Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Cicatrix, Hypertrophic D017439 4 associated lipids
Varicose Ulcer D014647 4 associated lipids
Lactose Intolerance D007787 2 associated lipids
Gastroschisis D020139 1 associated lipids
Fat Necrosis D005218 1 associated lipids
Mucositis D052016 7 associated lipids
Child Nutrition Disorders D015362 1 associated lipids
Carcinoma, Krebs 2 D002287 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Hong CY et al. Effect of pravastatin on fatty acid profile of low density lipoprotein in patients with hypercholesterolemia. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8446653
Decsi T et al. Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17321122
Claassen N et al. The effect of different n-6/n-3 essential fatty acid ratios on calcium balance and bone in rats. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7675819
Prisco D et al. Platelet activation and platelet lipid composition in pulmonary cancer. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7675825
Stachowska E et al. Exchange of unsaturated fatty acids between adipose tissue and atherosclerotic plaque studied with artificial neural networks. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:14643180
Zhang J et al. Characteristics of fatty acid distribution is associated with colorectal cancer prognosis. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23465412
Singer P et al. Extreme decrease of linoleic acid in renal medulla from rats after a diet supplemented with cod liver oil. 1990 Prostaglandins Leukot. Essent. Fatty Acids pmid:2353033
Bellini MJ et al. Effect of simvastatin on the uptake and metabolic conversion of palmitic, dihomo-gamma-linoleic and alpha-linolenic acids in A549 cells. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:14580370
Al-Turkmani MR et al. Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036797
Simopoulos AP Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10991765
Galli C Commentary on the workshop statement. Essentiality of and recommended dietary intake of Omega-6 and Omega-3 fatty acids. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10991767
Crawford MA Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10991768
Cunnane SC Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10991770
Horrobin DF Commentary on the workshop statement: are we really sure that arachidonic acid and linoleic acid are bad things? 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10991771
Hsi LC et al. Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells. 2001 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:11418015
Okita M et al. Effect of arachidonic acid-rich oil on lipids and arachidonate metabolites in ethanol- treated rats. 2001 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:11418023
Abeywardena MY et al. Dietary n-3 and n-6 polyunsaturated oils and airway contractility. 2001 Apr-May Prostaglandins Leukot. Essent. Fatty Acids pmid:11418024
Whelan J The health implications of changing linoleic acid intakes. 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18990554
Fritsche KL Too much linoleic acid promotes inflammation-doesn't it? 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18990555
Ober MD and Hart CM Attenuation of oxidant-mediated endothelial cell injury with docosahexaenoic acid: the role of intracellular iron. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9774176
Wander RC et al. Influence of long-chain polyunsaturated fatty acids on oxidation of low density lipoprotein. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9774178
Gueck T et al. Effects of essential fatty acids on mediators of mast cells in culture. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711248
Louw L et al. Comparison of the fatty acid compositions in intraepithelial and infiltrating lesions of the cervix: part I, total fatty acid profiles. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9849650
Nixon JB et al. Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711249
Pasqualini ME et al. Association between E-cadherin expression by human colon, bladder and breast cancer cells and the 13-HODE:15-HETE ratio. A possible role of their metastatic potential. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538085
Harris WS Linoleic acid and coronary heart disease. 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18951772
Gonzalez B et al. Metabolism of n -9, n -6 and n -3 fatty acids in hepatoma Morris 7777 cells. Preferential accumulation of linoleic acid in cardiolipin. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10883061
Angela Liou Y and Innis SM Dietary linoleic acid has no effect on arachidonic acid, but increases n-6 eicosadienoic acid, and lowers dihomo-gamma-linolenic and eicosapentaenoic acid in plasma of adult men. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19356914
Wenger FA et al. Does alpha-linolenic acid in combination with linoleic acid influence liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters? 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10913224
Ramchurren N and Karmali R Effects of gamma-linolenic and dihomo-gamma-linolenic acids on 7,12-dimethylbenz(alpha)anthracene-induced mammary tumors in rats. 1995 Prostaglandins Leukot. Essent. Fatty Acids pmid:7480079
Harris WS et al. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23375840
