Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Nushida H et al. | Adipocere formation via hydrogenation of linoleic acid in a victim kept under dry concealment. | 2008 | Forensic Sci. Int. | pmid:17644293 |
Spacek T et al. | Glucose-stimulated insulin secretion of insulinoma INS-1E cells is associated with elevation of both respiration and mitochondrial membrane potential. | 2008 | Int. J. Biochem. Cell Biol. | pmid:18248766 |
Feng DD et al. | Linoleic acid induces Ca2+-induced inactivation of voltage-dependent Ca2+ currents in rat pancreatic beta-cells. | 2008 | J. Endocrinol. | pmid:18252961 |
Yen CH et al. | Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. | 2008 | Ann. Allergy Asthma Immunol. | pmid:18254485 |
Sikorski AM et al. | Conjugated Linoleic Acid (CLA) inhibits new vessel growth in the mammalian brain. | 2008 | Brain Res. | pmid:18456247 |
Pandey NR et al. | Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein A-I secretion. | 2008 | Biochemistry | pmid:18189424 |
Maicas VT and Rochina IJ | [Linoleic acid emulsion on the peri-lesion skin of venal ulcers. Action and cicatrizant effect. Corpus study]. | 2008 | Rev Enferm | pmid:18564784 |
Jang A et al. | Comparison of hypolipidemic activity of synthetic gallic acid-linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice. | 2008 | Chem. Biol. Interact. | pmid:18571153 |
Koszelak-Rosenblum M et al. | His-311 and Arg-559 are key residues involved in fatty acid oxygenation in pathogen-inducible oxygenase. | 2008 | J. Biol. Chem. | pmid:18596034 |
Frenette M and Scaiano JC | Evidence for hydroxyl radical generation during lipid (linoleate) peroxidation. | 2008 | J. Am. Chem. Soc. | pmid:18597469 |
Pinnick KE et al. | Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. | 2008 | Obesity (Silver Spring) | pmid:18239594 |
Eder E et al. | Lipid peroxidation-related 1,N2-propanodeoxyguanosine-DNA adducts induced by endogenously formed 4-hydroxy-2-nonenal in organs of female rats fed diets supplemented with sunflower, rapeseed, olive or coconut oil. | 2008 | Mutat. Res. | pmid:18602860 |
Li Y et al. | Molecular recognition of nitrated fatty acids by PPAR gamma. | 2008 | Nat. Struct. Mol. Biol. | pmid:18604218 |
Kuiper HC et al. | Mercapturic acid conjugates of 4-hydroxy-2-nonenal and 4-oxo-2-nonenal metabolites are in vivo markers of oxidative stress. | 2008 | J. Biol. Chem. | pmid:18442969 |
Ohmori H et al. | Linoleic-acid-induced growth suppression induces quiescent cancer cell nests in nude mice. | 2008 | Pathobiology | pmid:18580068 |
Xin HL et al. | [Alpha-linolenic acid and linoleic acid in extract of Portulaca oleracea L. determined by high-performance liquid chromatography]. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18990345 |
Wang L et al. | The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation. | 2008 | Metab. Clin. Exp. | pmid:18803934 |
Morishita M et al. | Usefulness of colon targeted DHA and EPA as novel diabetes medications that promote intrinsic GLP-1 secretion. | 2008 | J Control Release | pmid:18804128 |
Koussoroplis AM et al. | From aquatic to terrestrial food webs: decrease of the docosahexaenoic acid/linoleic acid ratio. | 2008 | Lipids | pmid:18335265 |
Ito-Inaba Y et al. | Characterization of the plant uncoupling protein, SrUCPA, expressed in spadix mitochondria of the thermogenic skunk cabbage. | 2008 | J. Exp. Bot. | pmid:18308738 |
Carrasco MP et al. | Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells. | 2008 | FEBS J. | pmid:18312412 |
Maeda H et al. | Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. | 2008 | Plant Cell | pmid:18314499 |
Lukovac S et al. | Essential fatty acid deficiency in mice impairs lactose digestion. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18653724 |
Fagali N and Catalá A | Antioxidant activity of conjugated linoleic acid isomers, linoleic acid and its methyl ester determined by photoemission and DPPH techniques. | 2008 | Biophys. Chem. | pmid:18656302 |
Gülçin I | In vitro prooxidant effect of caffeine. | 2008 | J Enzyme Inhib Med Chem | pmid:18341268 |
