Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Sakai T et al. | A lipid peroxidation-derived aldehyde, 4-hydroxy-2-nonenal and omega 6 fatty acids contents in meats. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7670203 |
Dürken M et al. | Deteriorating free radical-trapping capacity and antioxidant status in plasma during bone marrow transplantation. | 1995 | Bone Marrow Transplant. | pmid:7670403 |
Egashira Y et al. | Effect of dietary linoleic acid on the tryptophan-niacin metabolism in streptozotocin diabetic rats. | 1995 | Comp. Biochem. Physiol. A Physiol. | pmid:7671148 |
Grechkin AN et al. | The lipoxygenase pathway in garlic (Allium sativum L.) bulbs: detection of the novel divinyl ether oxylipins. | 1995 | FEBS Lett. | pmid:7672118 |
Bailey JM et al. | Dietary linoleic acid in alcohol-induced liver cirrhosis. | 1995 | Biochem. Soc. Trans. | pmid:7672270 |
Claassen N et al. | The effect of different n-6/n-3 essential fatty acid ratios on calcium balance and bone in rats. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7675819 |
Prisco D et al. | Platelet activation and platelet lipid composition in pulmonary cancer. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7675825 |
Sud'ina GF et al. | Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. | 1993 | FEBS Lett. | pmid:7689063 |
Shi X et al. | Silica radical-induced DNA damage and lipid peroxidation. | 1994 | Environ. Health Perspect. | pmid:7705289 |
van Greevenbroek MM et al. | Palmitic acid and linoleic acid metabolism in Caco-2 cells: different triglyceride synthesis and lipoprotein secretion. | 1995 | J. Lipid Res. | pmid:7706938 |
Bayon Y et al. | Effect of specific phospholipid molecular species incorporated in human platelet membranes on thromboxane A2/prostaglandin H2 receptors. | 1995 | J. Lipid Res. | pmid:7706947 |
Jiang WG et al. | Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. | 1995 | Br. J. Cancer | pmid:7710939 |
Umezawa M et al. | Dietary alpha-linolenate/linoleate balance influences learning and memory in the senescence-accelerated mouse (SAM). | 1995 | Brain Res. | pmid:7712178 |
Mohan VR and Janardhanan K | Chemical and nutritional evaluation of two germplasms of the tribal pulse, Bauhinia racemosa Lamk. | 1994 | Plant Foods Hum Nutr | pmid:7716120 |
Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
Degousée N et al. | Measurement of thermally produced volatile alkanes: an assay for plant hydroperoxy fatty acid evaluation. | 1995 | Anal. Biochem. | pmid:7733454 |
Angerman-Stewart JA et al. | Prostaglandin H synthase-2 is induced in Syrian hamster embryo cells in response to basic fibroblast growth factor. | 1995 | Arch. Biochem. Biophys. | pmid:7733666 |
Campbell FM et al. | Plasma membrane fatty-acid-binding protein in human placenta: identification and characterization. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7733952 |
Leis HJ et al. | On the inhibition of prostanoid formation by SK&F 96365, a blocker of receptor-operated calcium entry. | 1995 | Br. J. Pharmacol. | pmid:7735686 |
Van Aswegen CH and Du Plessis DJ | Can linoleic acid and gamma-linolenic acid be important in cancer treatment? | 1994 | Med. Hypotheses | pmid:7739415 |
Nelson MJ et al. | Photolysis of "purple" lipoxygenase: implications for the structure of the chromophore. | 1995 | Biochemistry | pmid:7742320 |
Radallah D et al. | Action of linoleic acid on phospholipase C activity at the rectal level of the African locust under the control of protein kinase C. | 1995 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:7749603 |
Welsch CW | Review of the effects of dietary fat on experimental mammary gland tumorigenesis: role of lipid peroxidation. | 1995 | Free Radic. Biol. Med. | pmid:7750800 |
López-Nicolás JM et al. | Use of 'soluble lipids' for biochemical processes: linoleic acid-cyclodextrin inclusion complexes in aqueous solutions. | 1995 | Biochem. J. | pmid:7755559 |
Labbe C et al. | Thermal acclimation and dietary lipids alter the composition, but not fluidity, of trout sperm plasma membrane. | 1995 | Lipids | pmid:7760685 |
