Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

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Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Atherosclerosis D050197 85 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Alzheimer Disease D000544 76 associated lipids
Stomach Ulcer D013276 75 associated lipids
Leukemia D007938 74 associated lipids
Coronary Disease D003327 70 associated lipids
Melanoma D008545 69 associated lipids
Colitis D003092 69 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Liver Cirrhosis D008103 67 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Authors Title Published Journal PubMed Link
Blair IA et al. Dietary modification of omega 6 fatty acid intake and its effect on urinary eicosanoid excretion. 1993 Am. J. Clin. Nutr. pmid:8424383
Bandyopadhyay GK et al. Role of polyunsaturated fatty acids as signal transducers: amplification of signals from growth factor receptors by fatty acids in mammary epithelial cells. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8424125
Cominacini L et al. Determination of lipid hydroperoxides in native low-density lipoprotein by a chemiluminescent flow-injection assay. 1993 Biochim. Biophys. Acta pmid:8418885
de Waard P et al. Heteronuclear NMR analysis of unsaturated fatty acids in poly(3-hydroxyalkanoates). Study of beta-oxidation in Pseudomonas putida. 1993 J. Biol. Chem. pmid:8416939
Seidelin KN et al. Percentage distribution of fatty acids in subcutaneous adipose tissue of patients with peptic ulcer disease. 1993 Am. J. Clin. Nutr. pmid:8416668
Keler T and Sorof S Growth promotion of transfected hepatoma cells by liver fatty acid binding protein. 1993 J. Cell. Physiol. pmid:8408240
Kleinveld HA et al. Oxidation resistance, oxidation rate, and extent of oxidation of human low-density lipoprotein depend on the ratio of oleic acid content to linoleic acid content: studies in vitamin E deficient subjects. 1993 Free Radic. Biol. Med. pmid:8406127
Wolever TM Comments on "Treatment of diabetic neuropathy with gamma-linolenic acid" by The gamma-Linolenic Multicenter Trial Group. 1993 Diabetes Care pmid:8404440
Toborek M and Hennig B Vitamin E attenuates induction of elastase-like activity by tumor necrosis factor-alpha, cholestan-3 beta,5 alpha,6 beta-triol and linoleic acid in cultured endothelial cells. 1993 Clin. Chim. Acta pmid:8403435
Rose DP et al. Effect of diets containing different levels of linoleic acid on human breast cancer growth and lung metastasis in nude mice. 1993 Cancer Res. pmid:8402646
Hatala MA et al. Characterization of phospholipase A2 activity in MDA-MB-435 human breast cancer cells. 1993 Cancer Lett. pmid:8402571
Baykousheva S Metabolism of [1-14C]linoleic acid in human promyelocytic leukemia HL-60 cells grown and differentiated in serum-free medium. 1993 Cancer Lett. pmid:8402565
Emken EA et al. Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans. 1993 Biochim. Biophys. Acta pmid:8399342
De Antueno RJ et al. Metabolism of radiolabelled 18:2n-6 and 18:3n-6 by NIH-3T3 cells and the DT subclone. 1993 Jul-Aug Anticancer Res. pmid:8394680
Reid G Metabolic disorders of cattle. 1993 Med. Hypotheses pmid:8394500
Laihia JK et al. Lucigenin and linoleate enhanced chemiluminescent assay for superoxide dismutase activity. 1993 Free Radic. Biol. Med. pmid:8394267
Turley CP and Brewster MA Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. 1993 J. Nutr. pmid:8391565
Reddy AS et al. Isolation of a delta 6-desaturase gene from the cyanobacterium Synechocystis sp. strain PCC 6803 by gain-of-function expression in Anabaena sp. strain PCC 7120. 1993 Plant Mol. Biol. pmid:8389613
Horrobin DF Fatty acid metabolism in health and disease: the role of delta-6-desaturase. 1993 Am. J. Clin. Nutr. pmid:8386433
Soliven B et al. Arachidonic acid and its metabolites increase Cai in cultured rat oligodendrocytes. 1993 Am. J. Physiol. pmid:8384786
Poisson JP et al. Effect of salt-loading and spontaneous hypertension on in vitro metabolism of [1-14C]linoleic and [2-14C]dihomo-gamma-linolenic acids. 1993 Biochem. Med. Metab. Biol. pmid:8382502
