| MeSH term | MeSH ID | Detail |
|---|---|---|
| Atherosclerosis | D050197 | 85 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
Linoelaidic acid
Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.
Cross Reference
Introduction
To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoelaidic acid?
Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoelaidic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoelaidic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoelaidic acid?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Linoelaidic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (1)
- Am. J. Physiol., Cell Physiol. (1)
- Hypertension (1)
- Others (3)
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoelaidic acid?
Related references are published most in these journals:
- Am. J. Physiol., Cell Physiol. (1)
- Plant Cell (1)
- Prostaglandins Leukot. Essent. Fatty Acids (1)
- Others (1)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoelaidic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoelaidic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kleinfeld AM et al. | Transport of long-chain native fatty acids across lipid bilayer membranes indicates that transbilayer flip-flop is rate limiting. | 1997 | Biochemistry | pmid:9369487 |
| Mizushina Y et al. | The inhibitory action of fatty acids on DNA polymerase beta. | 1997 | Biochim. Biophys. Acta | pmid:9367179 |
| Singer S et al. | Correlation of lipid content and composition with liposarcoma histology and grade. | 1997 Oct-Nov | Ann. Surg. Oncol. | pmid:9367021 |
| Anthony FA et al. | Psoralen-fatty acid adducts activate melanocyte protein kinase C: a proposed mechanism for melanogenesis induced by 8-methoxypsoralen and ultraviolet A light. | 1997 Feb-Apr | Photodermatol Photoimmunol Photomed | pmid:9361122 |
| Jie MS et al. | Synthesis and nuclear magnetic resonance properties of all geometrical isomers of conjugated linoleic acids. | 1997 | Lipids | pmid:9358429 |
| Ali I and Steele JE | Fatty acids stimulate trehalose synthesis in trophocytes of the cockroach (Periplaneta americana) fat body. | 1997 | Gen. Comp. Endocrinol. | pmid:9356224 |
| O'donnell VB and Kühn H | Co-oxidation of NADH and NADPH by a mammalian 15-lipoxygenase: inhibition of lipoxygenase activity at near-physiological NADH concentrations. | 1997 | Biochem. J. | pmid:9355754 |
| Yamamoto A et al. | Improvement of the pulmonary absorption of (Asu1,7)-eel calcitonin by various absorption enhancers and their pulmonary toxicity in rats. | 1997 | J Pharm Sci | pmid:9344172 |
| Heiskanen KM et al. | Effect of linoleic acid, linoleic acid anilide, and arachidonic acid on the expression of adhesion molecules on human neutrophils. | 1997 | Arch. Toxicol. | pmid:9332699 |
| Ratnayake WM et al. | Essential fatty acids and their trans geometrical isomers in powdered and liquid infant formulas sold in Canada. | 1997 | J. Pediatr. Gastroenterol. Nutr. | pmid:9327370 |
| Louw L et al. | Keloids: peripheral and central differences in cell morphology and fatty acid compositions of lipids. | 1997 | Adv. Exp. Med. Biol. | pmid:9322000 |
| Eling TE et al. | Modulation of epidermal growth factor signal transduction by linoleic acid metabolites. | 1997 | Adv. Exp. Med. Biol. | pmid:9321970 |
| Meyer C et al. | Human kidney free fatty acid and glucose uptake: evidence for a renal glucose-fatty acid cycle. | 1997 | Am. J. Physiol. | pmid:9316458 |
| Chatterjee MT et al. | Alterations in cellular lipids may be responsible for the transient nature of the yeast heat shock response. | 1997 | Microbiology (Reading, Engl.) | pmid:9308188 |
