Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Cattle Diseases D002418 24 associated lipids
Fatty Liver D005234 48 associated lipids
Infertility, Male D007248 11 associated lipids
Varicocele D014646 4 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Foreign-Body Reaction D005549 10 associated lipids
Carcinoma D002277 18 associated lipids
Gastritis D005756 27 associated lipids
Heart Failure D006333 36 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Rosenthal MD and Whitehurst MC Selective effects of isomeric cis and trans fatty acids on fatty acyl delta 9 and delta 6 desaturation by human skin fibroblasts. 1983 Biochim. Biophys. Acta pmid:6615875
Emken EA et al. Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans. 1993 Biochim. Biophys. Acta pmid:8399342
Haas TA et al. Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity. 1990 Biochim. Biophys. Acta pmid:2155665
Melton JL et al. Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs. 1987 Biochim. Biophys. Acta pmid:3651483
LEVIN E et al. OCCURRENCE AND LOCALIZATION OF ALPHA-LINOLENIC ACID CONTAINING GALACTOLIPIDS IN THE PHOTOSYNTHETIC APPARATUS OF ANABAENA VARIABILLIS. 1964 Biochim. Biophys. Acta pmid:14230825
STEIN O and STEIN Y METABOLISM OF FATTY ACIDS IN THE ISOLATED PERFUSED RAT HEART. 1963 Biochim. Biophys. Acta pmid:14085937
Laakso S Inhibition of lipid peroxidation by casein. Evidence of molecular encapsulation of 1,4-pentadiene fatty acids. 1984 Biochim. Biophys. Acta pmid:6419780
Grossman S et al. Methylmercuric iodide modification of lipoxygenase-1. Effects on the anaerobic reaction and pigment bleaching. 1984 Biochim. Biophys. Acta pmid:6424722
PRITCHARD ET and NICHOL NE CHOLESTEROL ESTERASE ACTIVITY IN DEVELOPING RAT BRAIN. 1964 Biochim. Biophys. Acta pmid:14266270
Miyashita K et al. Preferential hydrolysis of monohydroperoxides of linoleoyl and linolenoyl triacylglycerol by pancreatic lipase. 1990 Biochim. Biophys. Acta pmid:2386795
Kühn H et al. The stoichiometry of oxygen uptake and conjugated diene formation during the dioxygenation of linoleic acid by the pure reticulocyte lipoxygenase. Evidence for aerobic hydroperoxidase activity. 1986 Biochim. Biophys. Acta pmid:3006782
Yamamoto T et al. Purification of the two forms of the high-molecular-weight neutral proteinase ingensin from rat liver. 1986 Biochim. Biophys. Acta pmid:3015226
Jakobsson A et al. Metabolism of fatty acids and their incorporation into phospholipids of the mitochondria and endoplasmic reticulum in isolated hepatocytes determined by isolation of fluorescence derivatives. 1990 Biochim. Biophys. Acta pmid:2223867
Walstra P et al. Demonstration of a 12-lipoxygenase activity in bovine polymorphonuclear leukocytes. 1987 Biochim. Biophys. Acta pmid:3115302
Colard O et al. Hydrolysis of endogenous phospholipids by rat platelet phospholipase A2: ether or acyl bond and polar head group selectivity. 1987 Biochim. Biophys. Acta pmid:3115303
SHAW R THE OCCURRENCE OF GAMMA-LINOLENIC ACID IN FUNGI. 1965 Biochim. Biophys. Acta pmid:14320219
Bernbäck S et al. Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase. 1989 Biochim. Biophys. Acta pmid:2917153
WILLS ED MECHANISMS OF LIPID PEROXIDE FORMATION IN TISSUES. ROLE OF METALS AND HAEMATIN PROTEINS IN THE CATALYSIS OF THE OXIDATION UNSATURATED FATTY ACIDS. 1965 Biochim. Biophys. Acta pmid:14325327
Igarashi M and Miyazawa T The growth inhibitory effect of conjugated linoleic acid on a human hepatoma cell line, HepG2, is induced by a change in fatty acid metabolism, but not the facilitation of lipid peroxidation in the cells. 2001 Biochim. Biophys. Acta pmid:11239819
Zhou L et al. Tissue uptake and interconversion of plasma unesterified 14C linoleic acid in the guinea pig. 1997 Biochim. Biophys. Acta pmid:9434134
Bauldry SA et al. Activation of cytosolic phospholipase A2 in permeabilized human neutrophils. 1996 Biochim. Biophys. Acta pmid:8555268
Hagve TA and Christophersen BO In vitro effects of alpha-bromopalmitate on metabolism of essential fatty acids studied in isolated rat hepatocytes: sex differences. 1987 Biochim. Biophys. Acta pmid:3099848
