Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Micronuclei, Chromosome-Defective D048629 33 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Mucositis D052016 7 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Refeeding Syndrome D055677 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Haas TA et al. Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity. 1990 Biochim. Biophys. Acta pmid:2155665
Pal S and Davis PJ N-3 polyunsaturated fatty acids enhance cholesterol efflux from human fibroblasts in culture. 1990 Biochem. Biophys. Res. Commun. pmid:2260969
Butovich IA et al. [Activation of 5-lipoxygenase by lipophilic n-alkyl-containing acids--an allosteric process]. 1990 Bioorg. Khim. pmid:2344387
Singer P et al. Extreme decrease of linoleic acid in renal medulla from rats after a diet supplemented with cod liver oil. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2353033
Katan MB and van Dusseldoys M [Premenstrual syndromes]. 1990 Ned Tijdschr Geneeskd pmid:2355986
Shimizu T et al. Prostaglandin and fatty acid metabolism in patients with extrahepatic biliary atresia. 1990 J. Pediatr. Gastroenterol. Nutr. pmid:2324889
Hennig B et al. Effect of vitamin E on linoleic acid-mediated induction of peroxisomal enzymes in cultured porcine endothelial cells. 1990 J. Nutr. pmid:2329387
Roe CR et al. 2,4-Dienoyl-coenzyme A reductase deficiency: a possible new disorder of fatty acid oxidation. 1990 J. Clin. Invest. pmid:2332510
Miyashita K et al. Preferential hydrolysis of monohydroperoxides of linoleoyl and linolenoyl triacylglycerol by pancreatic lipase. 1990 Biochim. Biophys. Acta pmid:2386795
Schlame M and Rüstow B Lysocardiolipin formation and reacylation in isolated rat liver mitochondria. 1990 Biochem. J. pmid:2268287
Jin SJ and Tserng KY Metabolic origins of urinary unsaturated dicarboxylic acids. 1990 Biochemistry pmid:2271537
Hamberg M and Hamberg G Hydroperoxide-dependent epoxidation of unsaturated fatty acids in the broad bean (Vicia faba L.). 1990 Arch. Biochem. Biophys. pmid:2275553
Ohtani H et al. Effects of dietary cholesterol and fatty acids on plasma cholesterol level and hepatic lipoprotein metabolism. 1990 J. Lipid Res. pmid:2280182
Lefkowith J et al. Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes. 1990 J. Exp. Med. pmid:2307932
Buckman DK et al. Modulation of mouse mammary tumor growth and linoleate enhanced metastasis by oleate. 1990 J. Nutr. pmid:2313378
MacIver DH et al. The effect of short chain fatty acid supplementation on membrane electrolyte transport and blood pressure. 1990 J Hum Hypertens pmid:2283638
Jakobsson A et al. Metabolism of fatty acids and their incorporation into phospholipids of the mitochondria and endoplasmic reticulum in isolated hepatocytes determined by isolation of fluorescence derivatives. 1990 Biochim. Biophys. Acta pmid:2223867
Buset M et al. Injury induced by fatty acids or bile acid in isolated human colonocytes prevented by calcium. 1990 Cancer Lett. pmid:2322935
Katzenellenbogen BS and Norman MJ Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen. 1990 Endocrinology pmid:2404751
Jensen MD et al. Measurement of non-steady-state free fatty acid turnover. 1990 Am. J. Physiol. pmid:2405695
Medini L et al. Diets rich in n-9, n-6 and n-3 fatty acids differentially affect the generation of inositol phosphates and of thromboxane by stimulated platelets, in the rabbit. 1990 Biochem. Pharmacol. pmid:2105092
Kinsella JE and Lokesh B Dietary lipids, eicosanoids, and the immune system. 1990 Crit. Care Med. pmid:2105185
Lernhardt W Fatty acid requirement of B lymphocytes activated in vitro. 1990 Biochem. Biophys. Res. Commun. pmid:2302243
Galaris D et al. Ferrylmyoglobin-catalyzed linoleic acid peroxidation. 1990 Arch. Biochem. Biophys. pmid:2383021
Conquer J and Mahadevappa VG Inhibition of protein kinase C by H-7 potentiates the release of oleic, linoleic and arachidonic acids in A23187-stimulated human neutrophils. 1990 Biochem. Biophys. Res. Commun. pmid:2106881
