Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Mucositis D052016 7 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Refeeding Syndrome D055677 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
WEENINK RO and SHORLAND FB THE ISOLATION OF TRANS-3-HEXADECENOIC ACID FROM THE LIPIDS OF RED-CLOVER (TRIFOLIUM PRATENSE) LEAVES. 1964 Biochim. Biophys. Acta pmid:14250500
Herzberg GR et al. Intestinal absorption of fish oil in rats previously adapted to diets containing fish oil or corn oil. 1992 Biochim. Biophys. Acta pmid:1531932
Puebla C et al. Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism. 2016 Biochim. Biophys. Acta pmid:26869446
Emken EA et al. Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans. 1993 Biochim. Biophys. Acta pmid:8399342
Girón MD et al. Changes in lipid composition and desaturase activities of duodenal mucosa induced by dietary fat. 1990 Biochim. Biophys. Acta pmid:2369586
Cheng Z et al. The effect of supplementation with n-6 polyunsaturated fatty acids on 1-, 2- and 3-series prostaglandin F production by ovine uterine epithelial cells. 2005 Biochim. Biophys. Acta pmid:16140575
Claeys M et al. Metabolic profile of linoleic acid in porcine leukocytes through the lipoxygenase pathway. 1985 Biochim. Biophys. Acta pmid:2996610
Lam YY et al. Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21570480
DeWille JW and Farmer SJ Linoleic acid controls neonatal tissue-specific stearoyl-CoA desaturase mRNA levels. 1993 Biochim. Biophys. Acta pmid:8105893
Lomnitski L et al. The interaction between beta-carotene and lipoxygenase in plant and animal systems. 1993 Biochim. Biophys. Acta pmid:8481396
Villasuso AL et al. Culture age and carbamoylcholine increase the incorporation of endogenously synthesized linoleic acid in lipids of Trypanosoma cruzi epimastigotes. 2005 Biochim. Biophys. Acta pmid:16024291
Mitranic MM et al. The effect of linoleic acid and benzyl alcohol on the activity of glycosyltransferases of rat liver Golgi membranes and some soluble glycosyltransferases. 1982 Biochim. Biophys. Acta pmid:6217837
Yang XB et al. Sulfation of a polysaccharide produced by a marine filamentous fungus Phoma herbarum YS4108 alters its antioxidant properties in vitro. 2005 Biochim. Biophys. Acta pmid:16054758
Dutta-Roy AK et al. Purification and characterization of fatty acid-binding proteins from brown adipose tissue of the rat. 1993 Biochim. Biophys. Acta pmid:8334153
Funk CD et al. Effects of selenium-deficient diets on the production of prostaglandins and other oxygenated metabolites of arachidonic acid and linoleic acid by rat and rabbit aortae. 1987 Biochim. Biophys. Acta pmid:3115301
Jakobsson A et al. Metabolism of fatty acids and their incorporation into phospholipids of the mitochondria and endoplasmic reticulum in isolated hepatocytes determined by isolation of fluorescence derivatives. 1990 Biochim. Biophys. Acta pmid:2223867
Walstra P et al. Demonstration of a 12-lipoxygenase activity in bovine polymorphonuclear leukocytes. 1987 Biochim. Biophys. Acta pmid:3115302
Colard O et al. Hydrolysis of endogenous phospholipids by rat platelet phospholipase A2: ether or acyl bond and polar head group selectivity. 1987 Biochim. Biophys. Acta pmid:3115303
Kitagawa S et al. Effects of four types of reagents on ADP-induced aggregation and Ca2+ mobilization of bovine blood platelets. 1984 Biochim. Biophys. Acta pmid:6324876
Simon I et al. Electron-spin resonance studies of lipid-modified microsomes from Friend erythroleukemia cells. 1984 Biochim. Biophys. Acta pmid:6326852
Gavigan SJ and Knight BL Catabolism of low-density lipoprotein by fibroblasts cultured in medium supplemented with saturated or unsaturated free fatty acids. 1981 Biochim. Biophys. Acta pmid:6271233
SHAW R THE OCCURRENCE OF GAMMA-LINOLENIC ACID IN FUNGI. 1965 Biochim. Biophys. Acta pmid:14320219
Bernbäck S et al. Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase. 1989 Biochim. Biophys. Acta pmid:2917153
Greenspan MD et al. Studies on the in vivo synthesis of triacylglycerol in mouse liver. 1982 Biochim. Biophys. Acta pmid:7055591
