Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Jump DB et al. | Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. | 2011 | Biochem. Pharmacol. | pmid:21184748 |
Penumetcha M et al. | Modulation of leptin levels by oxidized linoleic acid: a connection to atherosclerosis? | 2011 | J Med Food | pmid:21186986 |
Park HG et al. | Production of conjugated linoleic acid (CLA) by Bifidobacterium breve LMC520 and its compatibility with CLA-producing rumen bacteria. | 2011 | J. Agric. Food Chem. | pmid:21192703 |
Loizzo MR et al. | In vitro antioxidant and hypoglycemic activities of Ethiopian spice blend Berbere. | 2011 | Int J Food Sci Nutr | pmid:21599464 |
Kruska N and Reiser G | Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40. | 2011 | Neurobiol. Dis. | pmid:21570468 |
Shirakawa J et al. | Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. | 2011 | J. Biol. Chem. | pmid:21613229 |
Labayen I et al. | Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. | 2011 | Atherosclerosis | pmid:21550607 |
Monfregola L et al. | Physical and water sorption properties of chemically modified pectin with an environmentally friendly process. | 2011 | Biomacromolecules | pmid:21553919 |
Márquez-Castillo A and Vidal-Quintanar RL | Improvements in the shelf life of commercial corn dry masa flour (CMF) by reducing lipid oxidation. | 2011 | J. Food Sci. | pmid:21535741 |
Shin D et al. | Dietary combination effects of conjugated linoleic acid and flaxseed or fish oil on the concentration of linoleic and arachidonic acid in poultry meat. | 2011 | Poult. Sci. | pmid:21597077 |
Yepuri G et al. | Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. | 2011 | Br. J. Nutr. | pmid:21281526 |
Wang L et al. | Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+]i increase in pancreatic islet {alpha}-cells. | 2011 | J. Endocrinol. | pmid:21565851 |
Nigam S et al. | On mechanism of quorum sensing in Candida albicans by 3(R)-hydroxy-tetradecaenoic acid. | 2011 | Curr. Microbiol. | pmid:20509029 |
de Lima-Salgado TM et al. | Molecular mechanisms by which saturated fatty acids modulate TNF-α expression in mouse macrophage lineage. | 2011 | Cell Biochem. Biophys. | pmid:20809180 |
Liu SJ et al. | Effect of ruminal pulse dose of polyunsaturated fatty acids on ruminal microbial populations and duodenal flow and milk profiles of fatty acids. | 2011 | J. Dairy Sci. | pmid:21605768 |
Palmieri-Thiers C et al. | Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies. | 2011 | Arch. Biochem. Biophys. | pmid:21345329 |
Kishino S et al. | Linoleic acid isomerase in Lactobacillus plantarum AKU1009a proved to be a multi-component enzyme system requiring oxidoreduction cofactors. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21307591 |
McFarland DC et al. | Effect of lipids on avian satellite cell proliferation, differentiation and heparan sulfate proteoglycan expression. | 2011 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:21356326 |
Retamal MA et al. | Biphasic effect of linoleic acid on connexin 46 hemichannels. | 2011 | Pflugers Arch. | pmid:21360038 |
Maqbool A et al. | The skinny on tuna fat: health implications. | 2011 | Public Health Nutr | pmid:21324226 |
Popescu FD et al. | Effects of season and reproductive state on lipid intake and fatty acid composition of gastrointestinal tract contents in the European hare. | 2011 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:21328065 |
Lee MJ et al. | The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. | 2011 | Mol. Cells | pmid:21331775 |
Cunnane SC and Guesnet P | Linoleic acid recommendations--A house of cards. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21963263 |
Royan M et al. | Effects of conjugated linoleic acid, fish oil and soybean oil on PPARs (α & γ) mRNA expression in broiler chickens and their relation to body fat deposits. | 2011 | Int J Mol Sci | pmid:22272093 |
P Wrobel T et al. | Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis. | 2011 | Analyst | pmid:22007352 |
