Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Dermatitis, Contact D003877 59 associated lipids
Diabetic Ketoacidosis D016883 16 associated lipids
Otitis Externa D010032 8 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lung Neoplasms D008175 171 associated lipids
Hepatolenticular Degeneration D006527 3 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Per page 10 20 50 100 | Total 198

PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Jump DB et al. Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. 2011 Biochem. Pharmacol. pmid:21184748
Penumetcha M et al. Modulation of leptin levels by oxidized linoleic acid: a connection to atherosclerosis? 2011 J Med Food pmid:21186986
Park HG et al. Production of conjugated linoleic acid (CLA) by Bifidobacterium breve LMC520 and its compatibility with CLA-producing rumen bacteria. 2011 J. Agric. Food Chem. pmid:21192703
Loizzo MR et al. In vitro antioxidant and hypoglycemic activities of Ethiopian spice blend Berbere. 2011 Int J Food Sci Nutr pmid:21599464
Kruska N and Reiser G Phytanic acid and pristanic acid, branched-chain fatty acids associated with Refsum disease and other inherited peroxisomal disorders, mediate intracellular Ca2+ signaling through activation of free fatty acid receptor GPR40. 2011 Neurobiol. Dis. pmid:21570468
Shirakawa J et al. Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. 2011 J. Biol. Chem. pmid:21613229
Labayen I et al. Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. 2011 Atherosclerosis pmid:21550607
Monfregola L et al. Physical and water sorption properties of chemically modified pectin with an environmentally friendly process. 2011 Biomacromolecules pmid:21553919
Shin D et al. Dietary combination effects of conjugated linoleic acid and flaxseed or fish oil on the concentration of linoleic and arachidonic acid in poultry meat. 2011 Poult. Sci. pmid:21597077
Yepuri G et al. Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. 2011 Br. J. Nutr. pmid:21281526
Wang L et al. Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+]i increase in pancreatic islet {alpha}-cells. 2011 J. Endocrinol. pmid:21565851
Nigam S et al. On mechanism of quorum sensing in Candida albicans by 3(R)-hydroxy-tetradecaenoic acid. 2011 Curr. Microbiol. pmid:20509029
Liu SJ et al. Effect of ruminal pulse dose of polyunsaturated fatty acids on ruminal microbial populations and duodenal flow and milk profiles of fatty acids. 2011 J. Dairy Sci. pmid:21605768
Palmieri-Thiers C et al. Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies. 2011 Arch. Biochem. Biophys. pmid:21345329
Kishino S et al. Linoleic acid isomerase in Lactobacillus plantarum AKU1009a proved to be a multi-component enzyme system requiring oxidoreduction cofactors. 2011 Biosci. Biotechnol. Biochem. pmid:21307591
McFarland DC et al. Effect of lipids on avian satellite cell proliferation, differentiation and heparan sulfate proteoglycan expression. 2011 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:21356326
Retamal MA et al. Biphasic effect of linoleic acid on connexin 46 hemichannels. 2011 Pflugers Arch. pmid:21360038
Maqbool A et al. The skinny on tuna fat: health implications. 2011 Public Health Nutr pmid:21324226
Popescu FD et al. Effects of season and reproductive state on lipid intake and fatty acid composition of gastrointestinal tract contents in the European hare. 2011 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:21328065
Lee MJ et al. The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. 2011 Mol. Cells pmid:21331775
Cunnane SC and Guesnet P Linoleic acid recommendations--A house of cards. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21963263
Royan M et al. Effects of conjugated linoleic acid, fish oil and soybean oil on PPARs (α & γ) mRNA expression in broiler chickens and their relation to body fat deposits. 2011 Int J Mol Sci pmid:22272093
P Wrobel T et al. Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis. 2011 Analyst pmid:22007352