Minami Y et al. | Occurrence of singlet oxygen oxygenation of oleic acid and linoleic acid in the skin of live mice. | 2008 | Free Radic. Res. | pmid:18344113 |
Zachut M et al. | Dietary unsaturated fatty acids influence preovulatory follicle characteristics in dairy cows. | 2008 | Reproduction | pmid:18296508 |
Horowitz Brown S et al. | Morphological transitions governed by density dependence and lipoxygenase activity in Aspergillus flavus. | 2008 | Appl. Environ. Microbiol. | pmid:18658287 |
Ashby RD et al. | Property control of sophorolipids: influence of fatty acid substrate and blending. | 2008 | Biotechnol. Lett. | pmid:18264681 |
Zhu H et al. | 15-lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity. | 2008 | Int. J. Cancer | pmid:18785202 |
Ringseis R et al. | Conjugated linoleic acid isomers inhibit platelet-derived growth factor-induced NF-kappaB transactivation and collagen formation in human vascular smooth muscle cells. | 2008 | Eur J Nutr | pmid:18264811 |
Kishino T et al. | Visceral fat thickness in overweight men correlates with alterations in serum fatty acid composition. | 2008 | Clin. Chim. Acta | pmid:18771663 |
Jones PJ et al. | The effect of dietary oleic, linoleic, and linolenic acids on fat oxidation and energy expenditure in healthy men. | 2008 | Metab. Clin. Exp. | pmid:18702944 |
Dai F et al. | Antioxidant synergism of green tea polyphenols with alpha-tocopherol and L-ascorbic acid in SDS micelles. | 2008 | Biochimie | pmid:18554517 |
McEntee MF et al. | Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer. | 2008 | Am. J. Pathol. | pmid:18556778 |
Or-Rashid MM et al. | Studies on the production of conjugated linoleic acid from linoleic and vaccenic acids by mixed rumen protozoa. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18797866 |
Simopoulos AP | The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. | 2008 | Exp. Biol. Med. (Maywood) | pmid:18408140 |
Satou T et al. | The toxin produced by pleurotus ostreatus reduces the head size of nematodes. | 2008 | Biol. Pharm. Bull. | pmid:18379043 |
Gallardo E et al. | Influence of lipids in the generation of phenylacetaldehyde in wort-related model systems. | 2008 | J. Agric. Food Chem. | pmid:18386901 |
Morawicki RO and Beelman RB | Study of the biosynthesis of 1-octen-3-ol using a crude homogenate of Agaricus bisporus in a bioreactor. | 2008 | J. Food Sci. | pmid:18387089 |
Kwon JI et al. | Induction of apoptosis by linoleic acid is associated with the modulation of Bcl-2 family and Fas/FasL system and activation of caspases in AGS human gastric adenocarcinoma cells. | 2008 | J Med Food | pmid:18361731 |
Warensjö E et al. | Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. | 2008 | Nutr Metab Cardiovasc Dis | pmid:18367385 |
Chung SH et al. | Synthesis of conjugated linoleic acid by human-derived Bifidobacterium breve LMC 017: utilization as a functional starter culture for milk fermentation. | 2008 | J. Agric. Food Chem. | pmid:18410112 |
Nasrollahzadeh J et al. | The influence of feeding linoleic, gamma-linolenic and docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and fatty acid binding protein 7 mRNA expression. | 2008 | Lipids Health Dis | pmid:19014610 |
Maqbool A et al. | Serum linoleic acid status as a clinical indicator of essential fatty acid status in children with cystic fibrosis. | 2008 | J. Pediatr. Gastroenterol. Nutr. | pmid:18955866 |
Zuo Y et al. | ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. | 2008 | J. Biol. Chem. | pmid:18957418 |
Zanoni S et al. | Growth kinetics on oligo- and polysaccharides and promising features of three antioxidative potential probiotic strains. | 2008 | J. Appl. Microbiol. | pmid:18778294 |
Tao M et al. | Relationship of polyunsaturated fatty acid intake to peripheral neuropathy among adults with diabetes in the National Health and Nutrition Examination Survey (NHANES) 1999 2004. | 2008 | Diabetes Care | pmid:17914029 |
Mateu-de Antonio J et al. | Comparative effects of olive oil-based and soyabean oil-based emulsions on infection rate and leucocyte count in critically ill patients receiving parenteral nutrition. | 2008 | Br. J. Nutr. | pmid:17916276 |