Salleh WM et al. | Chemical compositions, antioxidant and antimicrobial activities of essential oils of Piper caninum Blume. | 2011 | Int J Mol Sci | pmid:22174627 |
Lebold KM et al. | Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). | 2011 | J. Nutr. | pmid:22013196 |
Nishioka N et al. | Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1. | 2011 | Br. J. Cancer | pmid:22015554 |
Vedtofte MS et al. | Dietary α-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease. | 2011 | Am. J. Clin. Nutr. | pmid:21865326 |
Alimi H et al. | Evaluation of antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis flowers extract in rats. | 2011 | Environ. Toxicol. Pharmacol. | pmid:22004960 |
Amtul Z et al. | Additive effects of fatty acid mixtures on the levels and ratio of amyloid β40/42 peptides differ from the effects of individual fatty acids. | 2011 | J. Neurosci. Res. | pmid:21748777 |
Strandvik B | The omega-6/omega-3 ratio is of importance! | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21945460 |
Ilić M et al. | Thrombin inhibitors with lipid peroxidation and lipoxygenase inhibitory activities. | 2011 | Bioorg. Med. Chem. Lett. | pmid:21757348 |
Espinosa-Neira R et al. | Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A. | 2011 | Int. J. Biochem. Cell Biol. | pmid:21945809 |
Mito F et al. | Oxygen concentration dependence of lipid peroxidation and lipid-derived radical generation: application of profluorescent nitroxide switch. | 2011 | Free Radic. Res. | pmid:21736483 |
Sousa A et al. | Chemical characterization of "alcaparras" stoned table olives from northeast Portugal. | 2011 | Molecules | pmid:22031066 |
Ranchordas MK et al. | A-z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--part 23. | 2011 | Br J Sports Med | pmid:21743106 |
Li J et al. | [Extraction and comparison of volatile oil components from water caltrop and kernel by supercritical carbon dioxide extraction]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22032133 |
Kikalishvili BIu et al. | [The most biological important constances of Rkatsiteli grape oil and its effect as a 5% and 10% food-additive]. | 2011 | Georgian Med News | pmid:21778549 |
Mahmmoud YA and Christensen SB | Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. | 2011 | Biochim. Biophys. Acta | pmid:21767529 |
Khadake R et al. | Functional and bioinformatic characterisation of sequence variants of Fad3 gene from flax. | 2011 | J. Sci. Food Agric. | pmid:21769878 |
Banta JP et al. | Effects of prepartum supplementation of linoleic and mid-oleic sunflower seed on cow performance, cow reproduction, and calf performance from birth through slaughter, and effects on intake and digestion in steers. | 2011 | J. Anim. Sci. | pmid:21788431 |
KonÄić MZ et al. | Antiradical, chelating and antioxidant activities of hydroxamic acids and hydroxyureas. | 2011 | Molecules | pmid:21788931 |
Ramsden CE et al. | All PUFAs are not created equal: absence of CHD benefit specific to linoleic acid in randomized controlled trials and prospective observational cohorts. | 2011 | World Rev Nutr Diet | pmid:21865817 |
Okuyama H et al. | New Cholesterol Guidelines for Longevity (2010). | 2011 | World Rev Nutr Diet | pmid:21865826 |
Legrand P et al. | Update of French nutritional recommendations for fatty acids. | 2011 | World Rev Nutr Diet | pmid:21865827 |
Khan AA et al. | Synthesis and characterization of novel PUFA esters exhibiting potential anticancer activities: an in vitro study. | 2011 | Eur J Med Chem | pmid:21868138 |
Ozcan B et al. | Antimicrobial and antioxidant activities of the various extracts of Verbascum pinetorum Boiss. O. Kuntze (Scrophulariaceae). | 2011 | Eur Rev Med Pharmacol Sci | pmid:21845800 |
Dailey MJ et al. | Jejunal linoleic acid infusions require GLP-1 receptor signaling to inhibit food intake: implications for the effectiveness of Roux-en-Y gastric bypass. | 2011 | Am. J. Physiol. Endocrinol. Metab. | pmid:21917638 |
Lee YJ and Jenkins TC | Identification of enriched conjugated linoleic acid isomers in cultures of ruminal microorganisms after dosing with 1-(13)C-linoleic acid. | 2011 | J. Microbiol. | pmid:21887646 |