Salleh WM et al. Chemical compositions, antioxidant and antimicrobial activities of essential oils of Piper caninum Blume. 2011 Int J Mol Sci pmid:22174627
Li YC et al. Effects of conjugated linoleic acid on cleavage of amyloid precursor protein via PPARγ. 2011 Neurol. Sci. pmid:21800078
Shofian NM et al. Effect of freeze-drying on the antioxidant compounds and antioxidant activity of selected tropical fruits. 2011 Int J Mol Sci pmid:21845104
Baâtour O et al. Salt effects on Origanum majorana fatty acid and essential oil composition. 2011 J. Sci. Food Agric. pmid:21800320
Lebold KM et al. Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). 2011 J. Nutr. pmid:22013196
Nishioka N et al. Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1. 2011 Br. J. Cancer pmid:22015554
Toledo L et al. Substrate binding to mammalian 15-lipoxygenase. 2011 J. Comput. Aided Mol. Des. pmid:21861154
Vedtofte MS et al. Dietary α-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease. 2011 Am. J. Clin. Nutr. pmid:21865326
Alimi H et al. Evaluation of antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis flowers extract in rats. 2011 Environ. Toxicol. Pharmacol. pmid:22004960
Amtul Z et al. Additive effects of fatty acid mixtures on the levels and ratio of amyloid β40/42 peptides differ from the effects of individual fatty acids. 2011 J. Neurosci. Res. pmid:21748777
Strandvik B The omega-6/omega-3 ratio is of importance! 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21945460
Ilić M et al. Thrombin inhibitors with lipid peroxidation and lipoxygenase inhibitory activities. 2011 Bioorg. Med. Chem. Lett. pmid:21757348
Espinosa-Neira R et al. Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A. 2011 Int. J. Biochem. Cell Biol. pmid:21945809
Mito F et al. Oxygen concentration dependence of lipid peroxidation and lipid-derived radical generation: application of profluorescent nitroxide switch. 2011 Free Radic. Res. pmid:21736483
Sousa A et al. Chemical characterization of "alcaparras" stoned table olives from northeast Portugal. 2011 Molecules pmid:22031066
Ranchordas MK et al. A-z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--part 23. 2011 Br J Sports Med pmid:21743106
Kikalishvili BIu et al. [The most biological important constances of Rkatsiteli grape oil and its effect as a 5% and 10% food-additive]. 2011 Georgian Med News pmid:21778549
Mahmmoud YA and Christensen SB Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. 2011 Biochim. Biophys. Acta pmid:21767529
Khadake R et al. Functional and bioinformatic characterisation of sequence variants of Fad3 gene from flax. 2011 J. Sci. Food Agric. pmid:21769878
Banta JP et al. Effects of prepartum supplementation of linoleic and mid-oleic sunflower seed on cow performance, cow reproduction, and calf performance from birth through slaughter, and effects on intake and digestion in steers. 2011 J. Anim. Sci. pmid:21788431
Končić MZ et al. Antiradical, chelating and antioxidant activities of hydroxamic acids and hydroxyureas. 2011 Molecules pmid:21788931
Ramsden CE et al. All PUFAs are not created equal: absence of CHD benefit specific to linoleic acid in randomized controlled trials and prospective observational cohorts. 2011 World Rev Nutr Diet pmid:21865817
Okuyama H et al. New Cholesterol Guidelines for Longevity (2010). 2011 World Rev Nutr Diet pmid:21865826
Legrand P et al. Update of French nutritional recommendations for fatty acids. 2011 World Rev Nutr Diet pmid:21865827
Khan AA et al. Synthesis and characterization of novel PUFA esters exhibiting potential anticancer activities: an in vitro study. 2011 Eur J Med Chem pmid:21868138
Ozcan B et al. Antimicrobial and antioxidant activities of the various extracts of Verbascum pinetorum Boiss. O. Kuntze (Scrophulariaceae). 2011 Eur Rev Med Pharmacol Sci pmid:21845800
Dailey MJ et al. Jejunal linoleic acid infusions require GLP-1 receptor signaling to inhibit food intake: implications for the effectiveness of Roux-en-Y gastric bypass. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21917638
