Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Tremor D014202 15 associated lipids
Tinea Versicolor D014010 5 associated lipids
Thrombosis D013927 49 associated lipids
Stomach Ulcer D013276 75 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Starvation D013217 47 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Sigmoid Neoplasms D012811 5 associated lipids
Seizures D012640 87 associated lipids
Dermatitis, Seborrheic D012628 10 associated lipids
Retinoblastoma D012175 12 associated lipids
Retinal Degeneration D012162 9 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Refsum Disease D012035 19 associated lipids
Refractive Errors D012030 1 associated lipids
Pulmonary Edema D011654 23 associated lipids
Psoriasis D011565 47 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Proteinuria D011507 30 associated lipids
Protein-Energy Malnutrition D011502 9 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Pregnancy Complications, Neoplastic D011252 4 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pre-Eclampsia D011225 16 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Dermatitis, Toxicodendron D011040 3 associated lipids
Pneumonia, Viral D011024 3 associated lipids
Peritoneal Neoplasms D010534 16 associated lipids
Pellagra D010383 1 associated lipids
Parkinson Disease D010300 53 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pain D010146 64 associated lipids
Otitis Externa D010032 8 associated lipids
Onchocerciasis D009855 1 associated lipids
Nerve Degeneration D009410 53 associated lipids
Neoplasms, Hormone-Dependent D009376 23 associated lipids
Nausea D009325 7 associated lipids
Migraine Disorders D008881 11 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Meningeal Neoplasms D008577 5 associated lipids
Melanosis D008548 4 associated lipids
Melanoma D008545 69 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Lymphopenia D008231 2 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Liver Diseases, Alcoholic D008108 13 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Rinker KD et al. Linoleic acid increases monocyte deformation and adhesion to endothelium. 2004 Atherosclerosis pmid:15530900
Huang YS et al. Most biological effects of zinc deficiency corrected by gamma-linolenic acid (18: 3 omega 6) but not by linoleic acid (18: 2 omega 6). 1982 Atherosclerosis pmid:6279122
Allman-Farinelli MA et al. Comparison of the effects of two low fat diets with different alpha-linolenic:linoleic acid ratios on coagulation and fibrinolysis. 1999 Atherosclerosis pmid:9920517
Hornstra G and Kester AD Effect of the dietary fat type on arterial thrombosis tendency: systematic studies with a rat model. 1997 Atherosclerosis pmid:9180241
de Waart FG et al. Vitamin E supplementation in elderly lowers the oxidation rate of linoleic acid in LDL. 1997 Atherosclerosis pmid:9298686
Válek J et al. Serum linoleic acid and cardiovascular death in postinfarction middle-aged men. 1985 Atherosclerosis pmid:3994777
Ohrvall M et al. Malondialdehyde concentration in plasma is inversely correlated to the proportion of linoleic acid in serum lipoprotein lipids. 1994 Atherosclerosis pmid:7980703
Lee KN et al. Conjugated linoleic acid and atherosclerosis in rabbits. 1994 Atherosclerosis pmid:7980704
Kurushima H et al. Comparison of hypocholesterolemic effects induced by dietary linoleic acid and oleic acid in hamsters. 1995 Atherosclerosis pmid:7605390
Liu SX et al. Oxidized cholesterol in oxidized low density lipoprotein may be responsible for the inhibition of LPS-induced nitric oxide production in macrophages. 1998 Atherosclerosis pmid:9544730