| Chinn KS et al. | Modulation of adjuvant-induced arthritis by dietary arachidonic acid in essential fatty acid-deficient rats. | 1997 | Lipids | pmid:9307941 |
| Bolton-Smith C et al. | Evidence for age-related differences in the fatty acid composition of human adipose tissue, independent of diet. | 1997 | Eur J Clin Nutr | pmid:9306089 |
| Hayakawa F et al. | DNA cleavage reaction and linoleic acid peroxidation induced by tea catechins in the presence of cupric ion. | 1997 | Biochim. Biophys. Acta | pmid:9305782 |
| Moran JH et al. | Cytotoxicity of linoleic acid diols to renal proximal tubular cells. | 1997 | Toxicol. Appl. Pharmacol. | pmid:9299596 |
| Rusnak A et al. | Cardiolipin remodeling in a Chinese hamster lung fibroblast cell line deficient in oxidative energy production. | 1997 | J. Bioenerg. Biomembr. | pmid:9298714 |
| de Waart FG et al. | Vitamin E supplementation in elderly lowers the oxidation rate of linoleic acid in LDL. | 1997 | Atherosclerosis | pmid:9298686 |
| Hall JA et al. | Lipid composition of hepatic and adipose tissues from normal cats and from cats with idiopathic hepatic lipidosis. | 1997 Jul-Aug | J. Vet. Intern. Med. | pmid:9298479 |
| López-Nicolás JM et al. | Kinetic characteristics of the enzymatic conversion in presence of cyclodextrins: study of the oxidation of polyunsaturated fatty acids by lipoxygenase. | 1997 | Biochim. Biophys. Acta | pmid:9295158 |
| Skrzypczak-Jankun E et al. | Structure of soybean lipoxygenase L3 and a comparison with its L1 isoenzyme. | 1997 | Proteins | pmid:9294864 |
| Jensen CL et al. | Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants. | 1997 | J. Pediatr. | pmid:9290604 |
| Carlson SE | Functional effects of increasing omega-3 fatty acid intake. | 1997 | J. Pediatr. | pmid:9290597 |
| Bambolkar S and Sainani GS | Evaluation of oxidative stress in diabetics with or without vascular complications. | 1995 | J Assoc Physicians India | pmid:9282629 |
| Usha S and Balakrishnan A | c-myc, c-H-ras, and IP3 elevation in 18:2 n-6 dependent proliferation of lung cells. | 1997 Jul-Aug | In Vitro Cell. Dev. Biol. Anim. | pmid:9282304 |
| Hou CT et al. | Microbial production of a novel trihydroxy unsaturated fatty acid from linoleic acid. | 1997 | J. Ind. Microbiol. Biotechnol. | pmid:9281851 |
| Tiurina II et al. | [Palmitoylcarnitine-important component of lipid bilayer synaptosome membranes reparation system in oxidative stress]. | 1997 | Biull Eksp Biol Med | pmid:9280517 |
| Batna A et al. | Lipid peroxidation in presence of ebselen. | 1997 | Chem. Phys. Lipids | pmid:9275309 |
| Fabritius D et al. | Biotransformation of linoleic acid with the Candida tropicalis M25 mutant. | 1997 | Appl. Microbiol. Biotechnol. | pmid:9274051 |
| Lopez Jimenez JA et al. | Linoleic acid metabolism in primary cultures of adult rat cardiomyocytes is impaired by aging. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9266846 |
| Jenkins TC | Ruminal fermentation and nutrient digestion in sheep fed hydroxyethylsoyamide. | 1997 | J. Anim. Sci. | pmid:9263076 |
| Feussner I et al. | Structural elucidation of oxygenated storage lipids in cucumber cotyledons. Implication of lipid body lipoxygenase in lipid mobilization during germination. | 1997 | J. Biol. Chem. | pmid:9261186 |
| Brouwer DA et al. | The dietary fatty acids of patients with coronary artery disease and controls in Curaçao. Implications for primary and secondary prevention. | 1997 | West Indian Med J | pmid:9260535 |
| Badart-Smook A et al. | Fetal growth is associated positively with maternal intake of riboflavin and negatively with maternal intake of linoleic acid. | 1997 | J Am Diet Assoc | pmid:9259708 |