Champe SP et al. | Sexual sporulation. | 1994 | Prog Ind Microbiol | pmid:7765136 |
Kobayashi M et al. | Enhancement effects of BSA and linoleic acid on hybridoma cell growth and antibody production. | 1994 | Cytotechnology | pmid:7765952 |
Lodge JK et al. | Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopy. | 1995 | Biochim. Biophys. Acta | pmid:7766690 |
Santanam N and Parthasarathy S | Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidases. | 1995 | J. Clin. Invest. | pmid:7769102 |
Bandyopadhyay GK et al. | Effect of reproductive states on lipid mobilization and linoleic acid metabolism in mammary glands. | 1995 | Lipids | pmid:7769972 |
Decker EA | The role of phenolics, conjugated linoleic acid, carnosine, and pyrroloquinoline quinone as nonessential dietary antioxidants. | 1995 | Nutr. Rev. | pmid:7770184 |
Sharma HM et al. | Effect of MAK-4 and MAK-5 on endothelial cell and soyabean lipoxygenase-induced LDL oxidation. | 1994 | Adv. Exp. Med. Biol. | pmid:7771286 |
Jones RE | A common factor for cardiac or respiratory failure in SIDS. | 1995 | Clin Pediatr (Phila) | pmid:7774147 |
Tanhuanpää PK et al. | Association of RAPD marker with linolenic acid concentration in the seed oil of rapeseed (Brassica napus L.). | 1995 | Genome | pmid:7774805 |
Noguchi M et al. | The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. | 1995 Jul-Aug | Oncology | pmid:7777237 |
Schürer N et al. | Differential utilization of linoleic and arachidonic acid by cultured human keratinocytes. | 1995 | Skin Pharmacol. | pmid:7786523 |
Schmitt A et al. | Phospholipid hydrolysis of mildly oxidized LDL reduces their cytotoxicity to cultured endothelial cells. Potential protective role against atherogenesis. | 1995 | Biochim. Biophys. Acta | pmid:7786889 |
Ghosh D et al. | Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase. | 1995 | Structure | pmid:7788294 |
Shiff CJ and Graczyk TK | A chemokinetic response in Schistosoma mansoni cercariae. | 1994 | J. Parasitol. | pmid:7799158 |
Benov LC et al. | Oxidative damage of the membrane lipids after electroporation. | 1994 | Gen. Physiol. Biophys. | pmid:7806071 |
Livrea MA and Tesoriere L | Lipoperoxyl radical-scavenging activity of vitamin A and analogs in homogeneous solution. | 1994 | Meth. Enzymol. | pmid:7808312 |
López-Nicolás JM et al. | An octaethylene glycol monododecyl ether-based mixed micellar assay for lipoxygenase acting at neutral pH. | 1994 | Anal. Biochem. | pmid:7810887 |
Jones RE | A hypothesis for early intervention in SIDS. | 1994 | Clin Pediatr (Phila) | pmid:7813148 |
Avery SV et al. | Low temperature-induced adaptations in lipid metabolism and physiological function in Acanthamoeba castellanii cultures of different ages. | 1994 | Biochem. Soc. Trans. | pmid:7821519 |
Nada MA et al. | Evidence for intermediate channeling in mitochondrial beta-oxidation. | 1995 | J. Biol. Chem. | pmid:7822275 |
Thompson L et al. | Inhibitory effect of polyunsaturated fatty acids on the growth of Helicobacter pylori: a possible explanation of the effect of diet on peptic ulceration. | 1994 | Gut | pmid:7828972 |
Saito M and Yamaguchi M | Liver microsomal mixed-function oxidases in response to dietary n-3 fatty acid levels in rats. | 1994 | Ann. Nutr. Metab. | pmid:7832581 |
Roberts TL et al. | trans isomers of oleic and linoleic acids in adipose tissue and sudden cardiac death. | 1995 | Lancet | pmid:7837861 |
Mantzioris E et al. | Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. | 1995 | Am. J. Clin. Nutr. | pmid:7840069 |
Siguel E | Does linoleic acid contribute to coronary artery disease? | 1995 | Am. J. Clin. Nutr. | pmid:7840081 |
Fuhrman B et al. | Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties. | 1994 | Atherosclerosis | pmid:7840815 |
Hammouda NA et al. | Schistosoma mansoni: a comparative study on two cercarial transformation methods. | 1994 | J Egypt Soc Parasitol | pmid:7844412 |
