Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Castillo M et al. | Effects of dietary fish oil on the fatty acid composition of the main lipid classes of chick plasma lipoproteins. | 2002 | J. Physiol. Biochem. | pmid:12603006 |
Barabino S et al. | Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. | 2003 | Cornea | pmid:12605039 |
Xu X et al. | Short-term intake of conjugated linoleic acid inhibits lipoprotein lipase and glucose metabolism but does not enhance lipolysis in mouse adipose tissue. | 2003 | J. Nutr. | pmid:12612134 |
Yamasaki M et al. | Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid. | 2003 | J. Nutr. | pmid:12612153 |
Arab L | Biomarkers of fat and fatty acid intake. | 2003 | J. Nutr. | pmid:12612178 |
Campbell W et al. | The impact of fortification with conjugated linoleic acid (CLA) on the quality of fluid milk. | 2003 | J. Dairy Sci. | pmid:12613847 |
Gonzalez S et al. | Oxidation and textural characteristics of butter and ice cream with modified fatty acid profiles. | 2003 | J. Dairy Sci. | pmid:12613850 |
Cui YF et al. | Effect of unsaturated fatty acid on muscarinic current in guinea pig gastric antral circular myocytes. | 2003 | Acta Pharmacol. Sin. | pmid:12617780 |
Waddington EI et al. | Fatty acid oxidation products in human atherosclerotic plaque: an analysis of clinical and histopathological correlates. | 2003 | Atherosclerosis | pmid:12618275 |
Henriksen EJ et al. | Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12618357 |
Koba K et al. | Effect of phytate in soy protein on the serum and liver cholesterol levels and liver fatty acid profile in rats. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12619668 |
Kishino S et al. | Structural analysis of conjugated linoleic acid produced by Lactobacillus plantarum, and factors affecting isomer production. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12619692 |
Bergman M et al. | Scavenging of reactive oxygen species by a novel glucurinated flavonoid antioxidant isolated and purified from spinach. | 2003 | Phytochemistry | pmid:12620328 |
Yang H et al. | Conjugated linoleic acid inhibits mutagenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the prostate of Big Blue rats. | 2003 | Mutagenesis | pmid:12621076 |
Adam O et al. | Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers. | 2003 | Ann. Nutr. Metab. | pmid:12624485 |
Fernández-Moya V et al. | Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds. | 2003 | Planta | pmid:12624771 |
Enoki M et al. | Oxidative degradation of cis- and trans-1,4-polyisoprenes and vulcanized natural rubber with enzyme-mediator systems. | 2003 Mar-Apr | Biomacromolecules | pmid:12625726 |
Bauman DE and Griinari JM | Nutritional regulation of milk fat synthesis. | 2003 | Annu. Rev. Nutr. | pmid:12626693 |
Park KY et al. | Antimutagenic effects of doenjang (Korean fermented soypaste) and its active compounds. | 2003 Feb-Mar | Mutat. Res. | pmid:12628502 |
Turgeon D et al. | Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases. | 2003 | J. Lipid Res. | pmid:12639971 |
Adlof RO and List GR | Synthesis and analysis of symmetrical and nonsymmetrical disaturated/monounsaturated triacylglycerols. | 2003 | J. Agric. Food Chem. | pmid:12643679 |
Joo NE and Park CS | Inhibition of excitotoxicity in cultured rat cortical neurons by a mixture of conjugated linoleic acid isomers. | 2003 | Pharmacol. Res. | pmid:12644387 |
Mackle TR et al. | Effects of abomasal infusion of conjugated linoleic acid on milk fat concentration and yield from pasture-fed dairy cows. | 2003 | J. Dairy Sci. | pmid:12647970 |
Maccarrone M et al. | Lipoxygenase activity during parabolic flights. | 2001 | J Gravit Physiol | pmid:12650198 |
Burton M et al. | Synthesis, structure-activity relationship and in vitro evaluation of coelenterazine and coelenteramine derivatives as inhibitors of lipid peroxidation. | 2003 | Free Radic. Res. | pmid:12653203 |
Ramachandran S et al. | Oxidants and antioxidants affect the expression of glycodelin. | 2003 | Free Radic. Biol. Med. | pmid:12654469 |