Beker BY et al. | Antioxidant protective effect of flavonoids on linoleic acid peroxidation induced by copper(II)/ascorbic acid system. | 2011 | Chem. Phys. Lipids | pmid:21925488 |
Zhou XR et al. | Caenorhabditis elegans Delta12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the Delta12 and Delta15 positions. | 2011 | J. Biol. Chem. | pmid:22041902 |
Ogawa E et al. | Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. | 2011 | J. Invest. Dermatol. | pmid:21068754 |
Arciniega JC et al. | Effects of free fatty acids on meibomian lipid films. | 2011 | Exp. Eye Res. | pmid:21718696 |
Odabasoglu F et al. | α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations. | 2011 | Br. J. Nutr. | pmid:21073761 |
Akrout A et al. | Antioxidant and antitumor activities of Artemisia campestris and Thymelaea hirsuta from southern Tunisia. | 2011 | Food Chem. Toxicol. | pmid:21075159 |
Cheng TM et al. | Haemoglobin-induced oxidative stress is associated with both endogenous peroxidase activity and H2O2 generation from polyunsaturated fatty acids. | 2011 | Free Radic. Res. | pmid:21034361 |
Lin YH et al. | Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. | 2011 | J. Nutr. Biochem. | pmid:21111595 |
Lam WM et al. | In Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement. | 2011 | J. Biomed. Mater. Res. Part B Appl. Biomater. | pmid:21053263 |
Yang Y et al. | Synthesis and antioxidant capacities of hydroxyl derivatives of cinnamoylphenethylamine in protecting DNA and scavenging radicals. | 2011 | Free Radic. Res. | pmid:21128731 |
Hubert DJ et al. | In vitro hepatoprotective and antioxidant activities of crude extract and isolated compounds from Ficus gnaphalocarpa. | 2011 | Inflammopharmacology | pmid:21088994 |
Jin G et al. | Crude lipoxygenase from pig muscle: partial characterization and interactions of temperature, NaCl and pH on its activity. | 2011 | Meat Sci. | pmid:21093161 |
Du YZ et al. | Linoleic acid-grafted chitosan oligosaccharide micelles for intracellular drug delivery and reverse drug resistance of tumor cells. | 2011 | Int. J. Biol. Macromol. | pmid:21093477 |
Huang YS et al. | Eicosadienoic acid differentially modulates production of pro-inflammatory modulators in murine macrophages. | 2011 | Mol. Cell. Biochem. | pmid:21688154 |
Blaul B and Ruther J | How parasitoid females produce sexy sons: a causal link between oviposition preference, dietary lipids and mate choice in Nasonia. | 2011 | Proc. Biol. Sci. | pmid:21429922 |
Gibson RA et al. | Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. | 2011 | Matern Child Nutr | pmid:21366864 |
Lauritzen L and Carlson SE | Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. | 2011 | Matern Child Nutr | pmid:21366866 |
Brenna JT | Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. | 2011 | Matern Child Nutr | pmid:21366867 |
Briend A et al. | Fatty acid status in early life in low-income countries--overview of the situation, policy and research priorities. | 2011 | Matern Child Nutr | pmid:21366873 |
Blasbalg TL et al. | Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. | 2011 | Am. J. Clin. Nutr. | pmid:21367944 |
Aewsiri T et al. | Surface activity and molecular characteristics of cuttlefish skin gelatin modified by oxidized linoleic acid. | 2011 | Int. J. Biol. Macromol. | pmid:21334373 |
You Q et al. | Purification, immobilization and characterization of linoleic acid isomerase on modified palygorskite. | 2011 | Bioprocess Biosyst Eng | pmid:21340675 |
Rybicka M et al. | Comparative effects of conjugated linoleic acid (CLA) and linoleic acid (LA) on the oxidoreduction status in THP-1 macrophages. | 2011 | J. Agric. Food Chem. | pmid:21391598 |
Rakib MA et al. | Preventive effect of t,t-conjugated linoleic acid on 12-O-tetradecanoylphorbol-13-acetate-induced inhibition of gap junctional intercellular communication in human mammary epithelial MCF-10A cells. | 2011 | J. Agric. Food Chem. | pmid:21391601 |
Tuei VC et al. | Effects of human serum albumin complexed with free fatty acids on cell viability and insulin secretion in the hamster pancreatic β-cell line HIT-T15. | 2011 | Life Sci. | pmid:21396379 |