Ramasamy S et al. Proteoglycans and endothelial barrier function: effect of linoleic acid exposure to porcine pulmonary artery endothelial cells. 1993 Atherosclerosis pmid:8292102
Abraham RD et al. Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. 1990 Atherosclerosis pmid:2112389
Tavendale R et al. Adipose tissue fatty acids in Scottish men and women: results from the Scottish Heart Health Study. 1992 Atherosclerosis pmid:1632870
SIMPSON-MORGAN MW and MORRIS B A comparison of the metabolism of palmitic, oleic and linoleic acids incorporated into chylomicron triglycerides. 1962 Aust J Exp Biol Med Sci pmid:13977574
Margetts BM et al. Dietary fats and blood pressure. 1984 Aust N Z J Med pmid:6596055
Namazi MR The beneficial and detrimental effects of linoleic acid on autoimmune disorders. 2004 Autoimmunity pmid:15115315
NaÄ­dina VP et al. [Changes in lipid composition of human plasma and erythrocyte membranes due to sodium hydroxybutyrate and normobaric hyperoxia during bed rest]. 2010 Jan-Feb Aviakosm Ekolog Med pmid:20804001
Stephens RJ et al. Lipid peroxidation and retinal phototoxic degeneration. 1988 Basic Life Sci. pmid:2977946
Renner HW Anticlastogenic dietary factors assessed in mammalian assays. 1990 Basic Life Sci. pmid:2183774
Szekeres L Cardioprotection by anti-ischaemic and cytoprotective drugs. 1987 Basic Res. Cardiol. pmid:3311014
Rüthrich HL et al. Perinatal linoleate deprivation impairs learning and memory in adult rats. 1984 Behav. Neural Biol. pmid:6539591
Schauder P et al. [The effect of free fatty acids on the leucine oxidation of human lymphocytes]. 1988 Beitr Infusionther Klin Ernahr pmid:3377747
Bartels T et al. [Effect of linoleic acid in food on spongioid bone density and prostaglandin biosynthesis in bones]. 1988 Beitr Orthop Traumatol pmid:3228436
De Weirdt R et al. A simulated mucus layer protects Lactobacillus reuteri from the inhibitory effects of linoleic acid. 2013 Benef Microbes pmid:24311313
Galli C Metabolic aspects of the biological roles of omega 3 fatty acids. 1988 Bibl Nutr Dieta pmid:3060104
Wolfram G et al. Pain, prostaglandins, and food lipids. Influences of dietary polyunsaturated fatty acids on eicosanoid synthesis and effects. 1986 Bibl Nutr Dieta pmid:2870709
Cho BH Lipid composition and cholesterol esterifying activity in microsomal preparations of porcine coronary arteries and heart tissue. 1983 Biochem Med pmid:6838501
Oliw EH Oxygenation of linolenic and linoleic acid to novel vicinal dihydroxy acids by hepatic microsomes of the rabbit. 1983 Biochem. Biophys. Res. Commun. pmid:6301473
Campbell FM et al. Plasma membrane fatty-acid-binding protein in human placenta: identification and characterization. 1995 Biochem. Biophys. Res. Commun. pmid:7733952
Pal S and Davis PJ N-3 polyunsaturated fatty acids enhance cholesterol efflux from human fibroblasts in culture. 1990 Biochem. Biophys. Res. Commun. pmid:2260969
Blee E et al. Regio- and stereoselectivity of cytochrome P-450 and peroxygenase-dependent formation of cis-12,13-epoxy-9(Z)-octadecenoic acid (vernolic acid) in Euphorbia lagascae. 1993 Biochem. Biophys. Res. Commun. pmid:8267615
Hicks M et al. Catalysis of lipid peroxidation by glucose and glycosylated collagen. 1988 Biochem. Biophys. Res. Commun. pmid:3126742
Lee CW et al. Structural basis for the ligand-binding specificity of fatty acid-binding proteins (pFABP4 and pFABP5) in gentoo penguin. 2015 Biochem. Biophys. Res. Commun. pmid:26206084
Pohl CH et al. Oxylipin formation in fungi: biotransformation of arachidonic acid to 3-hydroxy-5,8-tetradecadienoic acid by Mucor genevensis. 1998 Biochem. Biophys. Res. Commun. pmid:9918790