Tisdale MJ Mechanism of lipid mobilization associated with cancer cachexia: interaction between the polyunsaturated fatty acid, eicosapentaenoic acid, and inhibitory guanine nucleotide-regulatory protein. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8380931
Brinkmeier H et al. Specific modifications of the membrane fatty acid composition of human myotubes and their effects on the muscular sodium channels. 1993 Biochim. Biophys. Acta pmid:8380720
James MJ et al. Simple relationships exist between dietary linoleate and the n-6 fatty acids of human neutrophils and plasma. 1993 Am. J. Clin. Nutr. pmid:8379505
Feunekes GI et al. Relative and biomarker-based validity of a food-frequency questionnaire estimating intake of fats and cholesterol. 1993 Am. J. Clin. Nutr. pmid:8379504
Kirchgessner M and Müller HL [The effect of palmitic, oleic and linoleic acids on thermogenesis in the model experiment in sows]. 1993 Z Ernahrungswiss pmid:8379216
Sigurdson SL and Ip MM Casein accumulation by rat mammary epithelial cells grown within a reconstituted basement membrane is modulated by fatty acids in a hormone- and time-dependent manner. 1993 Exp. Cell Res. pmid:8375465
van Zoeren-Grobben D et al. Lipid peroxidation in human milk and infant formula: effect of storage, tube feeding and exposure to phototherapy. 1993 Acta Paediatr. pmid:8374211
Black JM and Kinsella JE Dietary n-3 fatty acids alter murine peritoneal macrophage cytotoxicity. 1993 Ann. Nutr. Metab. pmid:8373135
Hong CY et al. Linoleate-rich triacylglycerol in Panax pseudo-ginseng improves erythrocyte deformability in vitro. 1993 Planta Med. pmid:8372148
Rabinowitch HD et al. Escherichia coli produces linoleic acid during late stationary phase. 1993 J. Bacteriol. pmid:8366020
Davis PA et al. A linoleate-enriched cheese product reduces low-density lipoprotein in moderately hypercholesterolemic adults. 1993 Ann. Intern. Med. pmid:8363165
Chang WC et al. Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells. 1993 J. Biol. Chem. pmid:8360167
Zheng RL et al. Inhibition of the autoxidation of linoleic acid by phenylpropanoid glycosides from Pedicularis in micelles. 1993 Chem. Phys. Lipids pmid:8358852
Buchanan MR and Brister SJ Altering vessel wall fatty acid metabolism: a new strategy for antithrombotic treatment. 1993 Semin. Thromb. Hemost. pmid:8356461
Roy SK et al. Lipoxygenase activity in rat embryos and its potential for xenobiotic oxidation. 1993 Biol. Neonate pmid:8353158
Mao-Qiang M et al. Inhibition of cholesterol and sphingolipid synthesis causes paradoxical effects on permeability barrier homeostasis. 1993 J. Invest. Dermatol. pmid:8345219
Roy R and Bélanger A ZR-75-1 breast cancer cells generate nonconjugated steroids from low density lipoprotein-incorporated lipoidal dehydroepiandrosterone. 1993 Endocrinology pmid:8344206
Guha SN et al. Free radical reductive degradation of vic-dibromoalkanes and reaction of bromine atoms with polyunsaturated fatty acids: possible involvement of Br(.) in the 1,2-dibromoethane-induced lipid peroxidation. 1993 Arch. Biochem. Biophys. pmid:8342946
Bioque G et al. Metabolism of N-phenyllinoleamide by rat liver. 1993 J. Chromatogr. pmid:8335697
Kühn H et al. Overexpression, purification and characterization of human recombinant 15-lipoxygenase. 1993 Biochim. Biophys. Acta pmid:8334154
Dutta-Roy AK et al. Purification and characterization of fatty acid-binding proteins from brown adipose tissue of the rat. 1993 Biochim. Biophys. Acta pmid:8334153
Jacobsen BK et al. Re: "Comparison of measures of fatty acid intake by subcutaneous fat aspirate, food frequency questionnaire, and diet records in a free-living population of US men". 1993 Am. J. Epidemiol. pmid:8333420
Hara I et al. Role of calcium ion in Schistosoma mansoni cercarial tail loss induced by unsaturated fatty acids. 1993 J. Parasitol. pmid:8331471
Rich MR Conformational analysis of arachidonic and related fatty acids using molecular dynamics simulations. 1993 Biochim. Biophys. Acta pmid:8329458
Hansen HS Linoleic acid as a precursor for acylation of transducin, a retinol G protein? 1993 Trends Biochem. Sci. pmid:8328015