| Bakker N et al. | Adipose fatty acids and cancers of the breast, prostate and colon: an ecological study. EURAMIC Study Group. | 1997 | Int. J. Cancer | pmid:9259395 |
| Risé P et al. | Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells. | 1997 | J. Lipid Res. | pmid:9254057 |
| Castelli F et al. | Dipalmitoylphosphatidylcholine/linoleic acid mixed unilamellar vesicles as model membranes for studies on novel free-radical scavengers. | 1997 | J Pharmacol Toxicol Methods | pmid:9253749 |
| Siguel E | Essential fatty acid status in patients. | 1997 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:9252955 |
| Howlett NG and Avery SV | Induction of lipid peroxidation during heavy metal stress in Saccharomyces cerevisiae and influence of plasma membrane fatty acid unsaturation. | 1997 | Appl. Environ. Microbiol. | pmid:9251184 |
| Parmentier HK et al. | Dietary unsaturated fatty acids affect antibody responses and growth of chickens divergently selected for humoral responses to sheep red blood cells. | 1997 | Poult. Sci. | pmid:9251147 |
| Bosca F et al. | Photophysical and photochemical characterization of a photosensitizing drug: a combined steady state photolysis and laser flash photolysis study on carprofen. | 1997 | Chem. Res. Toxicol. | pmid:9250417 |
| Thomson AB et al. | Nutrient uptake into undifferentiated and differentiated HT-29 cells in culture. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9250367 |
| Hannah JS et al. | High fat, high cholesterol diets alter low density lipoprotein size and binding affinity in monkeys. | 1997 | Atherosclerosis | pmid:9247355 |
| Lanson M et al. | Supplementation of MCF-7 cells with essential fatty acids induces the activation of protein kinase C in response to IGF-1. | 1997 | J Lipid Mediat Cell Signal | pmid:9246607 |
| Haraguchi H et al. | Antioxidative action of diterpenoids from Podocarpus nagi. | 1997 | Planta Med. | pmid:9225601 |
| Shi F et al. | Permeability and metabolic properties of a trophoblast cell line (HRP-1) derived from normal rat placenta. | 1997 | Exp. Cell Res. | pmid:9223380 |
| Quoc KP and Dubacq JP | Effect of growth temperature on the biosynthesis of eukaryotic lipid molecular species by the cyanobacterium Spirulina platensis. | 1997 | Biochim. Biophys. Acta | pmid:9219908 |
| Jira W et al. | Increased levels of lipid oxidation products in low density lipoproteins of patients suffering from rheumatoid arthritis. | 1997 | Chem. Phys. Lipids | pmid:9219348 |
| Durgam VR and Fernandes G | The growth inhibitory effect of conjugated linoleic acid on MCF-7 cells is related to estrogen response system. | 1997 | Cancer Lett. | pmid:9215854 |
| Usha S et al. | Mitogenic stimulation of primary cultures of lung epithelial cells by linoleic acid. | 1996 | Biochem. Cell Biol. | pmid:9213439 |
| Stein CA | Controversies in the cellular pharmacology of oligodeoxynucleotides. | 1997 | Antisense Nucleic Acid Drug Dev. | pmid:9212912 |
| Nicolosi RJ et al. | Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. | 1997 | Artery | pmid:9209699 |
| Yehuda S et al. | Essential fatty acid preparation improves biochemical and cognitive functions in experimental allergic encephalomyelitis rats. | 1997 | Eur. J. Pharmacol. | pmid:9203563 |
| Miura K et al. | The effects of unsaturated fatty acids, oxidizing agents and Michael reaction acceptors on the induction of N-ethylmaleimide reductase in Escherichia coli: possible application for drug design of chemoprotectors. | 1997 | Methods Find Exp Clin Pharmacol | pmid:9203161 |
