Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Embolism, Fat D004620 4 associated lipids
Encopresis D004688 1 associated lipids
Enuresis D004775 1 associated lipids
Epilepsy, Temporal Lobe D004833 4 associated lipids
Esophagitis, Peptic D004942 4 associated lipids
Facial Nerve Diseases D005155 1 associated lipids
Fat Necrosis D005218 1 associated lipids
Fatty Liver D005234 48 associated lipids
Fatty Liver, Alcoholic D005235 11 associated lipids
Foreign-Body Reaction D005549 10 associated lipids
Gastritis D005756 27 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Glioma D005910 112 associated lipids
Glomerulonephritis D005921 35 associated lipids
Haemophilus Infections D006192 3 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Hepatolenticular Degeneration D006527 3 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hyperlipoproteinemias D006951 15 associated lipids
Hyperplasia D006965 34 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Hypertension, Renal D006977 9 associated lipids
Infant, Newborn, Diseases D007232 9 associated lipids
Infertility D007246 3 associated lipids
Infertility, Male D007248 11 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Keloid D007627 12 associated lipids
Darier Disease D007644 2 associated lipids
Kidney Diseases D007674 29 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Lactose Intolerance D007787 2 associated lipids
Leptospirosis D007922 2 associated lipids
Leukemia D007938 74 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Liposarcoma D008080 1 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Liver Diseases D008107 31 associated lipids
Liver Diseases, Alcoholic D008108 13 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Verwoert I et al. The molecular basis of the high linoleic acid content in Petunia seed oil: analysis of a seed-specific linoleic acid mutant. 2000 Biochem. Soc. Trans. pmid:11171150
Kamisaka Y and Noda N Intracellular transport of phosphatidic acid and phosphatidylcholine into lipid bodies: use of fluorescent lipids to study lipid-body formation in an oleaginous fungus. 2000 Biochem. Soc. Trans. pmid:11171185
Grechkin AN et al. Lipoxygenase pathway in tulip: biosynthesis of ketols. 2000 Biochem. Soc. Trans. pmid:11171230
Kashulin PA et al. Extremely rapid effects of polyunsaturated fatty acids and N-acetylglucosamine on free-radical metabolism in cultured potato plant cells. 2000 Biochem. Soc. Trans. pmid:11171236
Nuñez A et al. Anaerobic lipoxygenase activity from Chlorella pyrenoidosa. 2000 Biochem. Soc. Trans. pmid:11171268
Kaushik N and Agnihotri A GLC analysis of Indian rapeseed-mustard to study the variability of fatty acid composition. 2000 Biochem. Soc. Trans. pmid:11171132
Bates D Lipids and multiple sclerosis. 1989 Biochem. Soc. Trans. pmid:2546837
Avery SV et al. Low temperature-induced adaptations in lipid metabolism and physiological function in Acanthamoeba castellanii cultures of different ages. 1994 Biochem. Soc. Trans. pmid:7821519
Sanderson P et al. Dietary fish oil diminishes the antigen presentation activity of rat dendritic cells. 1997 Biochem. Soc. Trans. pmid:9191396
Campbell FM and Dutta-Roy AK Asymmetric distribution of the plasma membrane fatty acid-binding protein (FABPpm) in the human placenta. 1996 Biochem. Soc. Trans. pmid:8736907
Oliver MF Linoleic acid, antioxidants and coronary heart disease. 1990 Biochem. Soc. Trans. pmid:2088801
Colquhoun A and Curi R Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. 1997 Biochem. Soc. Trans. pmid:9450108
Lloyd D et al. Adaptive changes in yeast membranes: catabolite repression and oxygen. 1983 Biochem. Soc. Trans. pmid:6617968
Kaushik N and Vir S Variations in fatty acid composition of neem seeds collected from the Rajasthan state of India. 2000 Biochem. Soc. Trans. pmid:11171243
Clouet P et al. Mitochondrial respiration on rumenic and linoleic acids. 2001 Biochem. Soc. Trans. pmid:11356175
Liu Q et al. Genetic modification of cotton seed oil using inverted-repeat gene-silencing techniques. 2000 Biochem. Soc. Trans. pmid:11288706
Mogul R and Holman TR Inhibition studies of soybean and human 15-lipoxygenases with long-chain alkenyl sulfate substrates. 2001 Biochemistry pmid:11284695