Sakono M et al. | Combined effects of dietary conjugated linoleic acid and sesamin triacylglycerol and ketone body production in rat liver. | 2002 | J. Nutr. Sci. Vitaminol. | pmid:12656216 |
Chartrand R et al. | Effect of dietary fat sources on systemic and intrauterine synthesis of prostaglandins during early pregnancy in gilts. | 2003 | J. Anim. Sci. | pmid:12661653 |
Lee C et al. | Quantitative trait loci mapping for fatty acid contents in the backfat on porcine chromosomes 1, 13, and 18. | 2003 | Mol. Cells | pmid:12661762 |
Kark JD et al. | Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids. | 2003 | Am. J. Clin. Nutr. | pmid:12663274 |
Djoussé L et al. | Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:12663278 |
Eitel K et al. | Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. | 2003 | Diabetes | pmid:12663471 |
Kelavkar U et al. | 15-lipoxygenase-1 overexpression in prostate adenocarcinoma. | 2002 | Adv. Exp. Med. Biol. | pmid:12664577 |
Mitchell LA et al. | Linoleic acid metabolites act to increase contractility in isolated rat heart. | 2002 | Cardiovasc. Toxicol. | pmid:12665667 |
Takahashi Y et al. | Activity and mRNA levels of enzymes involved in hepatic fatty acid synthesis and oxidation in mice fed conjugated linoleic acid. | 2003 | Biochim. Biophys. Acta | pmid:12668178 |
Yang M and Cook ME | Dietary CLA decreased weight loss and extended survival following the onset of kidney failure in NZB/W F1 mice. | 2003 | Lipids | pmid:12669815 |
Kondo H et al. | Digestion and assimilation features of dietary DAG in the rat small intestine. | 2003 | Lipids | pmid:12669816 |
Siddhuraju P and Becker K | Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves. | 2003 | J. Agric. Food Chem. | pmid:12670148 |
Considine MJ et al. | Superoxide stimulates a proton leak in potato mitochondria that is related to the activity of uncoupling protein. | 2003 | J. Biol. Chem. | pmid:12672801 |
Yang XF et al. | In vitro release and antibacterial activity of poly (oleic/linoleic acid dimer: sebacic acid)-gentamicin. | 2003 | Acta Pharmacol. Sin. | pmid:12676068 |
Torres-Duarte AP and Vanderhoek JY | Conjugated linoleic acid exhibits stimulatory and inhibitory effects on prostanoid production in human endothelial cells and platelets. | 2003 | Biochim. Biophys. Acta | pmid:12676356 |
Davidson BC et al. | Individual fatty acids influence cultured human liver cells differently when compared to plant oils. | 2003 Jan-Feb | Anticancer Res. | pmid:12680255 |
Qian SY et al. | Identification of all classes of spin-trapped carbon-centered radicals in soybean lipoxygenase-dependent lipid peroxidations of omega-6 polyunsaturated fatty acids via LC/ESR, LC/MS, and tandem MS. | 2003 | Free Radic. Biol. Med. | pmid:12684086 |
Nakanishi T et al. | Dietary conjugated linoleic acid reduces cerebral prostaglandin E(2) in mice. | 2003 | Neurosci. Lett. | pmid:12686384 |
Bruder ED et al. | An oxidized metabolite of linoleic acid stimulates corticosterone production by rat adrenal cells. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12689852 |
Itakura K and Uchida K | Lysine-derived fluorophores formed by autoxidation of linoleic acid. | 2003 | Chem. Phys. Lipids | pmid:12691851 |
Prout RE and Odutuga AA | Fatty acid composition of neutral lipids and phospholipids of enamel and dentine from human molars. | 1974 | Arch. Oral Biol. | pmid:12692911 |
Nagler LG et al. | Rate of free-radical oxidation of C18 diene and triene fatty acids in aqueous micellar solutions and effectiveness of beta-carotene as an inhibitor of their oxidation. | 2003 | Biochemistry Mosc. | pmid:12693967 |
Foti MC and Ingold KU | Mechanism of inhibition of lipid peroxidation by gamma-terpinene, an unusual and potentially useful hydrocarbon antioxidant. | 2003 | J. Agric. Food Chem. | pmid:12696969 |
Albers R et al. | Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men. | 2003 | Eur J Clin Nutr | pmid:12700622 |