Kvilekval K et al. | Fatty acids as determinants of triglyceride and cholesteryl ester synthesis by isolated hepatocytes: kinetics as a function of various fatty acids. | 1994 | J. Lipid Res. | pmid:7852855 |
Siguel EN and Ratnayake WM | Trans-fatty acid patterns in patients with demonstrated coronary artery disease. | 1995 | Am. J. Cardiol. | pmid:7856548 |
Croft KD et al. | Oxidation of low-density lipoproteins: effect of antioxidant content, fatty acid composition and intrinsic phospholipase activity on susceptibility to metal ion-induced oxidation. | 1995 | Biochim. Biophys. Acta | pmid:7857965 |
Kouba M et al. | Comparative study of hepatic VLDL secretion in vivo in the growing turkey (Meleagris gallopavo) and chicken (Gallus domesticus). | 1995 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:7858950 |
Endresen MJ et al. | Effects of free fatty acids found increased in women who develop pre-eclampsia on the ability of endothelial cells to produce prostacyclin, cGMP and inhibit platelet aggregation. | 1994 | Scand. J. Clin. Lab. Invest. | pmid:7863232 |
Chen ZY et al. | Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. | 1995 | Am. J. Physiol. | pmid:7864247 |
Lawrence JF et al. | An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection. | 1994 | Nat. Toxins | pmid:7866668 |
Bulan EJ et al. | Immature maxi-K channels exhibit heterogeneous properties in the embryonic rat telencephalon. | 1994 | Dev. Neurosci. | pmid:7867514 |
Horan KL et al. | Kinetic evaluation of lipophilic inhibitors of lipid peroxidation in DLPC liposomes. | 1994 | Free Radic. Biol. Med. | pmid:7867975 |
Lenzi A et al. | Glutathione treatment of dyspermia: effect on the lipoperoxidation process. | 1994 | Hum. Reprod. | pmid:7868672 |
Pawlosky R et al. | Essential fatty acid metabolism in the feline: relationship between liver and brain production of long-chain polyunsaturated fatty acids. | 1994 | J. Lipid Res. | pmid:7868981 |
Budowski P et al. | Mature milk from Israeli mothers is rich in polyunsaturated fatty acids. | 1994 | World Rev Nutr Diet | pmid:7871809 |
Postle AD et al. | Molecular species composition of plasma phosphatidylcholine in human pregnancy. | 1994 | World Rev Nutr Diet | pmid:7871810 |
Yavin E and Green P | Distribution, processing and selective esterification of essential fatty acid metabolites in the fetal brain. | 1994 | World Rev Nutr Diet | pmid:7871815 |
Lien EL | The ratio of linoleic acid to alpha-linolenic acid in infant formulas: current facts and future research directions. | 1994 | World Rev Nutr Diet | pmid:7871839 |
Boissonneault GA et al. | Oxidized low-density lipoproteins delay endothelial wound healing: lack of effect of vitamin E. | 1995 | Ann. Nutr. Metab. | pmid:7872651 |
Decsi T and Koletzko B | Do trans fatty acids impair linoleic acid metabolism in children? | 1995 | Ann. Nutr. Metab. | pmid:7872654 |
Santos MJ et al. | Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. | 1995 | Ann. Nutr. Metab. | pmid:7872656 |
Bellavite P et al. | Correlations between the intensity of fMLP-dependent respiratory burst and cellular fatty acid composition in human neutrophils. | 1995 | Br. J. Haematol. | pmid:7873377 |
Fushiki T et al. | Swimming endurance capacity of mice is increased by chronic consumption of medium-chain triglycerides. | 1995 | J. Nutr. | pmid:7876928 |
Narce M et al. | Age-related changes in linoleic acid bioconversion by isolated hepatocytes from spontaneously hypertensive and normotensive rats. | 1994 | Mol. Cell. Biochem. | pmid:7877612 |
Yu WK and Wells PG | Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice. | 1995 | Toxicol. Appl. Pharmacol. | pmid:7878664 |
Frank CL and Storey KB | The optimal depot fat composition for hibernation by golden-mantled ground squirrels (Spermophilus lateralis). | 1995 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:7884064 |
Kim C et al. | A comprehensive evaluation of the vial equilibration method for quantification of the metabolism of volatile organic chemicals. Trichloroethylene. | 1994 Nov-Dec | Drug Metab. Dispos. | pmid:7895602 |