Schächtele C et al. Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine. 1988 Biochem. Biophys. Res. Commun. pmid:2831891
Inoue N et al. Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats. 2004 Biochem. Biophys. Res. Commun. pmid:15369804
Iwase H et al. Monoepoxide production from linoleic acid by cytochrome c in the presence of cardiolipin. 1996 Biochem. Biophys. Res. Commun. pmid:8630079
Garscha U and Oliw E Pichia expression and mutagenesis of 7,8-linoleate diol synthase change the dioxygenase and hydroperoxide isomerase. 2008 Biochem. Biophys. Res. Commun. pmid:18586008
Laugier C et al. Differential regulation of calmodulin-dependent and -independent cyclic AMP phosphodiesterases from oviduct by fatty acids. 1991 Biochem. Biophys. Res. Commun. pmid:1645959
Iwase H et al. Superoxide anion reduces the ability of myeloperoxidase to damage lipids. 1996 Biochem. Biophys. Res. Commun. pmid:8605038
Wooten MW and Wrenn RW Linoleic acid is a potent activator of protein kinase C type III-alpha isoform in pancreatic acinar cells; its role in amylase secretion. 1988 Biochem. Biophys. Res. Commun. pmid:2454109
Canfield LM et al. Anti-oxidant/pro-oxidant reactions of vitamin K. 1985 Biochem. Biophys. Res. Commun. pmid:3985964
Kelley RI Beta-oxidation of long-chain fatty acids by human fibroblasts: evidence for a novel long-chain acyl-coenzyme A dehydrogenase. 1992 Biochem. Biophys. Res. Commun. pmid:1540149
Connor HD et al. A search for oxygen-centered free radicals in the lipoxygenase/linoleic acid system. 1986 Biochem. Biophys. Res. Commun. pmid:3026385
Byczkowski JZ and Kulkarni AP Lipoxygenase-catalyzed epoxidation of benzo(a)pyrene-7,8-dihydrodiol. 1989 Biochem. Biophys. Res. Commun. pmid:2494999
Jung KC et al. Determination of the dissociation constants for recombinant c-Myc, Max, and DNA complexes: the inhibitory effect of linoleic acid on the DNA-binding step. 2005 Biochem. Biophys. Res. Commun. pmid:16002048
Lernhardt W Fatty acid requirement of B lymphocytes activated in vitro. 1990 Biochem. Biophys. Res. Commun. pmid:2302243
Sakurada K et al. cis-9,10-Methylenehexadecanoic acid inhibits contractility and actomyosin ATPase activity of guinea pig myocardium. 2000 Biochem. Biophys. Res. Commun. pmid:10913372
van Himbergen TM et al. Paraoxonase-1 and linoleic acid oxidation in familial hypercholesterolemia. 2005 Biochem. Biophys. Res. Commun. pmid:15963464
Kang K and Pariza MW trans-10,cis-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes. 2001 Biochem. Biophys. Res. Commun. pmid:11554738
Iwase H et al. Effect of monochlorohydrins of linoleic acid on guinea-pig cardiac papillary muscles. 1997 Biochem. Biophys. Res. Commun. pmid:9070266
McPherson PA et al. Mechanism for the enhanced peroxidation of linoleic acid by a titanium dioxide/hypochlorite system. 2013 Biochem. Biophys. Res. Commun. pmid:23178466
Iwase H et al. pH dependent alterations of monoepoxides and monochlorohydrins of linoleic acid, and their existence in vivo. 1995 Biochem. Biophys. Res. Commun. pmid:7488065
Andrianarison RH et al. Oxodiene formation during the Vicia sativa lipoxygenase-catalyzed reaction: occurrence of dioxygenase and fatty acid lyase activities associated in a single protein. 1991 Biochem. Biophys. Res. Commun. pmid:1953704
Nakayama T et al. Visible spectrophotometric assay, purification, and molecular properties of a lipoxygenase from eggplant (Solanum melongena Linne) fruits. 1995 Biochem. Biophys. Res. Commun. pmid:7575511
