| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colitis | D003092 | 69 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Cattle Diseases | D002418 | 24 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Varicocele | D014646 | 4 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Stomach Neoplasms | D013274 | 24 associated lipids |
| Foreign-Body Reaction | D005549 | 10 associated lipids |
| Carcinoma | D002277 | 18 associated lipids |
| Gastritis | D005756 | 27 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
Linoelaidic acid
Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
Cross Reference
Introduction
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoelaidic acid?
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoelaidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Linoelaidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (1)
- Am. J. Physiol., Cell Physiol. (1)
- Hypertension (1)
- Others (3)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol., Cell Physiol. (1)
- Plant Cell (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoelaidic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoelaidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Verwoert I et al. | The molecular basis of the high linoleic acid content in Petunia seed oil: analysis of a seed-specific linoleic acid mutant. | 2000 | Biochem. Soc. Trans. | pmid:11171150 |
| Bailey JM et al. | Dietary linoleic acid in alcohol-induced liver cirrhosis. | 1995 | Biochem. Soc. Trans. | pmid:7672270 |
| Kaushik N and Agnihotri A | GLC analysis of Indian rapeseed-mustard to study the variability of fatty acid composition. | 2000 | Biochem. Soc. Trans. | pmid:11171132 |
| Bates D | Lipids and multiple sclerosis. | 1989 | Biochem. Soc. Trans. | pmid:2546837 |
| Peres CM et al. | Transference of fatty acids from macrophages to lymphocytes in culture. | 1997 | Biochem. Soc. Trans. | pmid:9191389 |
| Sanderson P et al. | Dietary fish oil diminishes the antigen presentation activity of rat dendritic cells. | 1997 | Biochem. Soc. Trans. | pmid:9191396 |
| Campbell FM and Dutta-Roy AK | Asymmetric distribution of the plasma membrane fatty acid-binding protein (FABPpm) in the human placenta. | 1996 | Biochem. Soc. Trans. | pmid:8736907 |
| Oliver MF | Linoleic acid, antioxidants and coronary heart disease. | 1990 | Biochem. Soc. Trans. | pmid:2088801 |
| Chaloner C et al. | Effect of oral supplementation with micronutrient antioxidants on trans fatty acid content of lipoproteins in healthy humans. | 1996 | Biochem. Soc. Trans. | pmid:8736849 |
| Das I et al. | Effects of aspirin and garlic on cyclooxygenase-induced chemiluminescence in human term placenta. | 1997 | Biochem. Soc. Trans. | pmid:9056997 |
| Kaushik N and Vir S | Variations in fatty acid composition of neem seeds collected from the Rajasthan state of India. | 2000 | Biochem. Soc. Trans. | pmid:11171243 |
| Emken EA et al. | Metabolism in vivo of deuterium-labelled linolenic and linoleic acids in humans. | 1990 | Biochem. Soc. Trans. | pmid:2083671 |
| James SR et al. | Linoleic acid increases cytosolic Ca2+ in lymphocytes. | 1990 | Biochem. Soc. Trans. | pmid:2083720 |
| Bell JG and Raynard RS | Effects of a high linoleic acid diet on the fatty acid composition of leucocytes from Atlantic salmon (Salmo salar). | 1990 | Biochem. Soc. Trans. | pmid:2083726 |
| Liu Q et al. | Genetic modification of cotton seed oil using inverted-repeat gene-silencing techniques. | 2000 | Biochem. Soc. Trans. | pmid:11288706 |
| Devery R et al. | Conjugated linoleic acid and oxidative behaviour in cancer cells. | 2001 | Biochem. Soc. Trans. | pmid:11356179 |
| Mogul R and Holman TR | Inhibition studies of soybean and human 15-lipoxygenases with long-chain alkenyl sulfate substrates. | 2001 | Biochemistry | pmid:11284695 |
| Kleinfeld AM et al. | Transport of long-chain native fatty acids across lipid bilayer membranes indicates that transbilayer flip-flop is rate limiting. | 1997 | Biochemistry | pmid:9369487 |
| Nelson MJ et al. | Photolysis of "purple" lipoxygenase: implications for the structure of the chromophore. | 1995 | Biochemistry | pmid:7742320 |
| Surette ME et al. | Relationship between arachidonate--phospholipid remodeling and apoptosis. | 1996 | Biochemistry | pmid:8703924 |
| Glickman MH and Klinman JP | Lipoxygenase reaction mechanism: demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover. | 1996 | Biochemistry | pmid:8841132 |