| Schut HA et al. | DNA adducts of heterocyclic amines: formation, removal and inhibition by dietary components. | 1997 | Mutat. Res. | pmid:9202755 |
| Sauer LA et al. | Dietary linoleic acid intake controls the arterial blood plasma concentration and the rates of growth and linoleic acid uptake and metabolism in hepatoma 7288CTC in Buffalo rats. | 1997 | J. Nutr. | pmid:9202100 |
| Petrek JA et al. | Fatty acid composition of adipose tissue, an indication of dietary fatty acids, and breast cancer prognosis. | 1997 | J. Clin. Oncol. | pmid:9193329 |
| Sharpe M et al. | Ligation, inhibition, and activation of cytochrome c oxidase by fatty acids. | 1997 | Biochem. Cell Biol. | pmid:9192076 |
| Sanderson P et al. | Dietary fish oil diminishes the antigen presentation activity of rat dendritic cells. | 1997 | Biochem. Soc. Trans. | pmid:9191396 |
| Peres CM et al. | Transference of fatty acids from macrophages to lymphocytes in culture. | 1997 | Biochem. Soc. Trans. | pmid:9191389 |
| Berry H et al. | Excess substrate inhibition of soybean lipoxygenase-1 is mainly oxygen-dependent. | 1997 | FEBS Lett. | pmid:9188786 |
| Ek BA et al. | Fatty acid binding proteins reduce 15-lipoxygenase-induced oxygenation of linoleic acid and arachidonic acid. | 1997 | Biochim. Biophys. Acta | pmid:9187305 |
| Memoli S et al. | Diffusible melanin-related metabolites are potent inhibitors of lipid peroxidation. | 1997 | Biochim. Biophys. Acta | pmid:9187303 |
| Banfi C et al. | Linoleic acid enhances the secretion of plasminogen activator inhibitor type 1 by HepG2 cells. | 1997 | J. Lipid Res. | pmid:9186904 |
| Ding ST and Lilburn MS | Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. | 1997 | Poult. Sci. | pmid:9181615 |
| Hornstra G and Kester AD | Effect of the dietary fat type on arterial thrombosis tendency: systematic studies with a rat model. | 1997 | Atherosclerosis | pmid:9180241 |
| Harvei S et al. | Prediagnostic level of fatty acids in serum phospholipids: omega-3 and omega-6 fatty acids and the risk of prostate cancer. | 1997 | Int. J. Cancer | pmid:9178806 |
| Nakayama T et al. | Lipid peroxidation in linoleic acid micelles caused by H2O2 in the presence of myoglobin. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9178558 |
| Matsusue K et al. | A highly toxic PCB produces unusual changes in the fatty acid composition of rat liver. | 1997 | Toxicol. Lett. | pmid:9175845 |
| Monette M and Lafleur M | Influence of lipid chain unsaturation on melittin-induced micellization. | 1996 | Biophys. J. | pmid:9172743 |
| Palombo JD et al. | Cyclic vs continuous enteral feeding with omega-3 and gamma-linolenic fatty acids: effects on modulation of phospholipid fatty acids in rat lung and liver immune cells. | 1997 May-Jun | JPEN J Parenter Enteral Nutr | pmid:9168366 |
| Rogers AE | Diet and breast cancer: studies in laboratory animals. | 1997 | J. Nutr. | pmid:9164267 |
| Salomaa VV et al. | Association of the fatty acid composition of serum phospholipids with hemostatic factors. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9157941 |
| Luthria DL et al. | Metabolites produced during the peroxisomal beta-oxidation of linoleate and arachidonate move to microsomes for conversion back to linoleate. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9144553 |
| Cunnane SC and Anderson MJ | Pure linoleate deficiency in the rat: influence on growth, accumulation of n-6 polyunsaturates, and [1-14C]linoleate oxidation. | 1997 | J. Lipid Res. | pmid:9144095 |
| Vargas F and Fuentes A | Evidence of formation and participation of singlet oxygen in the in vitro phototoxicity of the combined diuretic triamterene and hydrochlorothiazide. | 1997 | Pharmazie | pmid:9140146 |