WILLS ED MECHANISMS OF LIPID PEROXIDE FORMATION IN TISSUES. ROLE OF METALS AND HAEMATIN PROTEINS IN THE CATALYSIS OF THE OXIDATION UNSATURATED FATTY ACIDS. 1965 Biochim. Biophys. Acta pmid:14325327
Okano G and Shimojo T Utilization of long-chain free fatty acids in white and red muscle of rats. 1982 Biochim. Biophys. Acta pmid:7066350
Cheah AM Effect of long chain unsaturated fatty acids on the calcium transport of sarcoplasmic reticulum. 1981 Biochim. Biophys. Acta pmid:6118177
Kanazawa K and Ashida H Catabolic fate of dietary trilinoleoylglycerol hydroperoxides in rat gastrointestines. 1998 Biochim. Biophys. Acta pmid:9748647
Kanazawa K and Ashida H Dietary hydroperoxides of linoleic acid decompose to aldehydes in stomach before being absorbed into the body. 1998 Biochim. Biophys. Acta pmid:9748650
BENNETT JR THE ESTERIFICATION OF CHOLESTEROL BY RAT-LIVER PREPARATIONS. 1963 Biochim. Biophys. Acta pmid:14067620
Jernerén F et al. Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus. 2010 Biochim. Biophys. Acta pmid:20045744
Quoc KP and Dubacq JP Effect of growth temperature on the biosynthesis of eukaryotic lipid molecular species by the cyanobacterium Spirulina platensis. 1997 Biochim. Biophys. Acta pmid:9219908
Venkatraman JT and Clandinin MT Ribonucleic acid efflux from isolated mouse liver nuclei is altered by diet and genotypically determined change in nuclear envelope composition. 1988 Biochim. Biophys. Acta pmid:2452656
Gardner HW Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. 1989 Biochim. Biophys. Acta pmid:2492826
Leekumjorn S et al. The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes. 2009 Biochim. Biophys. Acta pmid:19371719
Emken EA et al. Dietary linoleic acid influences desaturation and acylation of deuterium-labeled linoleic and linolenic acids in young adult males. 1994 Biochim. Biophys. Acta pmid:7914092
HEALD PJ et al. LIPID METABOLISM AND THE LAYING HEN. II. THE NATURE AND QUANTITIES OF THE FREE FATTY ACIDS OF THE PLASMA DURING THE ONSET OF LAYING. 1964 Biochim. Biophys. Acta pmid:14124752
Gurvitz A et al. Degradation of conjugated linoleic acid isomers in the yeast Saccharomyces cerevisiae. 2001 Biochim. Biophys. Acta pmid:11566445
Saddik M and Lopaschuk GD The fate of arachidonic acid and linoleic acid in isolated working rat hearts containing normal or elevated levels of coenzyme A. 1991 Biochim. Biophys. Acta pmid:1932104
Moghaddam M et al. Novel metabolic pathways for linoleic and arachidonic acid metabolism. 1996 Biochim. Biophys. Acta pmid:8765137
Hrboticky N et al. Linoleic acid esterified in low density lipoprotein serves as substrate for increased arachidonic acid synthesis in differentiating monocytic cells. 1996 Biochim. Biophys. Acta pmid:8765140
Yu Y et al. Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. 2002 Biochim. Biophys. Acta pmid:12020636
van Haaster CM et al. Formation of prostanoids and hydroxy fatty acids by stimulated peritoneal mast cells: role of the dietary fat type in rat. 1993 Biochim. Biophys. Acta pmid:8466942
Meuillet EJ et al. Incorporation of exogenous lipids modulates insulin signaling in the hepatoma cell line, HepG2. 1999 Biochim. Biophys. Acta pmid:10354513
Garg ML et al. Desaturation of linoleic acid in the small bowel is increased by short-term fasting and by dietary content of linoleic acid. 1992 Biochim. Biophys. Acta pmid:1606171
Beyers EC and Emken EA Metabolites of cis,trans, and trans,cis isomers of linoleic acid in mice and incorporation into tissue lipids. 1991 Biochim. Biophys. Acta pmid:2029547
Lester DS In vitro linoleic acid activation of protein kinase C. 1990 Biochim. Biophys. Acta pmid:2207179
Mahmmoud YA and Christensen SB Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. 2011 Biochim. Biophys. Acta pmid:21767529
Rich MR Conformational analysis of arachidonic and related fatty acids using molecular dynamics simulations. 1993 Biochim. Biophys. Acta pmid:8329458
Battu S et al. Linoleic acid peroxidation by Solanum tuberosum lipoxygenase was activated in the presence of human 5-lipoxygenase-activating protein. 1998 Biochim. Biophys. Acta pmid:9630716