Yu IS et al. | Conversion of linoleic acid into 10-Hydroxy-12(Z)-octadecenoic acid by whole cells of Stenotrophomonas nitritireducens. | 2008 Jan-Feb | Biotechnol. Prog. | pmid:18197675 |
Mendis S et al. | Fatty acid profile of Canadian dairy products with special attention to the trans-octadecenoic acid and conjugated linoleic acid isomers. | 2008 Jul-Aug | J AOAC Int | pmid:18727541 |
Magalhães MS et al. | Effect of a combination of medium chain triglycerides, linoleic acid, soy lecithin and vitamins A and E on wound healing in rats. | 2008 May-Jun | Acta Cir Bras | pmid:18552998 |
Chua AC et al. | Characterization of oil bodies in jelly fig achenes. | 2008 May-Jun | Plant Physiol. Biochem. | pmid:18434174 |
Skaterna TD and Kharchenko OV | [Effect of phosphatidic acid on the reaction of linoleic acid oxidation by 5-lipooxygenase from potatoes]. | 2008 May-Jun | Ukr Biokhim Zh (1999) | pmid:18959024 |
Webb AN et al. | Tolerability and safety of olive oil-based lipid emulsion in critically ill neonates: a blinded randomized trial. | 2008 Nov-Dec | Nutrition | pmid:18619813 |
Libkind D et al. | Fatty acid composition of cold-adapted carotenogenic basidiomycetous yeasts. | 2008 Oct-Dec | Rev. Argent. Microbiol. | pmid:19213239 |
Whelan J | The health implications of changing linoleic acid intakes. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18990554 |
Fritsche KL | Too much linoleic acid promotes inflammation-doesn't it? | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18990555 |
Harris WS | Linoleic acid and coronary heart disease. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18951772 |
Adam O et al. | Impact of linoleic acid intake on arachidonic acid formation and eicosanoid biosynthesis in humans. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18973995 |
Liavonchanka A et al. | On the mechanism of a polyunsaturated fatty acid double bond isomerase from Propionibacterium acnes. | 2009 | J. Biol. Chem. | pmid:19164287 |
Ibrahim A et al. | Impact of maternal dietary fatty acid composition on glucose and lipid metabolism in male rat offspring aged 105 d. | 2009 | Br. J. Nutr. | pmid:19166630 |
Calder PC | Early life programming of immune and lung function: can we now exclude a role of arachidonic acid exposure? | 2009 | Br. J. Nutr. | pmid:19166631 |
Oku H et al. | The effects of 2-bromopalmitate on the fatty acid composition in differentiating adipocytes of red sea bream (Pagrus major). | 2009 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:19166960 |
Schwartz J et al. | Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 long-chain polyunsaturated fatty acid synthesis in healthy infants: a double blinded randomised controlled trial. | 2009 | Arch. Dis. Child. | pmid:19193660 |
HÃ¥versen L et al. | Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. | 2009 | Atherosclerosis | pmid:18599066 |
Ishitsuka Y et al. | Effects of bolus injection of soybean-based fat emulsion and fatty acids on pulmonary gas exchange function. | 2009 | Biol. Pharm. Bull. | pmid:19252304 |
de Meijer VE et al. | Parenteral fish oil as monotherapy for patients with parenteral nutrition-associated liver disease. | 2009 | Pediatr. Surg. Int. | pmid:18828026 |
Saitou K et al. | Contribution of gustation to the palatability of linoleic acid. | 2009 | Physiol. Behav. | pmid:18835400 |
RodrÃguez-Cruz M et al. | Effect of dietary levels of corn oil on maternal arachidonic acid synthesis and fatty acid composition in lactating rats. | 2009 | Nutrition | pmid:18849148 |
Wang S et al. | In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation. | 2009 | Br. J. Nutr. | pmid:19660150 |
Chow CK | Dietary beta-tocopherol and serum concentrations of sex hormone-binding globulin. | 2009 | J. Nutr. | pmid:19710160 |
Roche M et al. | Olive phenols efficiently inhibit the oxidation of serum albumin-bound linoleic acid and butyrylcholine esterase. | 2009 | Biochim. Biophys. Acta | pmid:19714864 |
Pianaro A et al. | Stingless bees: chemical differences and potential functions in Nannotrigona testaceicornis and Plebeia droryana males and workers. | 2009 | J. Chem. Ecol. | pmid:19730955 |
