Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Cattle Diseases D002418 24 associated lipids
Fatty Liver D005234 48 associated lipids
Infertility, Male D007248 11 associated lipids
Varicocele D014646 4 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Precancerous Conditions D011230 48 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Foreign-Body Reaction D005549 10 associated lipids
Carcinoma D002277 18 associated lipids
Gastritis D005756 27 associated lipids
Heart Failure D006333 36 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

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What functions are associated with Linoelaidic acid?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Brodersen R et al. Multiple fatty acid binding to albumin in human blood plasma. 1990 Eur. J. Biochem. pmid:2338079
Sams GH et al. Isolation and characterization of a fatty acid binding protein in adipose tissue of Gallus domesticus. 1990 Comp. Biochem. Physiol., B pmid:1697230
Girón MD et al. Changes in lipid composition and desaturase activities of duodenal mucosa induced by dietary fat. 1990 Biochim. Biophys. Acta pmid:2369586
Barros H et al. Arachidonic acid absorption in human jejunum in organ culture: effects of ethanol. 1990 Eur. J. Clin. Invest. pmid:2124981
Teter BB et al. Milk fat depression in C57Bl/6J mice consuming partially hydrogenated fat. 1990 J. Nutr. pmid:2380791
DeLange RJ and Glazer AN Bile acids: antioxidants or enhancers of peroxidation depending on lipid concentration. 1990 Arch. Biochem. Biophys. pmid:2297222
Ha YL et al. Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivatives of linoleic acid. 1990 Cancer Res. pmid:2297758
Kawahara J et al. Dietary linoleic acid prevents the development of deoxycorticosterone acetate-salt hypertension. 1990 Hypertension pmid:2298478
Borgeson CE et al. Characterization of the delta 12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate. 1990 Biochim. Biophys. Acta pmid:2248971
Appel MJ et al. Azaserine-induced pancreatic carcinogenesis in rats: promotion by a diet rich in saturated fat and inhibition by a standard laboratory chow. 1990 Cancer Lett. pmid:2257542
Parinandi NL et al. Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. 1990 Biochim. Biophys. Acta pmid:2123402
Kawada H et al. Improved maintenance of adult rat alveolar type II cell differentiation in vitro: effect of serum-free, hormonally defined medium and a reconstituted basement membrane. 1990 Am. J. Respir. Cell Mol. Biol. pmid:2363935
Miller CC and Ziboh VA Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). 1990 J. Invest. Dermatol. pmid:2106562
Okuyama H [Does food affect brain functions?]. 1990 Tanpakushitsu Kakusan Koso pmid:1970438
elAttar TM et al. Comparison of the inhibitory effect of polyunsaturated fatty acids on prostaglandin synthesis. II. Fibroblasts. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:1971442
Kestin M et al. n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. 1990 Am. J. Clin. Nutr. pmid:1971991
Watanabe S et al. Effect of dietary alpha-linolenate/linoleate balance on crescent type-anti-glomerular basement membrane nephritis in rats. 1990 Lipids pmid:1972260
Singer P et al. Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension. 1990 J Hum Hypertens pmid:1972963
Lipids and multiple sclerosis. 1990 Lancet pmid:1973215
Oxholm A et al. Abnormal essential fatty acid metabolism in Darier's disease. 1990 Arch Dermatol pmid:1977367
Lester DS In vitro linoleic acid activation of protein kinase C. 1990 Biochim. Biophys. Acta pmid:2207179
Høy CE and Hølmer G Influence of dietary linoleic acid and trans fatty acids on the fatty acid profile of cardiolipins in rats. 1990 Lipids pmid:2215088
Buko VU Beef fat prevents alcoholic liver disease in the rat. 1990 Alcohol. Clin. Exp. Res. pmid:2221295
Opara EC et al. Enhancement of endocrine pancreatic secretions by essential fatty acids. 1990 J. Surg. Res. pmid:2187112
Dupont J and Dowd MK Icosanoid synthesis as a functional measurement of essential fatty acid requirement. 1990 J Am Coll Nutr pmid:2193052
