. | 2012 | Nat. Prod. Res. | pmid:21714737 |
| Gören AC et al. | Fatty acid composition and chemotaxonomic evaluation of species of Stachys. | 2012 | Nat. Prod. Res. | pmid:21859257 |
| Bitis L et al. | Flavonoids and antioxidant activity of Rosa agrestis leaves. | 2010 | Nat. Prod. Res. | pmid:20397108 |
| Barua P et al. | Seed oils from non-conventional sources in north-east India: potential feedstock for production of biodiesel. | 2014 | Nat. Prod. Res. | pmid:24483850 |
| Matthaus B and Özcan MM | Fatty acid and tocopherol contents of several soybean oils. | 2014 | Nat. Prod. Res. | pmid:24499198 |
| Xie J et al. | Composition of fatty oils from semen ziziphi spinosae and its cardiotonic effect on isolated toad hearts. | 2012 | Nat. Prod. Res. | pmid:21707231 |
| Tel-Çayan G et al. | A new fatty acid ester from an edible mushroom Rhizopogon luteolus. | 2016 | Nat. Prod. Res. | pmid:26987031 |
| Yaylayan VA et al. | MAP: microwave-assisted extraction of cockroaches. | 2002 | Nat Prod Lett | pmid:11990429 |
| Oliveira RF et al. | Biflavonoids from the unripe fruits of Clusia paralicola and their antioxidant activity. | 2012 | Nat Prod Commun | pmid:23413562 |
| Salleh WM et al. | Chemical compositions, antioxidant and antimicrobial activity of the essential oils of Piper officinarum (Piperaceae). | 2012 | Nat Prod Commun | pmid:23413576 |
| Pintore G et al. | Rosmarinus officinalis L.: chemical modifications of the essential oil and evaluation of antioxidant and antimicrobial activity. | 2009 | Nat Prod Commun | pmid:20120107 |
| da Silva JK et al. | Essential oil composition, antioxidant capacity and antifungal activity of Piper divaricatum. | 2010 | Nat Prod Commun | pmid:20420331 |
| Jirovetz L et al. | Chemical composition, olfactory evaluation and antioxidant effects of essential oil from Mentha canadensis. | 2009 | Nat Prod Commun | pmid:19731614 |
| Gharby S et al. | Can fruit-form be a marker for argan oil production? | 2013 | Nat Prod Commun | pmid:23472452 |
| Hasegawa T et al. | Constituents of the green tea seeds of Camellia sinensis. | 2011 | Nat Prod Commun | pmid:21485277 |
| Watanabe A et al. | In vitro free radical scavenging activity of platinum nanoparticles. | 2009 | Nanotechnology | pmid:19834242 |
| Khan AA et al. | Anticancer efficacy of a novel propofol-linoleic acid-loaded escheriosomal formulation against murine hepatocellular carcinoma. | 2013 | Nanomedicine (Lond) | pmid:23311988 |
| Huang HY et al. | Antioxidant and angiotension-converting enzyme inhibition capacities of various parts of Benincasa hispida (wax gourd). | 2004 | Nahrung | pmid:15285118 |
| Bertrandt J et al. | Influence of vitamin B6 supplementation on polyunsaturated fatty acids concentration in serum and liver of rats fed a diet restricted in protein. | 2004 | Nahrung | pmid:15146965 |
| Precht D and Molkentin J | C18:1, C18:2 and C18:3 trans and cis fatty acid isomers including conjugated cis delta 9, trans delta 11 linoleic acid (CLA) as well as total fat composition of German human milk lipids. | 1999 | Nahrung | pmid:10481820 |
| Kaya A | Properties and stability of butter oil obtained from milk and yoghurt. | 2000 | Nahrung | pmid:10795582 |
| FUJISHIRO N | STUDY ON REGRESSION OF ATHEROSCLEROSIS IN RABBITS. | 1963 | Nagoya J Med Sci | pmid:14092174 |
| Simpson LO | Unsaturated fatty acids. | 1988 | N. Z. Med. J. | pmid:3357629 |
| Kida Y | Eicosanoids in cystic fibrosis. | 2004 | N. Engl. J. Med. | pmid:15128902 |
| Willett WC et al. | Dietary fat and the risk of breast cancer. | 1987 | N. Engl. J. Med. | pmid:3785347 |
| Owen S et al. | Evidence of free-radical activity in asthma. | 1991 | N. Engl. J. Med. | pmid:1857396 |
| Kim BS et al. | Effect of surfactant on the production of oxygenated unsaturated fatty acids by Bacillus megaterium ALA2. | 2010 | N Biotechnol | pmid:19748603 |
| Walters D et al. | Antifungal activities of four fatty acids against plant pathogenic fungi. | 2004 | Mycopathologia | pmid:15008350 |
| Beeharry N et al. | Linoleic acid and antioxidants protect against DNA damage and apoptosis induced by palmitic acid. | 2003 | Mutat. Res. | pmid:14563528 |
| Eder E et al. | Lipid peroxidation-related 1,N2-propanodeoxyguanosine-DNA adducts induced by endogenously formed 4-hydroxy-2-nonenal in organs of female rats fed diets supplemented with sunflower, rapeseed, olive or coconut oil. | 2008 | Mutat. Res. | pmid:18602860 |
| Schut HA et al. | DNA adducts of heterocyclic amines: formation, removal and inhibition by dietary components. | 1997 | Mutat. Res. | pmid:9202755 |
| Yang H et al. | Effect of conjugated linoleic acid on the formation of spontaneous and PhIP-induced mutation in the colon and cecum of rats. | 2002 | Mutat. Res. | pmid:11890945 |
| Iwado H et al. | Mutagenicity and antimutagenicity of air-borne particulates. | 1991 | Mutat. Res. | pmid:1986270 |
| Fang Q et al. | Etheno-DNA adduct formation in rats gavaged with linoleic acid, oleic acid and coconut oil is organ- and gender specific. | 2007 | Mutat. Res. | pmid:17521682 |