Kleinfeld AM et al. Transport of long-chain native fatty acids across lipid bilayer membranes indicates that transbilayer flip-flop is rate limiting. 1997 Biochemistry pmid:9369487
Nelson MJ et al. Photolysis of "purple" lipoxygenase: implications for the structure of the chromophore. 1995 Biochemistry pmid:7742320
Surette ME et al. Relationship between arachidonate--phospholipid remodeling and apoptosis. 1996 Biochemistry pmid:8703924
Glickman MH and Klinman JP Lipoxygenase reaction mechanism: demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover. 1996 Biochemistry pmid:8841132
Jin SJ and Tserng KY Metabolic origins of urinary unsaturated dicarboxylic acids. 1990 Biochemistry pmid:2271537
Biro A et al. Complement protein C1q recognizes enzymatically modified low-density lipoprotein through unesterified fatty acids generated by cholesterol esterase. 2010 Biochemistry pmid:20166680
Pandey NR et al. Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein A-I secretion. 2008 Biochemistry pmid:18189424
SGOUTAS DS and KUMMEROW FA CHEMICAL SYNTHESIS OF TRITIUM-LABELED LINOLEIC ACID. 1964 Biochemistry pmid:14155105
Lima ES et al. Characterization of linoleic acid nitration in human blood plasma by mass spectrometry. 2002 Biochemistry pmid:12186558
Glickman MH and Klinman JP Nature of rate-limiting steps in the soybean lipoxygenase-1 reaction. 1995 Biochemistry pmid:7578005
Nieuwenhuizen WF et al. Lipoxygenase is irreversibly inactivated by the hydroperoxides formed from the enynoic analogues of linoleic acid. 1997 Biochemistry pmid:9109655
Jones GD et al. Role of lipid hydroperoxides in the activation of 15-lipoxygenase. 1996 Biochemistry pmid:8679548
Kleinfeld AM et al. Transport of long-chain native fatty acids across human erythrocyte ghost membranes. 1998 Biochemistry pmid:9609694
Léger CL et al. Evidence for a structurally specific role of essential polyunsaturated fatty acids depending on their peculiar double-bond distribution in biomembranes. 1990 Biochemistry pmid:2169876
Wecksler AT et al. Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. 2009 Biochemistry pmid:19469483
Nelson MJ et al. Structural characterization of alkyl and peroxyl radicals in solutions of purple lipoxygenase. 1994 Biochemistry pmid:8161558
Rickert KW and Klinman JP Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects. 1999 Biochemistry pmid:10493789
Desmarais SR et al. Inhibition of soybean lipoxygenase-1 by a diaryl-N-hydroxyurea by reduction of the ferric enzyme. 1994 Biochemistry pmid:7947748
Mukherjee A et al. Molecular oxygen dependent steps in fatty acid oxidation by cyclooxygenase-1. 2007 Biochemistry pmid:17355126
Henderson WR et al. Toxoplasma gondii stimulates the release of 13- and 9-hydroxyoctadecadienoic acids by human platelets. 1992 Biochemistry pmid:1606159
BAER E and BLACKWELL J SYNTHESIS OF ALPHA-CEPHALINS BY A NEW PROCEDURE. II. DIOLEOYL AND DILINOLEOYL L-ALPHA-CEPHALINS. 1964 Biochemistry pmid:14214090
Mogul R et al. Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase. 2000 Biochemistry pmid:10769137
Widstrom RL et al. Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase. 2003 Biochemistry pmid:14529287
Arnold WR et al. Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase. 2016 Biochemistry pmid:27992998
Widstrom RL et al. Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. 2001 Biochemistry pmid:11170430
Nagler LG et al. Rate of free-radical oxidation of C18 diene and triene fatty acids in aqueous micellar solutions and effectiveness of beta-carotene as an inhibitor of their oxidation. 2003 Biochemistry Mosc. pmid:12693967
Yang J et al. Study of the inhibitory effect of fatty acids on the interaction between DNA and polymerase beta. 2009 Biochemistry Mosc. pmid:19747104
Zhan ZJ et al. Preparation and characterization of Cu,Zn-superoxide dismutase covalently modified by polyunsaturated fatty acids. 2009 Biochemistry Mosc. pmid:19916943
Chechetkin IR et al. Specificity of oxidation of linoleic acid homologs by plant lipoxygenases. 2009 Biochemistry Mosc. pmid:19817685
Puebla C et al. Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism. 2016 Biochim. Biophys. Acta pmid:26869446