Oliver MF Linoleic acid, antioxidants and coronary heart disease. 1990 Biochem. Soc. Trans. pmid:2088801
Bian RL et al. [Antianaphylactic components of Asarum forbsii Maxin]. 1990 Yao Xue Xue Bao pmid:2099089
Kitagawa S et al. Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. 1990 Biochim. Biophys. Acta pmid:2166588
Green P et al. Effects of fish-oil ingestion on cardiovascular risk factors in hyperlipidemic subjects in Israel: a randomized, double-blind crossover study. 1990 Am. J. Clin. Nutr. pmid:2239789
Fletcher JE et al. Fatty acid uptake and catecholamine-stimulated phospholipid metabolism in immortalized airway epithelial cells established from primary cultures. 1990 Biochem. Int. pmid:2241999
Mimouni V and Poisson JP Spontaneous diabetes in BB rats: evidence for insulin dependent liver microsomal delta 6 and delta 5 desaturase activities. 1990 Horm. Metab. Res. pmid:2227799
Pariza MW and Ha YL Conjugated dienoic derivatives of linoleic acid: a new class of anticarcinogens. 1990 Med Oncol Tumor Pharmacother pmid:2232933
Nikolaev V et al. Stereochemical nature of the products of linoleic acid oxidation catalyzed by lipoxygenases from potato and soybean. 1990 Biochem. Biophys. Res. Commun. pmid:2116790
Mensink RP et al. Effect of a monounsaturated diet vs. a polyunsaturated fatty acid-enriched diet on blood pressure in normotensive women and men. 1990 Eur. J. Clin. Invest. pmid:2121507
Newman MJ Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2371287
Gyllenhammar H et al. Dietary linoleate supplementation modulates formyl-peptide receptor expression and functional responses of rat neutrophils. 1990 J. Lab. Clin. Med. pmid:2157784
Chatterjee S and Ghosh N Phosphatidylcholine stimulates the activity of UDP-Gal beta 1-4 galactosyltransferase in normal human kidney proximal tumour cells. 1990 Indian J. Biochem. Biophys. pmid:2129343
Kawashima Y et al. Peroxisome proliferators enhance linoleic acid metabolism in rat liver. Increased biosynthesis of omega 6 polyunsaturated fatty acids. 1990 J. Biol. Chem. pmid:2160962
Bedotti R et al. Stimulatory effect of serum albumin on the proliferation of serum-free SV40-transformed Balb/c 3T3 cells. 1990 Biochim. Biophys. Acta pmid:2163687
Koba K and Sugano M Dietary protein influences polyunsaturated fatty acid patterns of rat tissue lipids. 1990 J. Nutr. Sci. Vitaminol. pmid:2130152
Akamatsu H et al. Suppressive effects of linoleic acid on neutrophil oxygen metabolism and phagocytosis. 1990 J. Invest. Dermatol. pmid:2143521
Yashiro K et al. [Changes in the free fatty acid composition of rat salivary glands induced by chronic administration of isoproterenol]. 1990 Gifu Shika Gakkai Zasshi pmid:2133668
Weaver BJ et al. Dietary canola oil: effect on the accumulation of eicosapentaenoic acid in the alkenylacyl fraction of human platelet ethanolamine phosphoglyceride. 1990 Am. J. Clin. Nutr. pmid:2181858
Renner HW Anticlastogenic dietary factors assessed in mammalian assays. 1990 Basic Life Sci. pmid:2183774
Field CJ et al. Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals. 1990 J. Biol. Chem. pmid:2113530
Kim D and Duff RA Regulation of K+ channels in cardiac myocytes by free fatty acids. 1990 Circ. Res. pmid:2119911
Molina MT et al. Caecal and colonic uptake of both linoleic acid and cholesterol in rats following intestinal resection. 1990 Lipids pmid:2079865
Corner EJ et al. Accumulation of eicosapentaenoic acid in plasma phospholipids of subjects fed canola oil. 1990 Lipids pmid:2079866
Henricks PA et al. Epithelium-derived linoleic acid metabolites modulate airway smooth muscle function. 1990 Agents Actions Suppl. pmid:2080762
Emken EA et al. Metabolism in vivo of deuterium-labelled linolenic and linoleic acids in humans. 1990 Biochem. Soc. Trans. pmid:2083671
James SR et al. Linoleic acid increases cytosolic Ca2+ in lymphocytes. 1990 Biochem. Soc. Trans. pmid:2083720
Bell JG and Raynard RS Effects of a high linoleic acid diet on the fatty acid composition of leucocytes from Atlantic salmon (Salmo salar). 1990 Biochem. Soc. Trans. pmid:2083726