Okuyama H [Does food affect brain functions?]. 1990 Tanpakushitsu Kakusan Koso pmid:1970438
elAttar TM et al. Comparison of the inhibitory effect of polyunsaturated fatty acids on prostaglandin synthesis. II. Fibroblasts. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:1971442
Thomas CR and Lowy C The use of two in-situ simultaneously-perfused placentas to investigate the effect of carrier proteins on linoleic and palmitic acid transfer in the guinea pig. 1990 J. Dev. Physiol. pmid:2100741
Singer P et al. A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. 1990 Atherosclerosis pmid:2146966
Anel A et al. Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. 1990 Biochim. Biophys. Acta pmid:2114179
van Doormaal JJ Linoleic acid metabolism in diabetes mellitus. 1990 Neth J Med pmid:2074912
Ando H et al. Protein kinase C and linoleic acid-induced inhibition of melanogenesis. 1990 Pigment Cell Res. pmid:2077533
Moch D et al. The linoleic acid metabolite 9DS-hydroxy-10,12(E,Z)-octadecadienoic acid is a strong proinflammatory mediator in an experimental wound healing model of the rat. 1990 Biomed. Biochim. Acta pmid:2169722
Léger CL et al. Evidence for a structurally specific role of essential polyunsaturated fatty acids depending on their peculiar double-bond distribution in biomembranes. 1990 Biochemistry pmid:2169876
Fletcher MP and Ziboh VA Effects of dietary supplementation with eicosapentaenoic acid or gamma-linolenic acid on neutrophil phospholipid fatty acid composition and activation responses. 1990 Inflammation pmid:2174410
Kulkarni AP et al. Hydrogen peroxide: a potent activator of dioxygenase activity of soybean lipoxygenase. 1990 Biochem. Biophys. Res. Commun. pmid:2105721
Umeda F et al. Modification of prostacyclin-stimulatory activity in sera by glucose, insulin, low density lipoprotein, linoleic acid and linoleic acid hydroperoxide. 1990 Diabetes Res. Clin. Pract. pmid:2106424
Lasekan JB et al. Dietary olive and safflower oils in promotion of DMBA-induced mammary tumorigenesis in rats. 1990 Nutr Cancer pmid:2106675
Tonogai Y and Tai HH Quantitation of 13-hydroxyoctadecadienoic acid (13-HODE) by radioimmunoassay. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2111553
Moore SA et al. Role of the blood-brain barrier in the formation of long-chain omega-3 and omega-6 fatty acids from essential fatty acid precursors. 1990 J. Neurochem. pmid:2115069
Chatterjee S and Ghosh N Phosphatidylcholine stimulates the activity of UDP-Gal beta 1-4 galactosyltransferase in normal human kidney proximal tumour cells. 1990 Indian J. Biochem. Biophys. pmid:2129343
Koba K and Sugano M Dietary protein influences polyunsaturated fatty acid patterns of rat tissue lipids. 1990 J. Nutr. Sci. Vitaminol. pmid:2130152
Piché LA and Mahadevappa VG Modification of rat platelet fatty acid composition by dietary lipids of animal and vegetable origin. 1990 J. Nutr. pmid:2111377
Marra CA and de Alaniz MJ Mineralocorticoids modify rat liver delta 6 desaturase activity and other parameters of lipid metabolism. 1990 Biochem. Int. pmid:1981670
Byczkowski JZ and Kulkarni AP Lipid peroxidation and benzo(a)pyrene derivative co-oxygenation by environmental pollutants. 1990 Bull Environ Contam Toxicol pmid:2176112
Masini E et al. Histamine release from rat mast cells induced by metabolic activation of polyunsaturated fatty acids into free radicals. 1990 Biochem. Pharmacol. pmid:1690007
Mullarkey CJ et al. Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. 1990 Biochem. Biophys. Res. Commun. pmid:2176495
Stocker R et al. Antioxidant activities of bile pigments: biliverdin and bilirubin. 1990 Meth. Enzymol. pmid:2233302
Glasgow WC and Eling TE Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts. 1990 Mol. Pharmacol. pmid:2233691
Hernández-Caselles T et al. Stability of liposomes on long term storage. 1990 J. Pharm. Pharmacol. pmid:1979618
Abraham RD et al. Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. 1990 Atherosclerosis pmid:2112389