López-Nicolás JM et al. Kinetic characteristics of the enzymatic conversion in presence of cyclodextrins: study of the oxidation of polyunsaturated fatty acids by lipoxygenase. 1997 Biochim. Biophys. Acta pmid:9295158
Brasitus TA and Dudeja PK Effect of hypothyroidism on the lipid composition and fluidity of rat colonic apical plasma membranes. 1988 Biochim. Biophys. Acta pmid:3128322
Nilsson A and Landin B Metabolism of chylomicron arachidonic and linoleic acid in the rat. 1988 Biochim. Biophys. Acta pmid:3128335
Liffmann SM and Lynch RD Incorporation of [3H]acetate into L-cell lipids. Dependence on method of linoleate administration and timing of the pulse label. 1981 Biochim. Biophys. Acta pmid:7295748
Daoud G et al. Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation. 2005 Biochim. Biophys. Acta pmid:15708366
Deva R et al. Arachidonic acid stimulates cell growth and forms a novel oxygenated metabolite in Candida albicans. 2000 Biochim. Biophys. Acta pmid:10903481
Lapenna D et al. Inhibitory activity of salicylic acid on lipoxygenase-dependent lipid peroxidation. 2009 Biochim. Biophys. Acta pmid:18950686
Seeley SK et al. Metabolism of oxidized linoleic acid by glutathione transferases: peroxidase activity toward 13-hydroperoxyoctadecadienoic acid. 2006 Biochim. Biophys. Acta pmid:16624487
Fitch CD et al. A role for linoleic acid in erythrocytes infected with Plasmodium berghei. 2000 Biochim. Biophys. Acta pmid:11113630
Cook HW and Spence MW Studies of the modulation of essential fatty acid metabolism by fatty acids in cultured neuroblastoma and glioma cells. 1987 Biochim. Biophys. Acta pmid:3105586
Park Y and Pariza MW The effects of dietary conjugated nonadecadienoic acid on body composition in mice. 2001 Biochim. Biophys. Acta pmid:11731328
Peters JM et al. Influence of conjugated linoleic acid on body composition and target gene expression in peroxisome proliferator-activated receptor alpha-null mice. 2001 Biochim. Biophys. Acta pmid:11731333
Mizushina Y et al. Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro. 1996 Biochim. Biophys. Acta pmid:8809118
Memoli S et al. Diffusible melanin-related metabolites are potent inhibitors of lipid peroxidation. 1997 Biochim. Biophys. Acta pmid:9187303
De Villiers M and Lochner A Mitochondrial Ca2+ fluxes: role of free fatty acids, acyl-CoA and acylcarnitine. 1986 Biochim. Biophys. Acta pmid:3955069
Minich DM et al. Bile diversion in rats leads to a decreased plasma concentration of linoleic acid which is not due to decreased net intestinal absorption of dietary linoleic acid. 1999 Biochim. Biophys. Acta pmid:10216285
del Carmen Boyano-Adánez M et al. Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. 1994 Biochim. Biophys. Acta pmid:7918608
Msika O et al. NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. 2012 Biochim. Biophys. Acta pmid:22564256
Yu Y et al. Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. 2002 Biochim. Biophys. Acta pmid:12020636
Wenli Y and Yaping Z Chemiluminescence evaluation of oxidative damage to biomolecules induced by singlet oxygen and the protective effects of antioxidants. 2005 Biochim. Biophys. Acta pmid:15936152
Earles SM et al. Metabolism of oxidized linoleic acid: characterization of 13-hydroxyoctadecadienoic acid dehydrogenase activity from rat colonic tissue. 1991 Biochim. Biophys. Acta pmid:1998735
Schick PK et al. Arachidonate synthesis and uptake in isolated guinea-pig megakaryocytes and platelets. 1984 Biochim. Biophys. Acta pmid:6433984
Garg ML et al. Desaturation of linoleic acid in the small bowel is increased by short-term fasting and by dietary content of linoleic acid. 1992 Biochim. Biophys. Acta pmid:1606171
Ek BA et al. Fatty acid binding proteins reduce 15-lipoxygenase-induced oxygenation of linoleic acid and arachidonic acid. 1997 Biochim. Biophys. Acta pmid:9187305
Hansen O Characterization of fatty acid interaction with ouabain and vanadate binding to (Na+ + K+)-activated ATPase. 1989 Biochim. Biophys. Acta pmid:2554979
SCHLENK H et al. INTERCONVERSION OF LONG-CHAIN FATTY ACIDS IN THE RAT. 1963 Biochim. Biophys. Acta pmid:14102761