Palmblad J Eicosanoids and modulation of inflammatory and immune responses. 1990 Scand. J. Clin. Lab. Invest. Suppl. pmid:1963704
Zakhariv OIa et al. [Metabolism of linoleic acid given with the feed in the calf liver]. 1990 Jan-Feb Ukr. Biokhim. Zh. pmid:2336726
Shultz TD Physiological free fatty acid concentrations do not increase free estradiol in plasma. 1991 J. Clin. Endocrinol. Metab. pmid:1986028
Hrboticky N et al. Retina fatty acid composition of piglets fed from birth with a linoleic acid-rich vegetable-oil formula for infants. 1991 Am. J. Clin. Nutr. pmid:1989416
Kearns EV et al. The role of cytochrome b5 in delta 12 desaturation of oleic acid by microsomes of safflower (Carthamus tinctorius L.). 1991 Arch. Biochem. Biophys. pmid:1989527
Hou SY et al. Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and x-ray diffraction. 1991 J. Invest. Dermatol. pmid:1991982
Muakkassa FF et al. Effect of dietary fish oil on plasma thromboxane B2 and 6-keto-prostaglandin F1 alpha levels in septic rats. 1991 Arch Surg pmid:1992995
Earles SM et al. Metabolism of oxidized linoleic acid: characterization of 13-hydroxyoctadecadienoic acid dehydrogenase activity from rat colonic tissue. 1991 Biochim. Biophys. Acta pmid:1998735
Hubbard NE and Erickson KL Role of dietary oleic acid in linoleic acid-enhanced metastasis of a mouse mammary tumor. 1991 Cancer Lett. pmid:1998946
Kim RS and Zaborniak CL The aldehydic metabolites of linoleic acid are cytotoxic against human breast cancer cells. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1946549
Pettersen J and Opstvedt J Trans fatty acids. 4. Effects on fatty acid composition of colostrum and milk. 1991 Lipids pmid:1762516
Stroh S and Elmadfa I [In vitro studies of the effect of different mixture proportions of omega-3 and omega-6 fatty acids on thrombocyte aggregation and thromboxane synthesis in human thrombocytes]. 1991 Z Ernahrungswiss pmid:1763556
Wright S and Sanders TA Adipose tissue essential fatty acid composition in patients with atopic eczema. 1991 Eur J Clin Nutr pmid:1782921
Butovich IA et al. The unusual action of (R,S)-2-hydroxy-2-trifluoromethyl-trans-n-octadec-4-enoic acid on 5-lipoxygenase from potato tubers. 1991 Eur. J. Biochem. pmid:2065670
Rose DP and Connolly JM Effects of fatty acids and eicosanoid synthesis inhibitors on the growth of two human prostate cancer cell lines. 1991 Prostate pmid:2020620
Bull AW et al. Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. 1991 Prostaglandins pmid:2020745
Schreiner GF Dietary treatment of immunologically mediated renal disease. 1991 Kidney Int. Suppl. pmid:2046271
Venkatraman JT et al. Influence of genotype on diet-induced changes in membrane phosphatidylcholine and phosphatidylethanolamine composition of splenocytes, liver nuclear envelope and liver mitochondria. 1991 Lipids pmid:2046486
Rubinstein A et al. Fatty acid composition of adipose tissue in Ethiopian immigrants: a prospective study during their first year in Israel. 1991 Isr. J. Med. Sci. pmid:2050506
Holman RT Highpoints in an affair with polyunsaturated fatty acids. 1991 World Rev Nutr Diet pmid:2053355
Stein Y et al. Metabolism of 3-[3H]sphingosine sphingomyelin labeled with [14C]palmitic or [14C]linoleic acid by Hep G2 cells and rat liver in vivo. 1991 Biochim. Biophys. Acta pmid:2054378
Reaven P et al. Feasibility of using an oleate-rich diet to reduce the susceptibility of low-density lipoprotein to oxidative modification in humans. 1991 Am. J. Clin. Nutr. pmid:1897476
Leyton J et al. Effects of type of dietary fat on phorbol ester-elicited tumor promotion and other events in mouse skin. 1991 Cancer Res. pmid:1899048
Iacono JM and Dougherty RM Lack of effect of linoleic acid on the high-density-lipoprotein-cholesterol fraction of plasma lipoproteins. 1991 Am. J. Clin. Nutr. pmid:1900384
Macías P et al. Hemin and hemeprotein bleaching during linoleic acid oxidation by lipoxygenases. 1991 Biochim. Biophys. Acta pmid:1903070