| Park KY et al. | Antimutagenic effects of doenjang (Korean fermented soypaste) and its active compounds. | 2003 Feb-Mar | Mutat. Res. | pmid:12628502 |
| Martin H | Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components. | 2010 | Mutat. Res. | pmid:20973164 |
| Yang H et al. | Conjugated linoleic acid inhibits mutagenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the prostate of Big Blue rats. | 2003 | Mutagenesis | pmid:12621076 |
| Payne ET et al. | Nutritional therapy improves function and complements corticosteroid intervention in mdx mice. | 2006 | Muscle Nerve | pmid:16149047 |
| SCHOEN H | [THE SIGNIFICANCE OF INSUFFICIENT CLEARANCE IN ATHEROGENESIS]. | 1963 | Munch Med Wochenschr | pmid:14133657 |
| Farkas O et al. | Quantitative structure-antioxidant activity relationships of flavonoid compounds. | 2004 | Molecules | pmid:18007505 |
| Duan X et al. | Evaluation of the antioxidant properties of litchi fruit phenolics in relation to pericarp browning prevention. | 2007 | Molecules | pmid:17851428 |
| You Y et al. | Identification of major phenolic compounds of Chinese water chestnut and their antioxidant activity. | 2007 | Molecules | pmid:17851436 |
| Qin G et al. | Evolution of the aroma volatiles of pear fruits supplemented with fatty acid metabolic precursors. | 2014 | Molecules | pmid:25474290 |
| Sousa A et al. | Chemical characterization of "alcaparras" stoned table olives from northeast Portugal. | 2011 | Molecules | pmid:22031066 |
| KonÄić MZ et al. | Antiradical, chelating and antioxidant activities of hydroxamic acids and hydroxyureas. | 2011 | Molecules | pmid:21788931 |
| Zhou H et al. | Purification and characterization of a novel ~18 kDa antioxidant protein from Ginkgo biloba seeds. | 2012 | Molecules | pmid:23519252 |
| Sandoval-Montemayor NE et al. | Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. | 2012 | Molecules | pmid:22992784 |
| Ndhlala AR et al. | Anti-oxidative and cholinesterase inhibitory effects of leaf extracts and their isolated compounds from two closely related Croton species. | 2013 | Molecules | pmid:23377133 |
| Olszewska MA et al. | Assessment of the content of phenolics and antioxidant action of inflorescences and leaves of selected species from the genus Sorbus sensu stricto. | 2010 | Molecules | pmid:21127463 |
| Manzoor M et al. | Variation in minerals, phenolics and antioxidant activity of peel and pulp of different varieties of peach (Prunus persica L.) fruit from Pakistan. | 2012 | Molecules | pmid:22728349 |
| Sajid ZI et al. | Antioxidant, antimicrobial properties and phenolics of different solvent extracts from bark, leaves and seeds of Pongamia pinnata (L.) Pierre. | 2012 | Molecules | pmid:22466852 |
| Ambrozova JV et al. | Influence of extractive solvents on lipid and fatty acids content of edible freshwater algal and seaweed products, the green Microalga Chlorella kessleri and the Cyanobacterium Spirulina platensis. | 2014 | Molecules | pmid:24566307 |
| Bazongo P et al. | Characteristics, composition and oxidative stability of Lannea microcarpa seed and seed oil. | 2014 | Molecules | pmid:24566330 |
| Gull J et al. | Variation in antioxidant attributes at three ripening stages of guava (Psidium guajava L.) fruit from different geographical regions of Pakistan. | 2012 | Molecules | pmid:22418924 |
| King LM et al. | Cloning of CYP2J2 gene and identification of functional polymorphisms. | 2002 | Mol. Pharmacol. | pmid:11901223 |
| Glasgow WC and Eling TE | Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts. | 1990 | Mol. Pharmacol. | pmid:2233691 |
| Ripoll-Rozada J et al. | Type IV traffic ATPase TrwD as molecular target to inhibit bacterial conjugation. | 2016 | Mol. Microbiol. | pmid:26915347 |
| Sakai H and Kajiwara S | Cloning and functional characterization of a Delta12 fatty acid desaturase gene from the basidiomycete Lentinula edodes. | 2005 | Mol. Genet. Genomics | pmid:15838640 |
| Kim SY et al. | S-adenosyl methionine prevents endothelial dysfunction by inducing heme oxygenase-1 in vascular endothelial cells. | 2013 | Mol. Cells | pmid:24046187 |
| Lee C et al. | Quantitative trait loci mapping for fatty acid contents in the backfat on porcine chromosomes 1, 13, and 18. | 2003 | Mol. Cells | pmid:12661762 |
| Lee MJ et al. | The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. | 2011 | Mol. Cells | pmid:21331775 |
| Grammatopoulos D et al. | The human myometrial CRH receptor: G proteins and second messengers. | 1994 | Mol. Cell. Endocrinol. | pmid:8206332 |
| Plaisance V et al. | Role of the transcriptional factor C/EBPbeta in free fatty acid-elicited beta-cell failure. | 2009 | Mol. Cell. Endocrinol. | pmid:19133313 |
| Warnotte C et al. | Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion. | 1999 | Mol. Cell. Endocrinol. | pmid:10459862 |
| Kim S et al. | C/EBPbeta (NF-M) is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts. | 1999 | Mol. Cell. Biol. | pmid:10409760 |