Vaughan PF and Ball SG The effect of unsaturated fatty acids on sodium nitroprusside stimulation of guanylate cyclase in the human astrocytoma clone, D384, and the human neuroblastoma clone, NB1-G. 1990 Biochem. Pharmacol. pmid:1968340
Hori T et al. Growth inhibition of human fibroblasts by epidermal growth factor in the presence of arachidonic acid. 1990 Biochem. Biophys. Res. Commun. pmid:2114113
Zakhariv OIa et al. [Metabolism of linoleic acid given with the feed in the calf liver]. 1990 Jan-Feb Ukr. Biokhim. Zh. pmid:2336726
Laugier C et al. Differential regulation of calmodulin-dependent and -independent cyclic AMP phosphodiesterases from oviduct by fatty acids. 1991 Biochem. Biophys. Res. Commun. pmid:1645959
Boor PJ et al. Synergistic vascular toxicity and fatty acid anilides in the toxic oil syndrome. 1991 J. Am. Coll. Cardiol. pmid:1960335
Kühn H et al. Formation of ketodienoic fatty acids by the pure pea lipoxygenase-1. 1991 Eicosanoids pmid:1905562
Beyers EC and Emken EA Metabolites of cis,trans, and trans,cis isomers of linoleic acid in mice and incorporation into tissue lipids. 1991 Biochim. Biophys. Acta pmid:2029547
Gerwick WH et al. Oxylipin metabolism in the red alga Gracilariopsis lemaneiformis: mechanism of formation of vicinal dihydroxy fatty acids. 1991 Arch. Biochem. Biophys. pmid:1929410
Ip C et al. Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. 1991 Cancer Res. pmid:1933874
Borgeson CE et al. Insect tissues, not microorganisms, produce linoleic acid in the house cricket and the American cockroach. 1991 Experientia pmid:2009929
Hendrich S et al. Phenobarbital increases rat hepatic prostaglandin F2 alpha, glutathione S-transferase activity and oxidative stress. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:2011611
Fusco AC et al. Schistosoma mansoni: the role of calcium in the stimulation of cercarial proteinase release. 1991 J. Parasitol. pmid:1717671
Zirvi KA Development of serum-free media for the growth of human gastrointestinal adenocarcinoma xenografts as primary tissue cultures. 1991 J. Cancer Res. Clin. Oncol. pmid:1720783
Fukuzawa K et al. Peroxide-dependent and -independent lipid peroxidations catalyzed by chelated iron. 1991 Arch. Biochem. Biophys. pmid:1656881
Iversen L et al. Linoleic acid and dihomogammalinolenic acid inhibit leukotriene B4 formation and stimulate the formation of their 15-lipoxygenase products by human neutrophils in vitro. Evidence of formation of antiinflammatory compounds. 1991 Agents Actions pmid:1659156
Gyllenhammar H et al. Effects of an essential fatty acid-supplemented diet on leukotriene B4-induced rat neutrophil functions. 1991 Scand. J. Clin. Lab. Invest. pmid:1662827
Butovich IA et al. The unusual action of (R,S)-2-hydroxy-2-trifluoromethyl-trans-n-octadec-4-enoic acid on 5-lipoxygenase from potato tubers. 1991 Eur. J. Biochem. pmid:2065670
Rose DP and Connolly JM Effects of fatty acids and eicosanoid synthesis inhibitors on the growth of two human prostate cancer cell lines. 1991 Prostate pmid:2020620
Engels F et al. Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. 1991 Prostaglandins pmid:1662406
Bull AW et al. Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. 1991 Prostaglandins pmid:2020745
Izumi T et al. Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes. 1991 Eur. J. Biochem. pmid:1662607
Nagao M et al. Effect of extracellular fatty acids on lipid metabolism in cultured rabbit articular chondrocytes. 1991 J. Orthop. Res. pmid:1901357
Sakai T et al. Chorea-acanthocytosis: abnormal composition of covalently bound fatty acids of erythrocyte membrane proteins. 1991 Ann. Neurol. pmid:1832532
Le Petit-Thevenin J et al. Changes in pattern of phospholipid acylation during in vivo aging of rat red blood cells. 1991 Am. J. Physiol. pmid:1887869
Liu B et al. Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C. 1991 Cell Regul. pmid:1801923