Keshavarz K | Further investigations on the effect of dietary manipulations of nutrients on early egg weight. | 1995 | Poult. Sci. | pmid:7899214 |
Yehuda S and Carasso RL | Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7901853 |
Leichsenring M et al. | Scaly skin alterations and plasma fatty acids in Congolese children. | 1993 | Acta Trop. | pmid:7902652 |
Green P and Yavin E | Elongation, desaturation, and esterification of essential fatty acids by fetal rat brain in vivo. | 1993 | J. Lipid Res. | pmid:7905509 |
Regdel D et al. | On the reaction specificity of the lipoxygenase from tomato fruits. | 1994 | Biochim. Biophys. Acta | pmid:7905748 |
Okuley J et al. | Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. | 1994 | Plant Cell | pmid:7907506 |
Freese R et al. | Comparison of the effects of two diets rich in monounsaturated fatty acids differing in their linoleic/alpha-linolenic acid ratio on platelet aggregation. | 1994 | Thromb. Haemost. | pmid:7909389 |
Huang YS et al. | Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. | 1994 | Biochem. Med. Metab. Biol. | pmid:7910749 |
Yang X and Dick TA | Dietary alpha-linolenic and linoleic acids competitively affect metabolism of polyunsaturated fatty acids in Arctic charr (Salvelinus alpinus). | 1994 | J. Nutr. | pmid:7913126 |
Makrides M et al. | Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. | 1994 | Am. J. Clin. Nutr. | pmid:7913291 |
Mourot J et al. | [Effects of dietary linoleic acid on lipogenesis enzyme activity in adipose tissue in the pig]. | 1994 | Reprod. Nutr. Dev. | pmid:7914083 |
Emken EA et al. | Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. | 1994 | Biochim. Biophys. Acta | pmid:7914092 |
Yang J et al. | Application of the balance method to determining accumulation, metabolism, and apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat. | 1994 | Metab. Clin. Exp. | pmid:7914345 |
Charnock JS and Poletti VM | Dietary lipids and adipose tissue fatty acids in the marmoset monkey (Callithrix jacchus). | 1994 Jun-Jul | Comp. Biochem. Physiol. Comp. Physiol. | pmid:7914864 |
Legrand P et al. | Stearoyl-CoA desaturase activity in primary culture of chicken hepatocytes. Influence of insulin, glucocorticoid, fatty acids and cordycepin. | 1994 | Int. J. Biochem. | pmid:7914877 |
Sacks GS et al. | Failure of topical vegetable oils to prevent essential fatty acid deficiency in a critically ill patient receiving long-term parenteral nutrition. | 1994 May-Jun | JPEN J Parenter Enteral Nutr | pmid:7914941 |
Ulmann L et al. | Incorporation of delta 6- and delta 5-desaturation fatty acids in liver microsomal lipid classes of obese Zucker rats fed n - 6 or n - 3 fatty acids. | 1994 | Biochim. Biophys. Acta | pmid:7915142 |
Watanabe S et al. | A high alpha-linolenate diet suppresses antigen-induced immunoglobulin E response and anaphylactic shock in mice. | 1994 | J. Nutr. | pmid:7916376 |
van Kuiken BA and Behnke WD | The activation of porcine pancreatic lipase by cis-unsaturated fatty acids. | 1994 | Biochim. Biophys. Acta | pmid:7918595 |
Roy P et al. | Superoxide generation by lipoxygenase in the presence of NADH and NADPH. | 1994 | Biochim. Biophys. Acta | pmid:7918597 |
Bakken AM et al. | The activities of acyl-CoA hydrolase in lysate and subcellular fractions of human blood platelets in relation to activities of acyl-CoA:1-acyl-lysophospholipid acyltransferase. | 1994 | Biochim. Biophys. Acta | pmid:7918598 |
del Carmen Boyano-Adánez M et al. | Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. | 1994 | Biochim. Biophys. Acta | pmid:7918608 |
MogoÅŸ T et al. | The hair levels of unsaturated fatty acids (oleic, linoleic, and linolenic) indicators of the lipid metabolic balance. | 1994 Apr-Jun | Rom J Intern Med | pmid:7920331 |
Quinlan GJ et al. | 4-hydroxy-2-nonenal levels increase in the plasma of patients with adult respiratory distress syndrome as linoleic acid appears to fall. | 1994 | Free Radic. Res. | pmid:7921168 |