Meerarani P et al. | Cholesterol attenuates linoleic acid-induced endothelial cell activation. | 2003 | Metab. Clin. Exp. | pmid:12701065 |
AbuGhazaleh AA et al. | Milk conjugated linoleic acid response to fish oil supplementation of diets differing in fatty acid profiles. | 2003 | J. Dairy Sci. | pmid:12703631 |
Zhang WH et al. | Model studies on protein side chain modification by 4-oxo-2-nonenal. | 2003 | Chem. Res. Toxicol. | pmid:12703968 |
Risé P et al. | Relative potencies of statins in reducing cholesterol synthesis and enhancing linoleic acid metabolism. | 2003 | Eur. J. Pharmacol. | pmid:12706457 |
Gueck T et al. | Effects of essential fatty acids on mediators of mast cells in culture. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711248 |
Nixon JB et al. | Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711249 |
Chen XG et al. | O/W emulsification for the self-aggregation and nanoparticle formation of linoleic acid-modified chitosan in the aqueous system. | 2003 | J. Agric. Food Chem. | pmid:12720404 |
Ju JW and Jung MY | Formation of conjugated linoleic acids in soybean oil during hydrogenation with a nickel catalyst as affected by sulfur addition. | 2003 | J. Agric. Food Chem. | pmid:12720406 |
Mattos R et al. | Polyunsaturated fatty acids and bovine interferon-tau modify phorbol ester-induced secretion of prostaglandin F2 alpha and expression of prostaglandin endoperoxide synthase-2 and phospholipase-A2 in bovine endometrial cells. | 2003 | Biol. Reprod. | pmid:12724278 |
Mun'im A et al. | Antioxidative compounds from Crotalaria sessiliflora. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12729010 |
Inagaki K et al. | Evidence of isozymes for delta6 fatty acid desaturase in rat hepatocytes. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12729021 |
Risérus U et al. | CLA and body weight regulation in humans. | 2003 | Lipids | pmid:12733745 |
Gruffat D et al. | In vitro comparison of hepatic metabolism of 9cis-11 trans and 10trans-12cis isomers of CLA in the rat. | 2003 | Lipids | pmid:12733748 |
Ma DW et al. | An enriched mixture of trans-10,cis-12-CLA inhibits linoleic acid metabolism and PGE2 synthesis in MDA-MB-231 cells. | 2002 | Nutr Cancer | pmid:12734056 |
Wiesenfeld PW et al. | Flaxseed increased alpha-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring. | 2003 | Food Chem. Toxicol. | pmid:12738189 |
Babu US et al. | Impact of high flaxseed diet on mitogen-induced proliferation, IL-2 production, cell subsets and fatty acid composition of spleen cells from pregnant and F1 generation Sprague-Dawley rats. | 2003 | Food Chem. Toxicol. | pmid:12738196 |
Mashek DG and Grummer RR | Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liver. | 2003 | J. Dairy Sci. | pmid:12741546 |
Nair VB and Panchagnula R | Effect of iontophoresis and fatty acids on permeation of arginine vasopressin through rat skin. | 2003 | Pharmacol. Res. | pmid:12742012 |
Gorinstein S et al. | Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging tests. | 2003 | J. Nutr. Biochem. | pmid:12742543 |
Wang JY et al. | Effect of docosahexaenoic acid and ascorbate on peroxidation of retinal membranes of ODS rats. | 2003 | Free Radic. Res. | pmid:12747736 |
Rotta AT et al. | Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems. | 2003 | Pediatr Crit Care Med | pmid:12749658 |
Buddington RK and Malo C | Postnatal development of nutrient transport in the intestine of dogs. | 2003 | Am. J. Vet. Res. | pmid:12755305 |
Yang YM et al. | [The effects of conjugated linoleic acid on the expression of invasiveness and metastasis-associated gene of human gastric carcinoma cell line]. | 2003 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:12760791 |
Buckner JS and Hagen MM | Triacylglycerol and phospholipid fatty acids of the silverleaf whitefly: composition and biosynthesis. | 2003 | Arch. Insect Biochem. Physiol. | pmid:12761874 |
Aletor VA et al. | The effects of conjugated linoleic acids or an alpha-glucosidase inhibitor on tissue lipid concentrations and fatty acid composition of broiler chicks fed a low-protein diet. | 2003 | Poult. Sci. | pmid:12762403 |