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Kim RS and Zaborniak CL The aldehydic metabolites of linoleic acid are cytotoxic against human breast cancer cells. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1946549
Mouradian M et al. Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth. 2014 Prostaglandins Leukot. Essent. Fatty Acids pmid:24374147
Harris MA et al. Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11487304
Cunnane SC and Guesnet P Linoleic acid recommendations--A house of cards. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21963263
Pickens CA et al. Plasma phospholipids, non-esterified plasma polyunsaturated fatty acids and oxylipids are associated with BMI. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25559239
Strandvik B The omega-6/omega-3 ratio is of importance! 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21945460
Tribole E What happened to do no harm? The issue of dietary omega-6 fatty acids. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19147337
Ramsden CE et al. Letter to the Editor re: Linoleic acid and coronary heart disease. Prostaglandins Leukot. Essent. Fatty Acids (2008), by W.S. Harris. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19147338
Gibson R and Makrides M α-Linolenate reduces the dietary requirement for linoleate in the growing rat. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:22019216
Pregnolato P et al. Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981629
Das I and Khan NS Increased arachidonic acid induced platelet chemiluminescence indicates cyclooxygenase overactivity in schizophrenic subjects. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610837
Kikuchi S et al. Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610849
Rosing U and Olund A Endometrial content of prostaglandin precursors during the menstrual cycle. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2780764
Strandvik B et al. Prostanoid biosynthesis in patients with cystic fibrosis. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:9014220
Ramsden CE et al. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22959954
Strandvik B Fatty acid metabolism in cystic fibrosis. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20673710
Gelderblom WC et al. Regulation of fatty acid biosynthesis as a possible mechanism for the mitoinhibitory effect of fumonisin B1 in primary rat hepatocytes. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10574646
Arun Kumar C and Das UN Lipid peroxides, nitric oxide and essential fatty acids in patients with Plasmodium falciparum malaria. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10574650
Kawakami Y et al. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. 2009 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:19457650
Kilian M et al. Influence of conjugated and conventional linoleic acid on tumor growth and lipid peroxidation in pancreatic adenocarcinoma in hamster. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12878453
Villa PM et al. Free fatty acid profiles in preeclampsia. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19497719
Peet M et al. Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888126
Bandyopadhyay GK et al. Role of polyunsaturated fatty acids as signal transducers: amplification of signals from growth factor receptors by fatty acids in mammary epithelial cells. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8424125
Goodfriend TL et al. An oxidized derivative of linoleic acid affects aldosterone secretion by adrenal cells in vitro. 2002 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12324236
Okui T et al. Cis-9,trans-11-conjugated linoleic acid promotes neuronal differentiation through regulation of Hes6 mRNA and cell cycle in cultured neural stem cells. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21723718
Matsuba S et al. Effect of dietary linoleate/alpha-linolenate balance on experimentally induced gastric injury in rats. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9888206
Shapiro H et al. Beyond the classic eicosanoids: Peripherally-acting oxygenated metabolites of polyunsaturated fatty acids mediate pain associated with tissue injury and inflammation. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:27067460
Kuipers RS et al. Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22425685
Cunnane SC et al. Carbon recycling into de novo lipogenesis is a major pathway in neonatal metabolism of linoleate and alpha-linolenate. 1999 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:10471127
Salem N et al. In vivo conversion of linoleic acid to arachidonic acid in human adults. 1999 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:10471130
Sakuma S et al. The effects of fatty acyl CoA esters on the formation of prostaglandin and arachidonoyl-CoA formed from arachidonic acid in rabbit kidney medulla microsomes. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161586
Perkins DM and Duncan JR The effect of gamma-linolenic acid and zinc supplementation on the growth of normal and tumour cells in vitro. 1991 Prostaglandins Leukot. Essent. Fatty Acids pmid:1881941
Punchard NA et al. Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10765976
Mohan IK and Das UN Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10765977