STEIN O and STEIN Y METABOLISM IN VITRO OF PALMITIC AND LINOLEIC ACID IN THE HEART AND DIAPHRAGM OF ESSENTIAL FATTY ACID-DEFICIENT RATS. 1964 Biochim. Biophys. Acta pmid:14266247
PRITCHARD ET and NICHOL NE CHOLESTEROL ESTERASE ACTIVITY IN DEVELOPING RAT BRAIN. 1964 Biochim. Biophys. Acta pmid:14266270
Mitranic MM et al. The effect of linoleic acid and benzyl alcohol on the activity of glycosyltransferases of rat liver Golgi membranes and some soluble glycosyltransferases. 1982 Biochim. Biophys. Acta pmid:6217837
Dutta-Roy AK et al. Purification and characterization of fatty acid-binding proteins from brown adipose tissue of the rat. 1993 Biochim. Biophys. Acta pmid:8334153
Funk CD et al. Effects of selenium-deficient diets on the production of prostaglandins and other oxygenated metabolites of arachidonic acid and linoleic acid by rat and rabbit aortae. 1987 Biochim. Biophys. Acta pmid:3115301
Kitagawa S et al. Effects of four types of reagents on ADP-induced aggregation and Ca2+ mobilization of bovine blood platelets. 1984 Biochim. Biophys. Acta pmid:6324876
Simon I et al. Electron-spin resonance studies of lipid-modified microsomes from Friend erythroleukemia cells. 1984 Biochim. Biophys. Acta pmid:6326852
Cheah AM Effect of long chain unsaturated fatty acids on the calcium transport of sarcoplasmic reticulum. 1981 Biochim. Biophys. Acta pmid:6118177
Takahashi Y et al. Activity and mRNA levels of enzymes involved in hepatic fatty acid synthesis and oxidation in mice fed conjugated linoleic acid. 2003 Biochim. Biophys. Acta pmid:12668178
Daoud G et al. Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation. 2005 Biochim. Biophys. Acta pmid:15708366
Deva R et al. Arachidonic acid stimulates cell growth and forms a novel oxygenated metabolite in Candida albicans. 2000 Biochim. Biophys. Acta pmid:10903481
Seeley SK et al. Metabolism of oxidized linoleic acid by glutathione transferases: peroxidase activity toward 13-hydroperoxyoctadecadienoic acid. 2006 Biochim. Biophys. Acta pmid:16624487
Figueroa V et al. Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca(2+)-dependent pathway. 2013 Biochim. Biophys. Acta pmid:23261389
Gardner HW Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. 1989 Biochim. Biophys. Acta pmid:2492826
Artmann A et al. Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine. 2008 Biochim. Biophys. Acta pmid:18316044
Gurvitz A et al. Degradation of conjugated linoleic acid isomers in the yeast Saccharomyces cerevisiae. 2001 Biochim. Biophys. Acta pmid:11566445
Roche M et al. Olive phenols efficiently inhibit the oxidation of serum albumin-bound linoleic acid and butyrylcholine esterase. 2009 Biochim. Biophys. Acta pmid:19714864
Saddik M and Lopaschuk GD The fate of arachidonic acid and linoleic acid in isolated working rat hearts containing normal or elevated levels of coenzyme A. 1991 Biochim. Biophys. Acta pmid:1932104
Yu Y et al. Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. 2002 Biochim. Biophys. Acta pmid:12020636
Wenli Y and Yaping Z Chemiluminescence evaluation of oxidative damage to biomolecules induced by singlet oxygen and the protective effects of antioxidants. 2005 Biochim. Biophys. Acta pmid:15936152
Meuillet EJ et al. Incorporation of exogenous lipids modulates insulin signaling in the hepatoma cell line, HepG2. 1999 Biochim. Biophys. Acta pmid:10354513
SCHLENK H et al. INTERCONVERSION OF LONG-CHAIN FATTY ACIDS IN THE RAT. 1963 Biochim. Biophys. Acta pmid:14102761
Beyers EC and Emken EA Metabolites of cis,trans, and trans,cis isomers of linoleic acid in mice and incorporation into tissue lipids. 1991 Biochim. Biophys. Acta pmid:2029547
Kanter JE et al. Acyl-CoA synthetase 1 is required for oleate and linoleate mediated inhibition of cholesterol efflux through ATP-binding cassette transporter A1 in macrophages. 2012 Biochim. Biophys. Acta pmid:22020260
Rich MR Conformational analysis of arachidonic and related fatty acids using molecular dynamics simulations. 1993 Biochim. Biophys. Acta pmid:8329458
Battu S et al. Linoleic acid peroxidation by Solanum tuberosum lipoxygenase was activated in the presence of human 5-lipoxygenase-activating protein. 1998 Biochim. Biophys. Acta pmid:9630716
