Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Leptospirosis D007922 2 associated lipids
Lactose Intolerance D007787 2 associated lipids
Disease D004194 2 associated lipids
Haemophilus Infections D006192 3 associated lipids
Hepatolenticular Degeneration D006527 3 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Dermatitis, Toxicodendron D011040 3 associated lipids
Infertility D007246 3 associated lipids
Wasting Syndrome D019282 3 associated lipids
Melanosis D008548 4 associated lipids
Varicocele D014646 4 associated lipids
Embolism, Fat D004620 4 associated lipids
Dermatitis, Phototoxic D017484 4 associated lipids
Esophagitis, Peptic D004942 4 associated lipids
Biliary Atresia D001656 4 associated lipids
Cicatrix, Hypertrophic D017439 4 associated lipids
Epilepsy, Temporal Lobe D004833 4 associated lipids
Varicose Ulcer D014647 4 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Choroidal Neovascularization D020256 5 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

Download all related citations
Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
Aarsland A and Wolfe RR Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men. 1998 J. Lipid Res. pmid:9643360
Murthy S et al. 13-hydroxy octadecadienoic acid (13-HODE) inhibits triacylglycerol-rich lipoprotein secretion by CaCo-2 cells. 1998 J. Lipid Res. pmid:9643357
Iwase H et al. Formation of keto and hydroxy compounds of linoleic acid in submitochondrial particles of bovine heart. 1998 Free Radic. Biol. Med. pmid:9641268
Hughes RK et al. Characterization of authentic recombinant pea-seed lipoxygenases with distinct properties and reaction mechanisms. 1998 Biochem. J. pmid:9639559
Mizushina Y et al. An ergosterol peroxide, a natural product that selectively enhances the inhibitory effect of linoleic acid on DNA polymerase beta. 1998 Biol. Pharm. Bull. pmid:9635497
Battu S et al. Linoleic acid peroxidation by Solanum tuberosum lipoxygenase was activated in the presence of human 5-lipoxygenase-activating protein. 1998 Biochim. Biophys. Acta pmid:9630716
Emken EA et al. Effect of dietary arachidonic acid on metabolism of deuterated linoleic acid by adult male subjects. 1998 Lipids pmid:9625594
Liu KL and Belury MA Conjugated linoleic acid reduces arachidonic acid content and PGE2 synthesis in murine keratinocytes. 1998 Cancer Lett. pmid:9619853
Ohnishi M et al. Inhibition in vitro linoleic acid peroxidation and haemolysis by caffeoyltryptophan. 1998 Phytochemistry pmid:9611825
Kikuchi S et al. Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610849
Das I and Khan NS Increased arachidonic acid induced platelet chemiluminescence indicates cyclooxygenase overactivity in schizophrenic subjects. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610837
Kleinfeld AM et al. Transport of long-chain native fatty acids across human erythrocyte ghost membranes. 1998 Biochemistry pmid:9609694
Kouba M and Mourot J Effect of a high linoleic acid diet on delta 9-desaturase activity, lipogenesis and lipid composition of pig subcutaneous adipose tissue. 1998 Jan-Feb Reprod. Nutr. Dev. pmid:9606747
Tsai WS et al. Inhibitory effects of n-3 polyunsaturated fatty acids on sigmoid colon cancer transformants. 1998 J. Gastroenterol. pmid:9605950
Geetha T et al. Effect of triterpenes from Crataeva nurvala stem bark on lipid peroxidation in adjuvant induced arthritis in rats. 1998 Pharmacol. Res. pmid:9602466
Schaloske R et al. Fatty acids induce release of Ca2+ from acidosomal stores and activate capacitative Ca2+ entry in Dictyostelium discoideum. 1998 Biochem. J. pmid:9601085
Dokko RC et al. Cellular uptake of stearic, oleic, linoleic, and linolenic acid and their effects on synthesis and secretion of lipids in Hep-G2 cells. 1998 Int. J. Biochem. Cell Biol. pmid:9597754
Egashira Y et al. Dietary linoleic acid alters alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), a key enzyme of niacin synthesis from tryptophan, in the process of protein expression in rat liver. 1998 J. Nutr. Sci. Vitaminol. pmid:9591240
Kwan KY et al. Inhibitory effect of linoleic acid on chain elongation and desaturation of 18:2 c,t isomers in lactating and neonatal rats. 1998 Lipids pmid:9590629
Kambayashi Y et al. Preferential hydrolysis of oxidized phosphatidylcholine in cholesterol-containing phosphatidylcholine liposome by phospholipase A2. 1998 Biochem. Biophys. Res. Commun. pmid:9588178
Peterson DB Long-chain fatty acids and cardiovascular disease risk in non-insulin-dependent diabetes. 1998 Nutrition pmid:9583379