Williams LL et al. Quantitative association between altered plasma esterified omega-6 fatty acid proportions and psychological stress. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1461929
Kuipers RS et al. Milk in the island of Chole [Tanzania] is high in lauric, myristic, arachidonic and docosahexaenoic acids, and low in linoleic acid reconstructed diet of infants born to our ancestors living in tropical coastal regions. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17383169
Tisdale MJ Mechanism of lipid mobilization associated with cancer cachexia: interaction between the polyunsaturated fatty acid, eicosapentaenoic acid, and inhibitory guanine nucleotide-regulatory protein. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8380931
Derian CK and Lewis DF Activation of 15-lipoxygenase by low density lipoprotein in vascular endothelial cells. Relationship to the oxidative modification of low density lipoprotein. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1546066
Brestel EP and Koes MT Heparin inhibits the "quasi-lipoxygenase" activity of hemoglobin toward linoleic acid by oxidant scavenging. 1989 Prostaglandins Leukot. Essent. Fatty Acids pmid:2500671
Crandall DL et al. Effect of varying concentrations of linoleic acid on alpha-adrenoceptor responses in spontaneously hypertensive rats. 1988 Prostaglandins Leukot. Essent. Fatty Acids pmid:2845438
Naidu MR et al. Intratumoral gamma-linoleic acid therapy of human gliomas. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1589443
Bell JG et al. Effects of increasing dietary linoleic acid on phospholipid fatty acid composition and eicosanoid production in leucocytes and gill cells of Atlantic salmon (Salmo salar). 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1589446
Louw L and Dannhauser A Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090250
Turpeinen AM et al. A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9844997
Louw L Keloids in rural black South Africans. Part 3: a lipid model for the prevention and treatment of keloid formations. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090251
Vaddadi KS The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. 1981 Prostaglandins Med pmid:6269135
Kummerow FA et al. Trans fatty acids in partially hydrogenated soybean oil inhibit prostacyclin release by endothelial cells in presence of high level of linoleic acid. 2007 Prostaglandins Other Lipid Mediat. pmid:17991616
Sammon AM Maize meal, non-esterified linoleic acid, and endemic cancer of the esophagus--preliminary findings. 1999 Prostaglandins Other Lipid Mediat. pmid:10410386
Yao X et al. Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: A targeted metabolomic approach. Prostaglandins Other Lipid Mediat. pmid:25841349
Zabielski P et al. The effect of high-fat diet on the sphingolipid pathway of signal transduction in regenerating rat liver. 2010 Prostaglandins Other Lipid Mediat. pmid:20599517
Rose DP and Connolly JM Effects of fatty acids and eicosanoid synthesis inhibitors on the growth of two human prostate cancer cell lines. 1991 Prostate pmid:2020620
Cohen LA et al. Effect of soy protein isolate and conjugated linoleic acid on the growth of Dunning R-3327-AT-1 rat prostate tumors. 2003 Prostate pmid:12518321
Griffiths G et al. Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. 1997 Prostate pmid:9108883
Connolly JM and Rose DP Interactions between epidermal growth factor-mediated autocrine regulation and linoleic acid-stimulated growth of a human prostate cancer cell line. 1992 Prostate pmid:1549552
Verlotta A and Trono D Expression, purification and refolding of active durum wheat (Triticum durum Desf.) secretory phospholipase A2 from inclusion bodies of Escherichia coli. 2014 Protein Expr. Purif. pmid:24925645
Skrzypczak-Jankun E et al. Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzyme. 1997 Proteins pmid:9294864
Dobryniewski J et al. [Biology of essential fatty acids (EFA)]. 2007 Prz. Lek. pmid:17892040
Buydens-Branchey L et al. Polyunsaturated fatty acid status and relapse vulnerability in cocaine addicts. 2003 Psychiatry Res pmid:14500111
Bazinet RP et al. Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat. 2005 Psychopharmacology (Berl.) pmid:15986187
Cheng G et al. Relative validity of a 3 d estimated food record in German toddlers. 2013 Public Health Nutr pmid:22874634
Segovia-Siapco G et al. Validation of a food-frequency questionnaire for measurement of nutrient intake in a dietary intervention study. 2007 Public Health Nutr pmid:17261227
Petrogianni M et al. Additional benefit in CVD risk indices derived from the consumption of fortified milk when combined with a lifestyle intervention. 2014 Public Health Nutr pmid:23249766
Cantwell MM et al. Development and validation of a food-frequency questionnaire for the determination of detailed fatty acid intakes. 2005 Public Health Nutr pmid:15705250
Maqbool A et al. The skinny on tuna fat: health implications. 2011 Public Health Nutr pmid:21324226
Fremann D et al. Dietary conjugated linoleic acid (CLA) intake assessment and possible biomarkers of CLA intake in young women. 2002 Public Health Nutr pmid:12001981
Ghisolfi J et al. Nutrient intakes of children aged 1-2 years as a function of milk consumption, cows' milk or growing-up milk. 2013 Public Health Nutr pmid:23098567
Vinceti M et al. A population-based case-control study of diet and melanoma risk in northern Italy. 2005 Public Health Nutr pmid:16372927