Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Mucositis D052016 7 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Refeeding Syndrome D055677 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Kageyama K et al. Synergistic inhibition of DNA synthesis in Ehrlich ascites tumour cells by a combination of unsaturated fatty acids and hyperthermia. 1989 J Appl Toxicol pmid:2926093
Booker ML et al. Effect of dietary cholesterol on phosphatidylcholines and phosphatidylethanolamines in bile and gallbladder mucosa in the prairie dog. 1989 Gastroenterology pmid:2507386
Garcia Zevallos M and Farkas T Manipulation of plasma membrane physical state affects desaturase activity in rat lymphocytes. 1989 Arch. Biochem. Biophys. pmid:2786374
Hubbard NE and Erickson KL Effect of dietary linoleic acid level on lodgement, proliferation and survival of mammary tumor metastases. 1989 Cancer Lett. pmid:2920371
Tchervenkov JI et al. The effect of donor-specific blood transfusion, cyclosporine, and dietary prostaglandin precursors on rat cardiac allograft survival. II. Effectiveness of a 24-hour induction period with DST and CsA in inducing long-term graft survival. 1989 Transplantation pmid:2643225
Balakrishnan A et al. Differential proliferative response to linoleate in cultures of epithelial cells from normal human breast and fibroadenomas. 1989 Cancer Res. pmid:2643465
Pitkänen OM et al. Determination of ethane and pentane in free oxygen radical-induced lipid peroxidation. 1989 Lipids pmid:2569148
Mertes N et al. [Experiences with a new fat emulsion in surgical intensive care medicine]. 1989 Infusionstherapie pmid:2569450
Bourre JM et al. The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats. 1989 J. Nutr. pmid:2576038
Fujiyama-Fujiwara Y et al. Metabolism of gamma-linolenic acid in primary cultures of rat hepatocytes and in Hep G2 cells. 1989 J. Nutr. Sci. Vitaminol. pmid:2576804
Kihata M [Effects of exogenous insulin on oxidation of glucose and fatty acid in septic rats]. 1989 Nihon Geka Gakkai Zasshi pmid:2668730
Perez RV et al. Augmentation of donor-specific transfusion and cyclosporine effects with dietary linoleic acid. 1989 Transplantation pmid:2660353
Fairbank J et al. Octadeca-9,11-dienoic acid in cervical intraepithelial neoplasia: a colposcopic study. 1989 Clin. Chim. Acta pmid:2612010
Park JH et al. Effects of dietary linoleic acid on mucosal adaptation after small bowel resection. 1989 Digestion pmid:2612750
Hiramatsu N et al. Effects of dietary pantethine levels on drug-metabolizing system in the liver of rats orally administered varying amounts of autoxidized linoleate. 1989 J. Nutr. Sci. Vitaminol. pmid:2585150
Chanussot B et al. Liver microsomal delta 6 and delta 5 linoleic acid desaturation in female BB rats. 1989 Diabetologia pmid:2591647
Clouet P et al. Pathway of alpha-linolenic acid through the mitochondrial outer membrane in the rat liver and influence on the rate of oxidation. Comparison with linoleic and oleic acids. 1989 Biochem. J. pmid:2597132
Bayorh MA et al. Acute and chronic effects of eicosapentaenoic acid (EPA) on the cardiovascular system. 1989 Res. Commun. Chem. Pathol. Pharmacol. pmid:2558405
Meikle AW et al. Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells. 1989 Am. J. Physiol. pmid:2558577
Hennig B and Watkins BA Linoleic acid and linolenic acid: effect on permeability properties of cultured endothelial cell monolayers. 1989 Am. J. Clin. Nutr. pmid:2563626
Grossi IM et al. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. 1989 Cancer Res. pmid:2492204
Gardner HW Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. 1989 Biochim. Biophys. Acta pmid:2492826
Anderson GJ and Connor WE On the demonstration of omega-3 essential-fatty-acid deficiency in humans. 1989 Am. J. Clin. Nutr. pmid:2494878