Ding XZ et al. Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells. 1999 Biochem. Biophys. Res. Commun. pmid:10405349
Conquer J and Mahadevappa VG Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils. 1990 Biochem. Biophys. Res. Commun. pmid:2106881
Takahashi K et al. Ester-exchange catalyzed by lipase modified with polyethylene glycol. 1985 Biochem. Biophys. Res. Commun. pmid:4052065
Whitehouse AS and Tisdale MJ Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation. 2001 Biochem. Biophys. Res. Commun. pmid:11453634
Giamalva D et al. A comparison of the rates of ozonation of biological antioxidants and oleate and linoleate esters. 1985 Biochem. Biophys. Res. Commun. pmid:4084297
Schneider C et al. A fatty acid alpha-ketol, a product of the plant lipoxygenase pathway, is oxidized to 3(Z)-dodecendioic acid by a bacterial monooxygenase. 1997 Biochem. Biophys. Res. Commun. pmid:9125182
Hrelia S et al. Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes. 1989 Biochem. Biophys. Res. Commun. pmid:2570573
Butovich IA et al. Oxidation of linoleyl alcohol by potato tuber lipoxygenase: possible mechanism and the role of carboxylic group in substrate binding. 1998 Biochem. Biophys. Res. Commun. pmid:9712698
Reinaud O et al. Oxidative metabolism of linoleic acid by human leukocytes. 1989 Biochem. Biophys. Res. Commun. pmid:2735926
Rose DP and Connolly JM Stimulation of growth of human breast cancer cell lines in culture by linoleic acid. 1989 Biochem. Biophys. Res. Commun. pmid:2803300
Aki T et al. Molecular cloning and functional characterization of rat delta-6 fatty acid desaturase. 1999 Biochem. Biophys. Res. Commun. pmid:10049752
Matsumoto M et al. D-galactosamine-induced cell damage enhances specific binding of prostaglandin E1 to rat hepatocytes. 1992 Biochem. Biophys. Res. Commun. pmid:1315527
Nikolaev V et al. Stereochemical nature of the products of linoleic acid oxidation catalyzed by lipoxygenases from potato and soybean. 1990 Biochem. Biophys. Res. Commun. pmid:2116790
Reddy N et al. Characterization of a 15-lipoxygenase in human breast carcinoma BT-20 cells: stimulation of 13-HODE formation by TGF alpha/EGF. 1997 Biochem. Biophys. Res. Commun. pmid:9070230
Yamada Y et al. Production of hydroxy fatty acid (10-hydroxy-12(Z)-octadecenoic acid) by Lactobacillus plantarum from linoleic acid and its cardiac effects to guinea pig papillary muscles. 1996 Biochem. Biophys. Res. Commun. pmid:8806645
Jacobs JM and Jacobs NJ Effect of unsaturated fatty acids on protoporphyrinogen oxidation, a step in heme and chlorophyll synthesis in plant organelles. 1984 Biochem. Biophys. Res. Commun. pmid:6487324
Iwase H et al. Calcium ions potentiate lipoxygenase activity of cytochrome c at the physiological pH. 1998 Biochem. Biophys. Res. Commun. pmid:9480835
Sani BP et al. Interference of retinoic acid binding to its binding protein by omega-6 fatty acids. 1987 Biochem. Biophys. Res. Commun. pmid:2820396
Mullarkey CJ et al. Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. 1990 Biochem. Biophys. Res. Commun. pmid:2176495
Chu CH et al. The activity of 3-hydroxyacyl-CoA epimerase is insufficient to account for the rate of linoleate oxidation in rat heart mitochondria. Evidence for a modified pathway of linoleate degradation. 1984 Biochem. Biophys. Res. Commun. pmid:6696754
Tannin-Spitz T et al. Cucurbitacin glucosides: antioxidant and free-radical scavenging activities. 2007 Biochem. Biophys. Res. Commun. pmid:17942079
Böhmer S et al. Oxidation of phenanthrene by a fungal laccase in the presence of 1-hydroxybenzotriazole and unsaturated lipids. 1998 Biochem. Biophys. Res. Commun. pmid:9514895