GOODMAN DW and SHIRATORI T THE TURNOVER OF INDIVIDUAL CHOLESTEROL ESTERS IN HUMAN AND RAT PLASMA. 1964 Biochim. Biophys. Acta pmid:14129407
Furukawa M et al. Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. 1984 Biochim. Biophys. Acta pmid:6089906
Regdel D et al. On the reaction specificity of the lipoxygenase from tomato fruits. 1994 Biochim. Biophys. Acta pmid:7905748
Ghafoorunissa A et al. Substituting dietary linoleic acid with alpha-linolenic acid improves insulin sensitivity in sucrose fed rats. 2005 Biochim. Biophys. Acta pmid:15801047
Kanter JE et al. Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages. 2012 Biochim. Biophys. Acta pmid:22020260
Hulea SA et al. Bilirubin sensitized photooxidation of human plasma low density lipoprotein. 1996 Biochim. Biophys. Acta pmid:8982266
Bull AW et al. Conjugation of the linoleic acid oxidation product, 13-oxooctadeca-9,11-dienoic acid, a bioactive endogenous substrate for mammalian glutathione transferase. 2002 Biochim. Biophys. Acta pmid:12031293
Gargouri M and Legoy MD The kinetic behaviour of a two-enzyme system in biphasic media: coupling hydrolysis and lipoxygenation. 1997 Biochim. Biophys. Acta pmid:9048899
Hansen HS et al. Apparent in vivo retroconversion of dietary arachidonic to linoleic acid in essential fatty acid-deficient rats. 1986 Biochim. Biophys. Acta pmid:3092868
Bolton-Smith C et al. The effect of dietary linoleic acid on rat platelet sialic acid. 1989 Biochim. Biophys. Acta pmid:2775771
Chambaz J et al. Essential fatty acid uptake and esterification in primary culture of rat hepatocytes. 1986 Biochim. Biophys. Acta pmid:3092869
Stein Y et al. Metabolism of 3-[3H]sphingosine sphingomyelin labeled with [14C]palmitic or [14C]linoleic acid by Hep G2 cells and rat liver in vivo. 1991 Biochim. Biophys. Acta pmid:2054378
Kitagawa S et al. Activation of bovine platelets induced by long-chain unsaturated fatty acids at just below their lytic concentrations, and its mechanism. 1984 Biochim. Biophys. Acta pmid:6435686
Zevenbergen JL and Houtsmuller UM Effect of dietary fats on linoleic acid metabolism. A radiolabel study in rats. 1989 Biochim. Biophys. Acta pmid:2713382
Stein O et al. Modification of cellular fatty acid composition of Hep-G2 cells: effect of antioxidants on cholesterol esterification and secretion. 1989 Biochim. Biophys. Acta pmid:2730885
Kanazawa K et al. The effect of orally administered secondary autoxidation products of linoleic acid on the activity of detoxifying enzymes in the rat liver. 1986 Biochim. Biophys. Acta pmid:3768385
Sprinz H et al. Mechanism of thiyl radical-catalyzed isomerization of unsaturated fatty acid residues in homogeneous solution and in liposomes. 2000 Biochim. Biophys. Acta pmid:10601698
Parsons HG et al. Modulation of human erythrocyte shape and fatty acids by diet. 1986 Biochim. Biophys. Acta pmid:3741859
Hirabara SM et al. Acute effect of fatty acids on metabolism and mitochondrial coupling in skeletal muscle. 2006 Biochim. Biophys. Acta pmid:16375848
Ringseis R et al. LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2. 2006 Biochim. Biophys. Acta pmid:16982210
Loidl-Stahlhofen A et al. Generation of alpha-hydroxyaldehydic compounds in the course of lipid peroxidation. 1994 Biochim. Biophys. Acta pmid:8025124
Ramanadham S et al. Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations. 2002 Biochim. Biophys. Acta pmid:11923099
Pirtle IL et al. Molecular cloning and functional expression of the gene for a cotton Delta-12 fatty acid desaturase (FAD2). 2001 Biochim. Biophys. Acta pmid:11750064
Park Y and Pariza MW Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid. 2001 Biochim. Biophys. Acta pmid:11750884
Christon R et al. Modification of fluidity and lipid-protein relationships in pig intestinal brush-border membrane by dietary essential fatty acid deficiency. 1989 Biochim. Biophys. Acta pmid:2538158
Macías P et al. Hemin and hemeprotein bleaching during linoleic acid oxidation by lipoxygenases. 1991 Biochim. Biophys. Acta pmid:1903070
Simpson RJ and Peters TJ Transport of Fe2+ across lipid bilayers: possible role of free fatty acids. 1987 Biochim. Biophys. Acta pmid:3828339