Wieland E et al. Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation? 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8327462
Kaneko T et al. Protective effect of lipophilic derivatives of ascorbic acid on lipid peroxide-induced endothelial injury. 1993 Arch. Biochem. Biophys. pmid:8323284
Louw L and van der Westhuizen JP Correlation between histopathology and linoleic acid levels in five meningioma types. 1993 Pathol. Res. Pract. pmid:8321745
Vázquez CM et al. Changes in fatty acid desaturation in hepatic and intestinal tissues induced by intestinal resection. 1993 Lipids pmid:8316056
Koba K et al. Effects of dietary proteins on linoleic acid desaturation and membrane fluidity in rat liver microsomes. 1993 Lipids pmid:8316055
Hernell O et al. Does the bile salt-stimulated lipase of human milk have a role in the use of the milk long-chain polyunsaturated fatty acids? 1993 J. Pediatr. Gastroenterol. Nutr. pmid:8315552
Larner JM et al. The isolation and characterization of estradiol-fatty acid esters in human ovarian follicular fluid. Identification of an endogenous long-lived and potent family of estrogens. 1993 J. Biol. Chem. pmid:8314757
Takatori T [Relationship between postmortem change and biological reaction]. 1993 Nihon Hoigaku Zasshi pmid:8309098
Yamaguchi Y et al. Enhancement of aortic cholesterol deposition by dietary linoleic acid in cholesterol-fed mice: an animal model for primary screening of antiatherosclerotic agents. 1993 J Pharmacol Toxicol Methods pmid:8305719
Marcelo CL and Dunham WR Fatty acid metabolism studies of human epidermal cell cultures. 1993 J. Lipid Res. pmid:8301228
Ramasamy S et al. Proteoglycans and endothelial barrier function: effect of linoleic acid exposure to porcine pulmonary artery endothelial cells. 1993 Atherosclerosis pmid:8292102
Li Y et al. Chemical and alpha-chymotrypsin-mediated proteolytic degradation of insulin in bile salt-unsaturated fatty acid mixed micellar systems. 1993 Pharm. Res. pmid:8290478
Sanjurjo P et al. Cross-sectional study of percentual changes in total plasmatic fatty acids during pregnancy. 1993 Horm. Metab. Res. pmid:8288163
Sunzeri FJ and Buehring GC Lipids alter the level and distribution of mouse mammary tumor virus gp52 in vitro. 1993 Cancer Lett. pmid:8287372
Grech ED et al. Differential free-radical activity after successful and unsuccessful thrombolytic reperfusion in acute myocardial infarction. 1993 Coron. Artery Dis. pmid:8287210
Judd JT and Clevidence BA Trans fatty acids in human nutrition. 1993 Acta Cardiol pmid:8284978
Saito M and Yamaguchi M Response of liver microsomal mixed-function oxidases to dietary linoleic acid levels in rats. 1993 J. Nutr. Sci. Vitaminol. pmid:8283320
Hrboticky N et al. Lovastatin increases arachidonic acid levels and stimulates thromboxane synthesis in human liver and monocytic cell lines. 1994 J. Clin. Invest. pmid:8282787
Murray MJ et al. Effects of endotoxin on pigs prefed omega-3 vs. omega-6 fatty acid-enriched diets. 1993 Am. J. Physiol. pmid:8279548
Bronstein JC and Bull AW The correlation between 13-hydroxyoctadecadienoate dehydrogenase (13-HODE dehydrogenase) and intestinal cell differentiation. 1993 Prostaglandins pmid:8278616
Lamb RG et al. An in vitro model of ethanol-dependent liver cell injury. 1994 Hepatology pmid:8276354
Oulhaj H et al. Synthesis and distribution of rat Sertoli cell proteoglycans are modulated by linoleate and vitamin E. 1993 Biochem. Mol. Biol. Int. pmid:8275018
Ettinger WH et al. Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells. 1994 Arterioscler. Thromb. pmid:8274481
Dehaut F et al. n-6 polyunsaturated fatty acids increase the neurite length of PC12 cells and embryonic chick motoneurons. 1993 Neurosci. Lett. pmid:8272254
Sullivan JL et al. Performance of dairy cows fed short staple, Pima, and cracked Pima cottonseed and feed characteristics. 1993 J. Dairy Sci. pmid:8270698
Blee E et al. Regio- and stereoselectivity of cytochrome P-450 and peroxygenase-dependent formation of cis-12,13-epoxy-9(Z)-octadecenoic acid (vernolic acid) in Euphorbia lagascae. 1993 Biochem. Biophys. Res. Commun. pmid:8267615