Chen Q et al. Delta-6 desaturase from borage converts linoleic acid to gamma-linolenic acid in HEK293 cells. 2011 Biochem. Biophys. Res. Commun. pmid:21679695
Jiang WG et al. Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids. 1998 Biochem. Biophys. Res. Commun. pmid:9514943
Nakagawa Y and Waku K Selective inhibition of free arachidonic acid production in activated alveolar macrophages by calmodulin antagonists. 1988 Biochem. Biophys. Res. Commun. pmid:3142466
Ou L et al. Conjugated linoleic acid induces apoptosis of murine mammary tumor cells via Bcl-2 loss. 2007 Biochem. Biophys. Res. Commun. pmid:17400188
Lee JY and Hwang DH Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line. 2002 Biochem. Biophys. Res. Commun. pmid:12419306
Blee E and Schuber F Enantioselectivity of the hydrolysis of linoleic acid monoepoxides catalyzed by soybean fatty acid epoxide hydrolase. 1992 Biochem. Biophys. Res. Commun. pmid:1520297
Tripathi AK et al. A physiochemical mechanism of hemozoin (beta-hematin) synthesis by malaria parasite. 2002 Biochem. Biophys. Res. Commun. pmid:11779214
Lopez Jimenez JA et al. Linoleic acid metabolism in primary cultures of adult rat cardiomyocytes is impaired by aging. 1997 Biochem. Biophys. Res. Commun. pmid:9266846
Kang K et al. Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity. 2004 Biochem. Biophys. Res. Commun. pmid:14975733
Aleynik MK and Lieber CS Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1. 2001 Biochem. Biophys. Res. Commun. pmid:11689017
Nagao K et al. The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty rats. 2003 Biochem. Biophys. Res. Commun. pmid:12788078
Chapkin RS and Ziboh VA Inability of skin enzyme preparations to biosynthesize arachidonic acid from linoleic acid. 1984 Biochem. Biophys. Res. Commun. pmid:6439197
Maccarrone M et al. Activation of different lipoxygenase isozymes induces apoptosis in human erythroleukemia and neuroblastoma cells. 2000 Biochem. Biophys. Res. Commun. pmid:10833416
Hernández-Ledesma B et al. Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages. 2009 Biochem. Biophys. Res. Commun. pmid:19836349
Hori T et al. Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid. 1990 Biochem. Biophys. Res. Commun. pmid:2114113
Stentz FB and Kitabchi AE Palmitic acid-induced activation of human T-lymphocytes and aortic endothelial cells with production of insulin receptors, reactive oxygen species, cytokines, and lipid peroxidation. 2006 Biochem. Biophys. Res. Commun. pmid:16782068
Verma SP and Wallach DF Action of ionizing radiation on lipid-protein interaction. 1982 Biochem. Biophys. Res. Commun. pmid:6896453
Fávaro RD et al. ZmPUMP encodes a fully functional monocot plant uncoupling mitochondrial protein whose affinity to fatty acid is increased with the introduction of a His pair at the second matrix loop. 2006 Biochem. Biophys. Res. Commun. pmid:16603126
Wang S et al. Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells. 2016 Biochem. Biophys. Res. Commun. pmid:26879142
Das UN Effect of phorbolmyristate acetate on fatty acid uptake and distribution in human promyelocytic leukemia (HL-60) cells in vitro. 1988 Biochem. Biophys. Res. Commun. pmid:3144272
Setty BN et al. 13-Hydroxyoctadecadienoic acid (13-HODE) stimulates prostacyclin production by endothelial cells. 1987 Biochem. Biophys. Res. Commun. pmid:3113422
Crutchley DJ Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. 1985 Biochem. Biophys. Res. Commun. pmid:2865954
Zhao G et al. Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. 2005 Biochem. Biophys. Res. Commun. pmid:16169525