| Jin SJ and Tserng KY | Metabolic origins of urinary unsaturated dicarboxylic acids. | 1990 | Biochemistry | pmid:2271537 |
| Biro A et al. | Complement protein C1q recognizes enzymatically modified low-density lipoprotein through unesterified fatty acids generated by cholesterol esterase. | 2010 | Biochemistry | pmid:20166680 |
| Pandey NR et al. | Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein A-I secretion. | 2008 | Biochemistry | pmid:18189424 |
| SGOUTAS DS and KUMMEROW FA | CHEMICAL SYNTHESIS OF TRITIUM-LABELED LINOLEIC ACID. | 1964 | Biochemistry | pmid:14155105 |
| Lima ES et al. | Characterization of linoleic acid nitration in human blood plasma by mass spectrometry. | 2002 | Biochemistry | pmid:12186558 |
| Glickman MH and Klinman JP | Nature of rate-limiting steps in the soybean lipoxygenase-1 reaction. | 1995 | Biochemistry | pmid:7578005 |
| Nieuwenhuizen WF et al. | Lipoxygenase is irreversibly inactivated by the hydroperoxides formed from the enynoic analogues of linoleic acid. | 1997 | Biochemistry | pmid:9109655 |
| Jones GD et al. | Role of lipid hydroperoxides in the activation of 15-lipoxygenase. | 1996 | Biochemistry | pmid:8679548 |
| Kleinfeld AM et al. | Transport of long-chain native fatty acids across human erythrocyte ghost membranes. | 1998 | Biochemistry | pmid:9609694 |
| Léger CL et al. | Evidence for a structurally specific role of essential polyunsaturated fatty acids depending on their peculiar double-bond distribution in biomembranes. | 1990 | Biochemistry | pmid:2169876 |
| Wecksler AT et al. | Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. | 2009 | Biochemistry | pmid:19469483 |
| Nelson MJ et al. | Structural characterization of alkyl and peroxyl radicals in solutions of purple lipoxygenase. | 1994 | Biochemistry | pmid:8161558 |
| Rickert KW and Klinman JP | Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects. | 1999 | Biochemistry | pmid:10493789 |
| Desmarais SR et al. | Inhibition of soybean lipoxygenase-1 by a diaryl-N-hydroxyurea by reduction of the ferric enzyme. | 1994 | Biochemistry | pmid:7947748 |
| Mukherjee A et al. | Molecular oxygen dependent steps in fatty acid oxidation by cyclooxygenase-1. | 2007 | Biochemistry | pmid:17355126 |
| Henderson WR et al. | Toxoplasma gondii stimulates the release of 13- and 9-hydroxyoctadecadienoic acids by human platelets. | 1992 | Biochemistry | pmid:1606159 |
| BAER E and BLACKWELL J | SYNTHESIS OF ALPHA-CEPHALINS BY A NEW PROCEDURE. II. DIOLEOYL AND DILINOLEOYL L-ALPHA-CEPHALINS. | 1964 | Biochemistry | pmid:14214090 |
| Mogul R et al. | Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase. | 2000 | Biochemistry | pmid:10769137 |
| Widstrom RL et al. | Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase. | 2003 | Biochemistry | pmid:14529287 |
| Arnold WR et al. | Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase. | 2016 | Biochemistry | pmid:27992998 |
| Widstrom RL et al. | Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. | 2001 | Biochemistry | pmid:11170430 |
| Nagler LG et al. | Rate of free-radical oxidation of C18 diene and triene fatty acids in aqueous micellar solutions and effectiveness of beta-carotene as an inhibitor of their oxidation. | 2003 | Biochemistry Mosc. | pmid:12693967 |
| Yang J et al. | Study of the inhibitory effect of fatty acids on the interaction between DNA and polymerase beta. | 2009 | Biochemistry Mosc. | pmid:19747104 |
| Zhan ZJ et al. | Preparation and characterization of Cu,Zn-superoxide dismutase covalently modified by polyunsaturated fatty acids. | 2009 | Biochemistry Mosc. | pmid:19916943 |
| Chechetkin IR et al. | Specificity of oxidation of linoleic acid homologs by plant lipoxygenases. | 2009 | Biochemistry Mosc. | pmid:19817685 |
| Haas TA et al. | Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity. | 1990 | Biochim. Biophys. Acta | pmid:2155665 |
| Melton JL et al. | Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs. | 1987 | Biochim. Biophys. Acta | pmid:3651483 |
| Haycock JC and Evers AS | Altered phosphoinositide fatty acid composition, mass and metabolism in brain essential fatty acid deficiency. | 1988 | Biochim. Biophys. Acta | pmid:2833931 |
| STEIN O and STEIN Y | METABOLISM IN VITRO OF PALMITIC AND LINOLEIC ACID IN THE HEART AND DIAPHRAGM OF ESSENTIAL FATTY ACID-DEFICIENT RATS. | 1964 | Biochim. Biophys. Acta | pmid:14266247 |