Mihaljević B et al. | Linoleic acid peroxidation vs. isomerization: a biomimetic model of free radical reactivity in the presence of thiols. | 2011 | Org. Biomol. Chem. | pmid:21442126 |
Blum JL et al. | Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. | 2011 | Toxicol In Vitro | pmid:21443943 |
Conforti F et al. | Correlation between environmental factors, chemical composition, and antioxidative properties of caper species growing wild in Calabria (South Italy). | 2011 | Chem. Biodivers. | pmid:21404435 |
Edris AE | The chemical composition and the content of volatile oil: potential factors that can contribute to the oxidative stability of Nigella sativa L. crude oil. | 2011 | J Diet Suppl | pmid:22432633 |
Serratosa MP et al. | Changes in hydrophilic and lipophilic antioxidant activity in relation to their phenolic composition during the chamber drying of red grapes at a controlled temperature. | 2011 | J. Agric. Food Chem. | pmid:21319807 |
Salem N and Kuratko CN | Lack of evidence for increased α-linolenic acid metabolism in vegetarians. | 2011 | Am. J. Clin. Nutr. | pmid:21430120 |
Parra-Cabrera S et al. | Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. | 2011 | Matern Child Nutr | pmid:21410881 |
Litinas KE et al. | Synthesis and biological evaluation of fused oxepinocoumarins as free radicals scavengers. | 2011 | J Enzyme Inhib Med Chem | pmid:21381887 |
Atri MS et al. | Structure and stability analysis of cytotoxic complex of camel α-lactalbumin and unsaturated fatty acids produced at high temperature. | 2011 | J. Biomol. Struct. Dyn. | pmid:21469752 |
Carrillo C et al. | Oleic acid versus linoleic and α-linolenic acid. different effects on Ca2+ signaling in rat thymocytes. | 2011 | Cell. Physiol. Biochem. | pmid:21471726 |
Subbaiah PV et al. | Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. | 2011 | Biochim. Biophys. Acta | pmid:20920595 |
Alloatti A and Uttaro AD | Highly specific methyl-end fatty-acid desaturases of trypanosomatids. | 2011 | Mol. Biochem. Parasitol. | pmid:20974196 |
Figueras M et al. | Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status. | 2011 | Obesity (Silver Spring) | pmid:20885391 |
Konkel A and Schunck WH | Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. | 2011 | Biochim. Biophys. Acta | pmid:20869469 |
Liou AP et al. | The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. | 2011 | Gastroenterology | pmid:20955703 |
Perona JS et al. | Olive oil phenols modulate the triacylglycerol molecular species of human very low-density lipoprotein. A randomized, crossover, controlled trial. | 2011 | Metab. Clin. Exp. | pmid:20934731 |
Mariutto M et al. | The elicitation of a systemic resistance by Pseudomonas putida BTP1 in tomato involves the stimulation of two lipoxygenase isoforms. | 2011 | BMC Plant Biol. | pmid:21294872 |
Pan Z et al. | Effects of linoleate on cell viability and lipid metabolic homeostasis in goose primary hepatocytes. | 2011 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:21295151 |
Tsubura A et al. | Anticancer effects of garlic and garlic-derived compounds for breast cancer control. | 2011 | Anticancer Agents Med Chem | pmid:21269259 |
Chohany LE et al. | Cationic substrates of soybean lipoxygenase-1. | 2011 | Bioorg. Chem. | pmid:21257189 |
Das R et al. | Synthesis of linoleic acid capped copper nanoparticles and their fluorescence study. | 2011 | J Fluoresc | pmid:21221748 |
White HM et al. | Differential regulation of bovine pyruvate carboxylase promoters by fatty acids and peroxisome proliferator-activated receptor-α agonist. | 2011 | J. Dairy Sci. | pmid:21700028 |
Siddique BM et al. | Chemical composition and antioxidant properties of candlenut oil extracted by supercritical CO2. | 2011 | J. Food Sci. | pmid:22417332 |
Chen HH and Chiu TH | Phytochemicals characterization of solvent extracts from taro-scented japonica rice bran. | 2011 | J. Food Sci. | pmid:22417350 |
Turk HF et al. | Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. | 2011 | Int. J. Cancer | pmid:20232381 |