Gibson RA et al. Incorporation of dietary oleate, linoleate, alpha-linolenate and eicosapentaenoate into the plasma lipid fractions of four strains of rat. 1992 Biochim. Biophys. Acta pmid:1351403
Hansen HS et al. Apparent in vivo retroconversion of dietary arachidonic to linoleic acid in essential fatty acid-deficient rats. 1986 Biochim. Biophys. Acta pmid:3092868
Chambaz J et al. Essential fatty acid uptake and esterification in primary culture of rat hepatocytes. 1986 Biochim. Biophys. Acta pmid:3092869
Konrad SD et al. Use of deuterium oxide to measure de novo fatty acid synthesis in normal subjects consuming different dietary fatty acid composition1. 1998 Biochim. Biophys. Acta pmid:9714781
Ryu SB and Wang X Increase in free linolenic and linoleic acids associated with phospholipase D-mediated hydrolysis of phospholipids in wounded castor bean leaves. 1998 Biochim. Biophys. Acta pmid:9714802
Hu ZY et al. cAMP inhibits linoleic acid-induced growth by antagonizing p27(kip1) depletion, but not interfering with the extracellular signal-regulated kinase or AP-1 activities. 1998 Biochim. Biophys. Acta pmid:9784625
Stein O et al. Modification of cellular fatty acid composition of Hep-G2 cells: effect of antioxidants on cholesterol esterification and secretion. 1989 Biochim. Biophys. Acta pmid:2730885
Mahfouz MM et al. Changes of linoleic acid metabolism and cellular phospholipid fatty acid composition in LLC-PK cells cultured at low magnesium concentrations. 1989 Biochim. Biophys. Acta pmid:2804072
Nordøy A et al. Effect of dietary (n--3) fatty acids on platelet function and lipid metabolism in rats. 1985 Biochim. Biophys. Acta pmid:2861854
Vrignaud P and Robert J Free fatty acid uptake is increased in doxorubicin-resistant rat glioblastoma cells. 1987 Biochim. Biophys. Acta pmid:2886153
Parsons HG et al. Modulation of human erythrocyte shape and fatty acids by diet. 1986 Biochim. Biophys. Acta pmid:3741859
Hirabara SM et al. Acute effect of fatty acids on metabolism and mitochondrial coupling in skeletal muscle. 2006 Biochim. Biophys. Acta pmid:16375848
Jensen E et al. Cell-density-dependent uptake of chylomicron remnants in rat hepatocyte monolayers. Effects of compactin and mevalonic acid. 1987 Biochim. Biophys. Acta pmid:3790613
Bedotti R et al. Stimulatory effect of serum albumin on the proliferation of serum-free SV40-transformed Balb/c 3T3 cells. 1990 Biochim. Biophys. Acta pmid:2163687
Göbel C et al. Oxylipin profiling in pathogen-infected potato leaves. 2002 Biochim. Biophys. Acta pmid:12213493
Loidl-Stahlhofen A et al. Generation of alpha-hydroxyaldehydic compounds in the course of lipid peroxidation. 1994 Biochim. Biophys. Acta pmid:8025124
Jyothirmayi N and Ramadoss CS Soybean lipoxygenase catalysed oxygenation of unsaturated fatty acid encapsulated in cyclodextrin. 1991 Biochim. Biophys. Acta pmid:1903659
Macrì F et al. Lipoxygenase activity associated to isolated soybean plasma membranes. 1994 Biochim. Biophys. Acta pmid:7947991
Park Y and Pariza MW Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid. 2001 Biochim. Biophys. Acta pmid:11750884
Christon R et al. Modification of fluidity and lipid-protein relationships in pig intestinal brush-border membrane by dietary essential fatty acid deficiency. 1989 Biochim. Biophys. Acta pmid:2538158
Chen Q et al. Hydrolysis of triacylglycerol arachidonic and linoleic acid ester bonds by human pancreatic lipase and carboxyl ester lipase. 1989 Biochim. Biophys. Acta pmid:2503032
Yavin E et al. Metabolic conversion of intra-amniotically-injected deuterium-labeled essential fatty acids by fetal rats following maternal n-3 fatty acid deficiency. 2014 Biochim. Biophys. Acta pmid:24960100
KHAN NA Infrared studies on initiation of the autoxidation of some fatty acid esters with and without light-sensitized chlorophyll, ultraviolet light and lipoxidase. 1955 Biochim. Biophys. Acta pmid:14363243
Raederstorff D and Moser U Influence of an increased intake of linoleic acid on the incorporation of dietary (n-3) fatty acids in phospholipids and on prostanoid synthesis in rat tissues. 1992 Biochim. Biophys. Acta pmid:1450214