Byczkowski JZ and Kulkarni AP Lipoxygenase-catalyzed epoxidation of benzo(a)pyrene-7,8-dihydrodiol. 1989 Biochem. Biophys. Res. Commun. pmid:2494999
Kaduce TL et al. Formation of 9-hydroxyoctadecadienoic acid from linoleic acid in endothelial cells. 1989 J. Biol. Chem. pmid:2496121
Hamazaki S et al. Oxygen reduction and lipid peroxidation by iron chelates with special reference to ferric nitrilotriacetate. 1989 Arch. Biochem. Biophys. pmid:2500058
Imaizumi K et al. Effect of phosphatidylethanolamine and its constituent base on the metabolism of linoleic acid in rat liver. 1989 Biochim. Biophys. Acta pmid:2508745
Hansen O Characterization of fatty acid interaction with ouabain and vanadate binding to (Na+ + K+)-activated ATPase. 1989 Biochim. Biophys. Acta pmid:2554979
D'Aquino M et al. Vitamin A and glutathione-mediated free radical damage: competing reactions with polyunsaturated fatty acids and vitamin C. 1989 Biochem. Biophys. Res. Commun. pmid:2568114
Braughler JM and Pregenzer JF The 21-aminosteroid inhibitors of lipid peroxidation: reactions with lipid peroxyl and phenoxy radicals. 1989 Free Radic. Biol. Med. pmid:2806938
Hrelia S et al. Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes. 1989 Biochem. Biophys. Res. Commun. pmid:2570573
Toda S et al. Peroxidation of linoleic acid induced by interaction with haemoglobin and hydrogen peroxide. 1989 Free Radic. Res. Commun. pmid:2806947
Stein O et al. Modification of cellular fatty acid composition of Hep-G2 cells: effect of antioxidants on cholesterol esterification and secretion. 1989 Biochim. Biophys. Acta pmid:2730885
Reinaud O et al. Oxidative metabolism of linoleic acid by human leukocytes. 1989 Biochem. Biophys. Res. Commun. pmid:2735926
Cunnane SC et al. Essential fatty acid and lipid profiles in plasma and erythrocytes in patients with multiple sclerosis. 1989 Am. J. Clin. Nutr. pmid:2801584
Rose DP and Connolly JM Stimulation of growth of human breast cancer cell lines in culture by linoleic acid. 1989 Biochem. Biophys. Res. Commun. pmid:2803300
Mahfouz MM et al. Changes of linoleic acid metabolism and cellular phospholipid fatty acid composition in LLC-PK cells cultured at low magnesium concentrations. 1989 Biochim. Biophys. Acta pmid:2804072
Furr HC et al. The effect of dietary fatty acid composition on liver retinyl ester (vitamin A ester) composition in the rat. 1989 J. Nutr. pmid:2703916
Christon R et al. Modification of fluidity and lipid-protein relationships in pig intestinal brush-border membrane by dietary essential fatty acid deficiency. 1989 Biochim. Biophys. Acta pmid:2538158
Chen Q et al. Hydrolysis of triacylglycerol arachidonic and linoleic acid ester bonds by human pancreatic lipase and carboxyl ester lipase. 1989 Biochim. Biophys. Acta pmid:2503032
Chapkin RS et al. Linoleic acid metabolism in metastatic and nonmetastatic murine mammary tumor cells. 1989 Cancer Res. pmid:2503244
Shires SE et al. Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. 1989 Biochim. Biophys. Acta pmid:2493807
Hamazaki T et al. Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake. 1989 Prostaglandins pmid:2503856
Mohsenin V and Gee JL Oxidation of alpha 1-protease inhibitor: role of lipid peroxidation products. 1989 J. Appl. Physiol. pmid:2787317
Schneider YJ Optimisation of hybridoma cell growth and monoclonal antibody secretion in a chemically defined, serum- and protein-free culture medium. 1989 J. Immunol. Methods pmid:2644356
Watkins BA Influences of biotin deficiency and dietary trans-fatty acids on tissue lipids in chickens. 1989 Br. J. Nutr. pmid:2923859
Bourre JM et al. Composition of nerve biomembranes and nutritional fatty acids. 1989 Jul-Aug Nutrition pmid:2577681