Lee YJ and Jenkins TC Identification of enriched conjugated linoleic acid isomers in cultures of ruminal microorganisms after dosing with 1-(13)C-linoleic acid. 2011 J. Microbiol. pmid:21887646
Beker BY et al. Antioxidant protective effect of flavonoids on linoleic acid peroxidation induced by copper(II)/ascorbic acid system. 2011 Chem. Phys. Lipids pmid:21925488
Zhou XR et al. Caenorhabditis elegans Delta12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the Delta12 and Delta15 positions. 2011 J. Biol. Chem. pmid:22041902
Ogawa E et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-κB signaling pathway. 2011 J. Invest. Dermatol. pmid:21068754
Arciniega JC et al. Effects of free fatty acids on meibomian lipid films. 2011 Exp. Eye Res. pmid:21718696
Odabasoglu F et al. α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations. 2011 Br. J. Nutr. pmid:21073761
Akrout A et al. Antioxidant and antitumor activities of Artemisia campestris and Thymelaea hirsuta from southern Tunisia. 2011 Food Chem. Toxicol. pmid:21075159
Cheng TM et al. Haemoglobin-induced oxidative stress is associated with both endogenous peroxidase activity and H2O2 generation from polyunsaturated fatty acids. 2011 Free Radic. Res. pmid:21034361
Lin YH et al. Altered essential fatty acid metabolism and composition in rat liver, plasma, heart and brain after microalgal DHA addition to the diet. 2011 J. Nutr. Biochem. pmid:21111595
Lam WM et al. In Vitro characterization of low modulus linoleic acid coated strontium-substituted hydroxyapatite containing PMMA bone cement. 2011 J. Biomed. Mater. Res. Part B Appl. Biomater. pmid:21053263
Yang Y et al. Synthesis and antioxidant capacities of hydroxyl derivatives of cinnamoylphenethylamine in protecting DNA and scavenging radicals. 2011 Free Radic. Res. pmid:21128731
Hubert DJ et al. In vitro hepatoprotective and antioxidant activities of crude extract and isolated compounds from Ficus gnaphalocarpa. 2011 Inflammopharmacology pmid:21088994
Jin G et al. Crude lipoxygenase from pig muscle: partial characterization and interactions of temperature, NaCl and pH on its activity. 2011 Meat Sci. pmid:21093161
Du YZ et al. Linoleic acid-grafted chitosan oligosaccharide micelles for intracellular drug delivery and reverse drug resistance of tumor cells. 2011 Int. J. Biol. Macromol. pmid:21093477
Lautenslager GT et al. Effects of nonenzymatic glycation and fatty acids on functional properties of human albumin. 2011 Metab. Clin. Exp. pmid:21632076
Blaul B and Ruther J How parasitoid females produce sexy sons: a causal link between oviposition preference, dietary lipids and mate choice in Nasonia. 2011 Proc. Biol. Sci. pmid:21429922
Gibson RA et al. Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. 2011 Matern Child Nutr pmid:21366864
Lauritzen L and Carlson SE Maternal fatty acid status during pregnancy and lactation and relation to newborn and infant status. 2011 Matern Child Nutr pmid:21366866
Brenna JT Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life. 2011 Matern Child Nutr pmid:21366867
Briend A et al. Fatty acid status in early life in low-income countries--overview of the situation, policy and research priorities. 2011 Matern Child Nutr pmid:21366873
Blasbalg TL et al. Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. 2011 Am. J. Clin. Nutr. pmid:21367944
Aewsiri T et al. Surface activity and molecular characteristics of cuttlefish skin gelatin modified by oxidized linoleic acid. 2011 Int. J. Biol. Macromol. pmid:21334373
You Q et al. Purification, immobilization and characterization of linoleic acid isomerase on modified palygorskite. 2011 Bioprocess Biosyst Eng pmid:21340675
Rybicka M et al. Comparative effects of conjugated linoleic acid (CLA) and linoleic acid (LA) on the oxidoreduction status in THP-1 macrophages. 2011 J. Agric. Food Chem. pmid:21391598