Iwahashi H et al. Isolation and identification of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenase. 1991 Arch. Biochem. Biophys. pmid:1846731
Thomson AB et al. Feeding rats a diet enriched with saturated fatty acids prevents the inhibitory effects of acute and chronic ethanol exposure on the in vitro uptake of hexoses and lipids. 1991 Biochim. Biophys. Acta pmid:1854796
Bellomonte G et al. Quantitative determination of linoleic acid in infant formulas. 1991 Int J Vitam Nutr Res pmid:1856052
Schmitz PG et al. Glomerular hemodynamic effects of dietary polyunsaturated fatty acid supplementation. 1991 J. Lab. Clin. Med. pmid:1856576
Kinsella JE Alpha-linolenic acid: functions and effects on linoleic acid metabolism and eicosanoid-mediated reactions. 1991 Adv. Food Nutr. Res. pmid:1681826
Eling TE and Glasgow WC Transduction of the epidermal growth factor mitogenic signal in BALB/c 3T3 fibroblasts involves linoleic acid metabolism. 1991 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:1825423
Ramasamy S et al. Linoleic acid-induced endothelial cell injury: role of membrane-bound enzyme activities and lipid oxidation. 1991 J. Biochem. Toxicol. pmid:1831858
Ledwozyw A et al. [Surfactant lipids of bovine lungs]. 1991 Pol Arch Weter pmid:1842618
Semplicini A et al. Effects of linoleic acid supplementation on blood pressure and kinetics of red cell sodium transport: the Piove di Sacco Study. 1991 J Hypertens Suppl pmid:1818979
Rose DP et al. Effect of dietary fat on human breast cancer growth and lung metastasis in nude mice. 1991 J. Natl. Cancer Inst. pmid:1920496
Batres-Cerezo R et al. Studies of women eating diets with different fatty acid composition. III. Fatty acids and prostaglandin synthesis by platelets and cultured human endothelial cells. 1991 J Am Coll Nutr pmid:1894889
Ikeda I et al. Lymphatic absorption of structured glycerolipids containing medium-chain fatty acids and linoleic acid, and their effect on cholesterol absorption in rats. 1991 Lipids pmid:1895884
van der Schouw YT et al. Fatty acid composition of serum lipids of mothers and their babies after normal and hypertensive pregnancies. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1815240
Mayer M Linoleic-acid-dependent slowing of erythrocyte sedimentation in multiple sclerosis. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1815242
Nègre-Salvayre A et al. Additional antilipoperoxidant activities of alpha-tocopherol and ascorbic acid on membrane-like systems are potentiated by rutin. 1991 Pharmacology pmid:1652140
Venkatraman JT et al. Effect of dietary fat on diabetes-induced changes in liver microsomal fatty acid composition and glucose-6-phosphatase activity in rats. 1991 Lipids pmid:1652672
Krumhardt B and Dupont J The relationship between thromboxane and cytosolic calcium modifiers in rat platelets. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1652770
Huynh S et al. Metabolic utilization of linoleate and alpha-linolenate in cultured Sertoli cells. 1991 Comp. Biochem. Physiol., B pmid:1684926
de Tomás ME et al. Metabolic transformation of intracraneally injected [1-14C]linoleic and [1-14C]alpha-linolenic acids in malnourished developing rats. 1991 Lipids pmid:1687158
Julu PO and Mutamba A Comparison of short-term effects of insulin and essential fatty acids on the slowed nerve conduction of streptozotocin diabetes in rats. 1991 J. Neurol. Sci. pmid:1663993
Benmansour N et al. Effects of castration, dietary fat and adipose tissue sites on adipocyte plasma-membranes cyclic AMP phosphodiesterase activity in the pig. 1991 Int. J. Biochem. pmid:1665423
Cant A et al. The effect of maternal supplementation with linoleic and gamma-linolenic acids on the fat composition and content of human milk: a placebo-controlled trial. 1991 J. Nutr. Sci. Vitaminol. pmid:1668100
Yamamoto N et al. Effects of a high-linoleate and a high-alpha-linolenate diet on the learning ability of aged rats. Evidence against an autoxidation-related lipid peroxide theory of aging. 1991 J Gerontol pmid:1670780