| PRITCHARD ET and NICHOL NE | CHOLESTEROL ESTERASE ACTIVITY IN DEVELOPING RAT BRAIN. | 1964 | Biochim. Biophys. Acta | pmid:14266270 |
| Kühn H et al. | The stoichiometry of oxygen uptake and conjugated diene formation during the dioxygenation of linoleic acid by the pure reticulocyte lipoxygenase. Evidence for aerobic hydroperoxidase activity. | 1986 | Biochim. Biophys. Acta | pmid:3006782 |
| Igarashi M and Miyazawa T | The growth inhibitory effect of conjugated linoleic acid on a human hepatoma cell line, HepG2, is induced by a change in fatty acid metabolism, but not the facilitation of lipid peroxidation in the cells. | 2001 | Biochim. Biophys. Acta | pmid:11239819 |
| Zhou L et al. | Tissue uptake and interconversion of plasma unesterified 14C linoleic acid in the guinea pig. | 1997 | Biochim. Biophys. Acta | pmid:9434134 |
| Bauldry SA et al. | Activation of cytosolic phospholipase A2 in permeabilized human neutrophils. | 1996 | Biochim. Biophys. Acta | pmid:8555268 |
| Takahashi Y et al. | Activity and mRNA levels of enzymes involved in hepatic fatty acid synthesis and oxidation in mice fed conjugated linoleic acid. | 2003 | Biochim. Biophys. Acta | pmid:12668178 |
| Hagve TA and Christophersen BO | In vitro effects of alpha-bromopalmitate on metabolism of essential fatty acids studied in isolated rat hepatocytes: sex differences. | 1987 | Biochim. Biophys. Acta | pmid:3099848 |
| Brasitus TA and Dudeja PK | Effect of hypothyroidism on the lipid composition and fluidity of rat colonic apical plasma membranes. | 1988 | Biochim. Biophys. Acta | pmid:3128322 |
| Nilsson A and Landin B | Metabolism of chylomicron arachidonic and linoleic acid in the rat. | 1988 | Biochim. Biophys. Acta | pmid:3128335 |
| Daoud G et al. | Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation. | 2005 | Biochim. Biophys. Acta | pmid:15708366 |
| Deva R et al. | Arachidonic acid stimulates cell growth and forms a novel oxygenated metabolite in Candida albicans. | 2000 | Biochim. Biophys. Acta | pmid:10903481 |
| Seeley SK et al. | Metabolism of oxidized linoleic acid by glutathione transferases: peroxidase activity toward 13-hydroperoxyoctadecadienoic acid. | 2006 | Biochim. Biophys. Acta | pmid:16624487 |
| Cook HW and Spence MW | Studies of the modulation of essential fatty acid metabolism by fatty acids in cultured neuroblastoma and glioma cells. | 1987 | Biochim. Biophys. Acta | pmid:3105586 |
| Memoli S et al. | Diffusible melanin-related metabolites are potent inhibitors of lipid peroxidation. | 1997 | Biochim. Biophys. Acta | pmid:9187303 |
| Nijssen JG and van den Bosch H | Cytosol-stimulated remodeling of phosphatidylcholine in rat lung microsomes. | 1986 | Biochim. Biophys. Acta | pmid:3947653 |
| Kryvi H et al. | Effects of essential fatty acid deficiency on mitochondria and peroxisomes in rat hepatocytes with special reference to a partially hydrogenated fish oil diet. | 1986 | Biochim. Biophys. Acta | pmid:3947675 |
| De Villiers M and Lochner A | Mitochondrial Ca2+ fluxes: role of free fatty acids, acyl-CoA and acylcarnitine. | 1986 | Biochim. Biophys. Acta | pmid:3955069 |
| Artmann A et al. | Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine. | 2008 | Biochim. Biophys. Acta | pmid:18316044 |
| Minich DM et al. | Bile diversion in rats leads to a decreased plasma concentration of linoleic acid which is not due to decreased net intestinal absorption of dietary linoleic acid. | 1999 | Biochim. Biophys. Acta | pmid:10216285 |
| Roy P et al. | Superoxide generation by lipoxygenase in the presence of NADH and NADPH. | 1994 | Biochim. Biophys. Acta | pmid:7918597 |
| Bakken AM et al. | The activities of acyl-CoA hydrolase in lysate and subcellular fractions of human blood platelets in relation to activities of acyl-CoA:1-acyl-lysophospholipid acyltransferase. | 1994 | Biochim. Biophys. Acta | pmid:7918598 |
| del Carmen Boyano-Adánez M et al. | Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. | 1994 | Biochim. Biophys. Acta | pmid:7918608 |
| Wenli Y and Yaping Z | Chemiluminescence evaluation of oxidative damage to biomolecules induced by singlet oxygen and the protective effects of antioxidants. | 2005 | Biochim. Biophys. Acta | pmid:15936152 |
| Schick PK et al. | Arachidonate synthesis and uptake in isolated guinea-pig megakaryocytes and platelets. | 1984 | Biochim. Biophys. Acta | pmid:6433984 |