Rakib MA et al. Preventive effect of t,t-conjugated linoleic acid on 12-O-tetradecanoylphorbol-13-acetate-induced inhibition of gap junctional intercellular communication in human mammary epithelial MCF-10A cells. 2011 J. Agric. Food Chem. pmid:21391601
Tuei VC et al. Effects of human serum albumin complexed with free fatty acids on cell viability and insulin secretion in the hamster pancreatic β-cell line HIT-T15. 2011 Life Sci. pmid:21396379
Mihaljević B et al. Linoleic acid peroxidation vs. isomerization: a biomimetic model of free radical reactivity in the presence of thiols. 2011 Org. Biomol. Chem. pmid:21442126
Blum JL et al. Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. 2011 Toxicol In Vitro pmid:21443943
Conforti F et al. Correlation between environmental factors, chemical composition, and antioxidative properties of caper species growing wild in Calabria (South Italy). 2011 Chem. Biodivers. pmid:21404435
Edris AE The chemical composition and the content of volatile oil: potential factors that can contribute to the oxidative stability of Nigella sativa L. crude oil. 2011 J Diet Suppl pmid:22432633
Serratosa MP et al. Changes in hydrophilic and lipophilic antioxidant activity in relation to their phenolic composition during the chamber drying of red grapes at a controlled temperature. 2011 J. Agric. Food Chem. pmid:21319807
Salem N and Kuratko CN Lack of evidence for increased α-linolenic acid metabolism in vegetarians. 2011 Am. J. Clin. Nutr. pmid:21430120
Parra-Cabrera S et al. Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. 2011 Matern Child Nutr pmid:21410881
Hasegawa T et al. Constituents of the green tea seeds of Camellia sinensis. 2011 Nat Prod Commun pmid:21485277
Atri MS et al. Structure and stability analysis of cytotoxic complex of camel α-lactalbumin and unsaturated fatty acids produced at high temperature. 2011 J. Biomol. Struct. Dyn. pmid:21469752
Carrillo C et al. Oleic acid versus linoleic and α-linolenic acid. different effects on Ca2+ signaling in rat thymocytes. 2011 Cell. Physiol. Biochem. pmid:21471726
Subbaiah PV et al. Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. 2011 Biochim. Biophys. Acta pmid:20920595
Alloatti A and Uttaro AD Highly specific methyl-end fatty-acid desaturases of trypanosomatids. 2011 Mol. Biochem. Parasitol. pmid:20974196
Figueras M et al. Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: improvement of the inflammatory status. 2011 Obesity (Silver Spring) pmid:20885391
Konkel A and Schunck WH Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. 2011 Biochim. Biophys. Acta pmid:20869469
Liou AP et al. The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. 2011 Gastroenterology pmid:20955703
Perona JS et al. Olive oil phenols modulate the triacylglycerol molecular species of human very low-density lipoprotein. A randomized, crossover, controlled trial. 2011 Metab. Clin. Exp. pmid:20934731
Mariutto M et al. The elicitation of a systemic resistance by Pseudomonas putida BTP1 in tomato involves the stimulation of two lipoxygenase isoforms. 2011 BMC Plant Biol. pmid:21294872
Pan Z et al. Effects of linoleate on cell viability and lipid metabolic homeostasis in goose primary hepatocytes. 2011 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:21295151
Tsubura A et al. Anticancer effects of garlic and garlic-derived compounds for breast cancer control. 2011 Anticancer Agents Med Chem pmid:21269259
Chohany LE et al. Cationic substrates of soybean lipoxygenase-1. 2011 Bioorg. Chem. pmid:21257189
White HM et al. Differential regulation of bovine pyruvate carboxylase promoters by fatty acids and peroxisome proliferator-activated receptor-α agonist. 2011 J. Dairy Sci. pmid:21700028
Siddique BM et al. Chemical composition and antioxidant properties of candlenut oil extracted by supercritical CO2. 2011 J. Food Sci. pmid:22417332
Chen HH and Chiu TH Phytochemicals characterization of solvent extracts from taro-scented japonica rice bran. 2011 J. Food Sci. pmid:22417350
Turk HF et al. Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. 2011 Int. J. Cancer pmid:20232381