Kamano K et al. Effects of a high-linoleate and a high-alpha-linolenate diet on spontaneous mammary tumourigenesis in mice. 1989 Nov-Dec Anticancer Res. pmid:2627137
Buko VU et al. [Changes in the fatty acid composition of erythrocyte membranes in patients with chronic alcoholism under the effect of a diet enriched with linoleic acid]. 1989 Nov-Dec Vopr Pitan pmid:2629246
Brodersen R et al. Multiple fatty acid binding to albumin in human blood plasma. 1990 Eur. J. Biochem. pmid:2338079
Sams GH et al. Isolation and characterization of a fatty acid binding protein in adipose tissue of Gallus domesticus. 1990 Comp. Biochem. Physiol., B pmid:1697230
Girón MD et al. Changes in lipid composition and desaturase activities of duodenal mucosa induced by dietary fat. 1990 Biochim. Biophys. Acta pmid:2369586
Barros H et al. Arachidonic acid absorption in human jejunum in organ culture: effects of ethanol. 1990 Eur. J. Clin. Invest. pmid:2124981
Teter BB et al. Milk fat depression in C57Bl/6J mice consuming partially hydrogenated fat. 1990 J. Nutr. pmid:2380791
Parinandi NL et al. Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. 1990 Biochim. Biophys. Acta pmid:2123402
Jin SJ and Tserng KY Metabolic origins of urinary unsaturated dicarboxylic acids. 1990 Biochemistry pmid:2271537
Hamberg M and Hamberg G Hydroperoxide-dependent epoxidation of unsaturated fatty acids in the broad bean (Vicia faba L.). 1990 Arch. Biochem. Biophys. pmid:2275553
Ohtani H et al. Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism. 1990 J. Lipid Res. pmid:2280182
Lefkowith J et al. Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes. 1990 J. Exp. Med. pmid:2307932
Buckman DK et al. Modulation of mouse mammary tumor growth and linoleate enhanced metastasis by oleate. 1990 J. Nutr. pmid:2313378
MacIver DH et al. The effect of short chain fatty acid supplementation on membrane electrolyte transport and blood pressure. 1990 J Hum Hypertens pmid:2283638
Jakobsson A et al. Metabolism of fatty acids and their incorporation into phospholipids of the mitochondria and endoplasmic reticulum in isolated hepatocytes determined by isolation of fluorescence derivatives. 1990 Biochim. Biophys. Acta pmid:2223867
Buset M et al. Injury induced by fatty acids or bile acid in isolated human colonocytes prevented by calcium. 1990 Cancer Lett. pmid:2322935
Katzenellenbogen BS and Norman MJ Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen. 1990 Endocrinology pmid:2404751
Jensen MD et al. Measurement of non-steady-state free fatty acid turnover. 1990 Am. J. Physiol. pmid:2405695
Miller CC and Ziboh VA Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode). 1990 J. Invest. Dermatol. pmid:2106562
Okuyama H [Does food affect brain functions?]. 1990 Tanpakushitsu Kakusan Koso pmid:1970438
elAttar TM et al. Comparison of the inhibitory effect of polyunsaturated fatty acids on prostaglandin synthesis. II. Fibroblasts. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:1971442
Kestin M et al. n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants. 1990 Am. J. Clin. Nutr. pmid:1971991
Watanabe S et al. Effect of dietary alpha-linolenate/linoleate balance on crescent type-anti-glomerular basement membrane nephritis in rats. 1990 Lipids pmid:1972260
Singer P et al. Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension. 1990 J Hum Hypertens pmid:1972963
Lipids and multiple sclerosis. 1990 Lancet pmid:1973215
Oxholm A et al. Abnormal essential fatty acid metabolism in Darier's disease. 1990 Arch Dermatol pmid:1977367
Lester DS In vitro linoleic acid activation of protein kinase C. 1990 Biochim. Biophys. Acta pmid:2207179