Hamberg M et al. Manganese lipoxygenase. Discovery of a bis-allylic hydroperoxide as product and intermediate in a lipoxygenase reaction. 1998 J. Biol. Chem. pmid:9582346
Lee M et al. Identification of non-heme diiron proteins that catalyze triple bond and epoxy group formation. 1998 Science pmid:9572738
Hill EM et al. Changes in expression of 15-lipoxygenase and prostaglandin-H synthase during differentiation of human tracheobronchial epithelial cells. 1998 Am. J. Respir. Cell Mol. Biol. pmid:9569236
Kelly ML et al. Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows. 1998 J. Nutr. pmid:9566998
Marra F et al. Effects of supplementation with unsaturated fatty acids on plasma and membrane lipid composition and platelet function in patients with cirrhosis and defective aggregation. 1998 J. Hepatol. pmid:9566835
Yehuda S et al. Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis. 1998 Neurochem. Res. pmid:9566600
Horrobin DF and Ziboh VA The importance of linoleic acid metabolites in cancer metastasis and in the synthesis and actions of 13-HODE. 1997 Adv. Exp. Med. Biol. pmid:9561154
Giménez-Arnau A et al. Effects of linoleic acid supplements on atopic dermatitis. 1997 Adv. Exp. Med. Biol. pmid:9561153
Brister SJ and Buchanan MR Effects of linoleic acid and/or marine fish oil supplements on vessel wall thromboresistance in patients undergoing cardiac surgery. 1997 Adv. Exp. Med. Biol. pmid:9561151
Riambau V et al. Effect of linoleic acid supplements on vessel wall hyperplasia in rabbits. 1997 Adv. Exp. Med. Biol. pmid:9561150
Hörnsten L et al. Bisallylic hydroxylation of linoleic and arachidonic acids by adult and fetal human liver microsomes and a comparison with human recombinant cytochromes P450. 1997 Adv. Exp. Med. Biol. pmid:9561118
You YQ et al. Effect of continuous enteral medium-chain fatty acid infusion on lipid metabolism in rats. 1998 Lipids pmid:9560800
Sugiyama K et al. Dietary methionine level affects linoleic acid metabolism through phosphatidylethanolamine N-methylation in rats. 1998 Lipids pmid:9560797
Kowaltowski AJ et al. Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain. 1998 FEBS Lett. pmid:9559650
Akamatsu H and Horio T The possible role of reactive oxygen species generated by neutrophils in mediating acne inflammation. 1998 Dermatology (Basel) pmid:9557235
Rosenfield RL et al. Mechanisms of androgen induction of sebocyte differentiation. 1998 Dermatology (Basel) pmid:9557223
Romanini D et al. Absorption and fluorescence spectra of polyene antibiotics in the presence of human serum albumin. 1998 Biochem. Mol. Biol. Int. pmid:9556221
Mennen L et al. Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. 1998 Arterioscler. Thromb. Vasc. Biol. pmid:9555866
Kataoka K et al. Pathophysiologic studies of experimental chronic pancreatitis in rats induced by injection of zein-oleic acid-linoleic acid solution into the pancreatic duct. 1998 Pancreas pmid:9548669
Li-Stiles B et al. Identification and characterization of several forms of phospholipase A2 in mouse epidermal keratinocytes. 1998 J. Lipid Res. pmid:9548589
Louw L et al. The importance of linoleic acid in the total fatty acid compositions of benign and malignant neuroglial tumors. 1997 Adv. Exp. Med. Biol. pmid:9547647
Louw L et al. Linoleic acid levels in cutaneous tumors with different growth patterns as an additional sensitive diagnostic feature. 1997 Adv. Exp. Med. Biol. pmid:9547646
Louw L et al. Impairment in the fatty acid composition of keloids. 1997 Adv. Exp. Med. Biol. pmid:9547645
Camacho M et al. IL-1 increases the ability of human endothelial cells to transform linoleic acid into monohydroxy-isomers and their incorporation into cell lipids. 1997 Adv. Exp. Med. Biol. pmid:9547616
Liu SX et al. Oxidized cholesterol in oxidized low density lipoprotein may be responsible for the inhibition of LPS-induced nitric oxide production in macrophages. 1998 Atherosclerosis pmid:9544730
Matthys LA and Widmaier EP Fatty acids inhibit adrenocorticotropin-induced adrenal steroidogenesis. 1998 Horm. Metab. Res. pmid:9543689
Voskuyl RA et al. Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. 1998 Eur. J. Pharmacol. pmid:9543232
Herrera JA et al. Prevention of preeclampsia by linoleic acid and calcium supplementation: a randomized controlled trial. 1998 Obstet Gynecol pmid:9540946
Liang JF and Akaike T Protective effect of linoleic acid on IFN gamma-induced cellular injury in primary culture hepatocytes. 1998 J. Biochem. pmid:9538194