Gibson RA et al. Incorporation of dietary oleate, linoleate, alpha-linolenate and eicosapentaenoate into the plasma lipid fractions of four strains of rat. 1992 Biochim. Biophys. Acta pmid:1351403
STEIN Y et al. Enzymic pathways of glyceride and phospholipid synthesis in aortic homogenates. 1963 Biochim. Biophys. Acta pmid:13983700
Mahfouz MM et al. Changes of linoleic acid metabolism and cellular phospholipid fatty acid composition in LLC-PK cells cultured at low magnesium concentrations. 1989 Biochim. Biophys. Acta pmid:2804072
Parsons HG et al. Modulation of human erythrocyte shape and fatty acids by diet. 1986 Biochim. Biophys. Acta pmid:3741859
DeMar JC et al. Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult rats. 2006 Biochim. Biophys. Acta pmid:16920015
Jensen E et al. Cell-density-dependent uptake of chylomicron remnants in rat hepatocyte monolayers. Effects of compactin and mevalonic acid. 1987 Biochim. Biophys. Acta pmid:3790613
Ringseis R et al. LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2. 2006 Biochim. Biophys. Acta pmid:16982210
Loidl-Stahlhofen A et al. Generation of alpha-hydroxyaldehydic compounds in the course of lipid peroxidation. 1994 Biochim. Biophys. Acta pmid:8025124
Macrì F et al. Lipoxygenase activity associated to isolated soybean plasma membranes. 1994 Biochim. Biophys. Acta pmid:7947991
Park Y and Pariza MW Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid. 2001 Biochim. Biophys. Acta pmid:11750884
Christon R et al. Modification of fluidity and lipid-protein relationships in pig intestinal brush-border membrane by dietary essential fatty acid deficiency. 1989 Biochim. Biophys. Acta pmid:2538158
Thomson AB et al. Feeding rats a diet enriched with saturated fatty acids prevents the inhibitory effects of acute and chronic ethanol exposure on the in vitro uptake of hexoses and lipids. 1991 Biochim. Biophys. Acta pmid:1854796
Bester R and Lochner A Sarcolemmal phospholipid fatty acid composition and permeability. 1988 Biochim. Biophys. Acta pmid:3382645
Shires SE et al. Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. 1989 Biochim. Biophys. Acta pmid:2493807
Leikin AI and Brenner RR Regulation of linoleic acid delta 6-desaturation by a cytosolic lipoprotein-like fraction in isolated rat liver microsomes. 1986 Biochim. Biophys. Acta pmid:2869785
Ulmann L et al. Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. 1991 Biochim. Biophys. Acta pmid:1657182
Nijssen JG and van den Bosch H Coenzyme A-mediated transacylation of sn-2 fatty acids from phosphatidylcholine in rat lung microsomes. 1986 Biochim. Biophys. Acta pmid:3081034
Mizushina Y et al. Mode analysis of binding of fatty acids to mammalian DNA polymerases. 2000 Biochim. Biophys. Acta pmid:10903472
DESAI ID et al. PEROXIDATIVE AND RADIATION DAMAGE TO ISOLATED LYSOSOMES. 1964 Biochim. Biophys. Acta pmid:14171002
Clementz T et al. Membrane potential, lipid regulation and adenylate energy charge in acyl chain modified Acholeplasma laidlawii. 1987 Biochim. Biophys. Acta pmid:3567184
Sasaki T et al. Effects of dietary docosahexaenoic acid on surface molecules involved in T cell proliferation. 1999 Biochim. Biophys. Acta pmid:9989281
Torres-Duarte AP and Vanderhoek JY Conjugated linoleic acid exhibits stimulatory and inhibitory effects on prostanoid production in human endothelial cells and platelets. 2003 Biochim. Biophys. Acta pmid:12676356
Kwon B et al. Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. 2014 Biochim. Biophys. Acta pmid:24732014
Egashira Y et al. Differential effects of dietary fatty acids on rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase activity and gene expression. 2004 Biochim. Biophys. Acta pmid:15522828
Tabachnick M and Korcek L Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. 1986 Biochim. Biophys. Acta pmid:2869786
Nugteren DH and Kivits GA Conversion of linoleic acid and arachidonic acid by skin epidermal lipoxygenases. 1987 Biochim. Biophys. Acta pmid:3113487
Elmes M et al. The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandins. 2004 Biochim. Biophys. Acta pmid:15522830