Høy CE and Hølmer G Influence of dietary linoleic acid and trans fatty acids on the fatty acid profile of cardiolipins in rats. 1990 Lipids pmid:2215088
Kitagawa S et al. Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. 1990 Biochim. Biophys. Acta pmid:2166588
Anel A et al. Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. 1990 Biochim. Biophys. Acta pmid:2114179
Moch D et al. The linoleic acid metabolite 9DS-hydroxy-10,12(E,Z)-octadecadienoic acid is a strong proinflammatory mediator in an experimental wound healing model of the rat. 1990 Biomed. Biochim. Acta pmid:2169722
Léger CL et al. Evidence for a structurally specific role of essential polyunsaturated fatty acids depending on their peculiar double-bond distribution in biomembranes. 1990 Biochemistry pmid:2169876
Fletcher MP and Ziboh VA Effects of dietary supplementation with eicosapentaenoic acid or gamma-linolenic acid on neutrophil phospholipid fatty acid composition and activation responses. 1990 Inflammation pmid:2174410
Kulkarni AP et al. Hydrogen peroxide: a potent activator of dioxygenase activity of soybean lipoxygenase. 1990 Biochem. Biophys. Res. Commun. pmid:2105721
Umeda F et al. Modification of prostacyclin-stimulatory activity in sera by glucose, insulin, low density lipoprotein, linoleic acid and linoleic acid hydroperoxide. 1990 Diabetes Res. Clin. Pract. pmid:2106424
Lasekan JB et al. Dietary olive and safflower oils in promotion of DMBA-induced mammary tumorigenesis in rats. 1990 Nutr Cancer pmid:2106675
Tonogai Y and Tai HH Quantitation of 13-hydroxyoctadecadienoic acid (13-HODE) by radioimmunoassay. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2111553
Moore SA et al. Role of the blood-brain barrier in the formation of long-chain omega-3 and omega-6 fatty acids from essential fatty acid precursors. 1990 J. Neurochem. pmid:2115069
Newman MJ Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2371287
Chatterjee S and Ghosh N Phosphatidylcholine stimulates the activity of UDP-Gal beta 1-4 galactosyltransferase in normal human kidney proximal tumour cells. 1990 Indian J. Biochem. Biophys. pmid:2129343
Koba K and Sugano M Dietary protein influences polyunsaturated fatty acid patterns of rat tissue lipids. 1990 J. Nutr. Sci. Vitaminol. pmid:2130152
Piché LA and Mahadevappa VG Modification of rat platelet fatty acid composition by dietary lipids of animal and vegetable origin. 1990 J. Nutr. pmid:2111377
Yashiro K et al. [Changes in the free fatty acid composition of rat salivary glands induced by chronic administration of isoproterenol]. 1990 Gifu Shika Gakkai Zasshi pmid:2133668
Byczkowski JZ and Kulkarni AP Lipid peroxidation and benzo(a)pyrene derivative co-oxygenation by environmental pollutants. 1990 Bull Environ Contam Toxicol pmid:2176112
Mullarkey CJ et al. Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. 1990 Biochem. Biophys. Res. Commun. pmid:2176495
Stocker R et al. Antioxidant activities of bile pigments: biliverdin and bilirubin. 1990 Meth. Enzymol. pmid:2233302
Glasgow WC and Eling TE Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts. 1990 Mol. Pharmacol. pmid:2233691
Hernández-Caselles T et al. Stability of liposomes on long term storage. 1990 J. Pharm. Pharmacol. pmid:1979618
Abraham RD et al. Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. 1990 Atherosclerosis pmid:2112389
Field CJ et al. Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals. 1990 J. Biol. Chem. pmid:2113530
Kim D and Duff RA Regulation of K+ channels in cardiac myocytes by free fatty acids. 1990 Circ. Res. pmid:2119911
Hori T et al. Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid. 1990 Biochem. Biophys. Res. Commun. pmid:2114113
Hjelte L et al. Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats. 1990 Am. J. Physiol. pmid:2115302