Chen Q et al. Hydrolysis of triacylglycerol arachidonic and linoleic acid ester bonds by human pancreatic lipase and carboxyl ester lipase. 1989 Biochim. Biophys. Acta pmid:2503032
DE GIER J and VAN DEENENL A DIETARY INVESTIGATION ON THE VARIATIONS IN PHOSPHOLIPID CHARACTERISTICS OF RED-CELL MEMBRANES. 1964 Biochim. Biophys. Acta pmid:14194234
Thomson AB et al. Feeding rats a diet enriched with saturated fatty acids prevents the inhibitory effects of acute and chronic ethanol exposure on the in vitro uptake of hexoses and lipids. 1991 Biochim. Biophys. Acta pmid:1854796
Yavin E et al. Metabolic conversion of intra-amniotically-injected deuterium-labeled essential fatty acids by fetal rats following maternal n-3 fatty acid deficiency. 2014 Biochim. Biophys. Acta pmid:24960100
MCMAHON V and STUMPF PK SYNTHESIS OF LINOLEIC ACID BY PARTICULATE SYSTEM FROM SAFFLOWER SEEDS. 1964 Biochim. Biophys. Acta pmid:14196780
Minich DM et al. Biliary phospholipid secretion is not required for intestinal absorption and plasma status of linoleic acid in mice. 1999 Biochim. Biophys. Acta pmid:10526224
Bester R and Lochner A Sarcolemmal phospholipid fatty acid composition and permeability. 1988 Biochim. Biophys. Acta pmid:3382645
Hayakawa F et al. DNA cleavage reaction and linoleic acid peroxidation induced by tea catechins in the presence of cupric ion. 1997 Biochim. Biophys. Acta pmid:9305782
Mizushina Y et al. The inhibitory action of fatty acids on DNA polymerase beta. 1997 Biochim. Biophys. Acta pmid:9367179
Croft KD et al. Differential inhibition of thromboxane B2 and leukotriene B4 biosynthesis by two naturally occurring acetylenic fatty acids. 1987 Biochim. Biophys. Acta pmid:2822134
Stimers JR et al. Effects of linoleic acid metabolites on electrical activity in adult rat ventricular myocytes. 1999 Biochim. Biophys. Acta pmid:10366778
Clementz T et al. Membrane potential, lipid regulation and adenylate energy charge in acyl chain modified Acholeplasma laidlawii. 1987 Biochim. Biophys. Acta pmid:3567184
Zhou L and Nilsson A Fasting increases tissue uptake and interconversion of plasma unesterified linoleic acid in guinea pigs. 1999 Biochim. Biophys. Acta pmid:9989279
Barceló-Coblijn G et al. Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. 2003 Biochim. Biophys. Acta pmid:12782153
Sasaki T et al. Effects of dietary docosahexaenoic acid on surface molecules involved in T cell proliferation. 1999 Biochim. Biophys. Acta pmid:9989281
VAN DEN BOSCH H and VAN DEENEN L THE FORMATION OF ISOMERIC LYSOLECITHINS. 1964 Biochim. Biophys. Acta pmid:14181312
Lodge JK et al. Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopy. 1995 Biochim. Biophys. Acta pmid:7766690
Spiteller P et al. Aldehydic lipid peroxidation products derived from linoleic acid. 2001 Biochim. Biophys. Acta pmid:11325611
Brightman AO et al. A growth factor- and hormone-stimulated NADH oxidase from rat liver plasma membrane. 1992 Biochim. Biophys. Acta pmid:1567890
Coté GG and Brody S Circadian rhythms in Neurospora crassa: a clock mutant, prd-1, is altered in membrane fatty acid composition. 1987 Biochim. Biophys. Acta pmid:2889471
Chander A and Fisher AB Choline-phosphate cytidyltransferase activity and phosphatidylcholine synthesis in rat granular pneumocytes are increased with exogenous fatty acids. 1988 Biochim. Biophys. Acta pmid:2893643
Cominacini L et al. Determination of lipid hydroperoxides in native low-density lipoprotein by a chemiluminescent flow-injection assay. 1993 Biochim. Biophys. Acta pmid:8418885
de Athayde Moncorvo Collado A et al. Cholesterol induces surface localization of polyphenols in model membranes thus enhancing vesicle stability against lysozyme, but reduces protection of distant double bonds from reactive-oxygen species. 2016 Biochim. Biophys. Acta pmid:27063609
Christophersen BO et al. Studies on the regulation of arachidonic acid synthesis in isolated rat liver cells. 1982 Biochim. Biophys. Acta pmid:6812639
Bordet JC et al. Hydroperoxides produced by n-6 lipoxygenation of arachidonic and linoleic acids potentiate synthesis of prostacyclin related compounds. 1988 Biochim. Biophys. Acta pmid:3124885