| Ohata T et al. | Suppression of nitric oxide production in lipopolysaccharide-stimulated macrophage cells by omega 3 polyunsaturated fatty acids. | 1997 | Jpn. J. Cancer Res. | pmid:9140106 |
| Rao PU | Nutrient composition and biological evaluation of mesta (Hibiscus sabdariffa) seeds. | 1996 | Plant Foods Hum Nutr | pmid:9139301 |
| Chew BP et al. | Effects of conjugated dienoic derivatives of linoleic acid and beta-carotene in modulating lymphocyte and macrophage function. | 1997 Mar-Apr | Anticancer Res. | pmid:9137456 |
| Wong MW et al. | Effects of dietary conjugated linoleic acid on lymphocyte function and growth of mammary tumors in mice. | 1997 Mar-Apr | Anticancer Res. | pmid:9137439 |
| Visonneau S et al. | Conjugated linoleic acid suppresses the growth of human breast adenocarcinoma cells in SCID mice. | 1997 Mar-Apr | Anticancer Res. | pmid:9137436 |
| Bourre JM et al. | Possible role of the choroid plexus in the supply of brain tissue with polyunsaturated fatty acids. | 1997 | Neurosci. Lett. | pmid:9132678 |
| Schneider C et al. | A fatty acid alpha-ketol, a product of the plant lipoxygenase pathway, is oxidized to 3(Z)-dodecendioic acid by a bacterial monooxygenase. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9125182 |
| Ip C and Scimeca JA | Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis. | 1997 | Nutr Cancer | pmid:9121939 |
| Goldreich D et al. | The effect of retinol and retinoic acids on lipoxygenase activity. | 1997 | Int J Vitam Nutr Res | pmid:9119612 |
| Fukushima M et al. | Comparative hypocholesterolemic effects of capybara (Hydrochoerus hydrochaeris dabbenei) oil, horse oil, and sardine oil in cholesterol-fed rats. | 1997 | Lipids | pmid:9113627 |
| Ip C et al. | Retention of conjugated linoleic acid in the mammary gland is associated with tumor inhibition during the post-initiation phase of carcinogenesis. | 1997 | Carcinogenesis | pmid:9111211 |
| Nieuwenhuizen WF et al. | Lipoxygenase is irreversibly inactivated by the hydroperoxides formed from the enynoic analogues of linoleic acid. | 1997 | Biochemistry | pmid:9109655 |
| Griffiths G et al. | Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. | 1997 | Prostate | pmid:9108883 |
| Nishizaki T et al. | Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid. | 1997 | Brain Res. | pmid:9099812 |
| Hayes KC | The linoleic acid content of test diets must be carefully monitored in cholesterol studies. | 1997 | Am. J. Clin. Nutr. | pmid:9094899 |
| Ikeda I et al. | Effect of dietary linoleic, alpha-linolenic and arachidonic acids on lipid metabolism, tissue fatty acid composition and eicosanoid production in rats. | 1996 | J. Nutr. Sci. Vitaminol. | pmid:9089480 |
| Yamaki T et al. | Acute and reversible fatty metamorphosis of cultured rat hepatocytes. | 1997 Feb-Mar | Pathol. Int. | pmid:9088028 |
| Iwase H et al. | Formation of leukotoxin (9,10-epoxy-12-octadecenoic acid) during the autoxidation of phospholipids promoted by hemoproteins. | 1997 | Biochim. Biophys. Acta | pmid:9084498 |
| Schneider C et al. | Analysis of lipoxygenase-derived fatty acid hydroperoxides by electrospray ionization tandem mass spectrometry. | 1997 | Lipids | pmid:9076671 |
| Barclay LR et al. | Photo-initiated peroxidation of lipids in micelles by azaaromatics. | 1997 | Lipids | pmid:9076660 |
| Belury MA and Kempa-Steczko A | Conjugated linoleic acid modulates hepatic lipid composition in mice. | 1997 | Lipids | pmid:9075211 |
| Iwase H et al. | Effect of monochlorohydrins of linoleic acid on guinea-pig cardiac papillary muscles. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070266 |