Jirovetz L et al. | Chemical composition, olfactory evaluation and antioxidant effects of essential oil from Mentha canadensis. | 2009 | Nat Prod Commun | pmid:19731614 |
de Castro J et al. | Platelet linoleic acid is a potential biomarker of advanced non-small cell lung cancer. | 2009 | Exp. Mol. Pathol. | pmid:19733167 |
Pandey NR et al. | An induction in hepatic HDL secretion associated with reduced ATPase expression. | 2009 | Am. J. Pathol. | pmid:19717637 |
Radunz AE et al. | Effects of dietary polyunsaturated fatty acid supplementation on fatty acid composition in muscle and subcutaneous adipose tissue of lambs. | 2009 | J. Anim. Sci. | pmid:19717771 |
Plaisance V et al. | Role of the transcriptional factor C/EBPbeta in free fatty acid-elicited beta-cell failure. | 2009 | Mol. Cell. Endocrinol. | pmid:19133313 |
Lee CM et al. | SPION-loaded chitosan-linoleic acid nanoparticles to target hepatocytes. | 2009 | Int J Pharm | pmid:19138733 |
Tan YL and Liu CG | Self-aggregated nanoparticles from linoleic acid modified carboxymethyl chitosan: Synthesis, characterization and application in vitro. | 2009 | Colloids Surf B Biointerfaces | pmid:19124228 |
Staiger H et al. | Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans. | 2009 | Diabetes | pmid:19074989 |
Jeng JY et al. | Linoleic acid promotes mitochondrial biogenesis and maintains mitochondrial structure for prevention of streptozotocin damage in RIN-m5F cells. | 2009 | Biosci. Biotechnol. Biochem. | pmid:19502730 |
Pinho RS et al. | Potential oilseed crops from the semiarid region of northeastern Brazil. | 2009 | Bioresour. Technol. | pmid:19577461 |
Guyenet SJ | High-fat diets: details matter. | 2009 | Obesity (Silver Spring) | pmid:19553921 |
Zhang HM et al. | Linoleic acid-induced mitochondrial Ca(2+) efflux causes peroxynitrite generation and protein nitrotyrosylation. | 2009 | PLoS ONE | pmid:19557129 |
Sarikurkcu C et al. | Studies on the antioxidant activity of essential oil and different solvent extracts of Vitexagnuscastus L. fruits from Turkey. | 2009 | Food Chem. Toxicol. | pmid:19595732 |
Shah KB et al. | The cardioprotective effects of fish oil during pressure overload are blocked by high fat intake: role of cardiac phospholipid remodeling. | 2009 | Hypertension | pmid:19597033 |
Hernández ML et al. | Expression analysis identifies FAD2-2 as the olive oleate desaturase gene mainly responsible for the linoleic acid content in virgin olive oil. | 2009 | J. Agric. Food Chem. | pmid:19601663 |
Hamel FG | Preliminary report: inhibition of cellular proteasome activity by free fatty acids. | 2009 | Metab. Clin. Exp. | pmid:19423142 |
Cheong SJ et al. | Superparamagnetic iron oxide nanoparticles-loaded chitosan-linoleic acid nanoparticles as an effective hepatocyte-targeted gene delivery system. | 2009 | Int J Pharm | pmid:19429277 |
Fukasawa R et al. | Anti-oxidative effects of rooibos tea extract on autoxidation and thermal oxidation of lipids. | 2009 | J Oleo Sci | pmid:19430189 |
Fang IM et al. | Comparative effects of fatty acids on proinflammatory gene cyclooxygenase 2 and inducible nitric oxide synthase expression in retinal pigment epithelial cells. | 2009 | Mol Nutr Food Res | pmid:19437483 |
Grasso EJ and Calderón RO | Urinary bladder membrane permeability differentially induced by membrane lipid composition. | 2009 | Mol. Cell. Biochem. | pmid:19412731 |
Yasuda M et al. | Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction. | 2009 | Carcinogenesis | pmid:19414503 |
Lata M et al. | Whole body protection against lethal ionizing radiation in mice by REC-2001: a semi-purified fraction of Podophyllum hexandrum. | 2009 | Phytomedicine | pmid:17574826 |
Artwohl M et al. | Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure. | 2009 | Atherosclerosis | pmid:18597758 |
Shimomura H et al. | Steroids mediate resistance to the bactericidal effect of phosphatidylcholines against Helicobacter pylori. | 2009 | FEMS Microbiol. Lett. | pmid:19843309 |
Chen Q et al. | Generation of fad2 transgenic mice that produce omega-6 fatty acids. | 2009 | Sci. China, C, Life Sci. | pmid:19937203 |
Detsi A et al. | Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. | 2009 | Bioorg. Med. Chem. | pmid:19853459 |