| Furukawa M et al. | Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. | 1984 | Biochim. Biophys. Acta | pmid:6089906 |
| Regdel D et al. | On the reaction specificity of the lipoxygenase from tomato fruits. | 1994 | Biochim. Biophys. Acta | pmid:7905748 |
| Hulea SA et al. | Bilirubin sensitized photooxidation of human plasma low density lipoprotein. | 1996 | Biochim. Biophys. Acta | pmid:8982266 |
| Anel A et al. | Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. | 1990 | Biochim. Biophys. Acta | pmid:2114179 |
| Bolton-Smith C et al. | The effect of dietary linoleic acid on rat platelet sialic acid. | 1989 | Biochim. Biophys. Acta | pmid:2775771 |
| Kanazawa K et al. | The effect of orally administered secondary autoxidation products of linoleic acid on the activity of detoxifying enzymes in the rat liver. | 1986 | Biochim. Biophys. Acta | pmid:3768385 |
| Loidl-Stahlhofen A and Spiteller G | alpha-Hydroxyaldehydes, products of lipid peroxidation. | 1994 | Biochim. Biophys. Acta | pmid:8117742 |
| Byczkowski JZ and Kulkarni AP | Vanadium redox cycling, lipid peroxidation and co-oxygenation of benzo(a)pyrene-7,8-dihydrodiol. | 1992 | Biochim. Biophys. Acta | pmid:1315157 |
| Ringseis R et al. | LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2. | 2006 | Biochim. Biophys. Acta | pmid:16982210 |
| Urquhart P et al. | The effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells. | 2002 | Biochim. Biophys. Acta | pmid:11880240 |
| Brinkmeier H et al. | Specific modifications of the membrane fatty acid composition of human myotubes and their effects on the muscular sodium channels. | 1993 | Biochim. Biophys. Acta | pmid:8380720 |
| Hajarine M and Lagarde M | Studies on polyenoic acid incorporation into human platelet lipid stores: interactions with linoleic and arachidonic acids. | 1986 | Biochim. Biophys. Acta | pmid:3719006 |
| Simpson RJ and Peters TJ | Transport of Fe2+ across lipid bilayers: possible role of free fatty acids. | 1987 | Biochim. Biophys. Acta | pmid:3828339 |
| Thomson AB et al. | Feeding rats a diet enriched with saturated fatty acids prevents the inhibitory effects of acute and chronic ethanol exposure on the in vitro uptake of hexoses and lipids. | 1991 | Biochim. Biophys. Acta | pmid:1854796 |
| Paiement J et al. | Modulation of GTP-dependent fusion by linoleic and arachidonic acid in derivatives of rough endoplasmic reticulum from rat liver. | 1994 | Biochim. Biophys. Acta | pmid:8142417 |
| Hayakawa F et al. | DNA cleavage reaction and linoleic acid peroxidation induced by tea catechins in the presence of cupric ion. | 1997 | Biochim. Biophys. Acta | pmid:9305782 |
| Schieberle P et al. | A study of oxygen isotope scrambling in the enzymic and non-enzymic oxidation of linoleic acid. | 1981 | Biochim. Biophys. Acta | pmid:6798993 |
| DESAI ID et al. | PEROXIDATIVE AND RADIATION DAMAGE TO ISOLATED LYSOSOMES. | 1964 | Biochim. Biophys. Acta | pmid:14171002 |
| Hagve TA and Christophersen BO | Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. | 1984 | Biochim. Biophys. Acta | pmid:6093889 |
| Lodge JK et al. | Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopy. | 1995 | Biochim. Biophys. Acta | pmid:7766690 |
| Spiteller P et al. | Aldehydic lipid peroxidation products derived from linoleic acid. | 2001 | Biochim. Biophys. Acta | pmid:11325611 |
| Torres-Duarte AP and Vanderhoek JY | Conjugated linoleic acid exhibits stimulatory and inhibitory effects on prostanoid production in human endothelial cells and platelets. | 2003 | Biochim. Biophys. Acta | pmid:12676356 |
| Cominacini L et al. | Determination of lipid hydroperoxides in native low-density lipoprotein by a chemiluminescent flow-injection assay. | 1993 | Biochim. Biophys. Acta | pmid:8418885 |
| de Athayde Moncorvo Collado A et al. | Cholesterol induces surface localization of polyphenols in model membranes thus enhancing vesicle stability against lysozyme, but reduces protection of distant double bonds from reactive-oxygen species. | 2016 | Biochim. Biophys. Acta | pmid:27063609 |
| Egashira Y et al. | Differential effects of dietary fatty acids on rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase activity and gene expression. | 2004 | Biochim. Biophys. Acta | pmid:15522828 |
| Elmes M et al. | The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandins. | 2004 | Biochim. Biophys. Acta | pmid:15522830 |