MCMAHON V and STUMPF PK SYNTHESIS OF LINOLEIC ACID BY PARTICULATE SYSTEM FROM SAFFLOWER SEEDS. 1964 Biochim. Biophys. Acta pmid:14196780
Bester R and Lochner A Sarcolemmal phospholipid fatty acid composition and permeability. 1988 Biochim. Biophys. Acta pmid:3382645
Shires SE et al. Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. 1989 Biochim. Biophys. Acta pmid:2493807
Leikin AI and Brenner RR Regulation of linoleic acid delta 6-desaturation by a cytosolic lipoprotein-like fraction in isolated rat liver microsomes. 1986 Biochim. Biophys. Acta pmid:2869785
Ulmann L et al. Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. 1991 Biochim. Biophys. Acta pmid:1657182
Nijssen JG and van den Bosch H Coenzyme A-mediated transacylation of sn-2 fatty acids from phosphatidylcholine in rat lung microsomes. 1986 Biochim. Biophys. Acta pmid:3081034
Mizushina Y et al. Mode analysis of binding of fatty acids to mammalian DNA polymerases. 2000 Biochim. Biophys. Acta pmid:10903472
Schmitt A et al. Phospholipid hydrolysis of mildly oxidized LDL reduces their cytotoxicity to cultured endothelial cells. Potential protective role against atherogenesis. 1995 Biochim. Biophys. Acta pmid:7786889
Doderer A et al. Purification and characterization of two lipoxygenase isoenzymes from germinating barley. 1992 Biochim. Biophys. Acta pmid:1554746
Dufour C and Loonis M Flavonoids and their oxidation products protect efficiently albumin-bound linoleic acid in a model of plasma oxidation. 2007 Biochim. Biophys. Acta pmid:17428609
Batna A et al. The occurrence of furan fatty acids in Isochrysis sp. and Phaeodactylum tricornutum. 1993 Biochim. Biophys. Acta pmid:8443233
Gaquerel E et al. Evidence for oxylipin synthesis and induction of a new polyunsaturated fatty acid hydroxylase activity in Chondrus crispus in response to methyljasmonate. 2007 Biochim. Biophys. Acta pmid:17428728
Subbaiah PV et al. Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. 2011 Biochim. Biophys. Acta pmid:20920595
Clementz T et al. Membrane potential, lipid regulation and adenylate energy charge in acyl chain modified Acholeplasma laidlawii. 1987 Biochim. Biophys. Acta pmid:3567184
Sasaki T et al. Effects of dietary docosahexaenoic acid on surface molecules involved in T cell proliferation. 1999 Biochim. Biophys. Acta pmid:9989281
Konkel A and Schunck WH Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. 2011 Biochim. Biophys. Acta pmid:20869469
Kwon B et al. Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. 2014 Biochim. Biophys. Acta pmid:24732014
Jaudszus A et al. Cis-9,trans-11-CLA exerts anti-inflammatory effects in human bronchial epithelial cells and eosinophils: comparison to trans-10,cis-12-CLA and to linoleic acid. 2005 Biochim. Biophys. Acta pmid:16303327
Banerjee N and Rosenthal MD High-affinity incorporation of 20-carbon polyunsaturated fatty acids by human skin fibroblasts. 1985 Biochim. Biophys. Acta pmid:2990563
Breiden B and Sandhoff K The role of sphingolipid metabolism in cutaneous permeability barrier formation. 2014 Biochim. Biophys. Acta pmid:23954553
Christophersen BO et al. Studies on the regulation of arachidonic acid synthesis in isolated rat liver cells. 1982 Biochim. Biophys. Acta pmid:6812639
Bruneau C et al. Influence of lipid environment on insulin binding in cultured hepatoma cells. 1987 Biochim. Biophys. Acta pmid:3552053
Bruneau C et al. Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells. 1987 Biochim. Biophys. Acta pmid:3552054
Biagi PL et al. Gamma-linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome delta 6-desaturase activity. 1991 Biochim. Biophys. Acta pmid:1674661
Tabachnick M and Korcek L Effect of long-chain fatty acids on the binding of thyroxine and triiodothyronine to human thyroxine-binding globulin. 1986 Biochim. Biophys. Acta pmid:2869786
Nugteren DH and Kivits GA Conversion of linoleic acid and arachidonic acid by skin epidermal lipoxygenases. 1987 Biochim. Biophys. Acta pmid:3113487