Linoelaidic acid

Linoelaidic acid is a lipid of Fatty Acyls (FA) class. Linoelaidic acid is associated with abnormalities such as Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease and Metabolic syndrome. The involved functions are known as Metabolic Inhibition, Steroid biosynthesis, Signal Transduction, Insulin Resistance and Inflammation. Linoelaidic acid often locates in Mitochondria, Membrane and Cytoplasmic matrix. The associated genes with Linoelaidic acid are FFAR1 gene, C9orf7 gene, TNF gene, CCL2 gene and TLR4 gene. The related lipids are Fatty Acids, octadecadienoic acid, Steroids, methyl linoleate and Cyanoketone.

Cross Reference

Introduction

To understand associated biological information of Linoelaidic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoelaidic acid?

Linoelaidic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Pneumonia, Chronic Obstructive Airway Disease, Metabolic syndrome and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoelaidic acid

MeSH term MeSH ID Detail
Reperfusion Injury D015427 65 associated lipids
Child Nutrition Disorders D015362 1 associated lipids
Dry Eye Syndromes D015352 10 associated lipids
Wounds, Penetrating D014950 10 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Varicose Ulcer D014647 4 associated lipids
Varicocele D014646 4 associated lipids
Tuberculosis D014376 20 associated lipids
Tremor D014202 15 associated lipids
Tinea Versicolor D014010 5 associated lipids
Thrombosis D013927 49 associated lipids
Stomach Ulcer D013276 75 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Starvation D013217 47 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Spirochaetales Infections D013145 2 associated lipids
Sigmoid Neoplasms D012811 5 associated lipids
Seizures D012640 87 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoelaidic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoelaidic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Linoelaidic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoelaidic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoelaidic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoelaidic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoelaidic acid

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Per page 10 20 50 100 | Total 5580
Authors Title Published Journal PubMed Link
Moran JH et al. Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s. 2000 Toxicol. Appl. Pharmacol. pmid:11042099
Ha J et al. Effect of linoleic acid metabolites on Na(+)/K(+) pump current in N20.1 oligodendrocytes: role of membrane fluidity. 2002 Toxicol. Appl. Pharmacol. pmid:12127265
Moran JH et al. Cytotoxicity of linoleic acid diols to renal proximal tubular cells. 1997 Toxicol. Appl. Pharmacol. pmid:9299596
Moran JH et al. Linoleic acid prevents chloride influx and cellular lysis in rabbit renal proximal tubules exposed to mitochondrial toxicants. 2001 Toxicol. Appl. Pharmacol. pmid:11714247
Yu WK and Wells PG Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice. 1995 Toxicol. Appl. Pharmacol. pmid:7878664
Wey HE et al. Essential fatty acid deficiency in cultured human keratinocytes attenuates toxicity due to lipid peroxidation. 1993 Toxicol. Appl. Pharmacol. pmid:8511784
Moran JH et al. Analysis of the toxic effects of linoleic acid, 12,13-cis-epoxyoctadecenoic acid, and 12,13-dihydroxyoctadecenoic acid in rabbit renal cortical mitochondria. 2001 Toxicol. Appl. Pharmacol. pmid:11298501
Slim R et al. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. 2001 Toxicol. Appl. Pharmacol. pmid:11243918
Alghazeer R et al. Cytotoxicity of oxidised lipids in cultured colonal human intestinal cancer cells (caco-2 cells). 2008 Toxicol. Lett. pmid:18625293
Shchepinov MS et al. Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease. 2011 Toxicol. Lett. pmid:21906664