Macrì A et al. | Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy. | 2003 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:12768289 |
Yamasaki M et al. | Dose-dependent effect of dietary conjugated linoleic acid on the growth of rat hepatoma dRLh-84 cells in vivo. | 2002 | J. Nutr. Sci. Vitaminol. | pmid:12775118 |
Ward AT et al. | Fresh forage and solin supplementation on conjugated linoleic acid levels in plasma and milk. | 2003 | J. Dairy Sci. | pmid:12778585 |
Vargas F et al. | Photochemistry and in vitro phototoxicity studies of levomepromazine (methotrimeprazine), a phototoxic neuroleptic drug. | 2003 | Pharmazie | pmid:12779046 |
Cho H et al. | Nonradiometric HPLC measurement of 13(S)-hydroxyoctadecadienoic acid from rat tissues. | 2003 | Anal. Biochem. | pmid:12782030 |
Barceló-Coblijn G et al. | Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. | 2003 | Biochim. Biophys. Acta | pmid:12782153 |
Beck S et al. | Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation. | 2003 | J. Biol. Chem. | pmid:12782627 |
Shimada Y et al. | Increased response of liver microsomal delta 6-desaturase activity to dietary methionine in rats. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12784613 |
Piazza GJ et al. | Isolation of unsaturated diols after oxidation of conjugated linoleic acid with peroxygenase. | 2003 | Lipids | pmid:12784865 |
Nagao K et al. | The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty rats. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12788078 |
pmid:12790685 | ||||
Chajes V et al. | Conjugated linoleic acid content in breast adipose tissue of breast cancer patients and the risk of metastasis. | 2003 | Nutr Cancer | pmid:12791500 |
Ristić V and Ristić G | [Role and importance of dietary polyunsaturated fatty acids in the prevention and therapy of atherosclerosis]. | 2003 Jan-Feb | Med. Pregl. | pmid:12793187 |
Hutley LJ et al. | Effects of rosiglitazone and linoleic acid on human preadipocyte differentiation. | 2003 | Eur. J. Clin. Invest. | pmid:12814394 |
Kim JY and Chung BH | Effects of combination dietary conjugated linoleic acid with vitamin A (retinol) and selenium on the response of the immunoglobulin production in mice. | 2003 | J. Vet. Sci. | pmid:12819373 |
Kamphuis MM et al. | The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects. | 2003 | Int. J. Obes. Relat. Metab. Disord. | pmid:12821971 |
Giron MD et al. | Long-term effects of dietary monounsaturated and polyunsaturated fatty acids on plasma lipids in dogs. | 1992 Sep-Oct | Arch Int Physiol Biochim Biophys | pmid:1282382 |
Tamura K et al. | Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants. | 2003 | J. Med. Chem. | pmid:12825946 |
Sehanputri PS and Hill CG | Lipase-mediated acidolysis of butteroil with free conjugated linoleic acid in a packed bed reactor. | 2003 | Biotechnol. Bioeng. | pmid:12827703 |
Politis I et al. | Effects of dietary conjugated linoleic acid isomers on several functional properties of macrophages and heterophils in laying hens. | 2003 | Br. Poult. Sci. | pmid:12828205 |
Mittendorfer B et al. | What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean? | 2003 | Diabetes | pmid:12829627 |
Nagao K et al. | The 10trans, 12cis isomer of conjugated linoleic acid promotes energy metabolism in OLETF rats. | 2003 Jul-Aug | Nutrition | pmid:12831953 |
McNeel RL and Mersmann HJ | Effects of isomers of conjugated linoleic acid on porcine adipocyte growth and differentiation. | 2003 | J. Nutr. Biochem. | pmid:12832030 |
Degrace P et al. | Association of liver steatosis with lipid oversecretion and hypotriglyceridaemia in C57BL/6j mice fed trans-10,cis-12-linoleic acid. | 2003 | FEBS Lett. | pmid:12832064 |
Domergue F et al. | Acyl carriers used as substrates by the desaturases and elongases involved in very long-chain polyunsaturated fatty acids biosynthesis reconstituted in yeast. | 2003 | J. Biol. Chem. | pmid:12835316 |