Lee JH et al. Dietary cholesterol influences on various lipid indices and eicosanoid production in rats fed dietary fat desirable for the protection of ischemic heart disease. 1991 J. Nutr. Sci. Vitaminol. pmid:1765843
Rainey PM et al. Biochemical and molecular characterization of Leishmania pifanoi amastigotes in continuous axenic culture. 1991 Mol. Biochem. Parasitol. pmid:1775152
Katan MB et al. Biological markers of dietary intake, with emphasis on fatty acids. 1991 Ann. Nutr. Metab. pmid:1776820
Christon R et al. Effects of a low dietary linoleic acid level on intestinal morphology and enterocyte brush border membrane lipid composition. 1991 Reprod. Nutr. Dev. pmid:1777061
Nihro Y et al. 3-O-alkylascorbic acids as free radical quenchers. II. Inhibitory effects on some lipid peroxidation models. 1991 Chem. Pharm. Bull. pmid:1777926
Sarkar G Beneficial ghee? 1991 Nature pmid:1876181
Vilchez C et al. Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Coturnix coturnix japonica). 1. Reproductive performance and tissue fatty acids. 1991 Poult. Sci. pmid:1784570
Pourplanche C et al. Comparison of polarographic and chemical measurements of oxygen uptake in complex media: the example of lipoxygenase reaction. 1991 Anal. Biochem. pmid:1789419
Pal S and Davis PJ Effects of different types of polyunsaturated fatty acids on cholesterol esterification in human fibroblasts. 1991 Biochem. Int. pmid:1789795
Jyothirmayi N and Ramadoss CS Soybean lipoxygenase catalysed oxygenation of unsaturated fatty acid encapsulated in cyclodextrin. 1991 Biochim. Biophys. Acta pmid:1903659
Uchida Y et al. Enhancement of keratin synthesis induced by lipokeratinogenoside, N-(O-linoleoyl)-omega-hydroxy fatty acyl sphingosyl glucose, in association with alteration of the intracellular Ca(2+)-content and protein kinase in cultured keratinocytes (FRSK). 1991 J. Biochem. pmid:1715342
Iwahashi H et al. Isolation and identification of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts formed by the decomposition of the hydroperoxides of linoleic acid, linolenic acid, and arachidonic acid by soybean lipoxygenase. 1991 Arch. Biochem. Biophys. pmid:1846731
Thomson AB et al. Feeding rats a diet enriched with saturated fatty acids prevents the inhibitory effects of acute and chronic ethanol exposure on the in vitro uptake of hexoses and lipids. 1991 Biochim. Biophys. Acta pmid:1854796
Hiramatsu N et al. Effects of dietary pantethine levels on contents of fatty acids and thiobarbituric acid reactive substances in the liver of rats orally administered varying amounts of autoxidized linoleate. 1991 J. Nutr. Sci. Vitaminol. pmid:1880633
Laganiere S and Fernandes G Study on the lipid composition of aging Fischer-344 rat lymphoid cells: effect of long-term calorie restriction. 1991 Lipids pmid:1881243
Perkins DM and Duncan JR The effect of gamma-linolenic acid and zinc supplementation on the growth of normal and tumour cells in vitro. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1881941
Iwado H et al. Mutagenicity and antimutagenicity of air-borne particulates. 1991 Mutat. Res. pmid:1986270
Ulmann L et al. Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. 1991 Biochim. Biophys. Acta pmid:1657182
Hollander D and Tarnawski A Is there a role for dietary essential fatty acids in gastroduodenal mucosal protection? 1991 J. Clin. Gastroenterol. pmid:1940200
Witte-Foster SR et al. Lipid profiles, serum immunoglobulins, dietary intake, and drug use of older rural Iowa women. 1991 J Am Diet Assoc pmid:2040782
Baer AN et al. Stereospecificity of the products of the fatty acid oxygenases derived from psoriatic scales. 1991 J. Lipid Res. pmid:1906083
Nemecz G et al. Interaction of fatty acids with recombinant rat intestinal and liver fatty acid-binding proteins. 1991 Arch. Biochem. Biophys. pmid:1897956
Owen S et al. Evidence of free-radical activity in asthma. 1991 N. Engl. J. Med. pmid:1857396
Okuyama H and Sakai K Effects of dietary oils with extreme omega 3/omega 6 ratios--selective incorporation and differential catabolism. 1991 World Rev Nutr Diet pmid:1675826