Whelan J et al. Dietary arachidonate enhances tissue arachidonate levels and eicosanoid production in Syrian hamsters. 1993 J. Nutr. pmid:8263613
Viola G et al. Absorption and distribution of arachidonate in rats receiving lysophospholipids by oral route. 1993 J. Lipid Res. pmid:8263409
Jones AL et al. Rapid induction of microsomal delta 12(omega 6)-desaturase activity in chilled Acanthamoeba castellanii. 1993 Biochem. J. pmid:8250841
Vargas F et al. Photodegradation and in vitro phototoxicity of fenofibrate, a photosensitizing anti-hyperlipoproteinemic drug. 1993 Photochem. Photobiol. pmid:8248320
Darmani H et al. Interferon-gamma-stimulated uptake and turnover of linoleate and arachidonate in macrophages: a possible pathway for hypersensitivity to endotoxin. 1993 Cell. Immunol. pmid:8242772
Tanner JT et al. Analysis of milk-based infant formula. Phase IV. Iodide, linoleic acid, and vitamins D and K: U.S. Food and Drug Administration-Infant Formula Council: collaborative study. 1993 Sep-Oct J AOAC Int pmid:8241809
Biagi PL et al. Erythrocyte membrane fatty acid composition in children with atopic dermatitis compared to age-matched controls. 1993 Acta Paediatr. pmid:8241678
Cantrill RC et al. Variations in temperature and oxygen content do not alter levels of thiobarbiturate reactive material in human breast tumour cells (ZR-75-1) incubated with gamma-linolenic acid. 1993 Sep-Oct Anticancer Res. pmid:8239521
Markovic DZ and Patterson LK Benzophenone-sensitized lipid peroxidation in linoleate micelles. 1993 Photochem. Photobiol. pmid:8234464
Chan JK et al. Effect of dietary alpha-linolenic acid and its ratio to linoleic acid on platelet and plasma fatty acids and thrombogenesis. 1993 Lipids pmid:8231657
Daret D et al. Synthesis of monohydroxylated fatty acids from linoleic acid by rat aortic smooth muscle cells and tissues: influence on prostacyclin production. 1993 J. Lipid Res. pmid:8228632
Spiteller G Review: on the chemistry of oxidative stress. 1993 J Lipid Mediat pmid:8219002
Jakobsen K et al. The biological activity of natural source tocopherols in chickens fed fresh or oxidized fat rich in linoleic acid. 1993 Arch Tierernahr pmid:8215903
de Deckere EA et al. Hepatic de novo fatty acid synthesis in the rat. 1993 Ann. Nutr. Metab. pmid:8215236
Viscardi RM and Max SR Unsaturated fatty acid modulation of glucocorticoid receptor binding in L2 cells. 1993 Steroids pmid:8212085
Sakuma S et al. Effect of 13-hydroperoxyoctadecadienoic acid on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex. 1993 Prostaglandins pmid:8210445
Grammatopoulos D et al. The human myometrial CRH receptor: G proteins and second messengers. 1994 Mol. Cell. Endocrinol. pmid:8206332
Glasgow WC and Eling TE Structure-activity relationship for potentiation of EGF-dependent mitogenesis by oxygenated metabolites of linoleic acid. 1994 Arch. Biochem. Biophys. pmid:8203891
Yamashiro Y et al. Effects of ursodeoxycholic acid treatment on essential fatty acid deficiency in patients with biliary atresia. 1994 J. Pediatr. Surg. pmid:8201513
Andrassy RJ et al. Linoleic acid enhances mitogen response and survival of septic weanling rats. 1994 J. Pediatr. Surg. pmid:8201499
Truswell AS Can linoleic acid contribute to coronary artery disease? 1994 Am. J. Clin. Nutr. pmid:8198070
Hodgson JM et al. Can linoleic acid contribute to coronary artery disease? 1993 Am. J. Clin. Nutr. pmid:8192728
Cronan JE and Rock CO The presence of linoleic acid in Escherichia coli cannot be confirmed. 1994 J. Bacteriol. pmid:8188608
Belluzzi A et al. Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease. 1994 Aliment. Pharmacol. Ther. pmid:8186338
Jakobsen K et al. Heat production and quantitative oxidation of nutrients by physical activity in pigs. 1994 Ann. Nutr. Metab. pmid:8185282
Avellini L et al. Linoleic acid passage through the blood-brain barrier and a possible effect of age. 1994 Neurochem. Res. pmid:8183422
Schilstra MJ et al. Effect of nonionic detergents on lipoxygenase catalysis. 1994 Lipids pmid:8177015
Appel MJ et al. Effects of dietary linoleic acid on pancreatic carcinogenesis in rats and hamsters. 1994 Cancer Res. pmid:8174115